{"id":"https://openalex.org/W2079701099","doi":"https://doi.org/10.1111/j.1600-0560.2012.01918.x","title":"Gemcitabine\u2010associated livedoid thrombotic microangiopathy with associated sclerema neonatorum\u2010like microscopic changes","display_name":"Gemcitabine\u2010associated livedoid thrombotic microangiopathy with associated sclerema neonatorum\u2010like microscopic changes","publication_year":2012,"publication_date":"2012-05-22","ids":{"openalex":"https://openalex.org/W2079701099","doi":"https://doi.org/10.1111/j.1600-0560.2012.01918.x","mag":"2079701099","pmid":"https://pubmed.ncbi.nlm.nih.gov/22612305"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0560.2012.01918.x","doi":"https://doi.org/10.1111/j.1600-0560.2012.01918.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0560.2012.01918.x","pdf_url":null,"source":{"id":"https://openalex.org/S92442678","display_name":"Journal of Cutaneous Pathology","issn_l":"0303-6987","issn":["0303-6987","1600-0560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cutaneous Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073946974","display_name":"Jos\u00e9 Mar\u00eda Mir-Bonaf\u00e9","orcid":"https://orcid.org/0000-0002-6104-8169","observed_orcids":["https://orcid.org/0000-0002-6104-8169"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210099034","display_name":"Complejo Hospitalario de Salamanca","ror":"https://ror.org/0131vfw26","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 M. Mir\u2010Bonaf\u00e9","raw_affiliation_strings":["Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain. jmirbonafe@gmail.com","Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain","These two authors have contributed equally in this manuscript"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain. jmirbonafe@gmail.com","institution_ids":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]},{"raw_affiliation_string":"Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]},{"raw_affiliation_string":"These two authors have contributed equally in this manuscript","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011526474","display_name":"Concepci\u00f3n Rom\u00e1n\u2010Curto","orcid":"https://orcid.org/0000-0001-6147-9412","observed_orcids":["https://orcid.org/0000-0001-6147-9412"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210099034","display_name":"Complejo Hospitalario de Salamanca","ror":"https://ror.org/0131vfw26","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Concepci\u00f3n Rom\u00e1n\u2010Curto","raw_affiliation_strings":["Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain","These two authors have contributed equally in this manuscript"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]},{"raw_affiliation_string":"These two authors have contributed equally in this manuscript","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061747149","display_name":"Angel Jr. Santos-Briz","orcid":"https://orcid.org/0000-0002-4711-5142","observed_orcids":["https://orcid.org/0000-0002-4711-5142"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c1ngel Santos\u2010Briz","raw_affiliation_strings":["Department of Pathology, University Hospital of Salamanca, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University Hospital of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086014330","display_name":"Javier Ca\u00f1ueto","orcid":"https://orcid.org/0000-0003-0037-7353","observed_orcids":["https://orcid.org/0000-0003-0037-7353"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Javier Ca\u00f1ueto","raw_affiliation_strings":["Department of Dermatology, Hospital Nuestra Sen\u0303ora De Sonsoles, A\u0301vila, Spain","Department of Dermatology, Hospital Nuestra Se\u00f1ora De Sonsoles, \u00c1vila, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Hospital Nuestra Sen\u0303ora De Sonsoles, A\u0301vila, Spain","institution_ids":[]},{"raw_affiliation_string":"Department of Dermatology, Hospital Nuestra Se\u00f1ora De Sonsoles, \u00c1vila, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072688342","display_name":"Emilia Fern\u00e1ndez\u2010L\u00f3pez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210099034","display_name":"Complejo Hospitalario de Salamanca","ror":"https://ror.org/0131vfw26","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Emilia Fern\u00e1ndez\u2010L\u00f3pez","raw_affiliation_strings":["Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110167107","display_name":"Pablo de Unamuno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210099034","display_name":"Complejo Hospitalario de Salamanca","ror":"https://ror.org/0131vfw26","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pablo Unamuno","raw_affiliation_strings":["Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073946974"],"corresponding_institution_ids":["https://openalex.org/I184999862","https://openalex.org/I4210099034"],"apc_list":{"value":3570,"currency":"USD","value_usd":3570},"apc_paid":null,"fwci":1.0851,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.75879833,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"39","issue":"7","first_page":"707","last_page":"711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sclerema-neonatorum","display_name":"sclerema neonatorum","score":0.8790000081062317},{"id":"https://openalex.org/keywords/drug-induced-skin-reaction","display_name":"drug-induced skin reaction","score":0.7770000100135803},{"id":"https://openalex.org/keywords/drug-induced-thrombotic-microangiopathy","display_name":"drug-induced thrombotic microangiopathy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/small-vessel-occlusion","display_name":"small vessel occlusion","score":0.753000020980835},{"id":"https://openalex.org/keywords/leukocyte-infiltration","display_name":"leukocyte