{"id":"https://openalex.org/W2079070592","doi":"https://doi.org/10.3349/ymj.2003.44.1.15","title":"Relationship between Utrophin and Regenerating Muscle Fibers in Duchenne Muscular Dystrophy","display_name":"Relationship between Utrophin and Regenerating Muscle Fibers in Duchenne Muscular Dystrophy","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2079070592","doi":"https://doi.org/10.3349/ymj.2003.44.1.15","mag":"2079070592","pmid":"https://pubmed.ncbi.nlm.nih.gov/12619170"},"language":"en","primary_location":{"id":"doi:10.3349/ymj.2003.44.1.15","doi":"https://doi.org/10.3349/ymj.2003.44.1.15","is_oa":true,"landing_page_url":"https://doi.org/10.3349/ymj.2003.44.1.15","pdf_url":null,"source":{"id":"https://openalex.org/S107862393","display_name":"Yonsei Medical Journal","issn_l":"0513-5796","issn":["0513-5796","1976-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319467","host_organization_name":"Yonsei University College of Medicine","host_organization_lineage":["https://openalex.org/P4310319467"],"host_organization_lineage_names":["Yonsei University College of Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3349/ymj.2003.44.1.15","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113487070","display_name":"Jeong Yun Shim","orcid":"https://orcid.org/0000-0002-4628-6660","observed_orcids":["https://orcid.org/0000-0002-4628-6660"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong Yun Shim","raw_affiliation_strings":["Department of Pathology, Pundang CHA Hospital, Pochun CHA Medical College and Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Pundang CHA Hospital, Pochun CHA Medical College and Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111711623","display_name":"Tai Seung Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tai Seung Kim","raw_affiliation_strings":["Department of Pathology, Pundang CHA Hospital, Pochun CHA Medical College and Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Pundang CHA Hospital, Pochun CHA Medical College and Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":700,"currency":"USD","value_usd":700},"apc_paid":{"value":700,"currency":"USD","value_usd":700},"fwci":0.0,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"44","issue":"1","first_page":"15","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/utrophin","display_name":"utrophin","score":0.8650000095367432},{"id":"https://openalex.org/keywords/duchenne-muscular-dystrophy","display_name":"Duchenne muscular dystrophy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/muscle-regeneration","display_name":"muscle regeneration","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dystrophin","display_name":"dystrophin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/inflammatory-myopathies","display_name":"myositis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/polymyositis","display_name":"polymyositis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dermatomyositis","display_name":"dermatomyositis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/desmin","display_name":"desmin","score":0.984000027179718},{"id":"https://openalex.org/keywords/dystrophinopathy","display_name":"dystrophinopathy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/xp21","display_name":"Xp21","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.9016892910003662},{"id":"https://openalex.org/C2779072444","wikidata":"https://www.wikidata.org/wiki/Q425146","display_name":"Desmin","level":4,"score":0.8986493349075317},{"id":"https://openalex.org/C78343239","wikidata":"https://www.wikidata.org/wiki/Q22683570","display_name":"Utrophin","level":4,"score":0.880251407623291},{"id":"https://openalex.org/C2780394045","wikidata":"https://www.wikidata.org/wiki/Q412285","display_name":"Dystrophin","level":3,"score":0.8704851865768433},{"id":"https://openalex.org/C2778943923","wikidata":"https://www.wikidata.org/wiki/Q1648484","display_name":"Duchenne muscular dystrophy","level":2,"score":0.8269104957580566},{"id":"https://openalex.org/C2779030066","wikidata":"https://www.wikidata.org/wiki/Q1137767","display_name":"Muscular dystrophy","level":2,"score":0.5599542260169983},{"id":"https://openalex.org/C78383274","wikidata":"https://www.wikidata.org/wiki/Q421987","display_name":"Intermediate filament","level":4,"score":0.5355622172355652},{"id":"https://openalex.org/C2777300911","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Myopathy","level":2,"score":0.47444093227386475},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4246843457221985},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4181777834892273},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39844760298728943},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39641016721725464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3503287136554718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30679798126220703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29449981451034546},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.13174474239349365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09269434213638306},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020388","descriptor_name":"Muscular Dystrophy, Duchenne","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D049411","descriptor_name":"Utrophin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3349/ymj.2003.44.1.15","doi":"https://doi.org/10.3349/ymj.2003.44.1.15","is_oa":true,"landing_page_url":"https://doi.org/10.3349/ymj.2003.44.1.15","pdf_url":null,"source":{"id":"https://openalex.org/S107862393","display_name":"Yonsei