{"id":"https://openalex.org/W2079433232","doi":"https://doi.org/10.1159/000124589","title":"Morphine or Capsaicin Administration Alters the Secretion of Beta-Endorphin into the Hypophysial Portal Vasculature of the Rat","display_name":"Morphine or Capsaicin Administration Alters the Secretion of Beta-Endorphin into the Hypophysial Portal Vasculature of the Rat","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W2079433232","doi":"https://doi.org/10.1159/000124589","mag":"2079433232","pmid":"https://pubmed.ncbi.nlm.nih.gov/2944026"},"language":"en","primary_location":{"id":"doi:10.1159/000124589","doi":"https://doi.org/10.1159/000124589","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000124589","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072516779","display_name":"James I. Koenig","orcid":"https://orcid.org/0000-0003-1930-6870","observed_orcids":["https://orcid.org/0000-0003-1930-6870"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James I. Koenig","raw_affiliation_strings":["Department of Psychiatry, University of Chicago, and Illinois State Psychiatric Institute, Chicago, Ill., USA","University-of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Chicago, and Illinois State Psychiatric Institute, Chicago, Ill., USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"University-of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060728653","display_name":"Herbert Y. Meltzer","orcid":"https://orcid.org/0000-0003-4901-8845","observed_orcids":["https://orcid.org/0000-0003-4901-8845"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert Y. Meltzer","raw_affiliation_strings":["Department of Psychiatry, University of Chicago, and Illinois State Psychiatric Institute, Chicago, Ill., USA","University of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Chicago, and Illinois State Psychiatric Institute, Chicago, Ill., USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112014625","display_name":"Gary A. Gudelsky","orcid":"https://orcid.org/0000-0003-2552-8592","observed_orcids":["https://orcid.org/0000-0003-2552-8592"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary A. Gudelsky","raw_affiliation_strings":["Department of Psychiatry, University of Chicago, and Illinois State Psychiatric Institute, Chicago, Ill., USA","University-of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Chicago, and Illinois State Psychiatric Institute, Chicago, Ill., USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"University-of Chicago","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.17691257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"43","issue":"5","first_page":"611","last_page":"617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-endorphin","display_name":"beta-endorphin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9129999876022339},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.7160000205039978},{"id":"https://openalex.org/keywords/naltrexone","display_name":"naltrexone","score":0.8560000061988831},{"id":"https://openalex.org/keywords/hypothalamic-neurons","display_name":"hypothalamic neurons","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.7170000076293945},{"id":"https://openalex.org/keywords/beta-lipotropin","display_name":"beta-lipotropin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/feedback-regulation","display_name":"feedback regulation","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7764451503753662},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7729083299636841},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.7302643060684204},{"id":"https://openalex.org/C2777557602","wikidata":"https://www.wikidata.org/wiki/Q2993328","display_name":"beta-Endorphin","level":2,"score":0.700905442237854},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5809056758880615},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.5791133642196655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4834095239639282},{"id":"https://openalex.org/C2778680817","wikidata":"https://www.wikidata.org/wiki/Q190528","display_name":"Endorphins","level":2,"score":0.46246713399887085},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.45632246136665344},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.45529651641845703},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.4468737244606018},{"id":"https://openalex.org/C56191518","wikidata":"https://www.wikidata.org/wiki/Q416997","display_name":"Peptide