{"id":"https://openalex.org/W2079179232","doi":"https://doi.org/10.1194/jlr.m600528-jlr200","title":"Model-based compartmental analysis indicates a reduced mobilization of hepatic vitamin A during inflammation in rats","display_name":"Model-based compartmental analysis indicates a reduced mobilization of hepatic vitamin A during inflammation in rats","publication_year":2007,"publication_date":"2007-01-19","ids":{"openalex":"https://openalex.org/W2079179232","doi":"https://doi.org/10.1194/jlr.m600528-jlr200","mag":"2079179232","pmid":"https://pubmed.ncbi.nlm.nih.gov/17235116"},"language":"en","primary_location":{"id":"doi:10.1194/jlr.m600528-jlr200","doi":"https://doi.org/10.1194/jlr.m600528-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m600528-jlr200","pdf_url":"http://www.jlr.org/article/S0022227520434431/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jlr.org/article/S0022227520434431/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026338053","display_name":"John Gieng","orcid":"https://orcid.org/0000-0002-1834-9708","observed_orcids":["https://orcid.org/0000-0002-1834-9708"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sin H. Gieng","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, Oakland, CA, USA","Children's Hospital Oakland Research Institute; Oakland; CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, Oakland, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Children's Hospital Oakland Research Institute; Oakland; CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031233296","display_name":"Michael H. Green","orcid":"https://orcid.org/0000-0002-8169-9313","observed_orcids":["https://orcid.org/0000-0002-8169-9313"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H. Green","raw_affiliation_strings":["Department of Nutritional Sciences, Pennsylvania State University, University Park, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, Pennsylvania State University, University Park, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074748805","display_name":"Joanne Balmer Green","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne B. Green","raw_affiliation_strings":["Department of Nutritional Sciences, Pennsylvania State University, University Park, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, Pennsylvania State University, University Park, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110722453","display_name":"Francisco J. Rosales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050884","display_name":"Mead Johnson (United States)","ror":"https://ror.org/05p4pn188","country_code":"US","type":"company","lineage":["https://openalex.org/I2802050884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Francisco J. Rosales","raw_affiliation_strings":["Mead Johnson Nutritionals, Evansville, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mead Johnson Nutritionals, Evansville, IN","institution_ids":["https://openalex.org/I2802050884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110722453"],"corresponding_institution_ids":["https://openalex.org/I2802050884"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.6167,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.63870737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"48","issue":"4","first_page":"904","last_page":"913"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9750000238418579},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/retinol","display_name":"retinol","score":0.8450000286102295},{"id":"https://openalex.org/keywords/compartmental-analysis","display_name":"compartmental analysis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/three-compartment-model","display_name":"three-compartment model","score":0.7509999871253967},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.7459999918937683},{"id":"https://openalex.org/keywords/measles","display_name":"measles","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.760888934135437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.695946216583252},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6679250597953796},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.6416657567024231},{"id":"https://openalex.org/C2779573558","wikidata":"https://www.wikidata.org/wiki/Q424976","display_name":"Retinol","level":3,"score":0.6196953654289246},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5208723545074463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35361021757125854}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1194/jlr.m600528-jlr200","doi":"https://doi.org/10.1194/jlr.m600528-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m600528-jlr200","pdf_url":"http://www.jlr.org/article/S0022227520434431/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:17235116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17235116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.sjsu.edu:nufs_pub-1022","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.sjsu.edu/nufs_pub/23","pdf_url":null,"source":{"id":"https://openalex.org/S4377196389","display_name":"San Jos\u00e9 State University ScholarWorks (San Jose State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51504820","host_organization_name":"San Jose State