{"id":"https://openalex.org/W2079664650","doi":"https://doi.org/10.1038/cddis.2014.156","title":"Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death","display_name":"Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death","publication_year":2014,"publication_date":"2014-04-24","ids":{"openalex":"https://openalex.org/W2079664650","doi":"https://doi.org/10.1038/cddis.2014.156","mag":"2079664650","pmid":"https://pubmed.ncbi.nlm.nih.gov/24763050","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4001310"},"language":"en","primary_location":{"id":"doi:10.1038/cddis.2014.156","doi":"https://doi.org/10.1038/cddis.2014.156","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2014.156","pdf_url":"https://www.nature.com/articles/cddis2014156.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/cddis2014156.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028323461","display_name":"Artem Kondratskyi","orcid":"https://orcid.org/0000-0003-3290-0524","observed_orcids":["https://orcid.org/0000-0003-3290-0524"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4387154560","display_name":"Universit\u00e9 Lille 1","ror":"https://ror.org/040hwdc70","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I4387154560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Kondratskyi","raw_affiliation_strings":["Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210095243","https://openalex.org/I4387154560"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Yassine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4387154560","display_name":"Universit\u00e9 Lille 1","ror":"https://ror.org/040hwdc70","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I4387154560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Yassine","raw_affiliation_strings":["Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210095243","https://openalex.org/I4387154560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108085386","display_name":"Christian Slomianny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4387154560","display_name":"Universit\u00e9 Lille 1","ror":"https://ror.org/040hwdc70","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I4387154560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Slomianny","raw_affiliation_strings":["Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210095243","https://openalex.org/I4387154560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034600603","display_name":"Kateryna Kondratska","orcid":"https://orcid.org/0000-0001-7232-3093","observed_orcids":["https://orcid.org/0000-0001-7232-3093"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4387154560","display_name":"Universit\u00e9 Lille 1","ror":"https://ror.org/040hwdc70","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I4387154560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"K Kondratska","raw_affiliation_strings":["Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210095243","https://openalex.org/I4387154560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076667801","display_name":"Dmitri V. Gordienko","orcid":"https://orcid.org/0000-0002-4118-9976","observed_orcids":["https://orcid.org/0000-0002-4118-9976"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4387154560","display_name":"Universit\u00e9 Lille 1","ror":"https://ror.org/040hwdc70","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I4387154560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D Gordienko","raw_affiliation_strings":["Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210095243","https://openalex.org/I4387154560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110155411","display_name":"Etienne Dewailly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4387154560","display_name":"Universit\u00e9 Lille 1","ror":"https://ror.org/040hwdc70","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I4387154560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E Dewailly","raw_affiliation_strings":["Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210095243","https://openalex.org/I4387154560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036612570","display_name":"V\u2019yacheslav Lehen\u2019kyi","orcid":"https://orcid.org/0000-0003-0806-8766","observed_orcids":["https://orcid.org/0000-0003-0806-8766"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4387154560","display_name":"Universit\u00e9 Lille 1","ror":"https://ror.org/040hwdc70","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I4387154560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V Lehen'kyi","raw_affiliation_strings":["Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210095243","https://openalex.org/I4387154560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073317781","display_name":"Roman N. Skryma","orcid":"https://orcid.org/0000-0002-9263-0477","observed_orcids":["https://orcid.org/0000-0002-9263-0477"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4387154560","display_name":"Universit\u00e9 Lille 1","ror":"https://ror.org/040hwdc70","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I4387154560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R Skryma","raw_affiliation_strings":["Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210095243","https://openalex.org/I4387154560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007220163","display_name":"Natalia B. Prevarskaya","orcid":"https://orcid.org/0000-0003-0316-197X","observed_orcids":["https://orcid.org/0000-0003-0316-197X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4387154560","display_name":"Universit\u00e9 Lille 1","ror":"https://ror.org/040hwdc70","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I4387154560"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"N Prevarskaya","raw_affiliation_strings":["Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U-1003, Equipe labellis\u00e9e par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics, Universit\u00e9 Lille 1, Villeneuve-d'Ascq, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210095243","https://openalex.org/I4387154560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007220163"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210095243","https://openalex.org/I4387154560"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":1.5692,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.78482847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"4","first_page":"e1193","last_page":"e1193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ml-9","display_name":"ML-9","score":1.0},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/lysosomotropic-agents","display_name":"lysosomotropic agents","score":0.8790000081062317},{"id":"https://openalex.org/keywords/akt-inhibitors","display_name":"AKT inhibitors","score":0.5920000076293945},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.7440000176429749},{"id":"https://openalex.org/keywords/myosin-light-chain-kinase","display_name":"myosin light chain kinase","score":0.8309999704360962},{"id":"https://openalex.org/keywords/stromal-interaction-molecule-1","display_name":"STIM1","score":0.996999979019165},{"id":"https://openalex.org/keywords/lysosomal-ph","display_name":"lysosomal