{"id":"https://openalex.org/W2079915768","doi":"https://doi.org/10.1006/bbrc.1998.8629","title":"Cobalamin Inhibition of HIV-1 Integrase and Integration of HIV-1 DNA into Cellular DNA","display_name":"Cobalamin Inhibition of HIV-1 Integrase and Integration of HIV-1 DNA into Cellular DNA","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W2079915768","doi":"https://doi.org/10.1006/bbrc.1998.8629","mag":"2079915768","pmid":"https://pubmed.ncbi.nlm.nih.gov/9610370"},"language":"en","primary_location":{"id":"doi:10.1006/bbrc.1998.8629","doi":"https://doi.org/10.1006/bbrc.1998.8629","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1998.8629","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067999368","display_name":"Jason B. Weinberg","orcid":"https://orcid.org/0000-0002-4768-4361","observed_orcids":["https://orcid.org/0000-0002-4768-4361"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.Brice Weinberg","raw_affiliation_strings":["VA Medical Center, Durham, North Carolina 27705, USA","VA and Duke University Medical Centers, 508 Fulton Street, Durham, North Carolina, 27705"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VA Medical Center, Durham, North Carolina 27705, USA","institution_ids":["https://openalex.org/I4210139568"]},{"raw_affiliation_string":"VA and Duke University Medical Centers, 508 Fulton Street, Durham, North Carolina, 27705","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108821760","display_name":"Diane C. Shugars","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane C. Shugars","raw_affiliation_strings":["University of North Carolina School of Dentistry, Dental Research Center, Chapel Hill, North Carolina, 27514"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina School of Dentistry, Dental Research Center, Chapel Hill, North Carolina, 27514","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111855989","display_name":"Paula A. Sherman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paula A. Sherman","raw_affiliation_strings":["Glaxo-Wellcome Company, 5 Moore Drive, Research Triangle Park, North Carolina, 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo-Wellcome Company, 5 Moore Drive, Research Triangle Park, North Carolina, 27709","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030690012","display_name":"Derrick L. Sauls","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derrick L. Sauls","raw_affiliation_strings":["VA and Duke University Medical Centers, 508 Fulton Street, Durham, North Carolina, 27705"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VA and Duke University Medical Centers, 508 Fulton Street, Durham, North Carolina, 27705","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035733849","display_name":"James A. Fyfe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James A. Fyfe","raw_affiliation_strings":["Glaxo-Wellcome Company, 5 Moore Drive, Research Triangle Park, North Carolina, 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo-Wellcome Company, 5 Moore Drive, Research Triangle Park, North Carolina, 27709","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":2.0096,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.87346491,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"246","issue":"2","first_page":"393","last_page":"397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.6782000064849854,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.6782000064849854,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.29660001397132874,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hiv-1-integrase","display_name":"HIV-1 integrase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/integrase-inhibitors","display_name":"integrase inhibitors","score":0.746999979019165},{"id":"https://openalex.org/keywords/hydroxocobalamin","display_name":"hydroxocobalamin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/methylcobalamin","display_name":"methylcobalamin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/adenosylcobalamin","display_name":"adenosylcobalamin","score":1.0},{"id":"https://openalex.org/keywords/cobinamide","display_name":"cobinamide","score":0.8429999947547913},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/viral-infection-inhibition","display_name":"viral infection inhibition","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.9227902889251709},{"id":"https://openalex.org/C2779761754","wikidata":"https://www.wikidata.org/wiki/Q250442","display_name":"Methylcobalamin","level":3,"score":0.7429540157318115},{"id":"https://openalex.org/C2778979354","wikidata":"https://www.wikidata.org/wiki/Q239593","display_name":"Adenosylcobalamin","level":4,"score":0.6938885450363159},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5823727250099182},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5649656653404236},{"id":"https://openalex.org/C2777302000","wikidata":"https://www.wikidata.org/wiki/Q412251","display_name":"Integrase inhibitor","level":5,"score":0.5591195821762085},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5242574214935303},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5224470496177673},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4907420873641968},{"id":"https://openalex.org/C2776619502","wikidata":"https://www.wikidata.org/wiki/Q73972","display_name":"Hydroxocobalamin","level":4,"score":0.4534365236759186},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45212438702583313},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4485453963279724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4073294997215271},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39701753854751587},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.36676114797592163},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3409035801887512},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.14972639083862305},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.14741691946983337},{"id":"https://openalex.org/C2780829489","wikidata":"https://www.wikidata.org/wiki/Q252251","display_name":"Cyanocobalamin","level":3,"score":0.11657732725143433},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.078165203332901},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.07378119230270386},{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.06028220057487488}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003038","descriptor_name":"Cobamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006879","descriptor_name":"Hydroxocobalamin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019428","descriptor_name":"HIV Integrase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/bbrc.1998.8629","doi":"https://doi.org/10.1006/bbrc.1998.8629","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1998.8629","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:9610370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9610370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1037971410","display_name":"SPECIALIZED CENTER OF RESEARCH IN RHEUMATOID ARTHRITIS","funder_award_id":"5p50ar039162-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1373135491","display_name":null,"funder_award_id":"AR39162","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G363353825","display_name":"HIV INHIBITION BY SECRETORY LEUKOCYTE PROTEASE INHIBITOR","funder_award_id":"5r01de012162-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5530496297","display_name":null,"funder_award_id":"DE12162","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W53917787","https://openalex.org/W605466568","https://openalex.org/W1912779594","https://openalex.org/W1964748084","https://openalex.org/W2030429605","https://openalex.org/W2042430050","https://openalex.org/W2046801869","https://openalex.org/W2055995901","https://openalex.org/W2066369900","https://openalex.org/W2077251478","https://openalex.org/W2110661303","https://openalex.org/W2128454891","https://openalex.org/W2138206705","https://openalex.org/W2152168979","https://openalex.org/W2157418548","https://openalex.org/W2167906381","https://openalex.org/W2175970307","https://openalex.org/W2418958163","https://openalex.org/W2916044971","https://openalex.org/W4253951442"],"related_works":["https://openalex.org/W2418958163","https://openalex.org/W2138206705","https://openalex.org/W2271291857","https://openalex.org/W2949743569","https://openalex.org/W4220785853","https://openalex.org/W2054461183","https://openalex.org/W2086295635","https://openalex.org/W2038196376","https://openalex.org/W2009050264","https://openalex.org/W2171711893"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}