{"id":"https://openalex.org/W207936530","doi":"https://doi.org/10.1016/s0021-9258(17)34769-5","title":"Folding of DNA by histones which lack their NH2-terminal regions.","display_name":"Folding of DNA by histones which lack their NH2-terminal regions.","publication_year":1978,"publication_date":"1978-06-01","ids":{"openalex":"https://openalex.org/W207936530","doi":"https://doi.org/10.1016/s0021-9258(17)34769-5","mag":"207936530","pmid":"https://pubmed.ncbi.nlm.nih.gov/649610"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)34769-5","doi":"https://doi.org/10.1016/s0021-9258(17)34769-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)34769-5","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)34769-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112727836","display_name":"James P. Whitlock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.P. Whitlock","raw_affiliation_strings":["From the Developmental Biochemistry Section, Laboratory of Nutrition and Endocrinology, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Developmental Biochemistry Section, Laboratory of Nutrition and Endocrinology, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113882277","display_name":"A. Stein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Stein","raw_affiliation_strings":["From the Developmental Biochemistry Section, Laboratory of Nutrition and Endocrinology, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Developmental Biochemistry Section, Laboratory of Nutrition and Endocrinology, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.5368,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.96038178,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"253","issue":"11","first_page":"3857","last_page":"3861"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-folding","display_name":"DNA folding","score":0.8600000143051147},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.7210000157356262},{"id":"https://openalex.org/keywords/histone-dna-complex","display_name":"histone-DNA complex","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C60325843","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Nucleoprotein","level":3,"score":0.9564900398254395},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.8017897605895996},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7939491271972656},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.7244110703468323},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.46197310090065},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4604296386241913},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.45178115367889404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4395582377910614},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38301482796669006},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36441588401794434},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3640592694282532},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1637125313282013},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)34769-5","doi":"https://doi.org/10.1016/s0021-9258(17)34769-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)34769-5","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:649610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/649610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)34769-5","doi":"https://doi.org/10.1016/s0021-9258(17)34769-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)34769-5","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1597773685","https://openalex.org/W1967903605","https://openalex.org/W1988591703","https://openalex.org/W2006431144","https://openalex.org/W2006851414","https://openalex.org/W2010304324","https://openalex.org/W2017568935","https://openalex.org/W2037599463","https://openalex.org/W2042511919","https://openalex.org/W2044504702","https://openalex.org/W2045003790","https://openalex.org/W2048988091","https://openalex.org/W2056413151","https://openalex.org/W2066176374","https://openalex.org/W2068360612","https://openalex.org/W2070655958","https://openalex.org/W2071807125","https://openalex.org/W2075180721","https://openalex.org/W2077203295","https://openalex.org/W2080108115","https://openalex.org/W2093541219","https://openalex.org/W2093727033","https://openalex.org/W2122574122","https://openalex.org/W2152193561","https://openalex.org/W2165633081"],"related_works":["https://openalex.org/W4247788366","https://openalex.org/W2016071989","https://openalex.org/W1984577227","https://openalex.org/W1597773685","https://openalex.org/W2048142108","https://openalex.org/W1645053603","https://openalex.org/W2066176374","https://openalex.org/W36253773","https://openalex.org/W1999946217","https://openalex.org/W2081468628"],"abstract_inverted_index":{"HeLa":[0],"chromatin":[1,132],"core":[2,99,133],"particles":[3],"were":[4,18,28],"digested":[5],"with":[6,45,87],"trypsin":[7],"to":[8,31,92,123],"excise":[9],"the":[10,24,35,42,46,85,93,113,121,131],"NH2-terminal":[11],"histone":[12],"regions.":[13],"The":[14,48,78,101],"resulting":[15],"nucleoprotein":[16,50,128],"complexes":[17,51],"dissociated":[19],"in":[20],"2.5":[21],"M":[22],"NaCl;":[23],"DNA":[25,43,125],"and":[26,69,120],"polypeptides":[27,86],"then":[29],"allowed":[30],"reassemble":[32],"by":[33,83,96],"lowering":[34],"NaCl":[36],"concentration.":[37],"Eighty":[38],"per":[39],"cent":[40],"of":[41,63,67,80],"reassociated":[44],"polypeptides.":[47],"reassembled":[49],"sediment":[52],"at":[53,60,74],"9.7":[54],"S,":[55],"have":[56],"a":[57,127],"molecular":[58],"elipticity":[59],"280":[61],"nm":[62],"3000":[64],"degrees":[65],"cm2/dmol":[66],"PO4,":[68],"contain":[70],"DNase":[71],"I-susceptible":[72],"sites":[73],"10":[75],"nucleotide":[76],"intervals.":[77],"pattern":[79,94],"products":[81],"generated":[82,95],"cross-linking":[84,97],"dimethylsuberimidate":[88],"is":[89],"very":[90],"similar":[91],"native":[98],"particles.":[100],"results":[102],"indicate":[103],"that":[104],"histones":[105],"which":[106],"lack":[107],"their":[108],"HN2-terminal":[109],"regions":[110],"retain":[111],"both":[112],"features":[114],"necessary":[115],"for":[116],"correct":[117],"protein-protein":[118],"interactions":[119],"ability":[122],"fold":[124],"into":[126],"complex":[129],"resembling":[130],"particle.":[134]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