Medical Journal","issn_l":"0513-5796","issn":["0513-5796","1976-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319467","host_organization_name":"Yonsei University College of Medicine","host_organization_lineage":["https://openalex.org/P4310319467"],"host_organization_lineage_names":["Yonsei University College of Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei Medical Journal","raw_type":"journal-article"},{"id":"pmid:12619170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12619170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei medical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3349/ymj.2003.44.1.15","doi":"https://doi.org/10.3349/ymj.2003.44.1.15","is_oa":true,"landing_page_url":"https://doi.org/10.3349/ymj.2003.44.1.15","pdf_url":null,"source":{"id":"https://openalex.org/S107862393","display_name":"Yonsei Medical Journal","issn_l":"0513-5796","issn":["0513-5796","1976-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319467","host_organization_name":"Yonsei University College of Medicine","host_organization_lineage":["https://openalex.org/P4310319467"],"host_organization_lineage_names":["Yonsei University College of Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1524890078","https://openalex.org/W1965369491","https://openalex.org/W1969781979","https://openalex.org/W1972049148","https://openalex.org/W1972383065","https://openalex.org/W1972568955","https://openalex.org/W1978898259","https://openalex.org/W1983555241","https://openalex.org/W1985433288","https://openalex.org/W1987993105","https://openalex.org/W1990074216","https://openalex.org/W1990585109","https://openalex.org/W1992970993","https://openalex.org/W1999008715","https://openalex.org/W2003377627","https://openalex.org/W2003922674","https://openalex.org/W2019563312","https://openalex.org/W2023972061","https://openalex.org/W2026728314","https://openalex.org/W2030425092","https://openalex.org/W2031263995","https://openalex.org/W2047015778","https://openalex.org/W2061990195","https://openalex.org/W2062746471","https://openalex.org/W2064385916","https://openalex.org/W2068018243","https://openalex.org/W2072221214","https://openalex.org/W2072336811","https://openalex.org/W2075323386","https://openalex.org/W2078680005","https://openalex.org/W2081597513","https://openalex.org/W2084386191","https://openalex.org/W2091212285","https://openalex.org/W2110431324","https://openalex.org/W2117044960","https://openalex.org/W2140477606","https://openalex.org/W2146367762","https://openalex.org/W2152919502","https://openalex.org/W2158049686","https://openalex.org/W2161366283","https://openalex.org/W2161498359","https://openalex.org/W2172287346","https://openalex.org/W2502757059"],"related_works":["https://openalex.org/W7213326063","https://openalex.org/W2299139921","https://openalex.org/W2897525758","https://openalex.org/W1972383065","https://openalex.org/W2601967091","https://openalex.org/W2039152625","https://openalex.org/W2034387481","https://openalex.org/W2003377627","https://openalex.org/W1985433288","https://openalex.org/W2930243077"],"abstract_inverted_index":{"Duchenne":[0],"muscular":[1],"dystrophy":[2],"(DMD)":[3],"is":[4,11,24,209,214,223],"a":[5,17],"dystrophinopathy,":[6],"and":[7,39,53,67,97,133,146,149,157,165,175,194,211],"its":[8],"associated":[9],"gene":[10],"located":[12],"on":[13],"Xp21.":[14],"Moreover,":[15],"utrophin,":[16,50,192],"recently":[18],"identified":[19],"structural":[20],"homologue":[21],"of":[22,61,65,70,79,86,95,100,103,144,151,191,219],"dystrophin":[23],"reported":[25],"to":[26,33,49,112,163,216],"be":[27],"up-regulated":[28],"in":[29,42,58,75,83,93,98,108,114,126,138,141,159,167,182,199],"DMD.":[30,227],"In":[31,117,171],"order":[32],"investigate":[34],"the":[35,104,217],"association":[36],"between":[37],"utrophin":[38,120,207],"muscle":[40],"regeneration":[41],"DMD,":[43,62,80,109,160],"an":[44],"immunohistochemical":[45],"study":[46],"using":[47],"antibodies":[48],"dystrophin,":[51],"vimentin":[52,156,174,193],"desmin":[54,134,158,176,195],"was":[55,73,91,122],"carried":[56],"out":[57],"17":[59],"cases":[60,64,78,85,143],"3":[63],"polymyositis":[66],"1":[68],"case":[69],"dermatomyositis.":[71],"Dystrophin":[72],"negative":[74],"almost":[76],"all":[77,84,142],"but":[81,222],"positive":[82,92,107,137,154],"inflammatory":[87],"myopathy":[88],"(IM).":[89],"Utrophin":[90],"94.0%":[94],"DMD":[96,145],"75.0%":[99],"IM.":[101,147],"36.4%":[102],"myofibers":[105,152],"were":[106,135,153,178,196],"as":[110,161],"compared":[111,162],"10.5%":[113],"IM":[115,168],"(p=0.001).":[116],"both":[118,172],"groups,":[119,173],"positivity":[121,177],"present":[123,179],"most":[124,180],"commonly":[125,181],"small":[127,183,200],"regenerating":[128,139,184,201,220],"fibers":[129,140,185],"(p=0.001,":[130,169,186],"0.013).":[131],"Vimentin":[132],"intensely":[136],"34.4%":[148],"35.4%":[150],"for":[155,226],"21.8%":[164],"20.9%":[166],"0.001).":[170,187],"The":[188],"staining":[189],"intensities":[190],"also":[197],"higher":[198],"fibers.":[202],"These":[203],"results":[204],"show":[205],"that":[206,212],"up-regulation":[208],"regeneration-associated,":[210],"it":[213],"proportional":[215],"quantity":[218],"myofibers,":[221],"not":[224],"specific":[225]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}