{"id":"https://openalex.org/W2079342016","doi":"https://doi.org/10.1021/ac3034097","title":"Quantitative Analysis of Oligosaccharides Derived from Sulfated Glycosaminoglycans by Nanodiamond-Based Affinity Purification and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry","display_name":"Quantitative Analysis of Oligosaccharides Derived from Sulfated Glycosaminoglycans by Nanodiamond-Based Affinity Purification and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry","publication_year":2013,"publication_date":"2013-03-27","ids":{"openalex":"https://openalex.org/W2079342016","doi":"https://doi.org/10.1021/ac3034097","mag":"2079342016","pmid":"https://pubmed.ncbi.nlm.nih.gov/23534486"},"language":"en","primary_location":{"id":"doi:10.1021/ac3034097","doi":"https://doi.org/10.1021/ac3034097","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac3034097","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052729647","display_name":"Chih-Chien Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134161618","display_name":"National Taiwan Normal University","ror":"https://ror.org/059dkdx38","country_code":"TW","type":"education","lineage":["https://openalex.org/I134161618"]},{"id":"https://openalex.org/I4210135784","display_name":"Institute of Atomic and Molecular Sciences, Academia Sinica","ror":"https://ror.org/03haqsp75","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210135784","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Chien Hsieh","raw_affiliation_strings":["Department of Chemistry, National Taiwan Normal University, Taipei 106, Taiwan","Institute\rof Atomic and Molecular\rSciences, Academia Sinica, Taipei 106,\rTaiwan","Institute#R#of Atomic and Molecular#R#Sciences, Academia Sinica, Taipei 106,#R#Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Taiwan Normal University, Taipei 106, Taiwan","institution_ids":["https://openalex.org/I134161618"]},{"raw_affiliation_string":"Institute\rof Atomic and Molecular\rSciences, Academia Sinica, Taipei 106,\rTaiwan","institution_ids":["https://openalex.org/I4210135784","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Institute#R#of Atomic and Molecular#R#Sciences, Academia Sinica, Taipei 106,#R#Taiwan","institution_ids":["https://openalex.org/I4210135784","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069515175","display_name":"Jiun You Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193365169","display_name":"National Chi Nan University","ror":"https://ror.org/03ha6v181","country_code":"TW","type":"education","lineage":["https://openalex.org/I193365169"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jiun You Guo","raw_affiliation_strings":["Department of Applied Chemistry, National Chi Nan University, Puli, Nantou 545, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, National Chi Nan University, Puli, Nantou 545, Taiwan","institution_ids":["https://openalex.org/I193365169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053096107","display_name":"Shain\u2010Un Hung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193365169","display_name":"National Chi Nan University","ror":"https://ror.org/03ha6v181","country_code":"TW","type":"education","lineage":["https://openalex.org/I193365169"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shain-Un Hung","raw_affiliation_strings":["Department of Applied Chemistry, National Chi Nan University, Puli, Nantou 545, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, National Chi Nan University, Puli, Nantou 545, Taiwan","institution_ids":["https://openalex.org/I193365169"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rui Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210116048","display_name":"Beijing National Laboratory for Molecular Sciences","ror":"https://ror.org/02601yx74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210116048"]},{"id":"https://openalex.org/I4210155088","display_name":"Institute of Chemistry","ror":"https://ror.org/048y1rc66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210155088"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Chen","raw_affiliation_strings":["Key Laboratory of Analytical Chemistry\rfor Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China and Beijing National Laboratory for Molecular Sciences,\rBeijing 100190, China","Key Laboratory of Analytical Chemistry#R#for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China and Beijing National Laboratory for Molecular Sciences,#R#Beijing 100190, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Analytical Chemistry\rfor Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China and Beijing National Laboratory for Molecular Sciences,\rBeijing 100190, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210116048","https://openalex.org/I4210155088"]},{"raw_affiliation_string":"Key Laboratory of Analytical Chemistry#R#for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China and Beijing National Laboratory for Molecular Sciences,#R#Beijing 100190, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210116048","https://openalex.org/I4210155088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027440639","display_name":"Zongxiu