{"id":"https://openalex.org/W2079229016","doi":"https://doi.org/10.1081/pdt-100000010","title":"A Comparison of Reflectance and Transmittance Near-Infrared Spectroscopic Techniques in Determining Drug Content in Intact Tablets","display_name":"A Comparison of Reflectance and Transmittance Near-Infrared Spectroscopic Techniques in Determining Drug Content in Intact Tablets","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2079229016","doi":"https://doi.org/10.1081/pdt-100000010","mag":"2079229016","pmid":"https://pubmed.ncbi.nlm.nih.gov/11247272"},"language":"en","primary_location":{"id":"doi:10.1081/pdt-100000010","doi":"https://doi.org/10.1081/pdt-100000010","is_oa":false,"landing_page_url":"https://doi.org/10.1081/pdt-100000010","pdf_url":null,"source":{"id":"https://openalex.org/S80622011","display_name":"Pharmaceutical Development and Technology","issn_l":"1083-7450","issn":["1083-7450","1097-9867"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Development and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031309843","display_name":"Shilpa S. Thosar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shilpa S. Thosar","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, 26 South Dunlap, 214 Feurt Building, Memphis, TN 38163, USA. ashukla@utmem.edu","Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, 26 South Dunlap, 214 Feurt Building, Memphis, TN 38163, USA. ashukla@utmem.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072087447","display_name":"Reba A. Forbess","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reba A. Forbess","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068250666","display_name":"Nkere K. Ebube","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nkere K. Ebube","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100393456","display_name":"Yixin Chen","orcid":"https://orcid.org/0009-0007-5620-8694","observed_orcids":["https://orcid.org/0009-0007-5620-8694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yixin Chen","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054302384","display_name":"Ronald L. Rubinovitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald L. Rubinovitz","raw_affiliation_strings":["Foss NIR Systems, Inc., Silver Spring, MD, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foss NIR Systems, Inc., Silver Spring, MD, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017584975","display_name":"Mark S. Kemper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark S. Kemper","raw_affiliation_strings":["Foss NIR Systems, Inc., Silver Spring, MD, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foss NIR Systems, Inc., Silver Spring, MD, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081812155","display_name":"George E. Reier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George E. Reier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108503058","display_name":"Thomas A. Wheatley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas A. Wheatley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Atul J. Shukla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atul J. Shukla","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN, U.S.A.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, 26 South Dunlap, 214 Feurt Building, Memphis, TN, 38163, U.S.A","Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, 26 South Dunlap, 214 Feurt Building, Memphis, TN, 38163, U.S.A","Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN, U.S.A.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, 26 South Dunlap, 214 Feurt Building, Memphis, TN, 38163, U.S.A","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, 26 South Dunlap, 214 Feurt Building, Memphis, TN, 38163, U.S.A","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1205,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.84654099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"19","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/near-infrared-spectroscopy","display_name":"near-infrared spectroscopy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/reflectance-spectroscopy","display_name":"reflectance spectroscopy","score":0.8809999823570251},{"id":"https://openalex.org/keywords/transmission-spectroscopy","display_name":"transmission spectroscopy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/drug-content-determination","display_name":"drug content determination","score":0.9490000009536743},{"id":"https://openalex.org/keywords/theophylline","display_name":"theophylline","score":0.9539999961853027},{"id":"https://openalex.org/keywords/avicel-ph-101","display_name":"Avicel PH 101","score":0.9390000104904175},{"id":"https://openalex.org/keywords/magnesium-stearate","display_name":"magnesium stearate","score":0.9890000224113464},{"id":"https://openalex.org/keywords/partial-least-squares-calibration","display_name":"partial least squares calibration","score":0.8050000071525574},{"id":"https://openalex.org/keywords/multiple-linear-regression","display_name":"multiple linear regression","score":0.8209999799728394},{"id":"https://openalex.org/keywords/second-derivative-spectra","display_name":"second derivative spectra","score":0.9290000200271606},{"id":"https://openalex.org/keywords/nondestructive-analysis","display_name":"non-destructive analysis","score":0.7129999995231628},{"id":"https://openalex.org/keywords/tablet-quality-control","display_name":"tablet