{"id":"https://openalex.org/W2079575180","doi":"https://doi.org/10.1152/ajpcell.00182.2003","title":"A stomatin and a degenerin interact in lipid rafts of the nervous system of Caenorhabditis elegans","display_name":"A stomatin and a degenerin interact in lipid rafts of the nervous system of Caenorhabditis elegans","publication_year":2004,"publication_date":"2004-04-27","ids":{"openalex":"https://openalex.org/W2079575180","doi":"https://doi.org/10.1152/ajpcell.00182.2003","mag":"2079575180","pmid":"https://pubmed.ncbi.nlm.nih.gov/15102610"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.00182.2003","doi":"https://doi.org/10.1152/ajpcell.00182.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00182.2003","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000879558","display_name":"Margaret M. Sedensky","orcid":"https://orcid.org/0000-0001-9822-6558","observed_orcids":["https://orcid.org/0000-0001-9822-6558"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. M. Sedensky","raw_affiliation_strings":["Departments of Anesthesiology and Genetics, University Hospitals and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Genetics, University Hospitals and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091550564","display_name":"J. M. Siefker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Siefker","raw_affiliation_strings":["","Case Western Reserve University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Case Western Reserve University ,","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Y. Koh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Y. Koh","raw_affiliation_strings":["","VA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"VA Medical Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102000361","display_name":"David M. Miller","orcid":"https://orcid.org/0000-0001-9048-873X","observed_orcids":["https://orcid.org/0000-0001-9048-873X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. M. Miller","raw_affiliation_strings":["","VA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"VA Medical Center","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006598602","display_name":"Philip G. Morgan","orcid":"https://orcid.org/0000-0003-4857-2756","observed_orcids":["https://orcid.org/0000-0003-4857-2756"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. G. Morgan","raw_affiliation_strings":["","Case Western Reserve University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Case Western Reserve University ,","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.367,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.77949612,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"287","issue":"2","first_page":"C468","last_page":"C474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.21780000627040863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stomatin","display_name":"stomatin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/unc-1","display_name":"unc-1","score":0.8489999771118164},{"id":"https://openalex.org/keywords/degenerin","display_name":"degenerin","score":0.8529999852180481},{"id":"https://openalex.org/keywords/unc-8","display_name":"unc-8","score":0.609000027179718},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.9909999966621399},{"id":"https://openalex.org/keywords/anesthetic-sensitivity","display_name":"anesthetic sensitivity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/volatile-anesthetics","display_name":"volatile anesthetics","score":0.9679999947547913},{"id":"https://openalex.org/keywords/sodium-channels","display_name":"sodium channels","score":0.652999997138977},{"id":"https://openalex.org/keywords/nervous-system","display_name":"nervous system","score":0.6629999876022339},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.7149999737739563},{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.9919999837875366},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7400000095367432},{"id":"https://openalex.org/keywords/locomotion","display_name":"locomotion","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.8583847880363464},{"id":"https://openalex.org/C79266657","wikidata":"https://www.wikidata.org/wiki/Q424178","display_name":"Lipid raft","level":3,"score":0.8562374114990234},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.7001797556877136},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6367452144622803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5844360589981079},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.4911148250102997},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.44339966773986816},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34617146849632263},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2502574920654297},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.250037282705307},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.20294269919395447}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002458","descriptor_name":"Cell Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.00182.2003","doi":"https://doi.org/10.1152/ajpcell.00182.