{"id":"https://openalex.org/W2079482822","doi":"https://doi.org/10.1159/000124752","title":"Effect of ApoE Genotype on Response to Donepezil in Patients with Alzheimer\u2019s Disease","display_name":"Effect of ApoE Genotype on Response to Donepezil in Patients with Alzheimer\u2019s Disease","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2079482822","doi":"https://doi.org/10.1159/000124752","mag":"2079482822","pmid":"https://pubmed.ncbi.nlm.nih.gov/18401173"},"language":"en","primary_location":{"id":"doi:10.1159/000124752","doi":"https://doi.org/10.1159/000124752","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000124752","pdf_url":null,"source":{"id":"https://openalex.org/S195598543","display_name":"Dementia and Geriatric Cognitive Disorders","issn_l":"1420-8008","issn":["1420-8008","1421-9824"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia and Geriatric Cognitive Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110020512","display_name":"Seong Hye Choi","orcid":"https://orcid.org/0000-0002-4180-8626","observed_orcids":["https://orcid.org/0000-0002-4180-8626","https://orcid.org/0000-0002-0680-8364"]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]},{"id":"https://openalex.org/I4210153373","display_name":"Inha University Hospital","ror":"https://ror.org/04gj5px28","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I191879574","https://openalex.org/I4210153373"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong Hye Choi","raw_affiliation_strings":["Department of Neurology, Inha University College of Medicine, Incheon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Inha University College of Medicine, Incheon, South Korea","institution_ids":["https://openalex.org/I191879574","https://openalex.org/I4210153373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001679413","display_name":"SangYun Kim","orcid":"https://orcid.org/0000-0002-9101-5704","observed_orcids":["https://orcid.org/0000-0002-9101-5704"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Yun Kim","raw_affiliation_strings":["Department of Neurology, Seoul National University College of Medicine,","SNUCM Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Seoul National University College of Medicine,","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"SNUCM Neurology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047552330","display_name":"Hae Ri Na","orcid":"https://orcid.org/0000-0002-3419-8428","observed_orcids":["https://orcid.org/0000-0002-3419-8428"]},"institutions":[{"id":"https://openalex.org/I4210118043","display_name":"Bobath memorial hospital","ror":"https://ror.org/028r7gw60","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210118043"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hae Ri Na","raw_affiliation_strings":["Department of Neurology, Bobath Memorial Hospital, Seongnam,","Bobath Memorial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Bobath Memorial Hospital, Seongnam,","institution_ids":["https://openalex.org/I4210118043"]},{"raw_affiliation_string":"Bobath Memorial Hospital","institution_ids":["https://openalex.org/I4210118043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041148039","display_name":"Byung\u2010Kun Kim","orcid":"https://orcid.org/0000-0003-1053-4682","observed_orcids":["https://orcid.org/0000-0003-1053-4682"]},"institutions":[{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]},{"id":"https://openalex.org/I4210164890","display_name":"Eulji Medical Center","ror":"https://ror.org/059x9n677","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I21028721","https://openalex.org/I4210164890"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byung-Kun Kim","raw_affiliation_strings":["Department of Neurology, Eulji University School of Medicine, and","Eulji University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Eulji University School of Medicine, and","institution_ids":["https://openalex.org/I21028721","https://openalex.org/I4210164890"]},{"raw_affiliation_string":"Eulji University","institution_ids":["https://openalex.org/I21028721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002790890","display_name":"Dong Won Yang","orcid":"https://orcid.org/0000-0002-4733-7298","observed_orcids":["https://orcid.org/0000-0002-4733-7298"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong Won Yang","raw_affiliation_strings":["Department of Neurology, Catholic University of Korea College of Medicine, Seoul,","Catholic University of Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Catholic University of Korea College of Medicine, Seoul,","institution_ids":["https://openalex.org/I87111246"]},{"raw_affiliation_string":"Catholic University of Korea;","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108390787","display_name":"Jay Cheol Kwon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jay C. Kwon","raw_affiliation_strings":["Department of Neurology, Changwon Fatima Hospital, Changwon, and","Changwon Fatima Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Changwon Fatima Hospital, Changwon, and","institution_ids":[]},{"raw_affiliation_string":"Changwon Fatima Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018027454","display_name":"Mee Young Park","orcid":"https://orcid.org/0000-0002-5683-1634","observed_orcids":["https://orcid.org/0000-0002-5683-1634"]},"institutions":[{"id":"https://openalex.org/I4400573303","display_name":"Yeungnam University College","ror":"https://ror.org/05e6g0130","country_code":"KR","type":"education","lineage":["https://openalex.org/I4400573303"]},{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mee Young Park","raw_affiliation_strings":["Department of Neurology, Yeungnam University College of Medicine, Daegu, South Korea","Yeungnam University#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Yeungnam University College of Medicine, Daegu, South Korea","institution_ids":["https://openalex.org/I4400573303","https://openalex.org/I55240360"]},{"raw_affiliation_string":"Yeungnam