{"id":"https://openalex.org/W2079784591","doi":"https://doi.org/10.1042/bj20031365","title":"Kinetic analysis of ligand-induced autocatalytic reactions","display_name":"Kinetic analysis of ligand-induced autocatalytic reactions","publication_year":2004,"publication_date":"2004-04-26","ids":{"openalex":"https://openalex.org/W2079784591","doi":"https://doi.org/10.1042/bj20031365","mag":"2079784591","pmid":"https://pubmed.ncbi.nlm.nih.gov/14705964","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1224100"},"language":"en","primary_location":{"id":"doi:10.1042/bj20031365","doi":"https://doi.org/10.1042/bj20031365","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20031365","pdf_url":"https://portlandpress.com/biochemj/article-pdf/379/3/697/713405/bj3790697.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/379/3/697/713405/bj3790697.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jiang-Hong LIU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang-Hong LIU","raw_affiliation_strings":["National Laboratory of Biomacromolecules, Center for Molecular Biology, Institute of Biophysics, Academia Sinica, Beijing 100101, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Center for Molecular Biology, Institute of Biophysics, Academia Sinica, Beijing 100101, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100641433","display_name":"Zhixin Wang","orcid":"https://orcid.org/0000-0003-1293-2078","observed_orcids":["https://orcid.org/0000-0003-1293-2078"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Xin WANG","raw_affiliation_strings":["National Laboratory of Biomacromolecules, Center for Molecular Biology, Institute of Biophysics, Academia Sinica, Beijing 100101, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Center for Molecular Biology, Institute of Biophysics, Academia Sinica, Beijing 100101, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6627,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.64614561,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"379","issue":"3","first_page":"697","last_page":"702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autocatalysis","display_name":"autocatalysis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.6949999928474426},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/limited-proteolysis","display_name":"limited proteolysis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.7120000123977661},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.8130000233650208},{"id":"https://openalex.org/keywords/trypsinogen-activation","display_name":"trypsinogen activation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/trypsin","display_name":"trypsin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/calcium-ions","display_name":"calcium ions","score":0.8859999775886536},{"id":"https://openalex.org/keywords/autoactivation","display_name":"self-activation","score":0.4410000145435333},{"id":"https://openalex.org/keywords/kinetic-parameter-estimation","display_name":"kinetic parameter estimation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/enzyme-substrate-affinity","display_name":"enzyme-substrate affinity","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2781286802","wikidata":"https://www.wikidata.org/wiki/Q421373","display_name":"Trypsinogen","level":4,"score":0.9337960481643677},{"id":"https://openalex.org/C2778775115","wikidata":"https://www.wikidata.org/wiki/Q245759","display_name":"Zymogen","level":3,"score":0.7889427542686462},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.735345721244812},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.6523259878158569},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.6217001676559448},{"id":"https://openalex.org/C37263863","wikidata":"https://www.wikidata.org/wiki/Q786897","display_name":"Autocatalysis","level":3,"score":0.6138789653778076},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.4876945912837982},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.45849621295928955},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44921875},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4297027885913849},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3460164964199066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11879530549049377},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.11279144883155823}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014362","descriptor_name":"Trypsinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj20031365","doi":"https://doi.org/10.1042/bj20031365","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20031365","pdf_url":"https://portlandpress.com/biochemj/article-pdf/379/3/697/713405/bj3790697.