{"id":"https://openalex.org/W2080075376","doi":"https://doi.org/10.1097/00007890-198805000-00018","title":"EFFECT OF BLOOD TRANSFUSION ON IL-2 PRODUCTION","display_name":"EFFECT OF BLOOD TRANSFUSION ON IL-2 PRODUCTION","publication_year":1988,"publication_date":"1988-05-01","ids":{"openalex":"https://openalex.org/W2080075376","doi":"https://doi.org/10.1097/00007890-198805000-00018","mag":"2080075376","pmid":"https://pubmed.ncbi.nlm.nih.gov/2967000"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-198805000-00018","doi":"https://doi.org/10.1097/00007890-198805000-00018","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-198805000-00018","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113573973","display_name":"MARY LEE WOOD","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARY L. WOOD","raw_affiliation_strings":["Department of Surgery, Harvard Medical School, Boston, Massachusetts 02140","Mary L. Wood, Cancer Research Institute, New England Deaconess Hospital, 185 Pilgrim Road, Boston, MA 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Harvard Medical School, Boston, Massachusetts 02140","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Mary L. Wood, Cancer Research Institute, New England Deaconess Hospital, 185 Pilgrim Road, Boston, MA 02215","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065633128","display_name":"Rita Gottschalk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RITA GOTTSCHALK","raw_affiliation_strings":["Department of Surgery, Harvard Medical School and New England Deaconess Hospital, Boston, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Harvard Medical School and New England Deaconess Hospital, Boston, Massachusetts 02140","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038938677","display_name":"Anthony P. Monaco","orcid":"https://orcid.org/0000-0001-7480-3197","observed_orcids":["https://orcid.org/0000-0001-7480-3197"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ANTHONY P. MONACO","raw_affiliation_strings":["Department of Surgery, Harvard Medical School and New England Deaconess Hospital, Boston, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Harvard Medical School and New England Deaconess Hospital, Boston, Massachusetts 02140","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":0.8762,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.73778977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"45","issue":"5","first_page":"930","last_page":"935"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.9710000157356262},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.8069999814033508},{"id":"https://openalex.org/keywords/suppressor-macrophages","display_name":"suppressor macrophages","score":0.7400000095367432},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.906000018119812},{"id":"https://openalex.org/keywords/il-2-receptor","display_name":"interleukin-2 receptor","score":0.699999988079071},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.4180000126361847},{"id":"https://openalex.org/keywords/b10-a-mice","display_name":"B10.A mice","score":0.7129999995231628},{"id":"https://openalex.org/keywords/b10-d2-mice","display_name":"B10.D2 mice","score":0.9409999847412109},{"id":"https://openalex.org/keywords/suppressor-cells","display_name":"suppressor cells","score":0.4580000042915344},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.42899999022483826},{"id":"https://openalex.org/keywords/sephadex-g-10","display_name":"Sephadex G-10","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6941878795623779},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6397421956062317},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6236343383789062},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6227062940597534},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5705563426017761},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5556532740592957},{"id":"https://openalex.org/C163994747","wikidata":"https://www.wikidata.org/wiki/Q2916358","display_name":"Sephadex","level":3,"score":0.5199602842330933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4426979124546051},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3310810923576355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3081798553466797},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23719576001167297},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1690993309020996},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06753462553024292},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015375","descriptor_name":"Receptors, Interleukin-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-198805000-00018","doi":"https://doi.org/10.1097/00007890-198805000-00018","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-198805000-00018","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:2967000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2967000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1410635241","display_name":"Induction