{"id":"https://openalex.org/W2079639372","doi":"https://doi.org/10.1016/j.drudis.2010.08.017","title":"Iminosugars past, present and future: medicines for tomorrow","display_name":"Iminosugars past, present and future: medicines for tomorrow","publication_year":2010,"publication_date":"2010-09-04","ids":{"openalex":"https://openalex.org/W2079639372","doi":"https://doi.org/10.1016/j.drudis.2010.08.017","mag":"2079639372","pmid":"https://pubmed.ncbi.nlm.nih.gov/20817006"},"language":"en","primary_location":{"id":"doi:10.1016/j.drudis.2010.08.017","doi":"https://doi.org/10.1016/j.drudis.2010.08.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drudis.2010.08.017","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113873355","display_name":"Graeme Horne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140851","display_name":"Summit (United Kingdom)","ror":"https://ror.org/03yfgnq74","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210140851"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graeme Horne","raw_affiliation_strings":["Summit Plc(1), 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Summit Plc(1), 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK","institution_ids":["https://openalex.org/I4210140851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040356418","display_name":"Francis X. Wilson","orcid":"https://orcid.org/0000-0002-4840-3277","observed_orcids":["https://orcid.org/0000-0002-4840-3277"]},"institutions":[{"id":"https://openalex.org/I4210140851","display_name":"Summit (United Kingdom)","ror":"https://ror.org/03yfgnq74","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210140851"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Francis X. Wilson","raw_affiliation_strings":["Summit Plc, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK","Summit Plc1, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Summit Plc, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK","institution_ids":["https://openalex.org/I4210140851"]},{"raw_affiliation_string":"Summit Plc1, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK","institution_ids":["https://openalex.org/I4210140851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108111943","display_name":"Jon M. Tinsley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140851","display_name":"Summit (United Kingdom)","ror":"https://ror.org/03yfgnq74","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210140851"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jon Tinsley","raw_affiliation_strings":["Summit Plc, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK","Summit Plc1, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Summit Plc, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK","institution_ids":["https://openalex.org/I4210140851"]},{"raw_affiliation_string":"Summit Plc1, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK","institution_ids":["https://openalex.org/I4210140851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103868686","display_name":"David H. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140851","display_name":"Summit (United Kingdom)","ror":"https://ror.org/03yfgnq74","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210140851"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David H. Williams","raw_affiliation_strings":["Summit Plc, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK","Summit Plc1, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Summit Plc, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK","institution_ids":["https://openalex.org/I4210140851"]},{"raw_affiliation_string":"Summit Plc1, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK","institution_ids":["https://openalex.org/I4210140851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050785711","display_name":"Richard Storer","orcid":"https://orcid.org/0000-0002-9186-786X","observed_orcids":["https://orcid.org/0000-0002-9186-786X"]},"institutions":[{"id":"https://openalex.org/I4210140851","display_name":"Summit (United Kingdom)","ror":"https://ror.org/03yfgnq74","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210140851"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Richard Storer","raw_affiliation_strings":["Summit Plc, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK","Summit Plc1, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Summit Plc, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK","institution_ids":["https://openalex.org/I4210140851"]},{"raw_affiliation_string":"Summit Plc1, 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK","institution_ids":["https://openalex.org/I4210140851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050785711"],"corresponding_institution_ids":["https://openalex.org/I4210140851"],"apc_list":{"value":4720,"currency":"USD","value_usd":4720},"apc_paid":null,"fwci":1.2328,"has_fulltext":false,"cited_by_count":326,"citation_normalized_percentile":{"value":0.76443418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"16","issue":"3-4","first_page":"107","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iminosugars","display_name":"iminosugars","score":0.9990000128746033},{"id":"https://openalex.org/keywords/carbohydrate-mimetics","display_name":"carbohydrate mimetics","score":0.9340000152587891},{"id":"https://openalex.org/keywords/glycobiology","display_name":"glycobiology","score":0.8180000185966492},{"id":"https://openalex.org/keywords/drug-selectivity","display_name":"drug selectivity","score":0.9200000166893005},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6579999923706055},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.4230000078678131},{"id":"https://openalex.org/keywords/glycosyltransferase-inhibitors","display_name":"glycosyltransferase inhibitors","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C204641814","wikidata":"https://www.wikidata.org/wiki/Q899224","display_name":"Glycobiology","level":4,"score":0.7594000101089478},{"id":"https://openalex.org/C2776792218","wikidata":"https://www.wikidata.org/wiki/Q18351124","display_name":"Iminosugar","level":3,"score":0.7094358801841736},{"id":"https://openalex.org/C2992829110","wikidata":"https://www.wikidata.org/wiki/Q3921615","display_name":"First