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00182.2003","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:15102610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15102610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Cell physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1045075802","display_name":"Training Program in Ion Channel and Transporter Biology","funder_award_id":"T32NS007491","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G119642272","display_name":"MOLECULAR PHYSIOLOGY OF MEMBRANE TRANSPORT IN C ELEGANS","funder_award_id":"P01DK058212","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5032483778","display_name":null,"funder_award_id":"NS26115","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8673554884","display_name":"Mechanism of Action of Volatile Anesthetics","funder_award_id":"R01GM045402","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000868268","display_name":"Postdoctoral Program in Functional Neurogenomics","funder_award_id":"T32MH065215","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W153185418","https://openalex.org/W1820962178","https://openalex.org/W1821435713","https://openalex.org/W1887384647","https://openalex.org/W1944127002","https://openalex.org/W1951387555","https://openalex.org/W1969648528","https://openalex.org/W1971615533","https://openalex.org/W1971642414","https://openalex.org/W1974216293","https://openalex.org/W1974926560","https://openalex.org/W1977606425","https://openalex.org/W1978354972","https://openalex.org/W1982600717","https://openalex.org/W1982816670","https://openalex.org/W1985309812","https://openalex.org/W1985777862","https://openalex.org/W1990257793","https://openalex.org/W1991935451","https://openalex.org/W1994304837","https://openalex.org/W1999384908","https://openalex.org/W2007732633","https://openalex.org/W2014275486","https://openalex.org/W2018315382","https://openalex.org/W2029227260","https://openalex.org/W2051545925","https://openalex.org/W2064356157","https://openalex.org/W2066887588","https://openalex.org/W2068146930","https://openalex.org/W2069232833","https://openalex.org/W2069291325","https://openalex.org/W2075856434","https://openalex.org/W2076506108","https://openalex.org/W2081025398","https://openalex.org/W2110022036","https://openalex.org/W2111447389","https://openalex.org/W2120726784","https://openalex.org/W2127161684","https://openalex.org/W2127782546","https://openalex.org/W2138115215","https://openalex.org/W2138570883","https://openalex.org/W2141071568","https://openalex.org/W2157166663","https://openalex.org/W2159565935","https://openalex.org/W2166609159","https://openalex.org/W2170524958","https://openalex.org/W2256088413"],"related_works":["https://openalex.org/W2256088413","https://openalex.org/W1951387555","https://openalex.org/W2007732633","https://openalex.org/W2127161684","https://openalex.org/W1999028714","https://openalex.org/W2022830951","https://openalex.org/W2161998014","https://openalex.org/W2064809250","https://openalex.org/W2175075441","https://openalex.org/W4402034621"],"abstract_inverted_index":{"In":[0,50,91],"Caenorhabditis":[1],"elegans,":[2],"the":[3,20,29,40,75,128,133,174,178,201],"gene":[4,176],"unc-1":[5],"controls":[6],"anesthetic":[7,161,190],"sensitivity":[8,191],"and":[9,24,60,89,111,130,151,168],"normal":[10],"locomotion.":[11],"The":[12,143],"protein":[13,22,42,86,112,126,135,145],"UNC-1":[14,41,134,170,181],"is":[15,25,55,136,146,163],"a":[16,45,96,210],"close":[17],"homolog":[18],"of":[19,53,77,103,125,180,186,200,204,213],"mammalian":[21],"stomatin":[23,54],"expressed":[26],"primarily":[27],"in":[28,34,63,74,149,165,173,182,192],"nervous":[30],"system.":[31],"Genetic":[32],"studies":[33],"C.":[35,104,193],"elegans":[36],"have":[37],"shown":[38],"that":[39,132],"interacts":[43],"with":[44,57,85,114],"sodium":[46,59],"channel":[47],"subunit,":[48],"UNC-8.":[49],"humans,":[51],"absence":[52],"associated":[56,84],"abnormal":[58],"potassium":[61],"levels":[62],"red":[64],"blood":[65],"cells.":[66],"Stomatin":[67],"also":[68,147,159],"has":[69],"been":[70],"postulated":[71],"to":[72,140],"participate":[73],"formation":[76],"lipid":[78,118,166,183,196],"rafts,":[79,167],"which":[80],"are":[81],"membrane":[82],"microdomains":[83],"complexes,":[87],"cholesterol,":[88,109],"sphingolipids.":[90],"this":[92,141],"study,":[93],"we":[94],"isolated":[95],"low-density,":[97],"detergent-resistant":[98],"fraction":[99,107],"from":[100,127],"cell":[101],"membranes":[102],"elegans.":[105,194],"This":[106],"contains":[108],"sphingolipids,":[110],"consistent":[113],"their":[115],"identification":[116],"as":[117],"rafts.":[119,184],"We":[120],"then":[121],"probed":[122],"Western":[123],"blots":[124],"rafts":[129,150,197],"found":[131,148,164],"almost":[137],"totally":[138],"restricted":[139],"fraction.":[142],"UNC-8":[144],"coimmunoprecipitates":[152],"UNC-1.":[153],"A":[154],"second":[155],"stomatin-like":[156],"protein,":[157],"UNC-24,":[158],"affects":[160],"sensitivity,":[162],"regulates":[169],"distribution.":[171],"Mutations":[172],"unc-24":[175],"alter":[177],"distribution":[179],"Each":[185],"these":[187],"mutations":[188],"alters":[189],"Because":[195],"contain":[198],"many":[199],"putative":[202],"targets":[203,214],"volatile":[205,216],"anesthetics,":[206],"they":[207],"may":[208],"represent":[209],"novel":[211],"class":[212],"for":[215],"anesthetics.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}