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:14705964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14705964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1224100","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1224100/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1042/bj20031365","doi":"https://doi.org/10.1042/bj20031365","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20031365","pdf_url":"https://portlandpress.com/biochemj/article-pdf/379/3/697/713405/bj3790697.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6644296574","display_name":"\u5171\u4ef7\u4fee\u9970\u5bf9\u9176\u6d3b\u6027\u8c03\u8282\u7684\u52a8\u529b\u5b66\u7814\u7a76","funder_award_id":"30270327","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8504528457","display_name":"REGULATION AND SIGNALING OF P21-ACTIVATED KINASES","funder_award_id":"R03TW001501","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2079784591.pdf","grobid_xml":"https://content.openalex.org/works/W2079784591.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W42839287","https://openalex.org/W235109673","https://openalex.org/W1499907727","https://openalex.org/W1558814513","https://openalex.org/W1569886016","https://openalex.org/W1995175116","https://openalex.org/W1998261085","https://openalex.org/W2000528855","https://openalex.org/W2017569531","https://openalex.org/W2040650395","https://openalex.org/W2049951402","https://openalex.org/W2054553764","https://openalex.org/W2057421277","https://openalex.org/W2061497413","https://openalex.org/W2083863693","https://openalex.org/W2094914071","https://openalex.org/W2114053013","https://openalex.org/W2117689741","https://openalex.org/W2119935620","https://openalex.org/W2124983348","https://openalex.org/W2137249911","https://openalex.org/W2161340336","https://openalex.org/W2212590994","https://openalex.org/W2314159022","https://openalex.org/W2325191907","https://openalex.org/W2325674731","https://openalex.org/W2337763092","https://openalex.org/W4253401978"],"related_works":["https://openalex.org/W2095052087","https://openalex.org/W2057421277","https://openalex.org/W2433106159","https://openalex.org/W2119935620","https://openalex.org/W2343431783","https://openalex.org/W1566736945","https://openalex.org/W3176537612","https://openalex.org/W1587879375","https://openalex.org/W2163765109","https://openalex.org/W2001937353"],"abstract_inverted_index":{"Protein":[0],"phosphorylation":[1],"and":[2,28,46,141],"limited":[3],"proteolysis":[4],"are":[5,49],"two":[6,131],"most":[7],"common":[8],"regulatory":[9,17,54,68],"mechanisms":[10],"involving":[11],"the":[12,37,57,73,76,86,90,101,107,120,144,161,166],"energy-dependent":[13],"covalent":[14],"modification":[15],"of":[16,63,75,89,95,98,103,110,133,146],"enzymes.":[18],"In":[19,56],"addition":[20],"to":[21,84,126],"modifying":[22],"other":[23,53],"proteins,":[24],"many":[25],"protein":[26],"kinases":[27],"proteases":[29],"catalyse":[30],"automodification":[31],"reactions":[32,34],"(i.e.":[33],"in":[35],"which":[36],"kinase":[38],"or":[39],"zymogen":[40],"serves":[41],"as":[42],"its":[43],"own":[44],"substrate),":[45],"their":[47],"activities":[48],"frequently":[50],"regulated":[51],"by":[52,67,112],"ligands.":[55],"present":[58],"study,":[59],"a":[60,79],"kinetic":[61,77,87],"analysis":[62],"autocatalytic":[64],"reaction":[65],"modulated":[66],"ligands":[69],"is":[70,82,114,128,154],"presented.":[71],"On":[72],"basis":[74],"equation,":[78],"novel":[80],"procedure":[81],"developed":[83],"evaluate":[85],"parameters":[88],"reaction.":[91],"As":[92],"an":[93,96],"example":[94],"application":[97],"this":[99],"method,":[100],"effects":[102],"calcium":[104],"ions":[105,148],"on":[106,149,165],"autoacatalytic":[108],"activation":[109],"trypsinogen":[111,125,153],"trypsin":[113,127],"re-examined.":[115],"The":[116],"results":[117],"indicate":[118],"that":[119,137,143,159],"binding":[121],"affinity":[122],"for":[123,138,152,160],"Ca2+-bound":[124],"at":[129],"least":[130],"orders":[132],"magnitude":[134],"higher":[135],"than":[136,158],"Ca2+-free":[139],"trypsinogen,":[140],"therefore":[142],"effect":[145],"Ca2+":[147],"K(m*)":[150],"values":[151],"very":[155],"much":[156],"greater":[157],"model":[162],"peptides.":[163],"Based":[164],"experimental":[167],"results,":[168],"one":[169],"possible":[170],"molecular":[171],"mechanism":[172],"has":[173],"been":[174],"proposed.":[175]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}