quality control","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C150493377","wikidata":"https://www.wikidata.org/wiki/Q1427863","display_name":"Transmittance","level":2,"score":0.7984143495559692},{"id":"https://openalex.org/C2778572730","wikidata":"https://www.wikidata.org/wiki/Q416713","display_name":"Magnesium stearate","level":3,"score":0.7126731276512146},{"id":"https://openalex.org/C22354355","wikidata":"https://www.wikidata.org/wiki/Q422009","display_name":"Partial least squares regression","level":2,"score":0.694200873374939},{"id":"https://openalex.org/C187714232","wikidata":"https://www.wikidata.org/wiki/Q2745207","display_name":"Anhydrous","level":2,"score":0.5799938440322876},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.5508895516395569},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.5369640588760376},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5366631746292114},{"id":"https://openalex.org/C43571822","wikidata":"https://www.wikidata.org/wiki/Q599037","display_name":"Near-infrared spectroscopy","level":2,"score":0.5237229466438293},{"id":"https://openalex.org/C156328458","wikidata":"https://www.wikidata.org/wiki/Q5275423","display_name":"Diffuse reflectance infrared fourier transform","level":4,"score":0.4905478358268738},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4323018789291382},{"id":"https://openalex.org/C108597893","wikidata":"https://www.wikidata.org/wiki/Q663650","display_name":"Reflectivity","level":2,"score":0.4147539436817169},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.39683809876441956},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.34479820728302},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2704324424266815},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09749546647071838},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.07939016819000244},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C65165184","wikidata":"https://www.wikidata.org/wiki/Q218831","display_name":"Photocatalysis","level":3,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013229","descriptor_name":"Stearic Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013678","descriptor_name":"Technology, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1081/pdt-100000010","doi":"https://doi.org/10.1081/pdt-100000010","is_oa":false,"landing_page_url":"https://doi.org/10.1081/pdt-100000010","pdf_url":null,"source":{"id":"https://openalex.org/S80622011","display_name":"Pharmaceutical Development and Technology","issn_l":"1083-7450","issn":["1083-7450","1097-9867"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Development and Technology","raw_type":"journal-article"},{"id":"pmid:11247272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11247272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical development and technology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W144470817","https://openalex.org/W180389365","https://openalex.org/W2023855951","https://openalex.org/W2024915923","https://openalex.org/W2029932006","https://openalex.org/W2034487587","https://openalex.org/W2107418475","https://openalex.org/W2110446021","https://openalex.org/W2154934736","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1987526024","https://openalex.org/W2049317953","https://openalex.org/W2252602594","https://openalex.org/W2030071438","https://openalex.org/W2073627124","https://openalex.org/W1993880806","https://openalex.org/W2151224960","https://openalex.org/W2157248417","https://openalex.org/W2051018824","https://openalex.org/W2047034263"],"abstract_inverted_index":{"Drug":[0],"contents":[1,72,116,133],"of":[2,22,33,73,108,117,144,147,156],"intact":[3,68,118,135],"tablets":[4,46,75,110,136],"were":[5,18,52,64,76,100,127,158],"determined":[6],"using":[7,79,170],"non-destructive":[8],"near":[9],"infrared":[10],"(NIR)":[11],"reflectance":[12,59,122],"and":[13,25,42,60,93,123],"transmittance":[14,61,125,172],"spectroscopic":[15],"techniques.":[16],"Tablets":[17],"compressed":[19],"from":[20,47,66,102,166],"blends":[21],"Avicel":[23],"PH-101":[24],"0.5%":[26],"w/w":[27],"magnesium":[28],"stearate":[29],"with":[30],"varying":[31],"concentrations":[32],"anhydrous":[34],"theophylline":[35],"(0,":[36],"1,":[37],"2,":[38],"5,":[39],"10,":[40],"20":[41],"40%":[43],"w/w).":[44],"Ten":[45],"each":[48],"drug":[49,71,115,132],"content":[50],"batch":[51],"randomly":[53],"selected":[54],"for":[55],"spectral":[56,106,167],"analysis.":[57],"Both":[58,120],"NIR":[62],"spectra":[63],"obtained":[65,169],"these":[67],"tablets.":[69,119],"Actual":[70],"the":[74,103,109,121,124,131,145,148,152,161,171],"then":[77],"ascertained":[78],"a":[80,138,142],"UV-spectrophotometer":[81],"at":[82,90],"268":[83],"nm.":[84],"Multiple":[85],"linear":[86],"regression":[87],"(MLR)":[88],"models":[89,99,164],"1116":[91],"nm":[92],"partial":[94],"least":[95],"squares":[96],"(PLS)":[97],"calibration":[98,163],"generated":[101,165],"second":[104],"derivative":[105],"data":[107,168],"in":[111,134],"order":[112],"to":[113,129],"predict":[114,130],"techniques":[126],"able":[128],"over":[137],"wide":[139],"range.":[140],"However,":[141],"comparison":[143],"results":[146],"study":[149],"indicated":[150],"that":[151],"lowest":[153],"percent":[154],"errors":[155],"prediction":[157],"provided":[159],"by":[160],"PLS":[162],"technique.":[173]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}