{"id":"https://openalex.org/W2079110602","doi":"https://doi.org/10.1111/j.1365-2133.1995.tb02662.x","title":"Irritant susceptibility and weal and flare reactions to bioactive agents in atopic dermatitis. II. Influence of season","display_name":"Irritant susceptibility and weal and flare reactions to bioactive agents in atopic dermatitis. II. Influence of season","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W2079110602","doi":"https://doi.org/10.1111/j.1365-2133.1995.tb02662.x","mag":"2079110602","pmid":"https://pubmed.ncbi.nlm.nih.gov/8546989"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2133.1995.tb02662.x","doi":"https://doi.org/10.1111/j.1365-2133.1995.tb02662.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.1995.tb02662.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008985880","display_name":"Ron A. Tupker","orcid":"https://orcid.org/0000-0003-2378-3741","observed_orcids":["https://orcid.org/0000-0003-2378-3741"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R.A. TUPKER","raw_affiliation_strings":["Department of Dermatology, University Hospital, Groningen, The Netherlands","Departmnent of Dermatology, Univrsity Hospital, PO Box 300001, NL-9700 RB Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]},{"raw_affiliation_string":"Departmnent of Dermatology, Univrsity Hospital, PO Box 300001, NL-9700 RB Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052257644","display_name":"Pieter Jan Coenraads","orcid":"https://orcid.org/0000-0001-9458-7129","observed_orcids":["https://orcid.org/0000-0001-9458-7129"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P.J. COENRAADS","raw_affiliation_strings":["Departmnent of Dermatology, Univrsity Hospital, PO Box 300001, NL\u20109700 RB Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmnent of Dermatology, Univrsity Hospital, PO Box 300001, NL\u20109700 RB Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113584753","display_name":"Vaclav Fidler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"V. FIDLER","raw_affiliation_strings":["Department of Medical Statistics, University of Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Statistics, University of Groningen, the Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109153333","display_name":"M.C.J.M. JONG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M.C.J.M. JONG","raw_affiliation_strings":["Departmnent of Dermatology, Univrsity Hospital, PO Box 300001, NL-9700 RB Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmnent of Dermatology, Univrsity Hospital, PO Box 300001, NL-9700 RB Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110154303","display_name":"Jan B. van der Meer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J.B. MEER","raw_affiliation_strings":["Departmnent of Dermatology, Univrsity Hospital, PO Box 300001, NL-9700 RB Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmnent of Dermatology, Univrsity Hospital, PO Box 300001, NL-9700 RB Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110225816","display_name":"Jan G.R. de Monchy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J.G.R. MONCHY","raw_affiliation_strings":["Department of Allergology, University Hospital Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergology, University Hospital Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3731,"currency":"GBP","value_usd":4920},"apc_paid":null,"fwci":1.9445,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.85933086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"133","issue":"3","first_page":"365","last_page":"370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":1.0},{"id":"https://openalex.org/keywords/seasonal-variation","display_name":"seasonal variation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/sodium-dodecyl-sulfate","display_name":"sodium dodecyl sulfate","score":0.9120000004768372},{"id":"https://openalex.org/keywords/skin-barrier-function","display_name":"skin barrier function","score":0.9120000004768372},{"id":"https://openalex.org/keywords/skin-hydration","display_name":"skin hydration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/codeine","display_name":"codeine","score":0.7870000004768372},{"id":"https://openalex.org/keywords/methacholine","display_name":"methacholine","score":0.9240000247955322},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.996999979019165},{"id":"https://openalex.org/keywords/trypsin","display_name":"trypsin","score":0.949999988079071},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.878000020980835},{"id":"https://openalex.org/keywords/fmlp","display_name":"fMLP","score":0.777999997138977},{"id":"https://openalex.org/keywords/winter-exacerbation","display_name":"winter exacerbation","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.6988906860351562},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.5653271079063416},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5576827526092529},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5534364581108093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5407741665840149},{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.4982626438140869},{"id":"https://openalex.org/C95150158","wikidata":"https://www.wikidata.org/wiki/Q7833972","display_name":"Transepidermal water loss","level":3,"score":0.4590773284435272},{"id":"https://openalex.org/C2779299482","wikidata":"https://www.wikidata.org/wiki/Q3705876","display_name":"Dermatomycosis","level":2,"score":0.4431675970554352},{"id":"https://openalex.org/C2778750689","wikidata":"https://www.wikidata.org/wiki/Q1799146","display_name":"Irritant contact dermatitis","level":4,"score":0.4335615038871765},{"id":"https://openalex.org/C2781260171","wikidata":"https://www.wikidata.org/wiki/Q413188","display_name":"Methacholine","level":4,"score":0.42720115184783936},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.41449007391929626},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.388011634349823},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.38638919591903687},{"id":"https://openalex.org/C2778091633","wikidata":"https://www.wikidata.org/wiki/Q783903","display_name":"Contact dermatitis","level":3,"score":0.35277512669563293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22845369577407837},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13136473298072815},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.0},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007509","descriptor_name":"Irritants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014581","descriptor_name":"Urticaria","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D014887","descriptor_name":"Weather","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1365-2133.1995.tb02662.x","doi":"https://doi.org/10.1111/j.1365-2133.1995.tb02662.