{"id":"https://openalex.org/W2079313178","doi":"https://doi.org/10.1371/journal.pone.0068234","title":"Detection of Escherichia coli and Associated \u03b2-Lactamases Genes from Diabetic Foot Ulcers by Multiplex PCR and Molecular Modeling and Docking of SHV-1, TEM-1, and OXA-1 \u03b2-Lactamases with Clindamycin and Piperacillin-Tazobactam","display_name":"Detection of Escherichia coli and Associated \u03b2-Lactamases Genes from Diabetic Foot Ulcers by Multiplex PCR and Molecular Modeling and Docking of SHV-1, TEM-1, and OXA-1 \u03b2-Lactamases with Clindamycin and Piperacillin-Tazobactam","publication_year":2013,"publication_date":"2013-07-04","ids":{"openalex":"https://openalex.org/W2079313178","doi":"https://doi.org/10.1371/journal.pone.0068234","mag":"2079313178","pmid":"https://pubmed.ncbi.nlm.nih.gov/23861873","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3701671"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0068234","doi":"https://doi.org/10.1371/journal.pone.0068234","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0068234","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0068234&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0068234&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060448060","display_name":"Shailesh K. Shahi","orcid":"https://orcid.org/0000-0002-8506-7655","observed_orcids":["https://orcid.org/0000-0002-8506-7655"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shailesh K. Shahi","raw_affiliation_strings":["School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India","School of Biotechnology, Faculty of Science, Banaras Hindu University,#R#Varanasi, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India","institution_ids":["https://openalex.org/I91357014"]},{"raw_affiliation_string":"School of Biotechnology, Faculty of Science, Banaras Hindu University,#R#Varanasi, Uttar Pradesh, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100668386","display_name":"Vinay Kumar Singh","orcid":"https://orcid.org/0000-0002-5572-0000","observed_orcids":["https://orcid.org/0000-0002-5572-0000"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vinay K. Singh","raw_affiliation_strings":["School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India","School of Biotechnology, Faculty of Science, Banaras Hindu University,#R#Varanasi, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India","institution_ids":["https://openalex.org/I91357014"]},{"raw_affiliation_string":"School of Biotechnology, Faculty of Science, Banaras Hindu University,#R#Varanasi, Uttar Pradesh, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100687576","display_name":"Ashok Kumar","orcid":"https://orcid.org/0000-0002-0561-9983","observed_orcids":["https://orcid.org/0000-0002-0561-9983"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ashok Kumar","raw_affiliation_strings":["School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India","School of Biotechnology, Faculty of Science, Banaras Hindu University,#R#Varanasi, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India","institution_ids":["https://openalex.org/I91357014"]},{"raw_affiliation_string":"School of Biotechnology, Faculty of Science, Banaras Hindu University,#R#Varanasi, Uttar Pradesh, India","institution_ids":["https://openalex.org/I91357014"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100687576"],"corresponding_institution_ids":["https://openalex.org/I91357014"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.2239,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.75180647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"7","first_page":"e68234","last_page":"e68234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9990000128746033},{"id":"https://openalex.org/keywords/extended-spectrum-beta-lactamase","display_name":"extended-spectrum beta-lactamase","score":0.921999990940094},{"id":"https://openalex.org/keywords/beta-lactamase-genes","display_name":"beta-lactamase genes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/blatem","display_name":"blaTEM","score":0.5619999766349792},{"id":"https://openalex.org/keywords/blashv","display_name":"blaSHV","score":0.8949999809265137},{"id":"https://openalex.org/keywords/blaoxa","display_name":"blaOXA","score":0.9929999709129333},{"id":"https://openalex.org/keywords/blactx-m-15","display_name":"blaCTX-M-15","score":0.8970000147819519},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.9419999718666077},{"id":"https://openalex.org/keywords/clindamycin","display_name":"clindamycin","score":0.878000020980835},{"id":"https://openalex.org/keywords/piperacillin-tazobactam","display_name":"piperacillin-tazobactam","score":1.0},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.9089999794960022},{"id":"https://openalex.org/keywords/protein-structure-modeling","display_name":"protein structure modeling","score":0.6230000257492065},{"id":"https://openalex.org/keywords/drug-resistance-mechanisms","display_name":"drug resistance