infiltration","score":0.621999979019165},{"id":"https://openalex.org/keywords/endothelial-swelling","display_name":"endothelial cell swelling","score":0.7300000190734863},{"id":"https://openalex.org/keywords/dermatopathology","display_name":"dermatopathology","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2777878052","wikidata":"https://www.wikidata.org/wiki/Q3312044","display_name":"Thrombotic microangiopathy","level":3,"score":0.9103580713272095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.866978645324707},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.7256729006767273},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6026749014854431},{"id":"https://openalex.org/C2776513394","wikidata":"https://www.wikidata.org/wiki/Q1412400","display_name":"Microangiopathy","level":3,"score":0.5831440091133118},{"id":"https://openalex.org/C2778397455","wikidata":"https://www.wikidata.org/wiki/Q50429865","display_name":"Antimetabolite","level":3,"score":0.5088439583778381},{"id":"https://openalex.org/C2778585876","wikidata":"https://www.wikidata.org/wiki/Q1426491","display_name":"Thrombotic thrombocytopenic purpura","level":3,"score":0.428009033203125},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.42461490631103516},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3342897295951843},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3337850272655487},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32459282875061035},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2236907184123993},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.09478482604026794},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.08617573976516724},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D057049","descriptor_name":"Thrombotic Microangiopathies","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D057049","descriptor_name":"Thrombotic Microangiopathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057049","descriptor_name":"Thrombotic Microangiopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0560.2012.01918.x","doi":"https://doi.org/10.1111/j.1600-0560.2012.01918.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0560.2012.01918.x","pdf_url":null,"source":{"id":"https://openalex.org/S92442678","display_name":"Journal of Cutaneous Pathology","issn_l":"0303-6987","issn":["0303-6987","1600-0560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cutaneous Pathology","raw_type":"journal-article"},{"id":"pmid:22612305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22612305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cutaneous pathology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1964719439","https://openalex.org/W1970507538","https://openalex.org/W1978350397","https://openalex.org/W1998985018","https://openalex.org/W2000513062","https://openalex.org/W2018854564","https://openalex.org/W2039898149","https://openalex.org/W2051236330","https://openalex.org/W2054456815","https://openalex.org/W2054537594","https://openalex.org/W2078229309","https://openalex.org/W2085165002","https://openalex.org/W2096691726","https://openalex.org/W2112474929","https://openalex.org/W2112548460","https://openalex.org/W2122226796","https://openalex.org/W2140698471","https://openalex.org/W2159176539","https://openalex.org/W2183596986"],"related_works":["https://openalex.org/W2039898149","https://openalex.org/W2002039118","https://openalex.org/W4405014714","https://openalex.org/W4226136158","https://openalex.org/W4327578294","https://openalex.org/W2568951865","https://openalex.org/W4402684656","https://openalex.org/W2140698471","https://openalex.org/W2040863616","https://openalex.org/W2753777474"],"abstract_inverted_index":{"Gemcitabine":[0],"is":[1,7,152],"a":[2,38,42,65,84,88],"deoxycytidine":[3],"analog":[4],"antimetabolite":[5],"that":[6,77],"now":[8],"accepted":[9],"as":[10,97],"first-line":[11],"treatment":[12],"for":[13],"advanced":[14],"and":[15,64,83,109,118,123,150],"metastatic":[16],"pancreatic":[17],"carcinoma.":[18],"Gemcitabine-related":[19],"thrombotic":[20,28,44,54],"microangiopathy":[21,45,55],"associated":[22,50],"with":[23,46,134],"systemic":[24],"hemolytic-uremic":[25,51],"syndrome":[26],"or":[27,87],"thrombocytopenia":[29],"purpura":[30],"has":[31],"rarely":[32],"been":[33,95],"described.":[34],"Herein,":[35],"we":[36,128],"report":[37],"patient":[39],"who":[40],"developed":[41],"livedoid":[43],"no":[47],"signs":[48],"of":[49,60,68,71,91,112,139,143],"syndrome.":[52],"Cutaneous":[53],"occurred":[56],"after":[57],"the":[58,98,107],"administration":[59],"his":[61],"17th":[62],"cycle":[63,86],"cumulative":[66,89],"dose":[67,90],"53.65":[69],"g/m(2)":[70,93],"gemcitabine.":[72],"Some":[73],"authors":[74],"have":[75,94],"suggested":[76],"this":[78,144],"toxicity":[79,147],"may":[80],"be":[81],"dose-related,":[82],"10th":[85],"9-56":[92],"proposed":[96],"prothrombotic":[99],"threshold.":[100],"Interestingly,":[101],"dermatopathologic":[102],"findings":[103],"were":[104],"limited":[105],"to":[106],"subcutis":[108],"they":[110],"consisted":[111],"small-vessel":[113],"occlusion":[114],"by":[115,148],"intravascular":[116],"fibrin":[117],"leukocytes,":[119],"vessel":[120],"wall":[121],"thickening":[122],"endothelial":[124],"cell":[125],"swelling.":[126],"Surprisingly,":[127],"observed":[129],"some":[130],"structures":[131],"arranged":[132],"radially":[133],"needle-shaped":[135],"clefts":[136],"resembling":[137],"those":[138],"sclerema":[140],"neonatorum.":[141],"Awareness":[142],"potential":[145],"cutaneous":[146],"dermatologists":[149],"dermatopathologists":[151],"extremely":[153],"important.":[154]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}