hormone","level":3,"score":0.4447958171367645},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3242272436618805},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.25768959522247314},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1767560839653015}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001615","descriptor_name":"beta-Endorphin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001615","descriptor_name":"beta-Endorphin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001615","descriptor_name":"beta-Endorphin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007016","descriptor_name":"Hypophysectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007016","descriptor_name":"Hypophysectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007016","descriptor_name":"Hypophysectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011168","descriptor_name":"Portal System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011168","descriptor_name":"Portal System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011168","descriptor_name":"Portal System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000124589","doi":"https://doi.org/10.1159/000124589","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000124589","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},{"id":"pmid:2944026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2944026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1413471085","display_name":null,"funder_award_id":"MH30938","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1854835905","display_name":null,"funder_award_id":"MH-30059","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2319008546","display_name":"PSYCHIATRY RESEARCH TRAINING PROGRAM","funder_award_id":"5t32mh014651-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3880079916","display_name":null,"funder_award_id":"T32 MH 14651","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306487","display_name":"Research Corporation for Science Advancement","ror":"https://ror.org/00jp8d455"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2023948226","https://openalex.org/W2046809670","https://openalex.org/W2007309883","https://openalex.org/W2054753816","https://openalex.org/W2044893079","https://openalex.org/W1971085268","https://openalex.org/W2004460221","https://openalex.org/W2042402543","https://openalex.org/W2081741081","https://openalex.org/W2034158074"],"abstract_inverted_index":{"Immunoreactive":[0],"beta-endorphin":[1,39],"(ir-beta-END)":[2],"concentrations":[3,86,118],"were":[4,89],"measured":[5],"in":[6,32,51,63,68,76,94,113,162,168,179,192,203],"the":[7,12,19,49,69,102,146,151,158,163,169,175,204,211,214],"hypophysial":[8,34],"portal":[9,35,52,70,84,180,193],"plasma":[10,36,53,71,85,181,194],"of":[11,21,48,56,73,87,98,101,106,116,150,160,177,213,216,228,236,241],"male":[13],"rat":[14,33],"under":[15],"urethane":[16],"anesthesia.":[17],"On":[18],"basis":[20],"immunochemical":[22],"studies":[23,188],"and":[24,41],"gel":[25],"filtration":[26],"chromatography":[27],"it":[28,207],"appears":[29],"that":[30,79,190,210],"ir-beta-END":[31,50,88,117,178,185,191,217,231],"is":[37,195,199,208],"primarily":[38],"(beta-END)":[40],"not":[42,166],"beta-lipotropin":[43],"(beta-LPH).":[44],"In":[45],"addition,":[46],"much":[47],"may":[54,233],"be":[55,234],"pituitary":[57],"origin":[58],"since":[59],"acute":[60],"hypophysectomy":[61],"resulted":[62,112],"approximately":[64],"an":[65],"80%":[66],"decrease":[67,115,157],"concentration":[72,176],"ir-beta-END.":[74],"Nevertheless,":[75],"anesthetized":[77],"animals":[78],"had":[80],"been":[81,154],"hypophysectomized":[82],"acutely,":[83],"still":[90],"5":[91],"times":[92],"those":[93],"systemic":[95,184],"plasma,":[96],"indicative":[97,235],"hypothalamic":[99],"secretion":[100,232],"peptide.":[103],"The":[104,225],"administration":[105],"morphine":[107],"sulfate":[108],"(3":[109],"mg/kg,":[110,136],"i.v.)":[111],"a":[114,237],"from":[119,201,218],"3,157":[120],"+/-":[121,126],"547":[122],"pg/ml":[123],"to":[124,156],"1,044":[125],"250":[127],"pg/ml.":[128],"This":[129],"effect":[130],"was":[131],"blocked":[132],"by":[133],"naltrexone":[134],"(1":[135],"s.c.)":[137],"pretreatment.":[138],"Capsaicin":[139],"(10":[140],"micrograms),":[141],"which,":[142],"when":[143],"infused":[144],"into":[145],"lateral":[147],"cerebral":[148],"ventricle":[149],"rat,":[152],"has":[153],"shown":[155],"amount":[159],"beta-END":[161,197],"hypothalamus,":[164],"but":[165],"elsewhere":[167],"central":[170],"nervous":[171],"system,":[172],"selectively":[173],"decreased":[174],"without":[182],"changing":[183],"concentrations.":[186],"These":[187],"indicate":[189],"probably":[196],"which":[198],"derived":[200],"neurons":[202,220],"hypothalamus.":[205],"Moreover,":[206],"concluded":[209],"regulation":[212,240],"release":[215],"these":[219],"involves":[221],"opiate":[222],"receptor":[223],"mechanisms.":[224],"inhibitory":[226],"influence":[227],"opiates":[229],"on":[230],"classical":[238],"feedback":[239],"ir-beta-END-containing":[242],"neurons.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}