{"id":"https://openalex.org/W2078995073","doi":"https://doi.org/10.1074/jbc.m105487200","title":"Antioxidative Function and Substrate Specificity of NAD(P)H- dependent Alkenal/one Oxidoreductase","display_name":"Antioxidative Function and Substrate Specificity of NAD(P)H- dependent Alkenal/one Oxidoreductase","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W2078995073","doi":"https://doi.org/10.1074/jbc.m105487200","mag":"2078995073","pmid":"https://pubmed.ncbi.nlm.nih.gov/11524419"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m105487200","doi":"https://doi.org/10.1074/jbc.m105487200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m105487200","pdf_url":"http://www.jbc.org/article/S0021925820779251/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820779251/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016159747","display_name":"Ryan A. Dick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan A. Dick","raw_affiliation_strings":["Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA","Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111686950","display_name":"Mi-Kyoung Kwak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mi-Kyoung Kwak","raw_affiliation_strings":["Division of Toxicological Sciences, Department of Environmental Health Sciences, Johns Hopkins Bloomburg School of Public Health, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Toxicological Sciences, Department of Environmental Health Sciences, Johns Hopkins Bloomburg School of Public Health, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058407840","display_name":"Thomas R. Sutter","orcid":"https://orcid.org/0000-0002-6088-6320","observed_orcids":["https://orcid.org/0000-0002-6088-6320"]},"institutions":[{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas R. Sutter","raw_affiliation_strings":["W. Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, Tennessee 38152"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W. Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, Tennessee 38152","institution_ids":["https://openalex.org/I94658018"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072089972","display_name":"Thomas W. Kensler","orcid":"https://orcid.org/0000-0002-6676-261X","observed_orcids":["https://orcid.org/0000-0002-6676-261X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas W. Kensler","raw_affiliation_strings":["Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205","Division of Toxicological Sciences, Department of Environmental Health Sciences, Johns Hopkins Bloomburg School of Public Health, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Division of Toxicological Sciences, Department of Environmental Health Sciences, Johns Hopkins Bloomburg School of Public Health, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072089972"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.8553,"has_fulltext":true,"cited_by_count":126,"citation_normalized_percentile":{"value":0.84825036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"276","issue":"44","first_page":"40803","last_page":"40810"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.1371999979019165,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.09690000116825104,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/4-hydroxynonenal","display_name":"4-hydroxynonenal","score":0.8730000257492065},{"id":"https://openalex.org/keywords/acrolein","display_name":"acrolein","score":0.9700000286102295},{"id":"https://openalex.org/keywords/lipid-peroxidation-products","display_name":"lipid peroxidation products","score":0.7829999923706055},{"id":"https://openalex.org/keywords/antioxidant-enzyme-activity","display_name":"antioxidant enzyme activity","score":0.5009999871253967},{"id":"https://openalex.org/keywords/protein-alkylation","display_name":"protein alkylation","score":0.753000020980835},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.4650000035762787},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.8474454879760742},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.820967435836792},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5846718549728394},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.531315267086029},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4867689609527588},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3921399712562561},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32769352197647095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31995558738708496},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21186476945877075},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20116740465164185},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.077423095703125}],"mesh":[{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007659","descriptor_name":"Ketones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011452","descriptor_name":"15-Oxoprostaglandin 13-Reductase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011452","descriptor_name":"15-Oxoprostaglandin 13-Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m105487200","doi":"https://doi.org/10.1074/jbc.m105487200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m105487200","pdf_url":"http://www.jbc.org/article/S0021925820779251/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11524419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11524419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m105487200","doi":"https://doi.org/10.1074/jbc.m105487200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m105487200","pdf_url":"http://www.jbc.org/article/S0021925820779251/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2952462169","display_name":null,"funder_award_id":"CA 39416","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3153396538","display_name":"Molecular Mechanisms of Chemoprevention:  NRF2 Signaling","funder_award_id":"R01CA039416","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7407267566","display_name":"Training in Anti-Cancer Drug Development","funder_award_id":"T32CA009243","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2078995073.pdf","grobid_xml":"https://content.openalex.org/works/W2078995073.