Nie","orcid":"https://orcid.org/0000-0001-8514-6348","observed_orcids":["https://orcid.org/0000-0001-8514-6348"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210116048","display_name":"Beijing National Laboratory for Molecular Sciences","ror":"https://ror.org/02601yx74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210116048"]},{"id":"https://openalex.org/I4210155088","display_name":"Institute of Chemistry","ror":"https://ror.org/048y1rc66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210155088"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zongxiu Nie","raw_affiliation_strings":["Key Laboratory of Analytical Chemistry\rfor Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China and Beijing National Laboratory for Molecular Sciences,\rBeijing 100190, China","Key Laboratory of Analytical Chemistry#R#for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China and Beijing National Laboratory for Molecular Sciences,#R#Beijing 100190, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Analytical Chemistry\rfor Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China and Beijing National Laboratory for Molecular Sciences,\rBeijing 100190, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210116048","https://openalex.org/I4210155088"]},{"raw_affiliation_string":"Key Laboratory of Analytical Chemistry#R#for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China and Beijing National Laboratory for Molecular Sciences,#R#Beijing 100190, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210116048","https://openalex.org/I4210155088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065102952","display_name":"Huan\u2010Cheng Chang","orcid":"https://orcid.org/0000-0002-3515-4128","observed_orcids":["https://orcid.org/0000-0002-3515-4128","https://orcid.org/0000-0002-2503-4405"]},"institutions":[{"id":"https://openalex.org/I134161618","display_name":"National Taiwan Normal University","ror":"https://ror.org/059dkdx38","country_code":"TW","type":"education","lineage":["https://openalex.org/I134161618"]},{"id":"https://openalex.org/I4210135784","display_name":"Institute of Atomic and Molecular Sciences, Academia Sinica","ror":"https://ror.org/03haqsp75","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210135784","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Huan-Cheng Chang","raw_affiliation_strings":["Department of Chemistry, National Taiwan Normal University, Taipei 106, Taiwan","Institute\rof Atomic and Molecular\rSciences, Academia Sinica, Taipei 106,\rTaiwan","Institute#R#of Atomic and Molecular#R#Sciences, Academia Sinica, Taipei 106,#R#Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Taiwan Normal University, Taipei 106, Taiwan","institution_ids":["https://openalex.org/I134161618"]},{"raw_affiliation_string":"Institute\rof Atomic and Molecular\rSciences, Academia Sinica, Taipei 106,\rTaiwan","institution_ids":["https://openalex.org/I4210135784","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Institute#R#of Atomic and Molecular#R#Sciences, Academia Sinica, Taipei 106,#R#Taiwan","institution_ids":["https://openalex.org/I4210135784","https://openalex.org/I84653119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103390032","display_name":"Chih\u2010Che Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193365169","display_name":"National Chi Nan University","ror":"https://ror.org/03ha6v181","country_code":"TW","type":"education","lineage":["https://openalex.org/I193365169"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chih-Che Wu","raw_affiliation_strings":["Department of Applied Chemistry, National Chi Nan University, Puli, Nantou 545, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, National Chi Nan University, Puli, Nantou 545, Taiwan","institution_ids":["https://openalex.org/I193365169"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5103390032"],"corresponding_institution_ids":["https://openalex.org/I193365169"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6566,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.62285514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"85","issue":"9","first_page":"4342","last_page":"4349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.32739999890327454,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfated-glycosaminoglycans","display_name":"sulfated glycosaminoglycans","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sulfated-oligosaccharides","display_name":"sulfated oligosaccharides","score":0.9179999828338623},{"id":"https://openalex.org/keywords/chondroitin-4-sulfate","display_name":"chondroitin 4-sulfate","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mucopolysaccharidoses","display_name":"mucopolysaccharidosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/affinity-sorbents","display_name":"affinity sorbents","score":0.7400000095367432},{"id":"https://openalex.org/keywords/deuterated-internal-standards","display_name":"deuterated internal standards","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.902999997138977},{"id":"https://openalex.org/keywords/high-throughput-assay","display_name":"high-throughput