{"id":"https://openalex.org/W2079482431","doi":"https://doi.org/10.1021/ac0613277","title":"Infrared Temperature Control System for a Completely Noncontact Polymerase Chain Reaction in Microfluidic Chips","display_name":"Infrared Temperature Control System for a Completely Noncontact Polymerase Chain Reaction in Microfluidic Chips","publication_year":2007,"publication_date":"2007-01-17","ids":{"openalex":"https://openalex.org/W2079482431","doi":"https://doi.org/10.1021/ac0613277","mag":"2079482431","pmid":"https://pubmed.ncbi.nlm.nih.gov/17297927"},"language":"en","primary_location":{"id":"doi:10.1021/ac0613277","doi":"https://doi.org/10.1021/ac0613277","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac0613277","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064958586","display_name":"Michael G. Roper","orcid":"https://orcid.org/0000-0002-0184-1333","observed_orcids":["https://orcid.org/0000-0002-0184-1333"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Roper","raw_affiliation_strings":["Department of Chemistry and Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, and Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, and Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017497897","display_name":"Christopher John Easley","orcid":"https://orcid.org/0000-0002-2403-4147","observed_orcids":["https://orcid.org/0000-0002-2403-4147"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Easley","raw_affiliation_strings":["Department of Chemistry and Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, and Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, and Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064729543","display_name":"Lindsay A. Legendre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay A. Legendre","raw_affiliation_strings":["Department of Chemistry and Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, and Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, and Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111702693","display_name":"J. A. C. Humphrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. C. Humphrey","raw_affiliation_strings":["Department of Chemistry and Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, and Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, and Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031563436","display_name":"James P. Landers","orcid":"https://orcid.org/0000-0002-9310-1796","observed_orcids":["https://orcid.org/0000-0002-9310-1796"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James P. Landers","raw_affiliation_strings":["Department of Chemistry and Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, and Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, and Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031563436"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":6.6555,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.9735781,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"79","issue":"4","first_page":"1294","last_page":"1300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infrared-pyrometer","display_name":"infrared pyrometer","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pcr","display_name":"PCR","score":0.8970000147819519},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.9269999861717224},{"id":"https://openalex.org/keywords/glass-microfluidic-chips","display_name":"glass microfluidic chips","score":0.6209999918937683},{"id":"https://openalex.org/keywords/pyrometer-calibration","display_name":"pyrometer calibration","score":0.8809999823570251},{"id":"https://openalex.org/keywords/on-chip-calibration","display_name":"on-chip calibration","score":0.7940000295639038},{"id":"https://openalex.org/keywords/heat-transfer-modeling","display_name":"heat transfer modeling","score":0.7239999771118164},{"id":"https://openalex.org/keywords/gold-mirror","display_name":"gold mirror","score":0.4620000123977661},{"id":"https://openalex.org/keywords/dna-amplification","display_name":"DNA amplification","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C32993116","wikidata":"https://www.wikidata.org/wiki/Q903715","display_name":"Pyrometer","level":3,"score":0.9048556089401245},{"id":"https://openalex.org/C168068576","wikidata":"https://www.wikidata.org/wiki/Q190241","display_name":"Thermocouple","level":2,"score":0.8419029712677002},{"id":"https://openalex.org/C157777378","wikidata":"https://www.wikidata.org/wiki/Q41716","display_name":"Boiling","level":2,"score":0.7044010758399963},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6515581607818604},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.5300388336181641},{"id":"https://openalex.org/C72293138","wikidata":"https://www.wikidata.org/wiki/Q909741","display_name":"Temperature