{"id":"https://openalex.org/W2079367229","doi":"https://doi.org/10.1021/jm00251a029","title":"Rigid amino acids related to .alpha.-methyldopa","display_name":"Rigid amino acids related to .alpha.-methyldopa","publication_year":1974,"publication_date":"1974-05-01","ids":{"openalex":"https://openalex.org/W2079367229","doi":"https://doi.org/10.1021/jm00251a029","mag":"2079367229","pmid":"https://pubmed.ncbi.nlm.nih.gov/4830265"},"language":"en","primary_location":{"id":"doi:10.1021/jm00251a029","doi":"https://doi.org/10.1021/jm00251a029","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00251a029","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109198541","display_name":"Joseph G. Cannon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph G. Cannon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050599439","display_name":"John P. O\u2019Donnell","orcid":"https://orcid.org/0000-0002-0571-3603","observed_orcids":["https://orcid.org/0000-0002-0571-3603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John P. O'Donnell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108605480","display_name":"John P. N. Rosazza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John P. Rosazza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072082950","display_name":"Charles R. Hoppin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles R. Hoppin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6654,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.66106628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"5","first_page":"565","last_page":"568"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.41670000553131104,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.41670000553131104,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.11599999666213989,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.09210000187158585,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methyldopa","display_name":"methyldopa","score":0.9430000185966492},{"id":"https://openalex.org/keywords/amino-acid-analogues","display_name":"amino acid analogs","score":0.6179999709129333},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.5699999928474426},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9161590337753296},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.6910699605941772},{"id":"https://openalex.org/C2776289377","wikidata":"https://www.wikidata.org/wiki/Q412621","display_name":"Methyldopa","level":3,"score":0.6464122533798218},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.46706897020339966},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3515336513519287},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34803444147109985},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26362699270248413},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19147205352783203},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.06428289413452148},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.05860459804534912},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008750","descriptor_name":"Methyldopa","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D008750","descriptor_name":"Methyldopa","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065105","descriptor_name":"Aromatic Amino Acid Decarboxylase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm00251a029","doi":"https://doi.org/10.1021/jm00251a029","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00251a029","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:4830265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4830265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1978639043","https://openalex.org/W1979376133","https://openalex.org/W2396062133","https://openalex.org/W2015093387","https://openalex.org/W2332457411","https://openalex.org/W2465981777","https://openalex.org/W2330733224","https://openalex.org/W177813873","https://openalex.org/W2090412250","https://openalex.org/W2057788784"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVArticleNEXTRigid":[3],"amino":[4],"acids":[5],"related":[6],"to":[7,76,81],".alpha.-methyldopaJoseph":[8],"G.":[9],"Cannon,":[10],"John":[11,14],"P.":[12,15],"O'Donnell,":[13],"Rosazza,":[16],"and":[17,64,69,98,142,159,175,177],"Charles":[18],"R.":[19],"HoppinCite":[20],"this:":[21],"J.":[22],"Med.":[23],"Chem.":[24],"1974,":[25],"17,":[26],"5,":[27],"565\u2013568Publication":[28],"Date":[29],"(Print):May":[30],"1,":[31],"1974Publication":[32],"History":[33],"Published":[34],"online1":[35],"May":[36,40],"2002Published":[37],"inissue":[38],"1":[39],"1974https://pubs.acs.org/doi/10.1021/jm00251a029https://doi.org/10.1021/jm00251a029research-articleACS":[41],"PublicationsRequest":[42],"reuse":[43],"permissionsArticle":[44],"Views125Altmetric-Citations8LEARN":[45],"ABOUT":[46],"THESE":[47],"METRICSArticle":[48],"Views":[49],"are":[50,73,86],"the":[51,82,87,116,127,140,143,148,155,161],"COUNTER-compliant":[52],"sum":[53],"of":[54,89,115],"full":[55],"text":[56],"article":[57,121],"downloads":[58],"since":[59],"November":[60],"2008":[61],"(both":[62],"PDF":[63],"HTML)":[65],"across":[66],"all":[67],"institutions":[68],"individuals.":[70],"These":[71],"metrics":[72],"regularly":[74],"updated":[75,99],"reflect":[77],"usage":[78],"leading":[79],"up":[80],"last":[83],"few":[84],"days.Citations":[85],"number":[88],"other":[90],"articles":[91],"citing":[92],"this":[93],"article,":[94],"calculated":[95],"by":[96],"Crossref":[97,105],"daily.":[100],"Find":[101,151],"more":[102,152],"information":[103,153],"about":[104,139],"citation":[106],"counts.The":[107],"Altmetric":[108,156],"Attention":[109,157],"Score":[110,158],"is":[111,163],"a":[112,119,132],"quantitative":[113],"measure":[114],"attention":[117],"that":[118],"research":[120],"has":[122],"received":[123],"online.":[124],"Clicking":[125],"on":[126,154],"donut":[128],"icon":[129],"will":[130],"load":[131],"page":[133],"at":[134],"altmetric.com":[135],"with":[136,171],"additional":[137],"details":[138],"score":[141,162],"social":[144],"media":[145],"presence":[146],"for":[147],"given":[149],"article.":[150],"how":[160],"calculated.":[164],"Share":[165,180],"Add":[166],"toView":[167],"InAdd":[168],"Full":[169],"Text":[170],"ReferenceAdd":[172],"Description":[173],"ExportRISCitationCitation":[174],"abstractCitation":[176],"referencesMore":[178],"Options":[179],"onFacebookTwitterWechatLinked":[181],"InRedditEmail":[182],"Other":[183],"access":[184],"optionsGet":[185],"e-Alertsclose":[186],"Get":[187],"e-Alerts":[188]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