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W18585763","https://openalex.org/W139660127","https://openalex.org/W1530462532","https://openalex.org/W1573773653","https://openalex.org/W1591951517","https://openalex.org/W1769545749","https://openalex.org/W1788236687","https://openalex.org/W1964147273","https://openalex.org/W1966059142","https://openalex.org/W1975593303","https://openalex.org/W1975669691","https://openalex.org/W1980497332","https://openalex.org/W1992333401","https://openalex.org/W1993289164","https://openalex.org/W1994071190","https://openalex.org/W1998645211","https://openalex.org/W2003699602","https://openalex.org/W2005568856","https://openalex.org/W2008417039","https://openalex.org/W2012928161","https://openalex.org/W2023468358","https://openalex.org/W2027697937","https://openalex.org/W2036917320","https://openalex.org/W2040333163","https://openalex.org/W2044271936","https://openalex.org/W2045965817","https://openalex.org/W2049192526","https://openalex.org/W2054894609","https://openalex.org/W2057522312","https://openalex.org/W2060532751","https://openalex.org/W2061077446","https://openalex.org/W2061757494","https://openalex.org/W2063140886","https://openalex.org/W2065847371","https://openalex.org/W2067191016","https://openalex.org/W2068810219","https://openalex.org/W2070157667","https://openalex.org/W2078442643","https://openalex.org/W2078936452","https://openalex.org/W2084791393","https://openalex.org/W2094392670","https://openalex.org/W2105319061","https://openalex.org/W2114744780","https://openalex.org/W2115338196","https://openalex.org/W2124524961","https://openalex.org/W2127071379","https://openalex.org/W2134996265","https://openalex.org/W2140927361","https://openalex.org/W2141819645","https://openalex.org/W2166888255","https://openalex.org/W2312461597","https://openalex.org/W2340583317","https://openalex.org/W2396981648","https://openalex.org/W2415102292","https://openalex.org/W2934602226"],"related_works":["https://openalex.org/W2087561606","https://openalex.org/W1975669691","https://openalex.org/W1986604347","https://openalex.org/W2335890598","https://openalex.org/W2736938810","https://openalex.org/W2014819189","https://openalex.org/W2056349878","https://openalex.org/W6990055414","https://openalex.org/W2036833045","https://openalex.org/W2031048338"],"abstract_inverted_index":{"There":[0],"are":[1],"several":[2],"known":[3,68],"routes":[4],"for":[5],"the":[6,23,45,48,187],"metabolic":[7],"detoxication":[8,42],"of":[9,22,41,47,160,181,186,210,234],"alpha,beta-unsaturated":[10],"aldehydes":[11],"and":[12,18,20,28,75,105,120,142,256],"ketones,":[13],"including":[14],"conjugation":[15],"to":[16,25,52,81,202,224,244,251],"glutathione":[17],"reduction":[19,46],"oxidation":[21],"aldehyde":[24],"an":[26,65],"alcohol":[27],"a":[29,38,53,166,230,235],"carboxylic":[30],"acid,":[31],"respectively.":[32],"In":[33],"this":[34],"study,":[35],"we":[36,228],"describe":[37,229],"fourth":[39],"class":[40],"that":[43,241],"involves":[44],"alpha,beta-carbon=carbon":[49],"double":[50],"bond":[51],"single":[54],"bond.":[55],"This":[56],"reaction":[57],"is":[58,79],"catalyzed":[59],"by":[60,217],"NAD(P)H-dependent":[61],"alkenal/one":[62],"oxidoreductase":[63],"(AO),":[64],"enzyme":[66,240],"heretofore":[67],"as":[69,89,125],"leukotriene":[70],"B4":[71],"12-hydroxydehydrogenase,":[72],"15-oxoprostaglandin":[73,143],"13-reductase,":[74],"dithiolethione-inducible":[76],"gene-1.":[77],"AO":[78,169,211],"shown":[80],"effectively":[82],"reduce":[83],"cytotoxic":[84],"lipid":[85],"peroxidation":[86],"products":[87],"such":[88,124],"4-hydroxy-2-nonenal":[90],"(HNE)":[91],"(k(cat)":[92,107,129,145],"=":[93,99,108,114,130,136,146,152],"4.0":[94],"x":[95,101,110,116,132,138,148,154],"10(3)":[96,133,149],"min(-1);":[97,112,134,150],"k(cat)/K(m)":[98,113,135,151],"3.3":[100],"10(7)":[102,139],"min(-1)":[103,118,140,156],"M(-1))":[104,119,141],"acrolein":[106],"2.2":[109],"10(2)":[111],"1.5":[115],"10(6)":[117],"common":[121],"industrial":[122],"compounds":[123],"ethyl":[126],"vinyl":[127],"ketone":[128],"9.6":[131],"8.8":[137],"E1":[144],"2.4":[147,153],"10(9)":[155],"M(-1)).":[157],"Furthermore,":[158],"transfection":[159],"human":[161],"embryonic":[162],"kidney":[163],"cells":[164,174,188,201],"with":[165,177],"rat":[167],"liver":[168],"expression":[170],"vector":[171],"protected":[172],"these":[173],"from":[175,195],"challenge":[176],"HNE.":[178],"The":[179],"concentration":[180],"HNE":[182,218],"at":[183,219],"which":[184],"50%":[185],"were":[189],"killed":[190],"after":[191],"24":[192],"h":[193],"increased":[194],"approximately":[196,203],"15":[197],"microM":[198,205],"in":[199,206],"control":[200],"70":[204],"AO-transfected":[207],"cells.":[208],"Overexpression":[209],"also":[212],"completely":[213],"abolished":[214],"protein":[215],"alkylation":[216],"all":[220],"concentrations":[221],"tested":[222],"(up":[223],"30":[225],"microM).":[226],"Thus,":[227],"novel":[231],"antioxidative":[232],"activity":[233],"previously":[236],"characterized":[237],"bioactive":[238],"lipid-metabolizing":[239],"could":[242],"prove":[243],"be":[245],"therapeutically":[246],"or":[247],"prophylactically":[248],"useful":[249],"due":[250],"its":[252],"high":[253],"catalytic":[254],"rate":[255],"inducibility.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
