{"id":"https://openalex.org/W2078916751","doi":"https://doi.org/10.1016/j.biochi.2013.09.020","title":"Myelin peroxisomes \u2013 Essential organelles for the maintenance of white matter in the nervous system","display_name":"Myelin peroxisomes \u2013 Essential organelles for the maintenance of white matter in the nervous system","publication_year":2013,"publication_date":"2013-10-09","ids":{"openalex":"https://openalex.org/W2078916751","doi":"https://doi.org/10.1016/j.biochi.2013.09.020","mag":"2078916751","pmid":"https://pubmed.ncbi.nlm.nih.gov/24120688"},"language":"en","primary_location":{"id":"doi:10.1016/j.biochi.2013.09.020","doi":"https://doi.org/10.1016/j.biochi.2013.09.020","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biochi.2013.09.020","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0300908413003416/pdf","source":{"id":"https://openalex.org/S75247133","display_name":"Biochimie","issn_l":"0037-9042","issn":["0037-9042","0300-9084","1638-6183"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimie","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0300908413003416/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025091702","display_name":"Celia M. Kassmann","orcid":"https://orcid.org/0000-0003-0993-9455","observed_orcids":["https://orcid.org/0000-0003-0993-9455"]},"institutions":[{"id":"https://openalex.org/I4210137682","display_name":"Max Planck Institute of Experimental Medicine","ror":"https://ror.org/04a7f6w43","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210137682","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Celia M. Kassmann","raw_affiliation_strings":["Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann-Rein-Stra\u00dfe 3, 37075 G\u00f6ttingen, Germany. Electronic address: Kassmann@em.mpg.de","Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann-Rein-Stra\u00dfe 3, 37075 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann-Rein-Stra\u00dfe 3, 37075 G\u00f6ttingen, Germany. Electronic address: Kassmann@em.mpg.de","institution_ids":["https://openalex.org/I4210137682"]},{"raw_affiliation_string":"Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann-Rein-Stra\u00dfe 3, 37075 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210137682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025091702"],"corresponding_institution_ids":["https://openalex.org/I4210137682"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":{"value":3110,"currency":"USD","value_usd":3110},"fwci":0.3435,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.28082192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"98","issue":null,"first_page":"111","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxisomes","display_name":"peroxisomes","score":0.765999972820282},{"id":"https://openalex.org/keywords/white-matter","display_name":"white matter","score":0.9369999766349792},{"id":"https://openalex.org/keywords/peroxisomal-disorders","display_name":"peroxisomal disorders","score":0.8619999885559082},{"id":"https://openalex.org/keywords/x-linked-adrenoleukodystrophy","display_name":"X-linked adrenoleukodystrophy","score":0.968999981880188},{"id":"https://openalex.org/keywords/myelin-sheath","display_name":"myelin sheath","score":0.8169999718666077},{"id":"https://openalex.org/keywords/nodes-of-ranvier","display_name":"nodes of Ranvier","score":0.9810000061988831},{"id":"https://openalex.org/keywords/myelin-pathology","display_name":"myelin pathology","score":0.7440000176429749},{"id":"https://openalex.org/keywords/myelinated-nerve-fibers","display_name":"myelinated axons","score":0.968999981880188},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.9227936267852783},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.9067239761352539},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.7720685005187988},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.7518106698989868},{"id":"https://openalex.org/C2777150068","wikidata":"https://www.wikidata.org/wiki/Q366964","display_name":"Adrenoleukodystrophy","level":4,"score":0.7492673397064209},{"id":"https://openalex.org/C2781317408","wikidata":"https://www.wikidata.org/wiki/Q3281322","display_name":"Peroxisomal disorder","level":4,"score":0.6572832465171814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6128519773483276},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5997921228408813},{"id":"https://openalex.org/C2776100374","wikidata":"https://www.wikidata.org/wiki/Q1821559","display_name":"Leukodystrophy","level":3,"score":0.5637921690940857},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5302215218544006},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.47133803367614746},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.41169214248657227},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3623559772968292},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22984114289283752},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1834975779056549},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.16405346989631653},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14830058813095093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10455414652824402},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05739486217498779},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000326","descriptor_name":"Adrenoleukodystrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000326","descriptor_name":"Adrenoleukodystrophy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018901","descriptor_name":"Peroxisomal Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020675","descriptor_name":"Peroxisomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.biochi.2013.09.020","doi":"https://doi.org/10.1016/j.biochi.2013.09.020","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biochi.2013.09.020","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0300908413003416/pdf","source":{"id":"https://openalex.org/S75247133","display_name":"Biochimie","issn_l":"0037-9042","issn":["0037-9042","0300-9084","1638-6183"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimie","raw_type":"journal-article"},{"id":"pmid:24120688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24120688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimie","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mpg.de:695689","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/695689","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochimie, v.98, 