University","host_organization_lineage":["https://openalex.org/I51504820"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:8c9d4e5c87394cf4a9172bc90d28569c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8c9d4e5c87394cf4a9172bc90d28569c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 48, Iss 4, Pp 904-913 (2007)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1194/jlr.m600528-jlr200","doi":"https://doi.org/10.1194/jlr.m600528-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m600528-jlr200","pdf_url":"http://www.jlr.org/article/S0022227520434431/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1445559730","display_name":"A KINETIC STUDY OF INFLAMMATION-INDUCED HYPORETINEMIA","funder_award_id":"R03DK062166","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2079179232.pdf","grobid_xml":"https://content.openalex.org/works/W2079179232.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W13928267","https://openalex.org/W73817730","https://openalex.org/W588943583","https://openalex.org/W1511102228","https://openalex.org/W1514834657","https://openalex.org/W1542705807","https://openalex.org/W1753544142","https://openalex.org/W1767301034","https://openalex.org/W1831301545","https://openalex.org/W1835909554","https://openalex.org/W1856639419","https://openalex.org/W1923263177","https://openalex.org/W1924267103","https://openalex.org/W1930067991","https://openalex.org/W1938949028","https://openalex.org/W1945371044","https://openalex.org/W1967379123","https://openalex.org/W1969876227","https://openalex.org/W2002591611","https://openalex.org/W2016383199","https://openalex.org/W2024266035","https://openalex.org/W2037565894","https://openalex.org/W2044952089","https://openalex.org/W2059768938","https://openalex.org/W2087957366","https://openalex.org/W2094135147","https://openalex.org/W2099265277","https://openalex.org/W2107717183","https://openalex.org/W2109732071","https://openalex.org/W2115959654","https://openalex.org/W2121882113","https://openalex.org/W2135366961","https://openalex.org/W2142635246","https://openalex.org/W2144772076","https://openalex.org/W2152111781","https://openalex.org/W2158231545","https://openalex.org/W2167033537","https://openalex.org/W2168895082","https://openalex.org/W2287213082","https://openalex.org/W2385020958","https://openalex.org/W2413344286"],"related_works":["https://openalex.org/W2099265277","https://openalex.org/W2254578813","https://openalex.org/W3124443712","https://openalex.org/W1938949028","https://openalex.org/W67001941","https://openalex.org/W2016383199","https://openalex.org/W1945371044","https://openalex.org/W2167033537","https://openalex.org/W2112406962","https://openalex.org/W3174717278"],"abstract_inverted_index":{"Vitamin":[0],"A":[1],"(VA)":[2],"kinetics":[3,94,158],"was":[4,26,80,95],"studied":[5],"in":[6,59,134,155,208],"rats":[7],"with":[8,31,211],"marginal":[9],"VA":[10,93,157],"stores":[11],"before,":[12],"during,":[13],"and":[14,24,56,77,86,105,124],"after":[15,147,186],"inflammation.":[16,187],"Rats":[17],"received":[18],"orally":[19],"[11,12-(3)H(N)]retinol":[20],"([(3)H]VA;":[21],"day":[22,29],"0),":[23],"inflammation":[25],"induced":[27],"on":[28],"21":[30],"lipopolysacchride":[32],"(LPS)":[33],"for":[34,45,151],"3":[35],"days":[36,47,185],"(n":[37,48],"=":[38,49,162],"5)":[39],"or":[40,66],"recombinant":[41],"human":[42],"interleukin-6":[43],"(rhIL-6)":[44],"7":[46],"5).":[50],"Both":[51],"the":[52,71,152],"fraction":[53],"of":[54,74,137,160],"[(3)H]VA":[55],"retinol":[57,111,138,195],"concentrations":[58],"plasma":[60,110,156],"were":[61,89,112],"reduced":[62],"significantly":[63],"by":[64,97,144,172,183],"LPS":[65,148],"rhIL-6.":[67],"Compartmental":[68],"analysis":[69],"using":[70],"Windows":[72],"version":[73],"Simulation,":[75],"Analysis,":[76],"Modeling":[78,128],"software":[79],"applied":[81],"to":[82,141,180,197,202],"group":[83],"mean":[84],"data,":[85],"non-steady-state":[87],"models":[88,176],"developed.":[90],"After":[91],"absorption,":[92],"described":[96],"a":[98,131,178],"three-compartment":[99],"model":[100],"that":[101,130],"included":[102],"plasma,":[103],"kidney/interstitium,":[104],"liver/carcass.":[106],"Four":[107],"mechanisms":[108],"decreasing":[109],"investigated:":[113],"increased":[114,117,120],"urinary":[115],"excretion,":[116],"irreversible":[118],"loss,":[119],"movement":[121],"into":[122],"interstitium,":[123],"decreased":[125],"hepatic":[126,135,194],"mobilization.":[127],"demonstrated":[129],"79%":[132],"reduction":[133,170],"mobilization":[136],"(from":[139],"4.3":[140],"0.9":[142],"nmol/h)":[143],"15":[145],"h":[146],"best":[149],"accounted":[150],"observed":[153,207],"changes":[154],"(sum":[159],"squares":[161],"9.05":[163],"x":[164],"10(-07)).":[165],"rhIL-6":[166],"caused":[167],"an":[168],"earlier":[169],"(75%":[171],"5.6":[173],"h).":[174],"These":[175],"predicted":[177],"return":[179],"control":[181],"values":[182],"10":[184],"If":[188],"prolonged,":[189],"inflammation-induced":[190],"hyporetinolemia":[191],"can":[192],"render":[193],"unavailable":[196],"extrahepatic":[198],"tissues,":[199],"possibly":[200],"leading":[201],"their":[203],"impaired":[204],"function,":[205],"as":[206],"VA-deficient":[209],"children":[210],"measles":[212],"infection.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
