{"id":"https://openalex.org/W2079911064","doi":"https://doi.org/10.1117/12.2005274","title":"Use of laser photomodulation in the evolution of oral mucositis associated to cyclophosphamide, methotrexate, 5-fluouracil - CMF in 5 fluouracil + adriamycin + cyclophosphamide - FAC chemotherapy protocols in patients with breast cancer","display_name":"Use of laser photomodulation in the evolution of oral mucositis associated to cyclophosphamide, methotrexate, 5-fluouracil - CMF in 5 fluouracil + adriamycin + cyclophosphamide - FAC chemotherapy protocols in patients with breast cancer","publication_year":2013,"publication_date":"2013-03-05","ids":{"openalex":"https://openalex.org/W2079911064","doi":"https://doi.org/10.1117/12.2005274","mag":"2079911064"},"language":"en","primary_location":{"id":"doi:10.1117/12.2005274","doi":"https://doi.org/10.1117/12.2005274","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2005274","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087173049","display_name":"Maria de F\u00e1tima Lima Ferreira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79889768","display_name":"Universidade Federal de Alagoas","ror":"https://ror.org/00dna7t83","country_code":"BR","type":"education","lineage":["https://openalex.org/I79889768"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria de F\u00e1tima Lima Ferreira","raw_affiliation_strings":["Federal Univ. of Alagoas (Brazil)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Univ. of Alagoas (Brazil)","institution_ids":["https://openalex.org/I79889768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006479460","display_name":"Fab\u00edola Bastos de Carvalho","orcid":"https://orcid.org/0000-0001-5326-9562","observed_orcids":["https://orcid.org/0000-0001-5326-9562"]},"institutions":[{"id":"https://openalex.org/I126158947","display_name":"Universidade Federal da Bahia","ror":"https://ror.org/03k3p7647","country_code":"BR","type":"education","lineage":["https://openalex.org/I126158947"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fabiola Bastos de Carvalho","raw_affiliation_strings":["Univ. Federal da Bahia (Brazil)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Federal da Bahia (Brazil)","institution_ids":["https://openalex.org/I126158947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032030503","display_name":"Susana C. P. S. de Oliveira","orcid":"https://orcid.org/0000-0002-6128-1630","observed_orcids":["https://orcid.org/0000-0002-6128-1630"]},"institutions":[{"id":"https://openalex.org/I126158947","display_name":"Universidade Federal da Bahia","ror":"https://ror.org/03k3p7647","country_code":"BR","type":"education","lineage":["https://openalex.org/I126158947"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Susana C. P. S. de Oliveira","raw_affiliation_strings":["Univ. Federal da Bahia (Brazil)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Federal da Bahia (Brazil)","institution_ids":["https://openalex.org/I126158947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019512642","display_name":"Juliana S. C. Monteiro","orcid":"https://orcid.org/0000-0001-5009-9115","observed_orcids":["https://orcid.org/0000-0001-5009-9115"]},"institutions":[{"id":"https://openalex.org/I126158947","display_name":"Universidade Federal da Bahia","ror":"https://ror.org/03k3p7647","country_code":"BR","type":"education","lineage":["https://openalex.org/I126158947"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juliana S. C. Monteiro","raw_affiliation_strings":["Univ. Federal da Bahia (Brazil)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Federal da Bahia (Brazil)","institution_ids":["https://openalex.org/I126158947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037033656","display_name":"Gustavo Miranda Pires Santos","orcid":"https://orcid.org/0000-0001-8605-7435","observed_orcids":["https://orcid.org/0000-0001-8605-7435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gustavo M. P. Santos","raw_affiliation_strings":["Gon\u00e7alo Muniz Institute (Brazil)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gon\u00e7alo Muniz Institute (Brazil)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084645200","display_name":"Maria de F\u00e1tima Malvar Gesteira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126158947","display_name":"Universidade Federal da Bahia","ror":"https://ror.org/03k3p7647","country_code":"BR","type":"education","lineage":["https://openalex.org/I126158947"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria F. M. Gesteira","raw_affiliation_strings":["Univ. Federal da Bahia (Brazil)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Federal da Bahia (Brazil)","institution_ids":["https://openalex.org/I126158947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030986118","display_name":"Tereza Cristina Teixeira Maia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79889768","display_name":"Universidade Federal de Alagoas","ror":"https://ror.org/00dna7t83","country_code":"BR","type":"education","lineage":["https://openalex.org/I79889768"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Tereza Cristina Teixeira Maia","raw_affiliation_strings":["Federal University of Alagoas, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Alagoas, Brazil","institution_ids":["https://openalex.org/I79889768"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029403107","display_name":"Ant\u00f4nio Luiz Barbosa Pinheiro","orcid":"https://orcid.org/0000-0002-5805-0321","observed_orcids":["https://orcid.org/0000-0002-5805-0321"]},"institutions":[{"id":"https://openalex.org/I126158947","display_name":"Universidade Federal da Bahia","ror":"https://ror.org/03k3p7647","country_code":"BR","type":"education","lineage":["https://openalex.org/I126158947"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ant\u00f4nio L. B. Pinheiro","raw_affiliation_strings":["Univ. Federal da Bahia (Brazil)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Federal da Bahia (Brazil)","institution_ids":["https://openalex.org/I126158947"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.2941,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.96642686,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"8569","issue":null,"first_page":"85690O","last_page":"85690O"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laser-photobiomodulation","display_name":"laser photobiomodulation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/low-level-laser-therapy","display_name":"low-level laser therapy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/oral-mucositis","display_name":"oral mucositis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chemotherapy-induced-mucositis","display_name":"chemotherapy-induced mucositis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cmf-chemotherapy","display_name":"CMF chemotherapy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/fac-chemotherapy","display_name":"FAC chemotherapy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/invasive-ductal-carcinoma","display_name":"invasive ductal carcinoma","score":0.921999990940094},{"id":"https://openalex.org/keywords/mucositis-prevention","display_name":"mucositis prevention","score":0.9539999961853027},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.7639999985694885},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.8389999866485596},{"id":"https://openalex.org/keywords/dental-care-protocol","display_name":"dental care protocol","score":0.492000013589859},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9319999814033508},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9200000166893005},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C2778496288","wikidata":"https://www.wikidata.org/wiki/Q6931269","display_name":"Mucositis","level":3,"score":0.937015175819397},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.8637723922729492},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8247538805007935},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6988644003868103},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.6677551865577698},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6344354152679443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4994080066680908},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4743812680244446},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.4279891848564148},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4187447428703308},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3851887881755829}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2005274","doi":"https://doi.org/10.1117/12.2005274","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2005274","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1970186590","https://openalex.org/W1984125328","https://openalex.org/W2015617634","https://openalex.org/W2015817748","https://openalex.org/W2015995074","https://openalex.org/W2053809553","https://openalex.org/W2067089217","https://openalex.org/W2080298514","https://openalex.org/W2154547984"],"related_works":["https://openalex.org/W2333918888","https://openalex.org/W3034325373","https://openalex.org/W2801741911","https://openalex.org/W7120432120","https://openalex.org/W4407175242","https://openalex.org/W6887896007","https://openalex.org/W2906247802","https://openalex.org/W3169462453","https://openalex.org/W2130083336","https://openalex.org/W7120419746"],"abstract_inverted_index":{"The":[0,170],"aim":[1],"of":[2,10,55,58,62,82,96,135,144,152,168,260],"this":[3],"study":[4],"was":[5,103,160],"to":[6,163,198],"evaluate":[7],"the":[8,11,46,150,208,229,247],"efficacy":[9],"laser":[12,250],"photobiomodulation":[13],"(FBML)":[14],"in":[15,36,138,207,241],"prevention":[16],"and":[17,29,141,159,173,234,239,257,262],"treatment\r\nof":[18],"oral":[19,176],"mucositis":[20,177,203],"induced":[21],"by":[22],"chemotherapy":[23,153],"protocols":[24],"CMF":[25,92,131],"(cyclophosphamide,":[26],"methotrexate,":[27],"5-Fluouracil)":[28],"FAC":[30,79,116],"(5\r\nFluouracil":[31],"+":[32,34,80,84,93,98,117,132],"Adriamycin":[33],"Cyclophosphamide)":[35],"cancer":[37],"patients":[38,43,77,90,112,126,226],"breast.":[39],"We":[40],"selected":[41],"28":[42],"treated":[44],"at":[45],"Center\r\nfor":[47],"High":[48],"Complexity":[49],"(CACON),":[50],"who":[51,201,227],"underwent":[52],"6":[53,89,125],"cycles":[54],"21":[56],"days":[57],"treatment,":[59],"with":[60,110,124,211],"diagnosis":[61],"infiltrating":[63],"ductal\r\ncarcinoma":[64],"(ICD":[65],"C50.9).":[66],"Were":[67],"randomly":[68],"divided":[69,104],"into":[70,105],"three":[71],"groups:":[72],"Group":[73,86,100,108,114,139],"A":[74,140,172],"-":[75,88,102],"eight":[76],"(Protocol":[78,91],"Dental\r\nprotocol":[81],"CACON":[83,97],"Laser),":[85,99],"B":[87],"Dental":[94,118,133],"protocol":[95,119,134],"C":[101],"two":[106],"sub-groups:":[107],"C1":[109],"8":[111],"(Control":[113],"1:":[115],"o":[120],"CACON)":[121],"and\r\ngroup":[122],"C2":[123],"(control":[127],"group":[128,199],"2:":[129],"Protocol":[130],"CACON).":[136],"Patients":[137],"B\r\nwere":[142],"use":[143],"preventive":[145,233],"FBML":[146,230],"24":[147],"hours":[148,158],"before":[149],"start":[151],"cycle,":[154],"then":[155],"every":[156],"48":[157],"extended":[161],"up":[162],"one":[164],"week":[165],"following":[166],"completion":[167],"chemotherapy.":[169],"groups":[171],"B,":[174],"presented":[175,202],"grade":[178,184,187,190,194,204,215,218,221,223],"0":[179,205],"(64.29%)":[180],"p":[181,212],"=":[182,213],"0.07,":[183],"I":[185,216],"(7.14%),":[186],"II":[188,219],"(14.29%),":[189],"III":[191],"(7.14":[192],"%),":[193],"IV":[195,224],"(7.14%)":[196],"compared":[197],"C,":[200],"(35.71%)":[206],"initial":[209],"evaluation":[210],"0.10,":[214],"(21.43%),":[217],"(28.57%),":[220],"III\r\n(14.29%),":[222],"(0.00%),":[225],"used":[228,252],"as":[231,255],"a":[232,237],"therapeutic":[235],"showed":[236,258],"reduction":[238],"pain\r\nrelief":[240],"42.86%.":[242],"It":[243],"is":[244],"concluded":[245],"that":[246],"low":[248],"power":[249],"when":[251],"preventively":[253],"or":[254],"therapy":[256],"immediate\r\nrelief":[259],"pain":[261],"accelerate":[263],"tissue":[264],"repair.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}