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.1995.tb02662.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:8546989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8546989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/8209a767-d3c7-41df-98a0-8cb774d9dc2c","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/8209a767-d3c7-41df-98a0-8cb774d9dc2c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tupker, R A, Coenraads, P J, Fidler, V, de Jong, M C J M, van der Meer, J B & de Monchy, J G R 1995, 'Irritant susceptibility and weal and flare reactions to bioactive agents in atopic dermatitis. II. Influence of season', British Journal of Dermatology, vol. 133, no. 3, pp. 365-370. https://doi.org/10.1111/j.1365-2133.1995.tb02662.x","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/8209a767-d3c7-41df-98a0-8cb774d9dc2c","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/8209a767-d3c7-41df-98a0-8cb774d9dc2c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BRITISH JOURNAL OF DERMATOLOGY, 133(3), 365 - 370. Wiley","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1563587102","https://openalex.org/W1573257422","https://openalex.org/W1970800052","https://openalex.org/W1971799578","https://openalex.org/W1974996534","https://openalex.org/W1977113178","https://openalex.org/W2003474259","https://openalex.org/W2008720096","https://openalex.org/W2022057260","https://openalex.org/W2051230766","https://openalex.org/W2061984506","https://openalex.org/W2068306606","https://openalex.org/W2077114868","https://openalex.org/W2077137686","https://openalex.org/W2084816344","https://openalex.org/W2092635728","https://openalex.org/W2120536939","https://openalex.org/W2131295341","https://openalex.org/W2137925869","https://openalex.org/W2400954485","https://openalex.org/W2413816261"],"related_works":["https://openalex.org/W2137925869","https://openalex.org/W2109361630","https://openalex.org/W2291315175","https://openalex.org/W4324145256","https://openalex.org/W2975807163","https://openalex.org/W2001177722","https://openalex.org/W4389477973","https://openalex.org/W1996181586","https://openalex.org/W4206948553","https://openalex.org/W2403780106"],"abstract_inverted_index":{"Many":[0],"atopic":[1],"dermatitis":[2,112,238],"(AD)":[3],"patients":[4,110,132,138,222],"have":[5],"exacerbations":[6,14],"of":[7,34,48,57,70,96,107,180,184,242],"their":[8],"skin":[9,38,61,72,156,176,277],"disease":[10],"in":[11,40,74,117,120,127,130,134,147,160,166,206,212,220,224,227,275],"winter.":[12],"These":[13],"may":[15,64,168,268],"be":[16,65,169,269],"caused":[17],"by":[18],"non-immunological":[19],"'non-specific'":[20],"factors,":[21],"such":[22],"as":[23,67],"low":[24,28],"sun":[25],"exposure":[26],"and":[27,87,90,133,150,155,201,230,258],"temperature.":[29],"To":[30],"date,":[31],"the":[32,49,55,181,191],"influence":[33,56],"season":[35,58],"on":[36,59,187],"non-specific":[37,71,276],"reactivity":[39,73,259],"AD":[41,109,131,137,213,221],"has":[42],"not":[43,247],"been":[44],"studied.":[45],"The":[46,162],"aim":[47],"present":[50],"investigation":[51],"was":[52,114,125],"to":[53,78,93,123,142,171,196,255,260,271],"assess":[54],"two":[60],"parameters":[62,266],"which":[63,113,267],"used":[66,270],"quantitative":[68],"measures":[69],"AD:":[75],"(i)":[76],"susceptibility":[77,165,254],"repeated":[79],"epicutaneous":[80,256],"irritant":[81,164],"(sodium":[82],"lauryl":[83],"sulphate,":[84],"SLS)":[85],"exposure,":[86],"(ii)":[88],"weal":[89],"flare":[91],"responses":[92,195,245],"intracutaneous":[94],"injection":[95],"bioactive":[97,263],"agents":[98,264],"(codeine,":[99],"FMLP,":[100],"histamine,":[101],"methacholine,":[102,198],"substance":[103,199],"P,":[104],"trypsin).":[105],"Four":[106],"16":[108],"had":[111],"more":[115,140],"severe":[116],"November":[118,167,207],"than":[119,144,223],"July.":[121],"Susceptibility":[122],"SLS":[124,143],"increased":[126,163,205],"November,":[128],"both":[129,148,228],"control":[135,145,225],"subjects.":[136],"were":[139,158,203,218,234],"susceptible":[141],"subjects":[146],"July":[149,229],"November.":[151,161,231],"Pre-exposure":[152],"barrier":[153,173],"function":[154],"hydration":[157],"reduced":[159,172,175],"attributed":[170],"function,":[174],"hydration,":[177],"and/or":[178],"absence":[179],"beneficial":[182],"effects":[183],"ultraviolet":[185],"light":[186],"cellular":[188],"targets":[189],"beneath":[190],"stratum":[192],"corneum.":[193],"Flare":[194,232],"codeine,":[197],"P":[200],"trypsin":[202],"also":[204],"compared":[208],"with":[209,237],"July,":[210],"especially":[211],"patients.":[214],"However,":[215],"smaller":[216],"flares":[217],"observed":[219],"subjects,":[226],"values":[233],"negatively":[235],"correlated":[236],"severity,":[239],"probably":[240],"because":[241],"down-regulation.":[243],"Weal":[244],"did":[246],"show":[248],"a":[249],"clear":[250],"seasonal":[251],"variation.":[252],"Hence,":[253],"irritants":[257],"intracutaneously":[261],"injected":[262],"are":[265],"monitor":[272],"season-dependent":[273],"changes":[274],"reactivity.":[278]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}