pH","score":0.8330000042915344},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7580000162124634},{"id":"https://openalex.org/keywords/docetaxel-combination-therapy","display_name":"docetaxel combination therapy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/autophagosomes","display_name":"autophagosomes","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9233930110931396},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7653474807739258},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7478424310684204},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6089661121368408},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5314784049987793},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4807562530040741},{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.47510871291160583},{"id":"https://openalex.org/C168296220","wikidata":"https://www.wikidata.org/wiki/Q14882441","display_name":"Autophagosome","level":4,"score":0.4721398651599884},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4619787931442261},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4605293869972229},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3938179612159729},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35278797149658203},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3406175374984741},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3181244730949402},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2983532249927521},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2139115035533905},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001381","descriptor_name":"Azepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010588","descriptor_name":"Phagosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010588","descriptor_name":"Phagosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010588","descriptor_name":"Phagosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058546","descriptor_name":"Class III Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/cddis.2014.156","doi":"https://doi.org/10.1038/cddis.2014.156","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2014.156","pdf_url":"https://www.nature.com/articles/cddis2014156.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2978338","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4001310","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:24763050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24763050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4001310","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4001310/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-04122744v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-04122744","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death and Disease, 2014, 5 (4), pp.e1193-e1193. &#x27E8;10.1038/cddis.2014.156&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/cddis.2014.156","doi":"https://doi.org/10.1038/cddis.2014.156","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2014.156","pdf_url":"https://www.nature.com/articles/cddis2014156.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2079664650.pdf","grobid_xml":"https://content.openalex.org/works/W2079664650.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W18850067","https://openalex.org/W1498131948","https://openalex.org/W1964708202","https://openalex.org/W1969187935","https://openalex.org/W1970285863","https://openalex.org/W1980942517","https://openalex.org/W1987769185","https://openalex.org/W1989016316","https://openalex.org/W1993643473","https://openalex.org/W1993908556","https://openalex.org/W1994817218","https://openalex.org/W1998786498","https://openalex.org/W2005727437","https://openalex.org/W2006771504","https://openalex.org/W2008473350","https://openalex.org/W2009959751","https://openalex.org/W2011350626","https://openalex.org/W2014918593","https://openalex.org/W2022288928","https://openalex.org/W2023465240","https://openalex.org/W2025319771","https://openalex.org/W2030372123","https://openalex.org/W2040595737","https://openalex.org/W2044767937","https://openalex.org/W2046250764","https://openalex.org/W2062828595","https://openalex.org/W2071067115","https://openalex.org/W2074185046","https://openalex.org/W2074528922","https://openalex.org/W2078444317","https://openalex.org/W2101399736","https://openalex.org/W2102690338","https://openalex.org/W2105114667","https://openalex.org/W2105266148","https://openalex.org/W2107601804","https://openalex.org/W2109467838","https://openalex.org/W2113118283","https://openalex.org/W2114645683","https://openalex.org/W2115806147","https://openalex.org/W2117958014","https://openalex.org/W2121312569","https://openalex.org/W2127916470","https://openalex.org/W2128280806","https://openalex.org/W2130498948","https://openalex.org/W2139269993","https://openalex.org/W2142845200","https://openalex.org/W2144380012","https://openalex.org/W2146124002","https://openalex.org/W2162026959","https://openalex.org/W2162797237","https://openalex.org/W2164778558","https://openalex.org/W2287436660"],"related_works":["https://openalex.org/W2113118283","https://openalex.org/W2088394529","https://openalex.org/W7100109272","https://openalex.org/W1989548787","https://openalex.org/W4318766029","https://openalex.org/W2584518172","https://openalex.org/W2271184418","https://openalex.org/W2320610285","https://openalex.org/W1160268340","https://openalex.org/W7097794593"],"abstract_inverted_index":{"The":[0],"growing":[1],"number":[2],"of":[3,8,13,30,55,90,99,119,139],"studies":[4],"suggested":[5],"that":[6,24,47,75],"inhibition":[7,138],"autophagy":[9,122,132],"enhances":[10,95],"the":[11,44,88,96,116,141,145],"efficacy":[12],"Akt":[14,31,142],"kinase":[15,35],"inhibitors":[16],"in":[17,133],"cancer":[18,83,134],"therapy.":[19],"Here,":[20],"we":[21],"provide":[22],"evidence":[23],"ML-9,":[25],"a":[26,66,78],"widely":[27],"used":[28],"inhibitor":[29],"kinase,":[32],"myosin":[33],"light-chain":[34],"(MLCK)":[36],"and":[37,59,69,123,144],"stromal":[38],"interaction":[39],"molecule":[40],"1":[41],"(STIM1),":[42],"represents":[43],"'two-in-one'":[45],"compound":[46],"stimulates":[48],"autophagosome":[49],"formation":[50],"(by":[51,63],"downregulating":[52],"Akt/mammalian":[53],"target":[54],"rapamycin":[56],"(mTOR)":[57],"pathway)":[58],"inhibits":[60],"their":[61],"degradation":[62],"acting":[64],"like":[65],"lysosomotropic":[67],"agent":[68],"increasing":[70],"lysosomal":[71],"pH).":[72],"We":[73],"show":[74],"ML-9":[76,94,120,125],"as":[77,105,126],"monotherapy":[79],"effectively":[80],"induces":[81],"prostate":[82],"cell":[84],"death":[85],"associated":[86],"with":[87],"accumulation":[89],"autophagic":[91],"vacuoles.":[92],"Further,":[93],"anticancer":[97,110],"activity":[98],"docetaxel,":[100],"suggesting":[101],"its":[102],"potential":[103],"application":[104],"an":[106,127],"adjuvant":[107],"to":[108],"existing":[109],"chemotherapy.":[111],"Altogether,":[112],"our":[113],"results":[114],"revealed":[115],"complex":[117],"effect":[118],"on":[121],"indentified":[124],"attractive":[128],"tool":[129],"for":[130],"targeting":[131],"therapy":[135],"through":[136],"dual":[137],"both":[140],"pathway":[143],"autophagy.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
