{"id":"https://openalex.org/W2079230910","doi":"https://doi.org/10.1016/j.febslet.2008.04.054","title":"Metabolic and signaling properties of an Itpk gene family in Glycine max","display_name":"Metabolic and signaling properties of an Itpk gene family in Glycine max","publication_year":2008,"publication_date":"2008-05-12","ids":{"openalex":"https://openalex.org/W2079230910","doi":"https://doi.org/10.1016/j.febslet.2008.04.054","mag":"2079230910","pmid":"https://pubmed.ncbi.nlm.nih.gov/18474240","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2515385"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2008.04.054","doi":"https://doi.org/10.1016/j.febslet.2008.04.054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2008.04.054","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2008.04.054","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2008.04.054","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084642284","display_name":"Amanda R. Stiles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda R. Stiles","raw_affiliation_strings":["Department of Plant Pathology, Physiology and Weed Science, Virginia Polytechnic Institute and State University, 413 Price Hall, Blacksburg, VA 24061, USA","Department of Plant Pathology, Physiology and Weed Science, Virginia Polytechnic Institute and State University, 413 Price Hall, Blacksburg, VA 24061, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Pathology, Physiology and Weed Science, Virginia Polytechnic Institute and State University, 413 Price Hall, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Plant Pathology, Physiology and Weed Science, Virginia Polytechnic Institute and State University, 413 Price Hall, Blacksburg, VA 24061, United States","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xun Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xun Qian","raw_affiliation_strings":["Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, NC 27709, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, NC 27709, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013107971","display_name":"Stephen B. Shears","orcid":"https://orcid.org/0000-0001-7309-8916","observed_orcids":["https://orcid.org/0000-0001-7309-8916"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B. Shears","raw_affiliation_strings":["Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, NC 27709, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, NC 27709, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027373920","display_name":"Elizabeth A. Grabau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth A. Grabau","raw_affiliation_strings":["Department of Plant Pathology, Physiology and Weed Science, Virginia Polytechnic Institute and State University, 413 Price Hall, Blacksburg, VA 24061, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Pathology, Physiology and Weed Science, Virginia Polytechnic Institute and State University, 413 Price Hall, Blacksburg, VA 24061, United States","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027373920"],"corresponding_institution_ids":["https://openalex.org/I859038795"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":2.821,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.90009884,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"582","issue":"13","first_page":"1853","last_page":"1858"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.20059999823570251,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.20059999823570251,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.1687999963760376,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.1143999993801117,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inositol-polyphosphate-kinase","display_name":"inositol polyphosphate kinase","score":0.8519999980926514},{"id":"https://openalex.org/keywords/soybean","display_name":"soybean","score":0.8939999938011169},{"id":"https://openalex.org/keywords/protein-kinase-substrate-specificity","display_name":"kinase substrate specificity","score":0.4189999997615814},{"id":"https://openalex.org/keywords/gene-cloning","display_name":"gene cloning","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.6868973970413208},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5612885355949402},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5486539006233215},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49079832434654236},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4899432063102722},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4855756163597107},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.47311827540397644},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4160200357437134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3860468864440918},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3460119366645813},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.20691582560539246},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16444739699363708}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010833","descriptor_name":"Phytic Acid","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013025","descriptor_name":"Glycine max","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013025","descriptor_name":"Glycine max","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.febslet.2008.04.054","doi":"https://doi.org/10.1016/j.febslet.2008.04.054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2008.04.054","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2008.04.054","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:18474240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18474240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2515385","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2515385","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FEBS Lett","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.febslet.2008.04.054","doi":"https://doi.org/10.1016/j.febslet.2008.04.054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2008.04.054","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2008.04.054","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1252572669","display_name":"Inositol Signalling","funder_award_id":"Z01ES080046","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320313191","display_name":"United Soybean Board","ror":"https://ror.org/03az66838"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2079230910.pdf","grobid_xml":"https://content.openalex.org/works/W2079230910.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W49051275","https://openalex.org/W181110245","https://openalex.org/W1495058583","https://openalex.org/W1521038582","https://openalex.org/W1966007528","https://openalex.org/W1984769860","https://openalex.org/W1999415747","https://openalex.org/W2010189445","https://openalex.org/W2021198651","https://openalex.org/W2023959712","https://openalex.org/W2029268837","https://openalex.org/W2066465046","https://openalex.org/W2069031972","https://openalex.org/W2080351019","https://openalex.org/W2092401154","https://openalex.org/W2096337022","https://openalex.org/W2100520855","https://openalex.org/W2105933335","https://openalex.org/W2143496752","https://openalex.org/W2150297520","https://openalex.org/W2153841727","https://openalex.org/W2160648204","https://openalex.org/W2165182802","https://openalex.org/W2166944332","https://openalex.org/W2338376495","https://openalex.org/W2395442271"],"related_works":["https://openalex.org/W1988000500","https://openalex.org/W2782249939","https://openalex.org/W4281939089","https://openalex.org/W2924399263","https://openalex.org/W4390228384","https://openalex.org/W2092401154","https://openalex.org/W1974432838","https://openalex.org/W3032187763","https://openalex.org/W2965596785","https://openalex.org/W2973971656"],"abstract_inverted_index":{"We":[0],"have":[1],"cloned":[2],"and":[3,50],"characterized":[4],"four":[5,11],"Itpk":[6,13],"genes":[7],"from":[8],"soybean.":[9],"All":[10],"recombinant":[12],"proteins":[14],"showed":[15],"canonical":[16],"Ins(1,3,4)P3":[17],"5/6-kinase":[18],"activity,":[19],"but":[20],"a":[21,56],"kinetic":[22],"analysis":[23],"raised":[24],"questions":[25],"about":[26],"its":[27,51],"biological":[28,37],"significance.":[29],"Instead,":[30],"we":[31],"provide":[32],"evidence":[33],"that":[34],"one":[35],"alternative":[36],"role":[38],"for":[39],"soybean":[40,60,74,77],"Itpks":[41,61,78],"is":[42],"to":[43,65,71],"interconvert":[44],"the":[45],"Cl(-)":[46],"channel":[47],"inhibitor,":[48],"Ins(3,4,5,6)P4,":[49],"metabolic":[52],"precursor,":[53],"Ins(1,3,4,5,6)P5,":[54],"within":[55],"substrate":[57],"cycle.":[58],"The":[59],"also":[62],"phosphorylated":[63,70],"Ins(3,4,6)P3":[64],"Ins(1,3,4,6)P4":[66],"which":[67],"was":[68],"further":[69],"Ins(1,3,4,5,6)P5":[72],"by":[73],"Ipk2.":[75],"Thus,":[76],"may":[79],"participate":[80],"in":[81],"an":[82],"inositol":[83],"lipid-independent":[84],"pathway":[85],"of":[86],"InsP6":[87],"synthesis.":[88]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}