{"id":"https://openalex.org/W2079928629","doi":"https://doi.org/10.1007/s00436-014-3868-y","title":"Ketanserin, an antidepressant, exerts its antileishmanial action via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) enzyme of Leishmania donovani","display_name":"Ketanserin, an antidepressant, exerts its antileishmanial action via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) enzyme of Leishmania donovani","publication_year":2014,"publication_date":"2014-04-11","ids":{"openalex":"https://openalex.org/W2079928629","doi":"https://doi.org/10.1007/s00436-014-3868-y","mag":"2079928629","pmid":"https://pubmed.ncbi.nlm.nih.gov/24728519"},"language":"en","primary_location":{"id":"doi:10.1007/s00436-014-3868-y","doi":"https://doi.org/10.1007/s00436-014-3868-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00436-014-3868-y","pdf_url":null,"source":{"id":"https://openalex.org/S155128447","display_name":"Parasitology Research","issn_l":"0044-3255","issn":["0044-3255","0932-0113","1432-1955"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033415701","display_name":"Sushma Singh","orcid":"https://orcid.org/0000-0002-7089-6442","observed_orcids":["https://orcid.org/0000-0002-7089-6442"]},"institutions":[{"id":"https://openalex.org/I4210146715","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/040dgqr26","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210146715"]},{"id":"https://openalex.org/I4210152674","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/0418yqg16","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210152674"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sushma Singh","raw_affiliation_strings":["Department of Biotechnology, National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, Punjab, 160062, India, sushmasingh76@rediffmail.com","National Institute of Pharmaceutical Education and Research, SAS Nagar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, Punjab, 160062, India, sushmasingh76@rediffmail.com","institution_ids":["https://openalex.org/I4210152674"]},{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research, SAS Nagar","institution_ids":["https://openalex.org/I4210146715","https://openalex.org/I4210152674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003388207","display_name":"Neeradi Dinesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146715","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/040dgqr26","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210146715"]},{"id":"https://openalex.org/I4210152674","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/0418yqg16","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210152674"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neeradi Dinesh","raw_affiliation_strings":["Department of Biotechnology, National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, Punjab, 160062, India","National Institute of Pharmaceutical Education and Research, SAS Nagar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, Punjab, 160062, India","institution_ids":["https://openalex.org/I4210146715","https://openalex.org/I4210152674"]},{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research, SAS Nagar","institution_ids":["https://openalex.org/I4210146715","https://openalex.org/I4210152674"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Preet Kamal Kaur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146715","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/040dgqr26","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210146715"]},{"id":"https://openalex.org/I4210152674","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/0418yqg16","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210152674"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Preet Kamal Kaur","raw_affiliation_strings":["Department of Biotechnology, National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, Punjab, 160062, India","National Institute of Pharmaceutical Education and Research, SAS Nagar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, Punjab, 160062, India","institution_ids":["https://openalex.org/I4210146715","https://openalex.org/I4210152674"]},{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research, SAS Nagar","institution_ids":["https://openalex.org/I4210146715","https://openalex.org/I4210152674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028636317","display_name":"Baigadda Shamiulla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146715","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/040dgqr26","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210146715"]},{"id":"https://openalex.org/I4210152674","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/0418yqg16","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210152674"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Baigadda Shamiulla","raw_affiliation_strings":["Department of Biotechnology, National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, Punjab, 160062, India","National Institute of Pharmaceutical Education and Research, SAS Nagar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, Punjab, 160062, India","institution_ids":["https://openalex.org/I4210146715","https://openalex.org/I4210152674"]},{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research, SAS