{"id":"https://openalex.org/W2079949985","doi":"https://doi.org/10.1016/s0303-7207(99)00032-5","title":"DNA binding and interaction with the nuclear receptor corepressor of thyroid hormone receptor are required for ligand-independent stimulation of the mouse preprothyrotropin-releasing hormone gene","display_name":"DNA binding and interaction with the nuclear receptor corepressor of thyroid hormone receptor are required for ligand-independent stimulation of the mouse preprothyrotropin-releasing hormone gene","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2079949985","doi":"https://doi.org/10.1016/s0303-7207(99)00032-5","mag":"2079949985","pmid":"https://pubmed.ncbi.nlm.nih.gov/10509808"},"language":"en","primary_location":{"id":"doi:10.1016/s0303-7207(99)00032-5","doi":"https://doi.org/10.1016/s0303-7207(99)00032-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0303-7207(99)00032-5","pdf_url":null,"source":{"id":"https://openalex.org/S191044671","display_name":"Molecular and Cellular Endocrinology","issn_l":"0303-7207","issn":["0303-7207","1872-8057"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110156003","display_name":"Teturou Satoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Teturou Satoh","raw_affiliation_strings":["First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan. tsato@sb.gunma-u.ac.jp","First Department of Internal Medicine, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi 371-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan. tsato@sb.gunma-u.ac.jp","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"First Department of Internal Medicine, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111646452","display_name":"Tsuyoshi Monden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Monden","raw_affiliation_strings":["First Department of Internal Medicine, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi 371-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110445742","display_name":"Takahiro Ishizuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Ishizuka","raw_affiliation_strings":["First Department of Internal Medicine, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi 371-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109191308","display_name":"Tomoaki Mitsuhashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoaki Mitsuhashi","raw_affiliation_strings":["Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103284218","display_name":"Masanobu Yamada","orcid":"https://orcid.org/0000-0002-2142-633X","observed_orcids":["https://orcid.org/0000-0002-2142-633X"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanobu Yamada","raw_affiliation_strings":["First Department of Internal Medicine, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi 371-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102099209","display_name":"Masatomo Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatomo Mori","raw_affiliation_strings":["First Department of Internal Medicine, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi 371-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110156003"],"corresponding_institution_ids":["https://openalex.org/I165735259"],"apc_list":{"value":3510,"currency":"USD","value_usd":3510},"apc_paid":null,"fwci":1.8309,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.84400893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"154","issue":"1-2","first_page":"137","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.42500001192092896,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.42500001192092896,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.3499000072479248,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.08240000158548355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-hormone-receptor","display_name":"thyroid hormone receptor","score":0.9779999852180481},{"id":"https://openalex.org/keywords/nuclear-receptor-corepressor","display_name":"nuclear receptor corepressor","score":0.8199999928474426},{"id":"https://openalex.org/keywords/ligand-independent-transcriptional-activation","display_name":"ligand-independent transcriptional activation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/retinoid-x-receptor","display_name":"retinoid X receptor","score":0.8149999976158142},{"id":"https://openalex.org/keywords/receptor-dimerization","display_name":"receptor dimerization","score":0.6209999918937683},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C146777309","wikidata":"https://www.wikidata.org/wiki/Q1132599","display_name":"Corepressor","level":5,"score":0.8198096752166748},{"id":"https://openalex.org/C109115496","wikidata":"https://www.wikidata.org/wiki/Q2539644","display_name":"Thyroid hormone receptor","level":3,"score":0.7939484715461731},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6071312427520752},{"id":"https://openalex.org/C51445715","wikidata":"https://www.wikidata.org/wiki/Q410477","display_name":"Hormone response element","level":5,"score":0.5733413100242615},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.5566846132278442},{"id":"https://openalex.org/C183978625","wikidata":"https://www.wikidata.org/wiki/Q903596","display_name":"Electrophoretic mobility shift assay","level":4,"score":0.5053830146789551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49421122670173645},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.48586031794548035},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.48556849360466003},{"id":"https://openalex.org/C160860887","wikidata":"https://www.wikidata.org/wiki/Q18031986","display_name":"Thyroid hormone receptor alpha","level":5,"score":0.43835288286209106},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4367339611053467},{"id":"https://openalex.org/C128821507","wikidata":"https://www.wikidata.org/wiki/Q3454518","display_name":"Retinoid X receptor","level":5,"score":0.41731858253479004},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3572385609149933},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3074498176574707},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24077251553535461},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19462046027183533},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07162201404571533},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.05235329270362854},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056971","descriptor_name":"Nuclear Receptor Co-Repressor 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0303-7207(99)00032-5","doi":"https://doi.org/10.1016/s0303-7207(99)00032-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0303-7207(99)00032-5","pdf_url":null,"source":{"id":"https://openalex.org/S191044671","display_name":"Molecular and Cellular Endocrinology","issn_l":"0303-7207","issn":["0303-7207","1872-8057"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Endocrinology","raw_type":"journal-article"},{"id":"pmid:10509808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10509808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W266477159","https://openalex.org/W311062589","https://openalex.org/W1483740421","https://openalex.org/W1524230030","https://openalex.org/W1547233041","https://openalex.org/W1588998681","https://openalex.org/W1598062712","https://openalex.org/W1970316586","https://openalex.org/W1972093962","https://openalex.org/W1972473911","https://openalex.org/W1981352359","https://openalex.org/W1985149481","https://openalex.org/W1986729598","https://openalex.org/W1990613292","https://openalex.org/W1995982458","https://openalex.org/W1998861020","https://openalex.org/W2000932762","https://openalex.org/W2007894474","https://openalex.org/W2011467252","https://openalex.org/W2016045432","https://openalex.org/W2024725484","https://openalex.org/W2026441085","https://openalex.org/W2027506189","https://openalex.org/W2029156328","https://openalex.org/W2033951853","https://openalex.org/W2038228771","https://openalex.org/W2039412078","https://openalex.org/W2049690354","https://openalex.org/W2055005788","https://openalex.org/W2055053601","https://openalex.org/W2056724579","https://openalex.org/W2060696024","https://openalex.org/W2063295358","https://openalex.org/W2063679634","https://openalex.org/W2064376022","https://openalex.org/W2068113812","https://openalex.org/W2068733538","https://openalex.org/W2069532898","https://openalex.org/W2070136069","https://openalex.org/W2075932427","https://openalex.org/W2076376728","https://openalex.org/W2083118347","https://openalex.org/W2085205986","https://openalex.org/W2090024435","https://openalex.org/W2093035480","https://openalex.org/W2097724305","https://openalex.org/W2119671728","https://openalex.org/W2134812217","https://openalex.org/W2140340936","https://openalex.org/W2142640185","https://openalex.org/W2143241514","https://openalex.org/W2145221641","https://openalex.org/W2155754912","https://openalex.org/W2409258464","https://openalex.org/W4229958257","https://openalex.org/W4254624568"],"related_works":["https://openalex.org/W3142686958","https://openalex.org/W2024725484","https://openalex.org/W1534969211","https://openalex.org/W2082066568","https://openalex.org/W2022853974","https://openalex.org/W2020453213","https://openalex.org/W1983883876","https://openalex.org/W7100915492","https://openalex.org/W2141262432","https://openalex.org/W2014035689"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}