{"id":"https://openalex.org/W2079999128","doi":"https://doi.org/10.1016/j.ejps.2003.08.004","title":"Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice","display_name":"Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice","publication_year":2003,"publication_date":"2003-10-15","ids":{"openalex":"https://openalex.org/W2079999128","doi":"https://doi.org/10.1016/j.ejps.2003.08.004","mag":"2079999128","pmid":"https://pubmed.ncbi.nlm.nih.gov/14592702"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejps.2003.08.004","doi":"https://doi.org/10.1016/j.ejps.2003.08.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejps.2003.08.004","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049438575","display_name":"Koichi Tan\u2013No","orcid":"https://orcid.org/0000-0001-6724-848X","observed_orcids":["https://orcid.org/0000-0001-6724-848X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Koichi Tan-No","raw_affiliation_strings":["Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima Aoba-ku, Sendai 981-8558, Japan. koichi@tohoku-pharm.ac.jp","Department of Pharmacology, Tohoku Pharmaceutical University, 4\u20134\u20131 Komatsushima, Aoba-ku, Sendai 981\u20138558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima Aoba-ku, Sendai 981-8558, Japan. koichi@tohoku-pharm.ac.jp","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, Tohoku Pharmaceutical University, 4\u20134\u20131 Komatsushima, Aoba-ku, Sendai 981\u20138558, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111978376","display_name":"Fukie Niijima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fukie Niijima","raw_affiliation_strings":["Department of Pharmacology, Tohoku Pharmaceutical University, 4\u20134\u20131 Komatsushima, Aoba-ku, Sendai 981\u20138558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tohoku Pharmaceutical University, 4\u20134\u20131 Komatsushima, Aoba-ku, Sendai 981\u20138558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046902868","display_name":"Osamu Nakagawasai","orcid":"https://orcid.org/0000-0002-4061-0802","observed_orcids":["https://orcid.org/0000-0002-4061-0802"]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Nakagawasai","raw_affiliation_strings":["Department of Pharmacology, Tohoku Pharmaceutical University, 4\u20134\u20131 Komatsushima, Aoba-ku, Sendai 981\u20138558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tohoku Pharmaceutical University, 4\u20134\u20131 Komatsushima, Aoba-ku, Sendai 981\u20138558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103189730","display_name":"Takumi Sato","orcid":"https://orcid.org/0000-0001-7699-8768","observed_orcids":["https://orcid.org/0000-0001-7699-8768"]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takumi Sato","raw_affiliation_strings":["Educational Center for Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Educational Center for Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113532678","display_name":"Susumu Satoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Satoh","raw_affiliation_strings":["Educational Center for Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Educational Center for Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112688384","display_name":"Takeshi Tadano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Tadano","raw_affiliation_strings":["Department of Pharmacology, Tohoku Pharmaceutical University, 4\u20134\u20131 Komatsushima, Aoba-ku, Sendai 981\u20138558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tohoku Pharmaceutical University, 4\u20134\u20131 Komatsushima, Aoba-ku, Sendai 981\u20138558, Japan","institution_ids":["https://openalex.org/I85324120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049438575"],"corresponding_institution_ids":[],"apc_list":{"value":3070,"currency":"USD","value_usd":3070},"apc_paid":null,"fwci":1.4914,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.83194519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"3","first_page":"357","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loperamide","display_name":"loperamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.7789999842643738},{"id":"https://openalex.org/keywords/opioid-tolerance","display_name":"opioid tolerance","score":0.7609999775886536},{"id":"https://openalex.org/keywords/mu-opioid-receptor-agonists","display_name":"mu-opioid receptor agonists","score":0.8489999771118164},{"id":"https://openalex.org/keywords/gastrointestinal-transit","display_name":"gastrointestinal transit","score":0.8939999938011169},{"id":"https://openalex.org/keywords/constipation","display_name":"constipation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/drug-efflux-pumps","display_name":"drug efflux pumps","score":0.8080000281333923},{"id":"https://openalex.org/keywords/antidiarrheal-agents","display_name":"antidiarrheal agents","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C2777573665","wikidata":"https://www.wikidata.org/wiki/Q423751","display_name":"Loperamide","level":3,"score":0.9896507263183594},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.7360689043998718},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6280918121337891},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6058511734008789},{"id":"https://openalex.org/C2779985140","wikidata":"https://www.wikidata.org/wiki/Q1425425","display_name":"Drug tolerance","level":2,"score":0.4956012964248657},{"id":"https://openalex.org/C2911073721","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal transit","level":2,"score":0.49112197756767273},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.4378143548965454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3976103663444519},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38140225410461426},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3644154667854309},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3619856536388397},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32868534326553345},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.09585389494895935}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005772","descriptor_name":"Gastrointestinal Transit","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005772","descriptor_name":"Gastrointestinal Transit","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008139","descriptor_name":"Loperamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejps.2003.08.004","doi":"https://doi.org/10.1016/j.ejps.2003.08.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejps.2003.08.004","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:14592702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14592702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1510301222","https://openalex.org/W1518096905","https://openalex.org/W1964470226","https://openalex.org/W1969686168","https://openalex.org/W1974856490","https://openalex.org/W1982000283","https://openalex.org/W1990474450","https://openalex.org/W1990509385","https://openalex.org/W2002619956","https://openalex.org/W2007174401","https://openalex.org/W2049520769","https://openalex.org/W2070410120","https://openalex.org/W2078364405","https://openalex.org/W2078587023","https://openalex.org/W2081577644","https://openalex.org/W2086141451","https://openalex.org/W2088060636","https://openalex.org/W2088453708","https://openalex.org/W2160296151","https://openalex.org/W2401188729","https://openalex.org/W4241665788"],"related_works":["https://openalex.org/W1561017277","https://openalex.org/W1982000283","https://openalex.org/W2272187774","https://openalex.org/W2327641561","https://openalex.org/W2269332751","https://openalex.org/W1973640136","https://openalex.org/W2411848109","https://openalex.org/W2220972777","https://openalex.org/W2356540179","https://openalex.org/W2086141451"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