assay","score":0.652999997138977},{"id":"https://openalex.org/keywords/diagnosis","display_name":"diagnosis","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.947421133518219},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7072615623474121},{"id":"https://openalex.org/C155138218","wikidata":"https://www.wikidata.org/wiki/Q994559","display_name":"Sulfation","level":2,"score":0.6884287595748901},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6246280670166016},{"id":"https://openalex.org/C75280812","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Matrix-assisted laser desorption/ionization","level":4,"score":0.6018015146255493},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.5000290870666504},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.4720495641231537},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4495667815208435},{"id":"https://openalex.org/C162711632","wikidata":"https://www.wikidata.org/wiki/Q905514","display_name":"Desorption","level":3,"score":0.4428532123565674},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.4146678149700165},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16575944423675537},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.07568565011024475},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06927862763404846}],"mesh":[{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ac3034097","doi":"https://doi.org/10.1021/ac3034097","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac3034097","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:23534486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23534486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W149540699","https://openalex.org/W1930879781","https://openalex.org/W1966138352","https://openalex.org/W1984402172","https://openalex.org/W1990685888","https://openalex.org/W1999652145","https://openalex.org/W2001101692","https://openalex.org/W2011696568","https://openalex.org/W2018553041","https://openalex.org/W2020625878","https://openalex.org/W2033959986","https://openalex.org/W2035252739","https://openalex.org/W2036429225","https://openalex.org/W2040598385","https://openalex.org/W2043490832","https://openalex.org/W2048686056","https://openalex.org/W2059999172","https://openalex.org/W2088174647","https://openalex.org/W2091106400","https://openalex.org/W2091978966","https://openalex.org/W2094882071","https://openalex.org/W2103457363","https://openalex.org/W2120799989","https://openalex.org/W2147890494","https://openalex.org/W2148437744","https://openalex.org/W2151879267","https://openalex.org/W2162573695","https://openalex.org/W2167531056","https://openalex.org/W2334659150"],"related_works":["https://openalex.org/W2009317046","https://openalex.org/W4220876975","https://openalex.org/W2036875747","https://openalex.org/W2076189913","https://openalex.org/W2463486294","https://openalex.org/W1968028120","https://openalex.org/W2026569325","https://openalex.org/W1481319330","https://openalex.org/W3109925021","https://openalex.org/W1471502"],"abstract_inverted_index":{"Degraded":[0],"fragments":[1],"of":[2,13,46,158,167],"sulfated":[3,47,53],"glycosaminoglycans":[4],"(GAGs)":[5],"are":[6],"key":[7],"reporters":[8],"for":[9,43,92,100,129,164],"profiling":[10],"the":[11,116,126,136],"burden":[12],"mucopolysaccharidosis":[14],"(MPS)":[15],"disease":[16],"at":[17],"baseline":[18],"and":[19,35,161],"during":[20],"therapy.":[21],"Here,":[22],"we":[23],"present":[24],"a":[25,107,155],"high-throughput":[26],"assay,":[27],"which":[28],"combines":[29],"microwave-assisted":[30,87],"degradation,":[31],"solid-phase":[32],"affinity":[33,78],"purification,":[34],"matrix-assisted":[36],"laser":[37],"desorption/ionization":[38],"mass":[39],"spectrometry":[40],"(MALDI":[41],"MS),":[42],"quantitative":[44,130],"analysis":[45,131],"oligosaccharides":[48,54],"in":[49],"biological":[50],"samples.":[51],"First,":[52],"such":[55],"as":[56,77],"chondroitin-4-sulfate":[57],"(CS)":[58],"were":[59,82,103,122],"efficiently":[60],"isolated":[61],"from":[62,106],"highly":[63],"diluted":[64],"solutions":[65],"or":[66,89],"spiked":[67],"artificial":[68],"cerebrospinal":[69],"fluid":[70],"(aCSF)":[71],"using":[72,135],"polyarginine-coated":[73],"nanodiamonds":[74],"(PA-coated":[75],"NDs)":[76],"sorbents.":[79],"Next,":[80],"they":[81],"degraded":[83],"to":[84,110],"disaccharides":[85,128],"through":[86],"methanolysis":[88],"enzymatic":[90],"digestion":[91],"subsequent":[93],"MALDI-TOF":[94,133],"MS":[95,134],"analysis.":[96],"The":[97,142],"reaction":[98],"times":[99],"GAG":[101],"depolymerization":[102],"significantly":[104],"reduced":[105],"few":[108],"hours":[109],"less":[111],"than":[112],"7":[113],"min":[114],"under":[115],"microwave":[117],"irradiation.":[118],"Deuterium-labeled":[119],"internal":[120],"standards":[121],"then":[123],"mixed":[124],"with":[125],"CS-derived":[127],"by":[132],"N-(1-naphthyl)":[137],"ethylenediamine":[138],"dihydrochloride":[139],"(NEDC)":[140],"matrix.":[141],"new":[143],"assay":[144],"is":[145],"facile,":[146],"specific":[147],"(with":[148,154],"distinct":[149],"chlorine-isotope":[150],"trait":[151],"markers),":[152],"sensitive":[153],"detection":[156],"limit":[157],"~70":[159],"pg),":[160],"potentially":[162],"useful":[163],"clinical":[165],"diagnosis":[166],"MPS.":[168]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}