{"id":"https://openalex.org/W2079927147","doi":"https://doi.org/10.1073/pnas.1210797109","title":"Pathway-specific control of reward learning and its flexibility via selective dopamine receptors in the nucleus accumbens","display_name":"Pathway-specific control of reward learning and its flexibility via selective dopamine receptors in the nucleus accumbens","publication_year":2012,"publication_date":"2012-07-16","ids":{"openalex":"https://openalex.org/W2079927147","doi":"https://doi.org/10.1073/pnas.1210797109","mag":"2079927147","pmid":"https://pubmed.ncbi.nlm.nih.gov/22802650","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3412032"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1210797109","doi":"https://doi.org/10.1073/pnas.1210797109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1210797109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3412032","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016472092","display_name":"Satoshi Yawata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoshi Yawata","raw_affiliation_strings":["Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048025014","display_name":"Takashi Yamaguchi","orcid":"https://orcid.org/0000-0001-5153-940X","observed_orcids":["https://orcid.org/0000-0001-5153-940X","https://orcid.org/0009-0004-6294-8005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi Yamaguchi","raw_affiliation_strings":["Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041928397","display_name":"Teruko Danjo","orcid":"https://orcid.org/0000-0003-1858-8917","observed_orcids":["https://orcid.org/0000-0003-1858-8917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teruko Danjo","raw_affiliation_strings":["Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030950258","display_name":"Takatoshi Hikida","orcid":"https://orcid.org/0000-0002-8653-311X","observed_orcids":["https://orcid.org/0000-0002-8653-311X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takatoshi Hikida","raw_affiliation_strings":["Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110880571","display_name":"Shigetada Nakanishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigetada Nakanishi","raw_affiliation_strings":["Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2373,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.93367918,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"109","issue":"31","first_page":"12764","last_page":"12769"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reward-learning","display_name":"reward learning","score":0.7059999704360962},{"id":"https://openalex.org/keywords/learning-flexibility","display_name":"learning flexibility","score":0.8489999771118164},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9150000214576721},{"id":"https://openalex.org/keywords/dopamine-receptors","display_name":"dopamine receptors","score":0.75},{"id":"https://openalex.org/keywords/dopamine-d1-receptor","display_name":"dopamine D1 receptor","score":0.9309999942779541},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":1.0},{"id":"https://openalex.org/keywords/direct-pathway","display_name":"direct pathway","score":0.9190000295639038},{"id":"https://openalex.org/keywords/indirect-pathway","display_name":"indirect pathway","score":1.0},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.7879999876022339},{"id":"https://openalex.org/keywords/goal-directed-learning","display_name":"goal-directed learning","score":0.6940000057220459},{"id":"https://openalex.org/keywords/tetanus-toxin","display_name":"tetanus toxin","score":0.6140000224113464},{"id":"https://openalex.org/keywords/strategy-switching","display_name":"strategy switching","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.7761765718460083},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6933393478393555},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5803014039993286},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5569258332252502},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.5067251324653625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4752521216869354},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.46609699726104736},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.4460827708244324},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44412797689437866},{"id":"https://openalex.org/C148132819","wikidata":"https://www.wikidata.org/wiki/Q5280374","display_name":"Direct pathway of