{"id":"https://openalex.org/W2079945228","doi":"https://doi.org/10.1002/(sici)1520-6823(1999)7:4<238::aid-roi5>3.0.co;2-4","title":"Circulating thrombomodulin during radiation therapy of lung cancer","display_name":"Circulating thrombomodulin during radiation therapy of lung cancer","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2079945228","doi":"https://doi.org/10.1002/(sici)1520-6823(1999)7:4<238::aid-roi5>3.0.co;2-4","mag":"2079945228","pmid":"https://pubmed.ncbi.nlm.nih.gov/10492164"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1520-6823(1999)7:4<238::aid-roi5>3.0.co;2-4","doi":"https://doi.org/10.1002/(sici)1520-6823(1999)7:4<238::aid-roi5>3.0.co;2-4","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6823(1999)7:4<238::aid-roi5>3.0.co;2-4","pdf_url":null,"source":{"id":"https://openalex.org/S79747828","display_name":"Radiation Oncology Investigations","issn_l":"1065-7541","issn":["1065-7541","1520-6823"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Oncology Investigations","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014015669","display_name":"Martin Hauer\u2010Jensen","orcid":"https://orcid.org/0000-0003-1776-4325","observed_orcids":["https://orcid.org/0000-0003-1776-4325"]},"institutions":[{"id":"https://openalex.org/I4210099013","display_name":"Central Arkansas Veterans Healthcare System","ror":"https://ror.org/01s5r6w32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099013","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martin Hauer-Jensen","raw_affiliation_strings":["Department of Surgery, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, USA. mhjensen@life.uams.edu","Departments of Surgery and Pathology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, USA. mhjensen@life.uams.edu","institution_ids":["https://openalex.org/I4210099013","https://openalex.org/I79620101"]},{"raw_affiliation_string":"Departments of Surgery and Pathology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas","institution_ids":["https://openalex.org/I4210099013","https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087107933","display_name":"Feng\u2010Ming Kong","orcid":"https://orcid.org/0000-0003-2652-098X","observed_orcids":["https://orcid.org/0000-0003-2652-098X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng-Ming Kong","raw_affiliation_strings":["Department of Radiation Oncology, Duke Comprehensive Cancer Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Duke Comprehensive Cancer Center, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111499875","display_name":"Louis M. Fink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099013","display_name":"Central Arkansas Veterans Healthcare System","ror":"https://ror.org/01s5r6w32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099013","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis M. Fink","raw_affiliation_strings":["Departments of Surgery and Pathology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery and Pathology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas","institution_ids":["https://openalex.org/I4210099013","https://openalex.org/I79620101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069874449","display_name":"Mitchell Steven Anscher","orcid":"https://orcid.org/0000-0003-4480-111X","observed_orcids":["https://orcid.org/0000-0003-4480-111X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell S. Anscher","raw_affiliation_strings":["Department of Radiation Oncology, Duke Comprehensive Cancer Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Duke Comprehensive Cancer Center, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5014015669"],"corresponding_institution_ids":["https://openalex.org/I4210099013","https://openalex.org/I79620101"],"apc_list":null,"apc_paid":null,"fwci":0.6396,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.70415225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"4","first_page":"238","last_page":"242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombomodulin","display_name":"thrombomodulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7870000004768372},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7720000147819519},{"id":"https://openalex.org/keywords/radiation-pneumonitis","display_name":"radiation pneumonitis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.7490000128746033},{"id":"https://openalex.org/keywords/pulmonary-toxicity","display_name":"pulmonary toxicity","score":0.8840000033378601},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/anticoagulants","display_name":"anticoagulants","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C201267052","wikidata":"https://www.wikidata.org/wiki/Q414446","display_name":"Thrombomodulin","level":4,"score":0.7353826761245728},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7015080451965332},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6361833810806274},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.6133148074150085},{"id":"https://openalex.org/C2781047374","wikidata":"https://www.wikidata.org/wiki/Q2100012","display_name":"Pulmonary