111-118 (2014)","raw_type":"Article"},{"id":"pmh:oai:pure.mpg.de:item_2186707","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-002A-EF98-F","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochimie","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.biochi.2013.09.020","doi":"https://doi.org/10.1016/j.biochi.2013.09.020","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biochi.2013.09.020","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0300908413003416/pdf","source":{"id":"https://openalex.org/S75247133","display_name":"Biochimie","issn_l":"0037-9042","issn":["0037-9042","0300-9084","1638-6183"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimie","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307357","display_name":"Myelin Project","ror":"https://ror.org/03z8jr008"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2078916751.pdf","grobid_xml":"https://content.openalex.org/works/W2078916751.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W77532061","https://openalex.org/W136233845","https://openalex.org/W137520651","https://openalex.org/W169485022","https://openalex.org/W177272458","https://openalex.org/W1526781454","https://openalex.org/W1542881762","https://openalex.org/W1544954258","https://openalex.org/W1552402707","https://openalex.org/W1719904978","https://openalex.org/W1914200614","https://openalex.org/W1922984638","https://openalex.org/W1956831573","https://openalex.org/W1965098641","https://openalex.org/W1965477287","https://openalex.org/W1966355534","https://openalex.org/W1967190893","https://openalex.org/W1971183383","https://openalex.org/W1971817019","https://openalex.org/W1977934760","https://openalex.org/W1979269349","https://openalex.org/W1980230515","https://openalex.org/W1981443842","https://openalex.org/W1992716449","https://openalex.org/W1993777075","https://openalex.org/W1994030229","https://openalex.org/W1996413415","https://openalex.org/W1997522187","https://openalex.org/W1999320061","https://openalex.org/W2000758650","https://openalex.org/W2003941072","https://openalex.org/W2004215030","https://openalex.org/W2006135287","https://openalex.org/W2006958191","https://openalex.org/W2008239986","https://openalex.org/W2011866525","https://openalex.org/W2012296410","https://openalex.org/W2012428359","https://openalex.org/W2019085219","https://openalex.org/W2028619725","https://openalex.org/W2034749536","https://openalex.org/W2035260979","https://openalex.org/W2037167329","https://openalex.org/W2038811384","https://openalex.org/W2051438136","https://openalex.org/W2058476273","https://openalex.org/W2061678260","https://openalex.org/W2063156662","https://openalex.org/W2064245163","https://openalex.org/W2065606463","https://openalex.org/W2066556435","https://openalex.org/W2071249409","https://openalex.org/W2072359008","https://openalex.org/W2074155226","https://openalex.org/W2075268322","https://openalex.org/W2078576948","https://openalex.org/W2084235175","https://openalex.org/W2085029391","https://openalex.org/W2087601962","https://openalex.org/W2088794057","https://openalex.org/W2090856671","https://openalex.org/W2093214855","https://openalex.org/W2094052948","https://openalex.org/W2101641567","https://openalex.org/W2104492370","https://openalex.org/W2112423730","https://openalex.org/W2117526022","https://openalex.org/W2118905653","https://openalex.org/W2128697397","https://openalex.org/W2131463176","https://openalex.org/W2132344671","https://openalex.org/W2134199998","https://openalex.org/W2136011227","https://openalex.org/W2136316795","https://openalex.org/W2138312139","https://openalex.org/W2138878645","https://openalex.org/W2141570423","https://openalex.org/W2145948329","https://openalex.org/W2156005483","https://openalex.org/W2320665909","https://openalex.org/W2331930580","https://openalex.org/W2332665774","https://openalex.org/W4255118548"],"related_works":["https://openalex.org/W1982696217","https://openalex.org/W2152692214","https://openalex.org/W225221521","https://openalex.org/W2087601962","https://openalex.org/W2917111967","https://openalex.org/W2091804901","https://openalex.org/W2136011227","https://openalex.org/W7155357834","https://openalex.org/W1979269349","https://openalex.org/W2611066600"],"abstract_inverted_index":{"Peroxisomes":[0],"are":[1],"cellular":[2],"compartments":[3],"primarily":[4],"associated":[5],"with":[6,41],"lipid":[7],"metabolism.":[8,112],"Most":[9],"cell":[10],"types,":[11],"including":[12],"nervous":[13,28],"system":[14,29],"cells,":[15],"harbor":[16],"several":[17],"hundred":[18],"of":[19,24,37,75,85,90,119,128,139],"these":[20,108],"organelles.":[21],"The":[22],"importance":[23],"peroxisomes":[25,76,92,121],"for":[26,107],"central":[27,105],"white":[30,47,54],"matter":[31,55],"is":[32,59,93,134],"evidenced":[33],"by":[34],"a":[35,60,104,137],"variety":[36],"human":[38],"peroxisomal":[39,61,143],"disorders":[40],"neurological":[42],"impairment":[43],"frequently":[44],"involving":[45],"the":[46,50,64,73,78,88,117,126,146],"matter.":[48],"Moreover,":[49],"most":[51],"frequent":[52],"childhood":[53],"disease,":[56],"X-linked":[57],"adrenoleukodystrophy,":[58],"disorder.":[62],"During":[63],"past":[65],"decade":[66],"advances":[67],"in":[68,110,145],"imaging":[69],"techniques":[70],"have":[71],"enabled":[72],"identification":[74],"within":[77],"myelin":[79,91,120,129],"sheath,":[80],"especially":[81],"close":[82],"to":[83],"nodes":[84],"Ranvier.":[86],"Although":[87],"function":[89],"not":[94],"solved":[95],"yet":[96],"on":[97,116,125],"molecular":[98],"level,":[99],"recently":[100],"acquired":[101],"knowledge":[102],"suggests":[103],"role":[106],"organelles":[109],"axo-glial":[111],"This":[113],"review":[114],"focuses":[115],"biology":[118],"as":[122,124,136],"well":[123],"pathology":[127],"and":[130],"myelinated":[131],"axons":[132],"that":[133],"observed":[135],"consequence":[138],"partial":[140],"or":[141],"complete":[142],"dysfunction":[144],"brain.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}