{"id":"https://openalex.org/W2079888561","doi":"https://doi.org/10.1006/jmbi.2001.4461","title":"An interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kda major secretory protein (antigen 85B), a mycolyl transferase11Edited by I. A. Wilson","display_name":"An interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kda major secretory protein (antigen 85B), a mycolyl transferase11Edited by I. A. Wilson","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2079888561","doi":"https://doi.org/10.1006/jmbi.2001.4461","mag":"2079888561","pmid":"https://pubmed.ncbi.nlm.nih.gov/11254389"},"language":"en","primary_location":{"id":"doi:10.1006/jmbi.2001.4461","doi":"https://doi.org/10.1006/jmbi.2001.4461","is_oa":false,"landing_page_url":"https://doi.org/10.1006/jmbi.2001.4461","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"book-review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/01k2x7bw","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110165868","display_name":"Daniel H. Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel H. Anderson","raw_affiliation_strings":["UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, CA 90095-1570, USA. dha@mbi.ucla.edu","UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, CA 90095-1570, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, CA 90095-1570, USA. dha@mbi.ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, CA 90095-1570, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108403542","display_name":"G\u00fcnter Harth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G\u00fcnter Harth","raw_affiliation_strings":["Department of Medicine CHS 37-121UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles CA, 90095-1688, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine CHS 37-121UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles CA, 90095-1688, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062026780","display_name":"Marcus A. Horwitz","orcid":"https://orcid.org/0000-0001-6525-7147","observed_orcids":["https://orcid.org/0000-0001-6525-7147"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus A. Horwitz","raw_affiliation_strings":["Department of Medicine CHS 37-121UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles CA, 90095-1688, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine CHS 37-121UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles CA, 90095-1688, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080439570","display_name":"David S Eisenberg","orcid":"https://orcid.org/0000-0003-2432-5419","observed_orcids":["https://orcid.org/0000-0003-2432-5419"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Eisenberg","raw_affiliation_strings":["UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, University of California Los Angeles Box 951570 Los Angeles CA, 90095-1570, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, University of California Los Angeles Box 951570 Los Angeles CA, 90095-1570, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110165868"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":123,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"307","issue":"2","first_page":"671","last_page":"681"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.6288999915122986,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.6288999915122986,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.36230000853538513,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ag85b","display_name":"Ag85B","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/trehalose-dimycolate","display_name":"trehalose dimycolate","score":0.8679999709129333},{"id":"https://openalex.org/keywords/trehalose-monomycolate","display_name":"trehalose monomycolate","score":0.9390000104904175},{"id":"https://openalex.org/keywords/bacterial-cell-wall-synthesis","display_name":"bacterial cell wall synthesis","score":0.7419999837875366},{"id":"https://openalex.org/keywords/ag85a","display_name":"Ag85A","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C2778452849","wikidata":"https://www.wikidata.org/wiki/Q421773","display_name":"Trehalose","level":2,"score":0.9192854762077332},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6275103688240051},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.539972186088562},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4993467330932617},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4802137315273285},{"id":"https://openalex.org/C2776376580","wikidata":"https://www.wikidata.org/wiki/Q407355","display_name":"Transferase","level":3,"score":0.44262591004371643},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3675788342952728},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3542783856391907},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21432620286941528},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.08768734335899353},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003461","descriptor_name":"Crystallography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009171","descriptor_name":"Mycolic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014199","descriptor_name":"Trehalose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1006/jmbi.2001.4461","doi":"https://doi.org/10.1006/jmbi.2001.4461","is_oa":false,"landing_page_url":"https://doi.org/10.1006/jmbi.2001.4461","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:11254389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11254389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Comparative Study"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt01k2x7bw","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/01k2x7bw","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Biology, vol 307, iss 2","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt01k2x7bw","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/01k2x7bw","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Biology, vol 307, iss 2","raw_type":"article"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320338289","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W197287723","https://openalex.org/W1487114236","https://openalex.org/W1539796472","https://openalex.org/W1563420813","https://openalex.org/W1710565104","https://openalex.org/W1880132961","https://openalex.org/W1986110906","https://openalex.org/W1988255658","https://openalex.org/W2000164429","https://openalex.org/W2001641653","https://openalex.org/W2004360551","https://openalex.org/W2009587821","https://openalex.org/W2022109487","https://openalex.org/W2024190203","https://openalex.org/W2028231353","https://openalex.org/W2033465185","https://openalex.org/W2035651986","https://openalex.org/W2038840577","https://openalex.org/W2047745952","https://openalex.org/W2049675690","https://openalex.org/W2049902088","https://openalex.org/W2053166689","https://openalex.org/W2053951102","https://openalex.org/W2055989425","https://openalex.org/W2080476827","https://openalex.org/W2080528351","https://openalex.org/W2088933990","https://openalex.org/W2092280488","https://openalex.org/W2106124696","https://openalex.org/W2117124707","https://openalex.org/W2129900122","https://openalex.org/W2136567909","https://openalex.org/W2137930295","https://openalex.org/W2140981202","https://openalex.org/W2157737997","https://openalex.org/W2159081899"],"related_works":["https://openalex.org/W2928003306","https://openalex.org/W1880132961","https://openalex.org/W2035651986","https://openalex.org/W2048259788","https://openalex.org/W2783504718","https://openalex.org/W1981058570","https://openalex.org/W2114767978","https://openalex.org/W1523012382","https://openalex.org/W1988255658","https://openalex.org/W1991467173"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
