{"id":"https://openalex.org/W2079907321","doi":"https://doi.org/10.1038/labinvest.2012.158","title":"Morphological and microarray analyses of human hepatocytes from xenogeneic host livers","display_name":"Morphological and microarray analyses of human hepatocytes from xenogeneic host livers","publication_year":2012,"publication_date":"2012-11-12","ids":{"openalex":"https://openalex.org/W2079907321","doi":"https://doi.org/10.1038/labinvest.2012.158","mag":"2079907321","pmid":"https://pubmed.ncbi.nlm.nih.gov/23147226"},"language":"en","primary_location":{"id":"doi:10.1038/labinvest.2012.158","doi":"https://doi.org/10.1038/labinvest.2012.158","is_oa":true,"landing_page_url":"https://doi.org/10.1038/labinvest.2012.158","pdf_url":null,"source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1038/labinvest.2012.158","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008377317","display_name":"Chise Tateno","orcid":"https://orcid.org/0000-0002-2640-3268","observed_orcids":["https://orcid.org/0000-0002-2640-3268"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4210124309","display_name":"PhoenixBio (Japan)","ror":"https://ror.org/03423rs03","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210124309"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Chise Tateno","raw_affiliation_strings":["PhoenixBio Co., Ltd., Higashihiroshima, Japan","Hiroshima University Liver Research Project Center, Hiroshima, Japan","Yoshizato Project, Hiroshima Prefectural Institute of Industrial Science and Technology, Cooperative Link of Unique Science and Technology for Economy Revitalization (CLUSTER), Higashihiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoenixBio Co., Ltd., Higashihiroshima, Japan","institution_ids":["https://openalex.org/I4210124309"]},{"raw_affiliation_string":"Hiroshima University Liver Research Project Center, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Yoshizato Project, Hiroshima Prefectural Institute of Industrial Science and Technology, Cooperative Link of Unique Science and Technology for Economy Revitalization (CLUSTER), Higashihiroshima, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053661053","display_name":"Fuyuki Miya","orcid":"https://orcid.org/0000-0001-6758-2015","observed_orcids":["https://orcid.org/0000-0001-6758-2015"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fuyuki Miya","raw_affiliation_strings":["Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN, Yokohama, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103563488","display_name":"Kenjiro Wake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114171174","display_name":"Tsurumi University","ror":"https://ror.org/04j8wth34","country_code":"JP","type":"education","lineage":["https://openalex.org/I114171174"]},{"id":"https://openalex.org/I4210090256","display_name":"Minophagen Pharmaceutical (Japan)","ror":"https://ror.org/0092gmc55","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210090256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenjiro Wake","raw_affiliation_strings":["Department of Anatomy, School of Dental Medicine, Tsurumi University, Yokohama, Japan","Liver Research Unit, Minophagen Pharmaceutical, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, School of Dental Medicine, Tsurumi University, Yokohama, Japan","institution_ids":["https://openalex.org/I114171174"]},{"raw_affiliation_string":"Liver Research Unit, Minophagen Pharmaceutical, Tokyo, Japan","institution_ids":["https://openalex.org/I4210090256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109134387","display_name":"Miho Kataoka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miho Kataoka","raw_affiliation_strings":["Yoshizato Project, Hiroshima Prefectural Institute of Industrial Science and Technology, Cooperative Link of Unique Science and Technology for Economy Revitalization (CLUSTER), Higashihiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yoshizato Project, Hiroshima Prefectural Institute of Industrial Science and Technology, Cooperative Link of Unique Science and Technology for Economy Revitalization (CLUSTER), Higashihiroshima, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054427357","display_name":"Yuji Ishida","orcid":"https://orcid.org/0000-0003-1855-6325","observed_orcids":["https://orcid.org/0000-0003-1855-6325"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4210124309","display_name":"PhoenixBio (Japan)","ror":"https://ror.org/03423rs03","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210124309"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Ishida","raw_affiliation_strings":["Hiroshima University Liver Research Project Center, Hiroshima, Japan","PhoenixBio Co., Ltd., Higashihiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hiroshima University Liver Research Project Center, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"PhoenixBio Co., Ltd., Higashihiroshima, Japan","institution_ids":["https://openalex.org/I4210124309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052923598","display_name":"Chihiro Yamasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124309","display_name":"PhoenixBio (Japan)","ror":"https://ror.org/03423rs03","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210124309"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chihiro Yamasaki","raw_affiliation_strings":["PhoenixBio Co., Ltd., Higashihiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoenixBio Co., Ltd., Higashihiroshima, Japan","institution_ids":["https://openalex.org/I4210124309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029321803","display_name":"Ami Yanagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124309","display_name":"PhoenixBio (Japan)","ror":"https://ror.org/03423rs03","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210124309"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ami Yanagi","raw_affiliation_strings":["PhoenixBio Co., Ltd., Higashihiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoenixBio Co., Ltd., Higashihiroshima, Japan","institution_ids":["https://openalex.org/I4210124309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020266861","display_name":"Masakazu Kakuni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124309","display_name":"PhoenixBio (Japan)","ror":"https://ror.org/03423rs03","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210124309"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masakazu Kakuni","raw_affiliation_strings":["PhoenixBio Co., Ltd., Higashihiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoenixBio Co., Ltd., Higashihiroshima, Japan","institution_ids":["https://openalex.org/I4210124309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015639828","display_name":"Eddie Wisse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eddie Wisse","raw_affiliation_strings":["Department of Molecular Biology, ELMI unit, University Maastricht, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, ELMI unit, University Maastricht, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113685448","display_name":"Fons Verheyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Fons Verheyen","raw_affiliation_strings":["Department of Molecular Biology, ELMI unit, University Maastricht, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, ELMI unit, University Maastricht, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111614663","display_name":"Kouji Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114171174","display_name":"Tsurumi University","ror":"https://ror.org/04j8wth34","country_code":"JP","type":"education","lineage":["https://openalex.org/I114171174"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouji Inoue","raw_affiliation_strings":["Institute of Electron Microscopy, School of Dental Medicine, Tsurumi University, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Electron Microscopy, School of Dental Medicine, Tsurumi University, Yokohama, Japan","institution_ids":["https://openalex.org/I114171174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101591164","display_name":"Kota Sato","orcid":"https://orcid.org/0009-0006-4422-4614","observed_orcids":["https://orcid.org/0009-0006-4422-4614"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kota Sato","raw_affiliation_strings":["Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103238825","display_name":"Atsushi Kudo","orcid":"https://orcid.org/0000-0002-5301-3847","observed_orcids":["https://orcid.org/0000-0002-5301-3847"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Kudo","raw_affiliation_strings":["Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113634518","display_name":"Shigeki Arii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Arii","raw_affiliation_strings":["Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110346134","display_name":"Toshiyuki Itamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Itamoto","raw_affiliation_strings":["Division of Frontier Medical Science, Department of Surgery, and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Frontier Medical Science, Department of Surgery, and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106132763","display_name":"Toshimasa Asahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshimasa Asahara","raw_affiliation_strings":["Division of Frontier Medical Science, Department of Surgery, and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan","Hiroshima University Liver Research Project Center, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Frontier Medical Science, Department of Surgery, and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Hiroshima University Liver Research Project Center, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049989071","display_name":"Tatsuhiko Tsunoda","orcid":"https://orcid.org/0000-0002-5439-7918","observed_orcids":["https://orcid.org/0000-0002-5439-7918"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuhiko Tsunoda","raw_affiliation_strings":["Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN, Yokohama, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087434980","display_name":"Katsutoshi Yoshizato","orcid":"https://orcid.org/0009-0004-2965-0215","observed_orcids":["https://orcid.org/0009-0004-2965-0215"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4210124309","display_name":"PhoenixBio (Japan)","ror":"https://ror.org/03423rs03","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210124309"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsutoshi Yoshizato","raw_affiliation_strings":["Department of Biological Science, Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Graduate School of Science, Hiroshima University, Higashihiroshima, Japan","Hiroshima University Liver Research Project Center, Hiroshima, Japan","PhoenixBio Co., Ltd., Higashihiroshima, Japan","Yoshizato Project, Hiroshima Prefectural Institute of Industrial Science and Technology, Cooperative Link of Unique Science and Technology for Economy Revitalization (CLUSTER), Higashihiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science, Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Graduate School of Science, Hiroshima University, Higashihiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Hiroshima University Liver Research Project