{"id":"https://openalex.org/W2079711957","doi":"https://doi.org/10.1073/pnas.192251199","title":"A push\u2013pull approach to maximize vaccine efficacy: Abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L","display_name":"A push\u2013pull approach to maximize vaccine efficacy: Abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L","publication_year":2002,"publication_date":"2002-09-13","ids":{"openalex":"https://openalex.org/W2079711957","doi":"https://doi.org/10.1073/pnas.192251199","mag":"2079711957","pmid":"https://pubmed.ncbi.nlm.nih.gov/12232042","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/130579"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.192251199","doi":"https://doi.org/10.1073/pnas.192251199","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.192251199","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/130579","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110105102","display_name":"Jeffrey D. Ahlers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Ahlers","raw_affiliation_strings":["Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066017072","display_name":"Igor M. Belyakov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor M. Belyakov","raw_affiliation_strings":["Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101822595","display_name":"Masaki Terabe","orcid":"https://orcid.org/0000-0002-1777-0189","observed_orcids":["https://orcid.org/0000-0002-1777-0189"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masaki Terabe","raw_affiliation_strings":["Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038958173","display_name":"Rima Koka","orcid":"https://orcid.org/0000-0002-0457-8489","observed_orcids":["https://orcid.org/0000-0002-0457-8489"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rima Koka","raw_affiliation_strings":["Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016860871","display_name":"Debra D. Donaldson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra D. Donaldson","raw_affiliation_strings":["Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041850461","display_name":"Elaine K. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine K. Thomas","raw_affiliation_strings":["Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056265030","display_name":"Jay A. Berzofsky","orcid":"https://orcid.org/0000-0002-0342-3194","observed_orcids":["https://orcid.org/0000-0002-0342-3194"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jay A. Berzofsky","raw_affiliation_strings":["Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Wyeth Genetics Institute, Andover, MA 01810; and Immunex Corporation, Seattle, WA 98101-2936","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056265030"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":2.5297,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.89619647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"99","issue":"20","first_page":"13020","last_page":"13025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/ctl-induction","display_name":"CTL induction","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cd4-t-cell-suppression","display_name":"CD4+ T cell suppression","score":0.824999988079071},{"id":"https://openalex.org/keywords/cd4-regulatory-t-cells","display_name":"CD4+ regulatory T cells","score":0.796999990940094},{"id":"https://openalex.org/keywords/cd4-nkt-cells","display_name":"CD4+ NKT cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cd40-ligand","display_name":"CD40 ligand","score":0.968999981880188},{"id":"https://openalex.org/keywords/t-cell-help","display_name":"T cell help","score":0.7609999775886536},{"id":"https://openalex.org/keywords/viral-infection-protection","display_name":"viral infection protection","score":0.5730000138282776},{"id":"https://openalex.org/keywords/hiv-vaccine","display_name":"HIV vaccine","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.6492379307746887},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6489889621734619},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5810651779174805},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.5777896642684937},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5098158717155457},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.4911012649536133},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.45751115679740906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4404182732105255},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3542238473892212},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.34501367807388306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05255517363548279},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014616","descriptor_name":"Vaccinia virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023201","descriptor_name":"CD40 Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.192251199","doi":"https://doi.org/10.1073/pnas.192251199","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.192251199","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:177209","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/130579","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:130579","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/130579","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:12232042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12232042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"mag:2764708710","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/80015615368","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:177209","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/130579","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W60866071","https://openalex.org/W1501518736","https://openalex.org/W1538328956","https://openalex.org/W1546960285","https://openalex.org/W1549087352","https://openalex.org/W1557171096","https://openalex.org/W1559556959","https://openalex.org/W1566941893","https://openalex.org/W1594509286","https://openalex.org/W1595814035","https://openalex.org/W1609155991","https://openalex.org/W1669165205","https://openalex.org/W1678167583","https://openalex.org/W1919804251","https://openalex.org/W1924533991","https://openalex.org/W1969372348","https://openalex.org/W1979341960","https://openalex.org/W1980621729","https://openalex.org/W1988317772","https://openalex.org/W1991148746","https://openalex.org/W2001824569","https://openalex.org/W2017873272","https://openalex.org/W2026223086","https://openalex.org/W2031477951","https://openalex.org/W2038917355","https://openalex.org/W2040729254","https://openalex.org/W2042212610","https://openalex.org/W2044058829","https://openalex.org/W2044306159","https://openalex.org/W2051359105","https://openalex.org/W2082927436","https://openalex.org/W2086356138","https://openalex.org/W2099535895","https://openalex.org/W2101230909","https://openalex.org/W2102777081","https://openalex.org/W2124969212","https://openalex.org/W2125556458","https://openalex.org/W2128983157","https://openalex.org/W2138733343","https://openalex.org/W2144882745","https://openalex.org/W2148785609","https://openalex.org/W2152115051","https://openalex.org/W2157303983","https://openalex.org/W2160613479","https://openalex.org/W2167174534","https://openalex.org/W2171425063","https://openalex.org/W2172466148","https://openalex.org/W2263690628","https://openalex.org/W2412515058","https://openalex.org/W4246686612","https://openalex.org/W4255724727","https://openalex.org/W4313333776"],"related_works":["https://openalex.org/W2764708710","https://openalex.org/W2062009379","https://openalex.org/W2125556458","https://openalex.org/W1583764054","https://openalex.org/W2418514794","https://openalex.org/W1924533991","https://openalex.org/W2161620477","https://openalex.org/W2094775324","https://openalex.org/W2320605421","https://openalex.org/W2049539366"],"abstract_inverted_index":{"Although":[0],"a":[1,24,52,128,149,161],"role":[2,26,129],"for":[3,130,160,169],"CD4(+)":[4,28,70,73,123],"helper":[5,101],"cells":[6,30],"in":[7,31,97,134],"CD8(+)":[8],"cytotoxic":[9],"T":[10,29,124,131],"lymphocyte":[11],"(CTL)":[12],"induction":[13,58,140],"by":[14,61,81,148,151],"vaccines":[15],"is":[16,21],"widely":[17],"recognized,":[18],"much":[19],"less":[20],"known":[22],"about":[23,36],"counterbalancing":[25],"of":[27,44,55,64,68,78,100,122],"down-modulating":[32],"this":[33,45,153],"response,":[34],"or":[35,76],"ways":[37],"to":[38,114,117,142,164],"optimize":[39],"vaccine":[40,150,166],"responses":[41],"through":[42,66],"abrogation":[43,121],"negative":[46],"regulatory":[47,69],"mechanism.":[48],"Here,":[49],"we":[50],"discovered":[51],"synergistic":[53,154],"enhancement":[54],"vaccine-mediated":[56],"CTL":[57,119,139],"and":[59,91,106,171],"protection":[60,144],"the":[62,86,92,98,107],"relief":[63],"suppression":[65],"depletion":[67],"cells,":[71,75,83],"including":[72],"NKT":[74],"blockade":[77],"IL-13":[79],"made":[80],"these":[82],"combined":[84,155],"with":[85],"cytokine":[87],"granulocyte/macrophage":[88,103],"colony-stimulating":[89,104],"factor":[90,105],"costimulatory":[93],"molecule":[94,109],"CD40L.":[95],"Indeed,":[96],"absence":[99],"epitopes,":[102],"helper-mimetic":[108],"CD40L":[110],"are":[111],"not":[112],"sufficient":[113],"replace":[115],"help":[116,133],"induce":[118],"without":[120],"cell-mediated":[125],"suppression,":[126],"suggesting":[127],"cell":[132],"overcoming":[135],"suppression.":[136],"The":[137],"increased":[138],"translated":[141],"striking":[143],"against":[145],"viral":[146],"infection":[147],"using":[152],"approach.":[156],"These":[157],"results":[158],"argue":[159],"push-pull":[162],"approach":[163],"maximize":[165],"efficacy,":[167],"especially":[168],"HIV":[170],"cancer.":[172]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
