{"id":"https://openalex.org/W2079649151","doi":"https://doi.org/10.1038/sj.onc.1203310","title":"The human non-muscle \u03b1-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells","display_name":"The human non-muscle \u03b1-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells","publication_year":2000,"publication_date":"2000-01-20","ids":{"openalex":"https://openalex.org/W2079649151","doi":"https://doi.org/10.1038/sj.onc.1203310","mag":"2079649151","pmid":"https://pubmed.ncbi.nlm.nih.gov/10656685"},"language":"en","primary_location":{"id":"doi:10.1038/sj.onc.1203310","doi":"https://doi.org/10.1038/sj.onc.1203310","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1203310","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112237746","display_name":"Sotiris N. Nikolopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I164389053","display_name":"Fordham University","ror":"https://ror.org/03qnxaf80","country_code":"US","type":"education","lineage":["https://openalex.org/I164389053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sotiris N Nikolopoulos","raw_affiliation_strings":["Department of Biological Sciences, Fordham University, Bronx, New York, NY 10458 USA","Department of Anatomy and Cell Biology, State University of New York at Syracuse, Syracuse, USA","Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, Bronx, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Fordham University, Bronx, New York, NY 10458 USA","institution_ids":["https://openalex.org/I164389053"]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, State University of New York at Syracuse, Syracuse, USA","institution_ids":["https://openalex.org/I1327163397"]},{"raw_affiliation_string":"Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, Bronx, USA","institution_ids":["https://openalex.org/I164389053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108260189","display_name":"Barbara A. Spengler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164389053","display_name":"Fordham University","ror":"https://ror.org/03qnxaf80","country_code":"US","type":"education","lineage":["https://openalex.org/I164389053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara A Spengler","raw_affiliation_strings":["Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, 441 East Fordham Road, Bronx, 10458, New York, NY, USA","Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, Bronx, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, 441 East Fordham Road, Bronx, 10458, New York, NY, USA","institution_ids":["https://openalex.org/I164389053"]},{"raw_affiliation_string":"Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, Bronx, USA","institution_ids":["https://openalex.org/I164389053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069577942","display_name":"Kristin D. Kisselbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin Kisselbach","raw_affiliation_strings":["Division of Oncology, Abramson Pediatric Research Center, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, 19104, PA, USA","Division of Oncology, Abramson Pediatric Research Center, The Children's Hospital of Philadelphia, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Abramson Pediatric Research Center, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, 19104, PA, USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Division of Oncology, Abramson Pediatric Research Center, The Children's Hospital of Philadelphia, Philadelphia, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108635422","display_name":"Audrey E. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Audrey E Evans","raw_affiliation_strings":["Division of Oncology, Abramson Pediatric Research Center, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, 19104, PA, USA","Division of Oncology, Abramson Pediatric Research Center, The Children's Hospital of Philadelphia, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Abramson Pediatric Research Center, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, 19104, PA, USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Division of Oncology, Abramson Pediatric Research Center, The Children's Hospital of Philadelphia, Philadelphia, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108218075","display_name":"June L. Biedler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164389053","display_name":"Fordham University","ror":"https://ror.org/03qnxaf80","country_code":"US","type":"education","lineage":["https://openalex.org/I164389053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"June L Biedler","raw_affiliation_strings":["Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, 441 East Fordham Road, Bronx, 10458, New York, NY, USA","Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, Bronx, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, 441 East Fordham Road, Bronx, 10458, New York, NY, USA","institution_ids":["https://openalex.org/I164389053"]},{"raw_affiliation_string":"Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, Bronx, USA","institution_ids":["https://openalex.org/I164389053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103441889","display_name":"Robert A. Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164389053","display_name":"Fordham University","ror":"https://ror.org/03qnxaf80","country_code":"US","type":"education","lineage":["https://openalex.org/I164389053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A Ross","raw_affiliation_strings":["Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, 441 East Fordham Road, Bronx, 10458, New York, NY, USA","Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, Bronx, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, 441 East Fordham Road, Bronx, 10458, New York, NY, USA","institution_ids":["https://openalex.org/I164389053"]},{"raw_affiliation_string":"Department of Biological Sciences, Laboratory of Neurobiology, Fordham University, Bronx, USA","institution_ids":["https://openalex.org/I164389053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":null,"fwci":2.6322,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.8965231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"19","issue":"3","first_page":"380","last_page":"386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/actinin-4","display_name":"actinin-4","score":0.8149999976158142},{"id":"https://openalex.org/keywords/actn4","display_name":"ACTN4","score":0.9010000228881836},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7900000214576721},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.8679999709129333},{"id":"https://openalex.org/keywords/substrate-adhesion","display_name":"substrate adhesion","score":0.8659999966621399},{"id":"https://openalex.org/keywords/calcium-regulation","display_name":"calcium regulation","score":0.6010000109672546},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.6819999814033508},{"id":"https://openalex.org/keywords/nude-mouse-tumorigenicity","display_name":"nude mouse tumorigenicity","score":0.6880000233650208},{"id":"https://openalex.org/keywords/be-2-c-cells","display_name":"BE(2)-C cells","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8436435461044312},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.689715564250946},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.668122410774231},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6675666570663452},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.5339037179946899},{"id":"https://openalex.org/C133702464","wikidata":"https://www.wikidata.org/wiki/Q3487083","display_name":"Actinin","level":4,"score":0.5317636132240295},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4988274574279785},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4919733703136444},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.45008769631385803},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.4449206292629242},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4166826009750366},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35733118653297424},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.2757991552352905},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2549639642238617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14102935791015625}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000185","descriptor_name":"Actinin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000185","descriptor_name":"Actinin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000185","descriptor_name":"Actinin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.onc.1203310","doi":"https://doi.org/10.1038/sj.onc.1203310","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1203310","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:10656685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10656685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W126840171","https://openalex.org/W1497300077","https://openalex.org/W1500148089","https://openalex.org/W1563191401","https://openalex.org/W1573817770","https://openalex.org/W1708468382","https://openalex.org/W1848263058","https://openalex.org/W1864905496","https://openalex.org/W1962628502","https://openalex.org/W1971531598","https://openalex.org/W1977860453","https://openalex.org/W1977911381","https://openalex.org/W1980295525","https://openalex.org/W1981581392","https://openalex.org/W1987483436","https://openalex.org/W1989215255","https://openalex.org/W1991954670","https://openalex.org/W2006924926","https://openalex.org/W2012847227","https://openalex.org/W2017384019","https://openalex.org/W2019544795","https://openalex.org/W2024499829","https://openalex.org/W2024880145","https://openalex.org/W2029231027","https://openalex.org/W2040980668","https://openalex.org/W2041267262","https://openalex.org/W2041534105","https://openalex.org/W2043682382","https://openalex.org/W2053530421","https://openalex.org/W2056104802","https://openalex.org/W2060136332","https://openalex.org/W2061385217","https://openalex.org/W2062911730","https://openalex.org/W2067083395","https://openalex.org/W2077416954","https://openalex.org/W2078794352","https://openalex.org/W2081950746","https://openalex.org/W2085987183","https://openalex.org/W2091444169","https://openalex.org/W2091587708","https://openalex.org/W2094297572","https://openalex.org/W2117314202","https://openalex.org/W2118122307","https://openalex.org/W2124499018","https://openalex.org/W2128086743","https://openalex.org/W2130837149","https://openalex.org/W2141397359","https://openalex.org/W2143805521","https://openalex.org/W2169991493","https://openalex.org/W2329830099","https://openalex.org/W2330411050","https://openalex.org/W2399295847","https://openalex.org/W2412234989","https://openalex.org/W4246404285"],"related_works":["https://openalex.org/W1536641694","https://openalex.org/W1983250148","https://openalex.org/W2175953601","https://openalex.org/W7010565472","https://openalex.org/W6998358772","https://openalex.org/W2040980668","https://openalex.org/W1966985735","https://openalex.org/W316740039","https://openalex.org/W2005015952","https://openalex.org/W7096136838"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}