toxicity","level":3,"score":0.5400631427764893},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5311974883079529},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5128788948059082},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5035256743431091},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4414016306400299},{"id":"https://openalex.org/C2779524853","wikidata":"https://www.wikidata.org/wiki/Q1284347","display_name":"Pneumonitis","level":3,"score":0.4233395457267761},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42059704661369324},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3540247082710266},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32582131028175354},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.13345679640769958},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.0},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017564","descriptor_name":"Radiation Pneumonitis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017564","descriptor_name":"Radiation Pneumonitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018180","descriptor_name":"Thrombomodulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018180","descriptor_name":"Thrombomodulin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1520-6823(1999)7:4<238::aid-roi5>3.0.co;2-4","doi":"https://doi.org/10.1002/(sici)1520-6823(1999)7:4<238::aid-roi5>3.0.co;2-4","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6823(1999)7:4<238::aid-roi5>3.0.co;2-4","pdf_url":null,"source":{"id":"https://openalex.org/S79747828","display_name":"Radiation Oncology Investigations","issn_l":"1065-7541","issn":["1065-7541","1520-6823"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Oncology Investigations","raw_type":"journal-article"},{"id":"pmid:10492164","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10492164","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation oncology investigations","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W18465970","https://openalex.org/W128594463","https://openalex.org/W1968608979","https://openalex.org/W1968875608","https://openalex.org/W1983689939","https://openalex.org/W1992560568","https://openalex.org/W1993858850","https://openalex.org/W1999799629","https://openalex.org/W2027321575","https://openalex.org/W2031077003","https://openalex.org/W2057806187","https://openalex.org/W2136845661","https://openalex.org/W2150608680","https://openalex.org/W2155219561","https://openalex.org/W2160714396","https://openalex.org/W2169145856","https://openalex.org/W2170329263","https://openalex.org/W2316328517","https://openalex.org/W2328363504","https://openalex.org/W2332407578","https://openalex.org/W2336807421","https://openalex.org/W2402274498","https://openalex.org/W2410208688","https://openalex.org/W2418294310","https://openalex.org/W2465227200","https://openalex.org/W2475186960"],"related_works":["https://openalex.org/W1999799629","https://openalex.org/W2091841629","https://openalex.org/W2030647416","https://openalex.org/W2371647259","https://openalex.org/W2328363504","https://openalex.org/W2069901637","https://openalex.org/W2413960876","https://openalex.org/W1993858850","https://openalex.org/W2032393507","https://openalex.org/W2150167499"],"abstract_inverted_index":{"The":[0,29,124],"endothelial":[1],"cell":[2,18],"glycoprotein,":[3],"thrombomodulin":[4],"(TM),":[5],"is":[6,12],"an":[7],"important":[8],"physiological":[9],"anticoagulant.":[10],"TM":[11,34,59,87,109,128],"downregulated":[13],"and":[14,26,40],"released":[15],"from":[16],"the":[17,21,90,98,111],"membrane":[19],"into":[20],"circulation":[22],"by":[23],"ionizing":[24],"radiation":[25,42,50,68,115],"during":[27,89,110],"inflammation.":[28],"present":[30],"study":[31,103],"measured":[32],"plasma":[33,86,127],"in":[35,64,85],"17":[36],"patients":[37,48,55,65,72],"before,":[38],"during,":[39],"after":[41],"therapy":[43,116],"of":[44,100,108,114,126,132],"lung":[45],"cancer:":[46],"nine":[47],"developed":[49,67],"pneumonitis,":[51],"whereas":[52],"eight":[53],"matched":[54],"did":[56,60,74],"not.":[57],"Plasma":[58],"not":[61,75],"change":[62],"significantly":[63],"who":[66,73],"pneumonitis.":[69],"In":[70],"contrast,":[71],"develop":[76],"pneumonitis":[77],"exhibited":[78],"a":[79,130],"moderate,":[80],"but":[81],"statistically":[82],"significant,":[83],"decrease":[84],"antigen":[88],"initial":[91],"1-2":[92],"weeks,":[93],"with":[94,120],"complete":[95],"normalization":[96],"towards":[97],"end":[99],"treatment.":[101],"Our":[102],"suggests":[104],"that":[105],"decreased":[106],"release":[107],"early":[112],"phase":[113],"may":[117],"be":[118],"associated":[119],"reduced":[121],"pulmonary":[122,133],"toxicity.":[123],"use":[125],"as":[129],"marker":[131],"toxicity":[134],"needs":[135],"further":[136],"study.":[137]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}