{"id":"https://openalex.org/W2080086131","doi":"https://doi.org/10.1093/nar/11.8.2391","title":"Coordinate regulation of multiple histone mRNAs during the cell cycle in HeLa cells","display_name":"Coordinate regulation of multiple histone mRNAs during the cell cycle in HeLa cells","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W2080086131","doi":"https://doi.org/10.1093/nar/11.8.2391","mag":"2080086131","pmid":"https://pubmed.ncbi.nlm.nih.gov/6304651","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/325892"},"language":"en","primary_location":{"id":"doi:10.1093/nar/11.8.2391","doi":"https://doi.org/10.1093/nar/11.8.2391","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/11.8.2391","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC325892","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109122075","display_name":"Mark Plumb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Plumb","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology Gainesville, FL 32610, USA","Department of Immunology and Medical Microbiology, University of Florida College of Medicine Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Immunology and Medical Microbiology, University of Florida College of Medicine Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081119848","display_name":"Janet Lee Stein","orcid":"https://orcid.org/0000-0002-2474-6822","observed_orcids":["https://orcid.org/0000-0002-2474-6822"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Stein","raw_affiliation_strings":["Department of Immunology and Medical Microbiology, University of Florida College of Medicine Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Medical Microbiology, University of Florida College of Medicine Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110166645","display_name":"Gary Stein","orcid":"https://orcid.org/0000-0001-8762-5422","observed_orcids":["https://orcid.org/0000-0001-8762-5422"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Stein","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":10.1509,"has_fulltext":false,"cited_by_count":255,"citation_normalized_percentile":{"value":0.99063147,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"8","first_page":"2391","last_page":"2410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-gene-expression","display_name":"histone gene expression","score":0.8240000009536743},{"id":"https://openalex.org/keywords/histone-mrna","display_name":"histone mRNA","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.7789999842643738},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mrna-turnover","display_name":"mRNA turnover","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.6909999847412109},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/uridine-incorporation","display_name":"uridine incorporation","score":0.6079999804496765},{"id":"https://openalex.org/keywords/hybrid-selection","display_name":"hybrid selection","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8847492337226868},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.671212375164032},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6589018106460571},{"id":"https://openalex.org/C56428682","wikidata":"https://www.wikidata.org/wiki/Q24785535","display_name":"Histone H2A","level":4,"score":0.6356037259101868},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.52606600522995},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5032536387443542},{"id":"https://openalex.org/C177707886","wikidata":"https://www.wikidata.org/wiki/Q48520","display_name":"Northern blot","level":4,"score":0.44748812913894653},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.4437284767627716},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.44037219882011414},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2916366755962372},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2772268056869507},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17105117440223694},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004262","descriptor_name":"DNA Restriction Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/11.8.2391","doi":"https://doi.org/10.1093/nar/11.8.2391","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/11.8.2391","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:281532","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC325892","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:325892","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/325892","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:6304651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6304651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:281532","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC325892","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1525654309","https://openalex.org/W1964969571","https://openalex.org/W1965750059","https://openalex.org/W1971175260","https://openalex.org/W1975477949","https://openalex.org/W1977532037","https://openalex.org/W1977895530","https://openalex.org/W1980018308","https://openalex.org/W1986932375","https://openalex.org/W1997362516","https://openalex.org/W1998231415","https://openalex.org/W1999101011","https://openalex.org/W1999685455","https://openalex.org/W2004054087","https://openalex.org/W2009115308","https://openalex.org/W2009138461","https://openalex.org/W2014038211","https://openalex.org/W2017791865","https://openalex.org/W2022834770","https://openalex.org/W2024441020","https://openalex.org/W2024875576","https://openalex.org/W2034219588","https://openalex.org/W2039416580","https://openalex.org/W2039474732","https://openalex.org/W2041383836","https://openalex.org/W2047835913","https://openalex.org/W2055478880","https://openalex.org/W2056892578","https://openalex.org/W2057528421","https://openalex.org/W2058569508","https://openalex.org/W2063450941","https://openalex.org/W2065979650","https://openalex.org/W2069148911","https://openalex.org/W2071581153","https://openalex.org/W2072993595","https://openalex.org/W2075956107","https://openalex.org/W2081612977","https://openalex.org/W2087498684","https://openalex.org/W2104755398","https://openalex.org/W4242845182","https://openalex.org/W4324263194","https://openalex.org/W7099918793"],"related_works":["https://openalex.org/W2049476059","https://openalex.org/W1922007066","https://openalex.org/W2075956107","https://openalex.org/W24047619","https://openalex.org/W2071581153","https://openalex.org/W2588811523","https://openalex.org/W1851773867","https://openalex.org/W6958974934","https://openalex.org/W1529579173","https://openalex.org/W2127777383"],"abstract_inverted_index":{"Core":[0],"histone":[1,21,26,61,104,123,151],"gene":[2,22],"expression":[3],"in":[4,47,51,71,116,125,129,144],"HeLa":[5,158],"S3":[6],"cells":[7],"has":[8],"been":[9],"examined":[10],"as":[11],"a":[12,90,133],"function":[13],"of":[14,54,101,122,132],"the":[15,72,130,148,157],"cell":[16,73,159],"cycle":[17],"using":[18],"cloned":[19],"human":[20],"probes.":[23],"Total":[24],"cellular":[25],"mRNAs":[27,62,105,124,152],"were":[28,82],"analyzed":[29],"by":[30,77],"Northern":[31],"blot":[32],"analysis,":[33],"and":[34,84,92],"their":[35,107],"relative":[36],"abundance":[37],"shown":[38],"to":[39,43,87],"be":[40],"temporally":[41],"coupled":[42],"DNA":[44],"synthesis":[45],"rates":[46],"S":[48,118,127],"phase.":[49,119],"The":[50,120],"vivo":[52],"incorporation":[53,100],"3H-uridine":[55,102],"into":[56,103],"at":[57,68],"least":[58],"fifteen":[59],"heterologous":[60],"(in":[63],"one":[64],"hour":[65],"pulse":[66],"intervals":[67],"various":[69],"times":[70],"cycle),":[74],"was":[75],"monitored":[76],"hybrid":[78],"selection.":[79],"Hybridized":[80],"RNAs":[81],"eluted":[83],"resolved":[85],"electrophoretically":[86],"give":[88],"both":[89],"quantitative":[91],"qualitative":[93],"assay":[94],"for":[95],"multiple":[96,150],"mRNA":[97],"species.":[98],"Maximal":[99],"precedes":[106],"maximal":[108],"accumulation,":[109],"indicating":[110,138],"that":[111,139],"transcriptional":[112],"regulation":[113,141],"is":[114,142],"predominant":[115,143],"early":[117],"turnover":[121],"late":[126,145],"occurs":[128],"presence":[131],"reduced":[134],"apparent":[135],"transcription":[136],"rate,":[137],"post-transcriptional":[140],"S.":[146],"All":[147],"detected":[149],"are":[153],"coordinately":[154],"regulated":[155],"during":[156],"cycle.":[160]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