measurement","level":2,"score":0.5014305114746094},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.4580570161342621},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.45252954959869385},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.44749966263771057},{"id":"https://openalex.org/C536315585","wikidata":"https://www.wikidata.org/wiki/Q7698332","display_name":"Temperature control","level":2,"score":0.43238145112991333},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.23746144771575928},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.22386187314987183},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.14118260145187378},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1330145001411438},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.11081594228744507},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001408","descriptor_name":"Bacillus anthracis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001408","descriptor_name":"Bacillus anthracis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007259","descriptor_name":"Infrared Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ac0613277","doi":"https://doi.org/10.1021/ac0613277","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac0613277","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:17297927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17297927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1968336943","https://openalex.org/W1976055891","https://openalex.org/W1985030772","https://openalex.org/W1988272565","https://openalex.org/W1992076170","https://openalex.org/W1993141305","https://openalex.org/W1997887128","https://openalex.org/W2016931197","https://openalex.org/W2047406822","https://openalex.org/W2056645539","https://openalex.org/W2063250806","https://openalex.org/W2094010576","https://openalex.org/W2105916799","https://openalex.org/W4240655968"],"related_works":["https://openalex.org/W2033266650","https://openalex.org/W2504883804","https://openalex.org/W2045785385","https://openalex.org/W2079153121","https://openalex.org/W2337486275","https://openalex.org/W1826434852","https://openalex.org/W1974762990","https://openalex.org/W2415851202","https://openalex.org/W869080765","https://openalex.org/W2035218414"],"abstract_inverted_index":{"A":[0,64],"completely":[1],"noncontact":[2],"temperature":[3,41],"system":[4],"is":[5],"described":[6],"for":[7,123,136,230],"amplification":[8,188,226],"of":[9,42,67,78,107,126,146,154,172,189,193,205],"DNA":[10],"via":[11],"the":[12,40,43,47,79,91,105,108,114,127,134,138,143,152,163,168,184,194,203,210,220],"polymerase":[13],"chain":[14],"reaction":[15],"(PCR)":[16],"in":[17,120,198],"glass":[18,44],"microfluidic":[19,221],"chips.":[20],"An":[21],"infrared":[22],"(IR)-sensitive":[23],"pyrometer":[24,139,147,164],"was":[25,72,87,94,148,179,217],"calibrated":[26],"against":[27,167],"a":[28,32,56,97,141,190,199,206,213,231],"thermocouple":[29],"inserted":[30],"into":[31,104],"550-nL":[33],"PCR":[34,48,225],"chamber":[35,49,200],"and":[36,52,59,81,110,158,161],"used":[37],"to":[38,129,227],"monitor":[39],"surface":[45],"above":[46,219],"during":[50],"heating":[51,76,211],"cooling":[53],"induced":[54],"by":[55,150,183],"tungsten":[57],"lamp":[58],"convective":[60],"air":[61],"source,":[62],"respectively.":[63],"time":[65,92,115],"lag":[66,93],"less":[68],"than":[69],"1":[70],"s":[71],"observed":[73],"between":[74],"maximum":[75],"rates":[77],"solution":[80],"surface,":[82],"indicating":[83],"that":[84,112],"thermal":[85],"equilibrium":[86],"attained":[88],"rapidly.":[89],"Moreover,":[90],"corroborated":[95],"using":[96],"one-dimensional":[98],"heat-transfer":[99],"model,":[100],"which":[101,223],"provided":[102],"insight":[103],"characteristics":[106],"device":[109],"environment":[111],"caused":[113],"lag.":[116],"This":[117],"knowledge":[118],"will,":[119],"turn,":[121],"allow":[122],"future":[124],"tailoring":[125],"devices":[128],"specific":[130],"applications.":[131],"To":[132,208],"alleviate":[133],"need":[135],"calibrating":[137],"with":[140],"thermocouple,":[142],"on-chip":[144],"calibration":[145],"accomplished":[149],"sensing":[151],"boiling":[153,170],"two":[155],"solutions,":[156],"water":[157],"an":[159],"azeotrope,":[160],"comparing":[162],"output":[165],"voltage":[166],"known":[169],"points":[171],"these":[173],"solutions.":[174],"The":[175],"\"boiling":[176],"point":[177],"calibration\"":[178],"successful":[180],"as":[181],"indicated":[182],"subsequent":[185],"chip-based":[186],"IR-PCR":[187],"211-bp":[191],"fragment":[192],"B.":[195],"anthracis":[196],"genome":[197],"reduced":[201],"beyond":[202],"dimensions":[204],"thermocouple.":[207],"improve":[209],"rates,":[212],"parabolic":[214],"gold":[215],"mirror":[216],"positioned":[218],"chip,":[222],"expedited":[224],"18.8":[228],"min":[229],"30-cycle,":[232],"three-temperature":[233],"protocol.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