movement","level":4,"score":0.415077805519104},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3281567692756653},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.19114890694618225},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.10154733061790466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07489201426506042},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013744","descriptor_name":"Tetanus Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018491","descriptor_name":"Dopamine Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1210797109","doi":"https://doi.org/10.1073/pnas.1210797109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1210797109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2555709","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3412032","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3412032","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3412032","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:22802650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22802650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2555709","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3412032","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2571419947","display_name":null,"funder_award_id":"23120011","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5468659179","display_name":"Molecular studies of motor learning and maturation of the cerebellar network","funder_award_id":"22220005","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W16776597","https://openalex.org/W1631357241","https://openalex.org/W1771503649","https://openalex.org/W1971999279","https://openalex.org/W1973788414","https://openalex.org/W1983297775","https://openalex.org/W1984336157","https://openalex.org/W1991603311","https://openalex.org/W1993614295","https://openalex.org/W2011335452","https://openalex.org/W2030749071","https://openalex.org/W2031170958","https://openalex.org/W2031336666","https://openalex.org/W2034457280","https://openalex.org/W2050947962","https://openalex.org/W2058279623","https://openalex.org/W2058578514","https://openalex.org/W2060588252","https://openalex.org/W2061805224","https://openalex.org/W2076457657","https://openalex.org/W2084676667","https://openalex.org/W2090599369","https://openalex.org/W2105511691","https://openalex.org/W2109142787","https://openalex.org/W2138641981","https://openalex.org/W2141556360","https://openalex.org/W2143850783","https://openalex.org/W2148908926","https://openalex.org/W2150626351","https://openalex.org/W2163383667","https://openalex.org/W2167021628","https://openalex.org/W2168526827","https://openalex.org/W2168844172"],"related_works":["https://openalex.org/W2053909022","https://openalex.org/W2164585558","https://openalex.org/W2275934442","https://openalex.org/W3000541956","https://openalex.org/W4283696305","https://openalex.org/W2436416136","https://openalex.org/W1975905871","https://openalex.org/W2144735860","https://openalex.org/W2114586089","https://openalex.org/W4378473720"],"abstract_inverted_index":{"In":[0,22,189],"the":[1,6,23,68,72,77,83,100,104,115,119,209,212,218],"basal":[2],"ganglia,":[3],"inputs":[4],"from":[5,154,184],"nucleus":[7],"accumbens":[8],"(NAc)":[9],"are":[10,46],"transmitted":[11],"through":[12],"both":[13,80],"direct":[14,69,101],"and":[15,18,43,51,92,114,167,193,227,239],"indirect":[16,73,105],"pathways":[17],"control":[19],"reward-based":[20],"learning.":[21],"NAc,":[24],"dopamine":[25],"(DA)":[26],"serves":[27],"as":[28],"a":[29,49,155,160,185,223,243],"key":[30],"neurotransmitter,":[31],"modulating":[32],"these":[33],"two":[34,57],"parallel":[35],"pathways.":[36],"This":[37],"study":[38],"explored":[39],"how":[40],"reward":[41,237],"learning":[42,129,135,177,201,213,222,238],"its":[44,240],"flexibility":[45,148,181,210,241],"controlled":[47],"in":[48,64,76,96,176,208,217,236,242],"pathway-specific":[50,244],"DA":[52,124],"receptor-dependent":[53],"manner.":[54,245],"We":[55],"used":[56],"techniques":[58,113],"(i)":[59],"reversible":[60],"neurotransmission":[61],"blocking":[62],"(RNB),":[63],"which":[65,97],"transmission":[66,98],"of":[67,82,99,118,221],"(D-RNB)":[70],"or":[71,103,126,143,163],"pathway":[74,106],"(I-RNB)":[75],"NAc":[78,120],"on":[79,138],"sides":[81],"hemispheres":[84],"was":[85,108,121,130,149],"selectively":[86],"blocked":[87,110],"by":[88,111,132,152],"transmission-blocking":[89],"tetanus":[90],"toxin;":[91],"(ii)":[93],"asymmetric":[94],"RNB,":[95],"(D-aRNB)":[102],"(I-aRNB)":[107],"unilaterally":[109],"RNB":[112],"intact":[116],"side":[117],"infused":[122],"with":[123],"agonists":[125],"antagonists.":[127],"Reward-based":[128],"assessed":[131],"measuring":[133],"goal-directed":[134],"ability":[136],"based":[137],"visual":[139],"cue":[140],"tasks":[141,145],"(VCTs)":[142],"response-direction":[144],"(RDTs).":[146],"Learning":[147],"then":[150],"tested":[151],"switching":[153],"previously":[156,186],"learned":[157,187],"VCT":[158,162],"to":[159,182,211],"new":[161,224],"RDT.":[164],"D-RNB":[165],"mice":[166,172,192,198],"D1":[168,226],"receptor":[169,195],"antagonist-treated":[170],"D-aRNB":[171],"showed":[173,199],"severe":[174,204],"impairments":[175,205],"acquisition":[178,202,220],"but":[179,203,215,233],"normal":[180,200],"switch":[183,214],"strategy.":[188,225],"contrast,":[190],"I-RNB":[191],"D2":[194,228],"agonist-treated":[196],"I-aRNB":[197],"not":[206],"only":[207],"also":[216],"subsequent":[219],"receptors":[229],"thus":[230],"play":[231],"distinct":[232],"cooperative":[234],"roles":[235]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}