of Tolerance to Allografts","funder_award_id":"R01AI014551","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5801630174","display_name":null,"funder_award_id":"5 R01 AI14551-10","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2474523517","https://openalex.org/W2095213570","https://openalex.org/W2059657413","https://openalex.org/W4254689399","https://openalex.org/W2031803221","https://openalex.org/W2020694122","https://openalex.org/W2298853923","https://openalex.org/W2026957866","https://openalex.org/W2464878522","https://openalex.org/W1927787393"],"abstract_inverted_index":{"Spleen":[0],"cells":[1,56,89,123,148,177,204,228,294,327],"from":[2,90,149,229,295,328],"B10.A":[3,15,31,91,116,158],"mice":[4,32,69,92,117,151,231,265,276,299,330,346],"transfused":[5,68,150,230,264,275,298,329,345],"with":[6,136,192],"B10.D2":[7,17,48,100],"blood":[8,208],"suppress":[9,106],"the":[10,28,55,58,65,85,103,145,153,166,169,176,187,202,211,221,244,251,260,280,334,342],"immune":[11],"responses":[12,113],"of":[13,30,67,80,114,156,175,213,223,246,253,263,272,282,317,344],"normal":[14,115,157,267,296,312],"to":[16,33,53,62,70,77,105,144,237,266,303,323,336,347,357,360],"in":[18,35,118,349,355],"coculture":[19],"as":[20,22,42,44,331],"early":[21,43],"2":[23,45,95,160,288],"days":[24,46,98,163,291],"posttransfusion.":[25,292],"In":[26,249],"addition,":[27,250],"ability":[29,104,236,302],"respond":[34,348],"cell-mediated":[36],"lymphocytotoxicity":[37],"(CML)":[38],"is":[39,75,311,351],"significantly":[40,285],"impaired":[41],"after":[47,99,207,313],"transfusion.":[49,314],"Experiments":[50],"were":[51,93,124,232],"performed":[52],"characterize":[54,84],"mediating":[57],"suppressive":[59,188],"effect":[60,167,222,252],"and":[61,111,161,215,240,242,256,289,297],"determine":[63,220],"whether":[64],"inability":[66,343,359],"generate":[71],"a":[72,128],"cytotoxic":[73],"response":[74,155,171,262,335],"due":[76],"an":[78,358],"inhibition":[79],"IL-2":[81,226,241,247,257,283,308],"production.":[82],"To":[83,219],"suppressor":[86,122,203],"cells,":[87],"spleen":[88],"assayed":[94,233],"or":[96,131,139,181],"16":[97,162,290],"transfusion":[101,209,224],"for":[102,234,243],"mixed":[107],"lymphocyte":[108],"culture":[109],"(MLC)":[110],"CML":[112,154,261,324,350],"coculture.":[119,146],"The":[120,270,315],"putative":[121],"either":[125],"passed":[126],"over":[127,178],"Sephadex":[129,179],"G-10":[130,180],"nylon":[132,182],"wool":[133,183],"column,":[134],"treated":[135],"anti-Thy":[137,193],"antibody":[138,194],"left":[140],"untreated":[141],"before":[142,184],"addition":[143,316],"Untreated":[147],"suppressed":[152,286],"both":[159,287],"posttransfusion,":[164],"while":[165,190,279],"on":[168,225,258],"MLC":[170],"was":[172,268,277,284],"inconsistent.":[173],"Passage":[174],"assaying":[185],"abrogated":[186],"effect,":[189],"treatment":[191],"had":[195],"no":[196],"effect.":[197],"These":[198,338],"results":[199,339],"suggest":[200],"that":[201,307,341],"appearing":[205],"shortly":[206],"have":[210],"characteristics":[212],"macrophages":[214],"not":[216,321],"T":[217],"lymphocytes.":[218],"production,":[227],"their":[235],"produce":[238,361],"IL-1":[239,255,273],"formation":[245,310],"receptors.":[248],"exogenous":[254,318],"restoring":[259],"assayed.":[269],"production":[271,281],"by":[274,367,370],"normal,":[278],"Activated":[293],"showed":[300],"equal":[301],"absorb":[304],"IL-2,":[305,319],"indicating":[306],"receptor":[309],"but":[320],"IL-1,":[322],"cultures":[325],"containing":[326],"responders":[332],"restored":[333],"normal.":[337],"indicate":[340],"due,":[352],"at":[353],"least":[354],"part,":[356],"IL-2.":[362],"This":[363],"could":[364],"be":[365],"mediated":[366],"prostaglandins":[368],"released":[369],"activated":[371],"macrophages.":[372]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
