{"id":"https://openalex.org/W2079106934","doi":"https://doi.org/10.3164/jcbn.08-254","title":"The Expression of Murine Double Minute 2 (MDM2) on Helicobacter pylori-Infected Intestinal Metaplasia and Gastric Cancer","display_name":"The Expression of Murine Double Minute 2 (MDM2) on Helicobacter pylori-Infected Intestinal Metaplasia and Gastric Cancer","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2079106934","doi":"https://doi.org/10.3164/jcbn.08-254","mag":"2079106934","pmid":"https://pubmed.ncbi.nlm.nih.gov/19308274","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654476"},"language":"en","primary_location":{"id":"doi:10.3164/jcbn.08-254","doi":"https://doi.org/10.3164/jcbn.08-254","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.08-254","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/44/2/44_08-254/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jcbn/44/2/44_08-254/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101504047","display_name":"Noriko Nakajima","orcid":"https://orcid.org/0000-0003-1824-0603","observed_orcids":["https://orcid.org/0000-0003-1824-0603"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Noriko Nakajima","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Nihon University School of Medicine, Tokyo 101-8309, Japan","Department of Gastroenterology and Hepatology, Nihon University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Nihon University School of Medicine, Tokyo 101-8309, Japan","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Nihon University School of Medicine","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoko Ito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Ito","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Nihon University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Nihon University School of Medicine","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112308236","display_name":"Kiyoshi Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Yokoyama","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Nihon University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Nihon University School of Medicine","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023981757","display_name":"Akitake Uno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akitake Uno","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Nihon University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Nihon University School of Medicine","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058077469","display_name":"Noriko Kinukawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriko Kinukawa","raw_affiliation_strings":["Department of Pathology, Nihon University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Nihon University School of Medicine","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113445708","display_name":"Norimichi Nemoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norimichi Nemoto","raw_affiliation_strings":["Department of Pathology, Nihon University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Nihon University School of Medicine","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055964691","display_name":"Mitsuhiko Moriyama","orcid":"https://orcid.org/0000-0002-4617-508X","observed_orcids":["https://orcid.org/0000-0002-4617-508X"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuhiko Moriyama","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Nihon University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Nihon University School of Medicine","institution_ids":["https://openalex.org/I104946051"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101504047"],"corresponding_institution_ids":["https://openalex.org/I104946051"],"apc_list":null,"apc_paid":null,"fwci":3.3797,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.91777972,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"44","issue":"2","first_page":"196","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/helicobacter-pylori-infection","display_name":"Helicobacter pylori infection","score":0.9760000109672546},{"id":"https://openalex.org/keywords/intestinal-metaplasia","display_name":"intestinal metaplasia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":1.0},{"id":"https://openalex.org/keywords/interleukin-16","display_name":"interleukin-16","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chronic-gastritis","display_name":"chronic gastritis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/gastric-epithelial-cell-proliferation","display_name":"gastric epithelial cell proliferation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8519999980926514},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/gastric-mucosa","display_name":"gastric mucosa","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.8194357752799988},{"id":"https://openalex.org/C2776497702","wikidata":"https://www.wikidata.org/wiki/Q872095","display_name":"Intestinal metaplasia","level":3,"score":0.738053560256958},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6493756175041199},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.6337879300117493},{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.6268306970596313},{"id":"https://openalex.org/C2780561475","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Chronic