mechanisms","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2778193466","wikidata":"https://www.wikidata.org/wiki/Q423787","display_name":"Piperacillin","level":4,"score":0.774502158164978},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7289903163909912},{"id":"https://openalex.org/C2776124114","wikidata":"https://www.wikidata.org/wiki/Q2353907","display_name":"Cefoxitin","level":4,"score":0.7164890766143799},{"id":"https://openalex.org/C2778266534","wikidata":"https://www.wikidata.org/wiki/Q423376","display_name":"Tazobactam","level":5,"score":0.6378570795059204},{"id":"https://openalex.org/C2777458120","wikidata":"https://www.wikidata.org/wiki/Q422273","display_name":"Clindamycin","level":3,"score":0.5892376899719238},{"id":"https://openalex.org/C2779375183","wikidata":"https://www.wikidata.org/wiki/Q421670","display_name":"Meropenem","level":4,"score":0.5807665586471558},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.5618283748626709},{"id":"https://openalex.org/C2778368673","wikidata":"https://www.wikidata.org/wiki/Q553220","display_name":"Ertapenem","level":5,"score":0.47774142026901245},{"id":"https://openalex.org/C2778719061","wikidata":"https://www.wikidata.org/wiki/Q417968","display_name":"Cefotaxime","level":3,"score":0.46834060549736023},{"id":"https://openalex.org/C2777050379","wikidata":"https://www.wikidata.org/wiki/Q2552927","display_name":"Cefepime","level":5,"score":0.44660478830337524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44189339876174927},{"id":"https://openalex.org/C2778353156","wikidata":"https://www.wikidata.org/wiki/Q415739","display_name":"Cefazolin","level":3,"score":0.43835172057151794},{"id":"https://openalex.org/C2776968632","wikidata":"https://www.wikidata.org/wiki/Q808845","display_name":"Ceftazidime","level":4,"score":0.4375240206718445},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3307563364505768},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3078225553035736},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.22744691371917725},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.21858271956443787},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.12137418985366821},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07924282550811768},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.05293703079223633}],"mesh":[{"descriptor_ui":"D000077725","descriptor_name":"Piperacillin, Tazobactam Drug Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002981","descriptor_name":"Clindamycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002981","descriptor_name":"Clindamycin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010397","descriptor_name":"Penicillanic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010397","descriptor_name":"Penicillanic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010397","descriptor_name":"Penicillanic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010878","descriptor_name":"Piperacillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010878","descriptor_name":"Piperacillin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017719","descriptor_name":"Diabetic Foot","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D017719","descriptor_name":"Diabetic Foot","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017719","descriptor_name":"Diabetic Foot","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018440","descriptor_name":"beta-Lactam Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D060885","descriptor_name":"Multiplex Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065093","descriptor_name":"beta-Lactamase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0068234","doi":"https://doi.org/10.1371/journal.pone.0068234","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0068234","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0068234&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2707550","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3701671","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23861873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23861873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3701671","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3701671/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.794.7205","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.794.7205","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d6/c2/pone.0068234.PMC3701671.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d97509bc33c54c6a80b28e950bbdb39e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d97509bc33c54c6a80b28e950bbdb39e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 7, p e68234 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/740294","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Detection_of_Escherichia_coli_and_Associated_Lactamases_Genes_from_Diabetic_Foot_Ulcers_by_Multiplex_PCR_and_Molecular_Modeling_and_Docking_of_SHV_1_TEM_1_and_OXA_1_Lactamases_with_Clindamycin_and_Piperacillin_Tazobactam/740294","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0068234","doi":"https://doi.org/10.1371/journal.pone.0068234","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0068234","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0068234&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320321447","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797"},{"id":"https://openalex.org/F4320323277","display_name":"Indian Agricultural Research Institute","ror":"https://ror.org/01bzgdw81"},{"id":"https://openalex.org/F4320335071","display_name":"National Bureau of Agriculturally Important Microorganisms","ror":"https://ror.org/02pnvb171"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2079313178.pdf","grobid_xml":"https://content.openalex.org/works/W2079313178.