University#TAB#","institution_ids":["https://openalex.org/I55240360"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4739,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.91618762,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"25","issue":"5","first_page":"445","last_page":"450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6425999999046326,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6425999999046326,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.32519999146461487,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9079999923706055},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8960000276565552},{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.8840000033378601},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9580000042915344},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibitors","display_name":"acetylcholinesterase inhibitors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6959999799728394},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.6000000238418579},{"id":"https://openalex.org/keywords/activities-of-daily-living","display_name":"activities of daily living","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.8664917945861816},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.8652324676513672},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6311326026916504},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5631036758422852},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5480220913887024},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5359054207801819},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.469414085149765},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4177423119544983},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.3967137038707733},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3672625422477722},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3509138822555542},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.321115642786026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15238407254219055},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13058879971504211},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077265","descriptor_name":"Donepezil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007189","descriptor_name":"Indans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000124752","doi":"https://doi.org/10.1159/000124752","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000124752","pdf_url":null,"source":{"id":"https://openalex.org/S195598543","display_name":"Dementia and Geriatric Cognitive Disorders","issn_l":"1420-8008","issn":["1420-8008","1421-9824"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia and Geriatric Cognitive Disorders","raw_type":"journal-article"},{"id":"pmid:18401173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18401173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia and geriatric cognitive disorders","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W26105875","https://openalex.org/W98152484","https://openalex.org/W267330029","https://openalex.org/W1847168837","https://openalex.org/W1953027527","https://openalex.org/W1969926447","https://openalex.org/W1980827933","https://openalex.org/W1987985059","https://openalex.org/W1990543766","https://openalex.org/W1991952617","https://openalex.org/W1992511388","https://openalex.org/W2010640607","https://openalex.org/W2018309238","https://openalex.org/W2021814611","https://openalex.org/W2022037315","https://openalex.org/W2025022665","https://openalex.org/W2026267640","https://openalex.org/W2036181392","https://openalex.org/W2039679365","https://openalex.org/W2057679568","https://openalex.org/W2064097612","https://openalex.org/W2085139257","https://openalex.org/W2107388590","https://openalex.org/W2107820540","https://openalex.org/W2111963393","https://openalex.org/W2137903730","https://openalex.org/W2141705100","https://openalex.org/W2142414637","https://openalex.org/W2156220037","https://openalex.org/W2331442217"],"related_works":["https://openalex.org/W2085139257","https://openalex.org/W2263319273","https://openalex.org/W2009140797","https://openalex.org/W2343183508","https://openalex.org/W2463737913","https://openalex.org/W2181635086","https://openalex.org/W2054879352","https://openalex.org/W4205109986","https://openalex.org/W1981613830","https://openalex.org/W2884889949"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"The":[1,139],"possible":[2],"influence":[3],"of":[4,25,37,72,82,107,134,153,160,180],"apolipoprotein":[5],"E":[6],"(ApoE)":[7],"genotype":[8,39],"on":[9,40,109,155],"the":[10,35,41,83,104,110,121,131,150,156,167,177,190],"response":[11,43],"to":[12,29,44,50,198],"acetylcholinesterase":[13],"inhibitor":[14],"therapy":[15],"in":[16,46,60],"patients":[17,47,62,85,187],"with":[18,48,63,69,96],"Alzheimer's":[19,112],"disease":[20],"(AD)":[21],"remains":[22],"a":[23,99,127,145,173],"matter":[24],"controversy.":[26],"In":[27],"order":[28],"address":[30],"this":[31],"issue,":[32],"we":[33],"investigated":[34],"effects":[36],"ApoE":[38,90,93,122,140,168,191],"clinical":[42],"donepezil":[45,73,199],"mild":[49],"moderate":[51],"AD.":[52],"METHODS:":[53],"An":[54],"open":[55],"study":[56],"was":[57],"carried":[58],"out":[59],"51":[61,84],"probable":[64],"AD":[65,97,186],"who":[66,188],"were":[67],"treated":[68],"5-10":[70],"mg":[71],"per":[74],"day":[75],"for":[76],"48":[77,118,164],"weeks.":[78],"RESULTS:":[79],"Eighteen":[80],"(35.3%)":[81],"had":[86],"1":[87],"or":[88],"2":[89],"epsilon4":[91,94,123,141,169,192,201],"alleles.":[92],"carriers":[95],"showed":[98,126],"mean":[100,146],"1.1-point":[101],"increase":[102,129],"from":[103,130,149,176],"baseline":[105,132,151,178],"score":[106,133,152,179],"23.9":[108],"70-point":[111],"Disease":[113],"Assessment":[114],"Scale-Cognitive":[115],"Component":[116],"at":[117,163],"weeks,":[119,165],"while":[120,166],"noncarrier":[124,170],"group":[125,143,171],"3.1-point":[128],"22.5":[135],"(p":[136,182],"=":[137,183],"0.03).":[138],"carrier":[142],"exhibited":[144,172],"0.13-point":[147],"worsening":[148,175],"0.97":[154],"Korean":[157],"Instrumental":[158],"Activities":[159],"Daily":[161],"Living":[162],"0.17-point":[174],"0.64":[181],"0.05).":[184],"CONCLUSION:":[185],"carry":[189],"allele":[193],"may":[194],"respond":[195],"more":[196],"favorably":[197],"than":[200],"noncarriers.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}