gastritis","level":4,"score":0.553987443447113},{"id":"https://openalex.org/C2778677798","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Gastritis","level":3,"score":0.5411658883094788},{"id":"https://openalex.org/C2779357193","wikidata":"https://www.wikidata.org/wiki/Q660713","display_name":"Metaplasia","level":2,"score":0.48864442110061646},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4768827557563782},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.4672427475452423},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4621008634567261},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4570595622062683},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40310969948768616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3964651823043823},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3807501792907715},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3492530882358551},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26498329639434814},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3164/jcbn.08-254","doi":"https://doi.org/10.3164/jcbn.08-254","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.08-254","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/44/2/44_08-254/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2654476","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654476","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Biochem Nutr","raw_type":"Text"},{"id":"pmid:19308274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19308274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical biochemistry and nutrition","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3164/jcbn.08-254","doi":"https://doi.org/10.3164/jcbn.08-254","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.08-254","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/44/2/44_08-254/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2079106934.pdf","grobid_xml":"https://content.openalex.org/works/W2079106934.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W190488077","https://openalex.org/W307700147","https://openalex.org/W1917735140","https://openalex.org/W1922753633","https://openalex.org/W1962044813","https://openalex.org/W1982517685","https://openalex.org/W1988497096","https://openalex.org/W1998817458","https://openalex.org/W2002898043","https://openalex.org/W2037062236","https://openalex.org/W2045730983","https://openalex.org/W2077502013","https://openalex.org/W2080173886","https://openalex.org/W2080213393","https://openalex.org/W2088597251","https://openalex.org/W2088923402","https://openalex.org/W2091129781","https://openalex.org/W2106835946","https://openalex.org/W2124154171","https://openalex.org/W2133452916","https://openalex.org/W2139172234","https://openalex.org/W2139785994","https://openalex.org/W2158441072","https://openalex.org/W2160854466","https://openalex.org/W2259806522","https://openalex.org/W4243180424"],"related_works":["https://openalex.org/W2978813670","https://openalex.org/W2398791624","https://openalex.org/W2387476708","https://openalex.org/W2017077532","https://openalex.org/W2978509025","https://openalex.org/W2392138775","https://openalex.org/W2351628217","https://openalex.org/W1917735140","https://openalex.org/W2390348278","https://openalex.org/W2340336758"],"abstract_inverted_index":{"The":[0,90,224],"overexpression":[1],"of":[2,17,27,38,48,59,72,92,107,126,140,194,218,226],"murine":[3],"double":[4],"minute":[5],"2":[6],"(MDM2)":[7],"is":[8,31,216],"found":[9],"in":[10,44,61,85,88,196,211],"several":[11],"human":[12],"tumors,":[13],"and":[14,22,35,64,76,82,109,123,144,165,177],"increased":[15,174],"expression":[16,58,84,91,139,159,176,193,225],"MDM2":[18,60,83,93,127,141,158,175,195,227],"inactivates":[19],"the":[20,36,45,57,70,124,138,157,192,219],"apoptotic":[21],"cell":[23,80,116,178],"cycle":[24],"arrest":[25],"function":[26],"p53.":[28],"Interleukin-16":[29],"(IL-16)":[30],"a":[32,105,205,232],"pleiotrophic":[33],"cytokine":[34],"properties":[37],"IL-16":[39,77,108,171,209],"suggest":[40],"that":[41],"it":[42],"involve":[43],"pathophysiological":[46],"process":[47],"chronic":[49,149,169],"inflammatory":[50],"diseases.":[51],"In":[52,151,190],"this":[53],"study,":[54],"we":[55],"investigated":[56],"intestinal":[62,163],"metaplasia":[63,164],"gastric":[65,86,95,155,166,201,222,235],"cancer":[66,167],"as":[67,69],"well":[68],"effect":[71],"H.":[73,146,152,187,198,212],"pylori":[74,111,147,153,188,199,213],"infection":[75],"on":[78,94,137,162,180,228],"epithelial":[79,115],"proliferation":[81,117,179],"cells":[87,101],"vitro.":[89],"biopsies":[96],"was":[97,118,133,160,173,184],"studied":[98,119,129],"immunohistochemistry.":[99],"AGS":[100,181],"were":[102,128],"incubated":[103],"with":[104,143],"combination":[106],"Helicobacter":[110],"(H.":[112],"pylori).":[113],"Gastric":[114],"by":[120,130,186],"BrdU":[121],"uptake":[122],"expressions":[125],"ELISA.":[131],"There":[132],"no":[134],"significant":[135],"difference":[136],"between":[142],"without":[145],"infected":[148,154,200,214],"gastritis.":[150,170],"mucosa;":[156],"higher":[161],"than":[168],"administration":[172],"cells,":[182],"which":[183],"decreased":[185],"infection.":[189],"conclusion,":[191],"long-term":[197],"mucosa":[202,215,229],"may":[203],"indicate":[204],"risk":[206],"for":[207,221,234],"carcinogenesis.":[208],"secretion":[210],"one":[217],"factors":[220],"cancer.":[223,236],"can":[230],"be":[231],"mediator":[233]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}