generation","level":3,"score":0.4515957534313202},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.44884854555130005},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4239242374897003},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4111577272415161},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34893086552619934},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34590858221054077},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29025283455848694},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.21915873885154724},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21450737118721008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19559019804000854},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.07820171117782593},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07404026389122009},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.06340175867080688},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050111","descriptor_name":"Imino Sugars","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D050111","descriptor_name":"Imino Sugars","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.drudis.2010.08.017","doi":"https://doi.org/10.1016/j.drudis.2010.08.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drudis.2010.08.017","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},{"id":"pmid:20817006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20817006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug discovery today","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W633891139","https://openalex.org/W1486213458","https://openalex.org/W1564602846","https://openalex.org/W1581406583","https://openalex.org/W1606766212","https://openalex.org/W1712519623","https://openalex.org/W1781787917","https://openalex.org/W1820870565","https://openalex.org/W1875906722","https://openalex.org/W1964803671","https://openalex.org/W1965629935","https://openalex.org/W1967186502","https://openalex.org/W1970216732","https://openalex.org/W1972610989","https://openalex.org/W1972892429","https://openalex.org/W1974060054","https://openalex.org/W1974081722","https://openalex.org/W1976688813","https://openalex.org/W1977077028","https://openalex.org/W1977186710","https://openalex.org/W1978118796","https://openalex.org/W1979123927","https://openalex.org/W1980191036","https://openalex.org/W1982949457","https://openalex.org/W1983510208","https://openalex.org/W1987202843","https://openalex.org/W1987227171","https://openalex.org/W1987775596","https://openalex.org/W1988843643","https://openalex.org/W1990428276","https://openalex.org/W1993465537","https://openalex.org/W1998161387","https://openalex.org/W1999110304","https://openalex.org/W2007236926","https://openalex.org/W2008270141","https://openalex.org/W2012035721","https://openalex.org/W2012097474","https://openalex.org/W2016800089","https://openalex.org/W2017887262","https://openalex.org/W2022636376","https://openalex.org/W2023655451","https://openalex.org/W2024101412","https://openalex.org/W2024191848","https://openalex.org/W2025008690","https://openalex.org/W2025626805","https://openalex.org/W2025687851","https://openalex.org/W2025742311","https://openalex.org/W2027988055","https://openalex.org/W2029318682","https://openalex.org/W2029498987","https://openalex.org/W2031200361","https://openalex.org/W2036632486","https://openalex.org/W2037122230","https://openalex.org/W2043290769","https://openalex.org/W2046302653","https://openalex.org/W2047682408","https://openalex.org/W2050980724","https://openalex.org/W2051381090","https://openalex.org/W2055349784","https://openalex.org/W2056356730","https://openalex.org/W2060125621","https://openalex.org/W2063047452","https://openalex.org/W2063767625","https://openalex.org/W2069482173","https://openalex.org/W2072630239","https://openalex.org/W2073804137","https://openalex.org/W2073804412","https://openalex.org/W2074645922","https://openalex.org/W2077854609","https://openalex.org/W2078086734","https://openalex.org/W2079700382","https://openalex.org/W2082818302","https://openalex.org/W2082845444","https://openalex.org/W2085285145","https://openalex.org/W2088340806","https://openalex.org/W2090636270","https://openalex.org/W2095643828","https://openalex.org/W2096328095","https://openalex.org/W2097563667","https://openalex.org/W2101927082","https://openalex.org/W2116068036","https://openalex.org/W2117398821","https://openalex.org/W2128402413","https://openalex.org/W2129232972","https://openalex.org/W2138152852","https://openalex.org/W2146877343","https://openalex.org/W2148394088","https://openalex.org/W2152708819","https://openalex.org/W2159558852","https://openalex.org/W2163634822","https://openalex.org/W2164338480","https://openalex.org/W2164906860","https://openalex.org/W2168728749","https://openalex.org/W2169461081","https://openalex.org/W2338266679","https://openalex.org/W2952148299","https://openalex.org/W2952157534","https://openalex.org/W2952356300","https://openalex.org/W2953015035","https://openalex.org/W4206701382","https://openalex.org/W4231173412","https://openalex.org/W4248375451","https://openalex.org/W4251153916","https://openalex.org/W4251546114","https://openalex.org/W4285719527","https://openalex.org/W4313162854"],"related_works":["https://openalex.org/W2182502196","https://openalex.org/W64499177","https://openalex.org/W194646270","https://openalex.org/W2125868974","https://openalex.org/W4211126902","https://openalex.org/W4387991505","https://openalex.org/W1974699475","https://openalex.org/W2169331940","https://openalex.org/W2050980724","https://openalex.org/W2317532233"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":37},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":35},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}