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W143521791","https://openalex.org/W1240542110","https://openalex.org/W1582600392","https://openalex.org/W1787342943","https://openalex.org/W1926932337","https://openalex.org/W1974466588","https://openalex.org/W1981122021","https://openalex.org/W1992816102","https://openalex.org/W2001838110","https://openalex.org/W2004490638","https://openalex.org/W2005638077","https://openalex.org/W2007697512","https://openalex.org/W2007770311","https://openalex.org/W2007788645","https://openalex.org/W2040335734","https://openalex.org/W2048741671","https://openalex.org/W2057122523","https://openalex.org/W2062663912","https://openalex.org/W2071407566","https://openalex.org/W2074525443","https://openalex.org/W2074986801","https://openalex.org/W2079342481","https://openalex.org/W2079579635","https://openalex.org/W2090372663","https://openalex.org/W2091448229","https://openalex.org/W2095685393","https://openalex.org/W2099140790","https://openalex.org/W2106882534","https://openalex.org/W2116561193","https://openalex.org/W2117179531","https://openalex.org/W2121293808","https://openalex.org/W2125121305","https://openalex.org/W2131946678","https://openalex.org/W2134352676","https://openalex.org/W2134783430","https://openalex.org/W2136931384","https://openalex.org/W2141888371","https://openalex.org/W2141900637","https://openalex.org/W2143863929","https://openalex.org/W2143874510","https://openalex.org/W2145091349","https://openalex.org/W2150835500","https://openalex.org/W2151496242","https://openalex.org/W2152054151","https://openalex.org/W2153963048","https://openalex.org/W2172264351","https://openalex.org/W2195337508","https://openalex.org/W2334248117","https://openalex.org/W2415870482","https://openalex.org/W2416097259","https://openalex.org/W2743041357"],"related_works":["https://openalex.org/W7099865785","https://openalex.org/W7217191488","https://openalex.org/W2898295574","https://openalex.org/W2575117272","https://openalex.org/W7170143743","https://openalex.org/W2316013803","https://openalex.org/W7167337261","https://openalex.org/W2034934080","https://openalex.org/W2169078975","https://openalex.org/W4366250297"],"abstract_inverted_index":{"Diabetic":[0],"foot":[1,30,57],"ulcer":[2],"(DFU)":[3],"is":[4,22],"a":[5,26],"common":[6],"and":[7,42,48,54,124,130,171,181,196,202,208,233,257,285,289],"devastating":[8],"complication":[9],"in":[10,102,120,126,132,264,272,279],"diabetes.":[11],"Antimicrobial":[12],"resistance":[13,262],"mediated":[14],"by":[15,20,110],"extended-spectrum":[16],"\u03b2-lactamases":[17,191],"(ESBLs)":[18],"production":[19,99],"bacteria":[21],"considered":[23],"to":[24,153,156,179,210],"be":[25,154,276],"major":[27],"threat":[28],"for":[29,78,250],"amputation.":[31],"The":[32,266],"present":[33,244],"study":[34,245,274],"deals":[35],"with":[36,73,206,224,237],"the":[37,43,114,135,144,186,212,220,243,251],"detection":[38],"of":[39,45,56,59,69,94,107,116,134,139,143,185,190,215,242,253,282],"Escherichia":[40],"coli":[41,84,149,284],"prevalence":[44],"bla(TEM),":[46,287],"bla(SHV)":[47,131],"bla(OXA)":[49,125,290],"genes":[50,109,119],"directly":[51],"from":[52,89],"biopsy":[53,90],"swab":[55,92],"ulcers":[58],"diabetic":[60],"patients.":[61,97],"In":[62],"total,":[63],"116":[64],"DFU":[65],"patients":[66],"were":[67,76,86,151,200],"screened,":[68],"which":[70],"42":[71],"suffering":[72],"severe":[74],"DFUs":[75],"selected":[77],"this":[79,273],"study.":[80],"Altogether":[81],"16":[82,137],"E.":[83,140,148,283],"strains":[85,128,138,150],"successfully":[87],"isolated":[88],"and/or":[91],"samples":[93],"15":[95],"(35.71%)":[96],"ESBL":[98,197],"was":[100,204],"noted":[101],"12":[103],"(75%)":[104],"strains.":[105],"Amplification":[106],"\u03b2-lactamase":[108],"multiplex":[111,268],"PCR":[112,269],"showed":[113,176,219],"presence":[115],"bla(CTX-M)":[117],"like":[118,291],"10":[121],"strains,":[122],"bla(TEM)":[123],"9":[127],"each,":[129],"8":[133],"total":[136],"coli.":[141],"Out":[142],"ten":[145],"antibiotics":[146],"tested,":[147],"found":[152],"resistant":[155],"ampicillin":[157],"(75%),":[158],"cefoxitin":[159],"(56.25%),":[160,170],"cefazolin":[161],"(50%),":[162],"meropenem":[163],"(37.5%),":[164],"cefoperazone":[165],"(25%),":[166],"cefepime":[167],"(31.25%),":[168],"ceftazidime":[169],"cefotaxime":[172],"(68.75%)":[173],"but":[174],"all":[175],"sensitivity":[177],"(100%)":[178],"clindamycin":[180,207],"piperacillin-tazobactam.":[182],"3D":[183],"models":[184],"most":[187],"prevalent":[188],"variants":[189],"namely":[192,198],"TEM-1,":[193],"SHV-1,":[194],"OXA-1,":[195],"CTX-M-15":[199],"predicted":[201],"docking":[203,222],"performed":[205],"piperacillin-tazobactam":[209],"reveal":[211],"molecular":[213],"basis":[214],"drug":[216],"sensitivity.":[217],"Docking":[218],"best":[221],"score":[223],"significant":[225],"interactions,":[226],"forming":[227],"hydrogen":[228],"bond,":[229],"Van":[230],"der":[231],"Waals":[232],"polar":[234],"level":[235],"interaction":[236],"active":[238],"site":[239],"residues.":[240],"Findings":[241],"may":[246,258,275],"provide":[247],"useful":[248],"insights":[249],"development":[252],"new":[254],"antibiotic":[255],"drugs":[256],"also":[259],"prevent":[260],"ESBLs-mediated":[261],"problem":[263],"DFU.":[265],"novel":[267],"assay":[270],"designed":[271],"routinely":[277],"used":[278],"clinical":[280],"diagnostics":[281],"associated":[286],"bla(SHV),":[288],"genes.":[292]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}