Nagar","institution_ids":["https://openalex.org/I4210146715","https://openalex.org/I4210152674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033415701"],"corresponding_institution_ids":["https://openalex.org/I4210146715","https://openalex.org/I4210152674"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":4.2023,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.93988566,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"113","issue":"6","first_page":"2161","last_page":"2168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketanserin","display_name":"ketanserin","score":1.0},{"id":"https://openalex.org/keywords/leishmania-donovani","display_name":"Leishmania donovani","score":0.8539999723434448},{"id":"https://openalex.org/keywords/leishmaniasis","display_name":"leishmaniasis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/3-hydroxy-3-methylglutaryl-coenzyme-a-reductase","display_name":"HMGR","score":0.9380000233650208},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8550000190734863},{"id":"https://openalex.org/keywords/antileishmanial-activity","display_name":"antileishmanial activity","score":0.8679999709129333},{"id":"https://openalex.org/keywords/sterol-biosynthesis","display_name":"sterol biosynthesis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ergosterol","display_name":"ergosterol","score":0.972000002861023},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.7829999923706055},{"id":"https://openalex.org/keywords/promastigotes","display_name":"promastigotes","score":0.9610000252723694},{"id":"https://openalex.org/keywords/amastigotes","display_name":"amastigotes","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2781333301","wikidata":"https://www.wikidata.org/wiki/Q1950752","display_name":"Leishmania donovani","level":4,"score":0.7386224865913391},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7321534752845764},{"id":"https://openalex.org/C98319499","wikidata":"https://www.wikidata.org/wiki/Q455445","display_name":"Amastigote","level":4,"score":0.7151326537132263},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6755873560905457},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.4938662648200989},{"id":"https://openalex.org/C2777910421","wikidata":"https://www.wikidata.org/wiki/Q143263","display_name":"Ergosterol","level":2,"score":0.42377588152885437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4010964035987854},{"id":"https://openalex.org/C2781092759","wikidata":"https://www.wikidata.org/wiki/Q524818","display_name":"Leishmania","level":3,"score":0.37734392285346985},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3611075282096863},{"id":"https://openalex.org/C2776555147","wikidata":"https://www.wikidata.org/wiki/Q331283","display_name":"Leishmaniasis","level":2,"score":0.3045894503593445},{"id":"https://openalex.org/C2778689377","wikidata":"https://www.wikidata.org/wiki/Q2046113","display_name":"Visceral leishmaniasis","level":3,"score":0.15459662675857544},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12403559684753418},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007650","descriptor_name":"Ketanserin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007893","descriptor_name":"Leishmania donovani","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00436-014-3868-y","doi":"https://doi.org/10.1007/s00436-014-3868-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00436-014-3868-y","pdf_url":null,"source":{"id":"https://openalex.org/S155128447","display_name":"Parasitology Research","issn_l":"0044-3255","issn":["0044-3255","0932-0113","1432-1955"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology Research","raw_type":"journal-article"},{"id":"pmid:24728519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24728519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W36714077","https://openalex.org/W1564221315","https://openalex.org/W1823258013","https://openalex.org/W1831714117","https://openalex.org/W1913340848","https://openalex.org/W1968510767","https://openalex.org/W1972323962","https://openalex.org/W1975601694","https://openalex.org/W1977462909","https://openalex.org/W1983349545","https://openalex.org/W1988023982","https://openalex.org/W1992871875","https://openalex.org/W1996308567","https://openalex.org/W1997067185","https://openalex.org/W2005892572","https://openalex.org/W2009372452","https://openalex.org/W2019111075","https://openalex.org/W2024187667","https://openalex.org/W2032441338","https://openalex.org/W2032911852","https://openalex.org/W2040607876","https://openalex.org/W2040924241","https://openalex.org/W2054029713","https://openalex.org/W2054780467","https://openalex.org/W2057677965","https://openalex.org/W2058184221","https://openalex.org/W2062526829","https://openalex.org/W2075961120","https://openalex.org/W2077946350","https://openalex.org/W2080190030","https://openalex.org/W2080788941","https://openalex.org/W2081218928","https://openalex.org/W2102084253","https://openalex.org/W2114602369","https://openalex.org/W2114772759","https://openalex.org/W2114918609","https://openalex.org/W2117945593","https://openalex.org/W2122428796","https://openalex.org/W2167620948","https://openalex.org/W2170956456","https://openalex.org/W2171194568","https://openalex.org/W2321191732","https://openalex.org/W2403636860"],"related_works":["https://openalex.org/W1976696166","https://openalex.org/W2897174881","https://openalex.org/W7166656876","https://openalex.org/W933054156","https://openalex.org/W3198484228","https://openalex.org/W2075961120","https://openalex.org/W2589531516","https://openalex.org/W1974102104","https://openalex.org/W2302665869","https://openalex.org/W3159111601"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}