Center, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"PhoenixBio Co., Ltd., Higashihiroshima, Japan","institution_ids":["https://openalex.org/I4210124309"]},{"raw_affiliation_string":"Yoshizato Project, Hiroshima Prefectural Institute of Industrial Science and Technology, Cooperative Link of Unique Science and Technology for Economy Revitalization (CLUSTER), Higashihiroshima, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5008377317"],"corresponding_institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4210124309"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":5.0032,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.95196818,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"93","issue":"1","first_page":"54","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.09889999777078629,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-hepatocytes","display_name":"human hepatocytes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/hepatocyte-gene-expression","display_name":"hepatocyte gene expression","score":0.5109999775886536},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.6129999756813049},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7749999761581421},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.8140000104904175},{"id":"https://openalex.org/keywords/scid-mice","display_name":"SCID mice","score":0.7649999856948853},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.30799999833106995},{"id":"https://openalex.org/keywords/hepatocyte-morphology","display_name":"hepatocyte morphology","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7636738419532776},{"id":"https://openalex.org/C30278631","wikidata":"https://www.wikidata.org/wiki/Q281721","display_name":"Chimera (genetics)","level":3,"score":0.6477218270301819},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5240426659584045},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.514889121055603},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5019822120666504},{"id":"https://openalex.org/C26260077","wikidata":"https://www.wikidata.org/wiki/Q5099361","display_name":"Chimeric gene","level":4,"score":0.43427056074142456},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4101219177246094},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40212544798851013},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3915947675704956},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1791180670261383},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12062212824821472},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09881359338760376}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007728","descriptor_name":"Kupffer Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/labinvest.2012.158","doi":"https://doi.org/10.1038/labinvest.2012.158","is_oa":true,"landing_page_url":"https://doi.org/10.1038/labinvest.2012.158","pdf_url":null,"source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},{"id":"pmid:23147226","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23147226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/2a3f57e9-61ae-4f02-b278-9cc774c396e9","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/2a3f57e9-61ae-4f02-b278-9cc774c396e9","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tateno, C, Miya, F, Wake, K, Kataoka, M, Ishida, Y, Yamasaki, C, Yanagi, A, Kakuni, M, Eddie Wisse, E, Verheyen, F K, Inoue, K, Sato, K, Kudo, A, Arii, S, Itamoto, T, Asahara, T, Tsunoda, T & Yoshizato, K 2013, 'Morphological and microarray analyses of human hepatocytes from xenogeneic host livers.', Laboratory Investigation, vol. 93, no. 1, pp. 54-71. https://doi.org/10.1038/labinvest.2012.158","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/2a3f57e9-61ae-4f02-b278-9cc774c396e9","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/2a3f57e9-61ae-4f02-b278-9cc774c396e9","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Laboratory Investigation, 93(1), 54 - 71. Nature Publishing Group","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/labinvest.2012.158","doi":"https://doi.org/10.1038/labinvest.2012.158","is_oa":true,"landing_page_url":"https://doi.org/10.1038/labinvest.2012.158","pdf_url":null,"source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1490154674","https://openalex.org/W1974150231","https://openalex.org/W1984921880","https://openalex.org/W1992676108","https://openalex.org/W2000101394","https://openalex.org/W2011021694","https://openalex.org/W2021497244","https://openalex.org/W2023724012","https://openalex.org/W2026647673","https://openalex.org/W2028958732","https://openalex.org/W2030638154","https://openalex.org/W2030944573","https://openalex.org/W2045099972","https://openalex.org/W2069488124","https://openalex.org/W2072477665","https://openalex.org/W2072611318","https://openalex.org/W2076192079","https://openalex.org/W2080142341","https://openalex.org/W2090952221","https://openalex.org/W2110065044","https://openalex.org/W2120865735","https://openalex.org/W2130727132","https://openalex.org/W2150926065","https://openalex.org/W2151401603","https://openalex.org/W2155497437","https://openalex.org/W2165178664","https://openalex.org/W2168938059","https://openalex.org/W2229208919"],"related_works":["https://openalex.org/W2887258981","https://openalex.org/W2011021694","https://openalex.org/W2033644237","https://openalex.org/W1992676108","https://openalex.org/W2076192079","https://openalex.org/W2160295102","https://openalex.org/W2161137250","https://openalex.org/W2058389060","https://openalex.org/W2056415843","https://openalex.org/W4245505383"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
