{"id":"https://openalex.org/W2078882956","doi":"https://doi.org/10.1371/journal.pone.0024873","title":"Genomewide Analysis of Inherited Variation Associated with Phosphorylation of PI3K/AKT/mTOR Signaling Proteins","display_name":"Genomewide Analysis of Inherited Variation Associated with Phosphorylation of PI3K/AKT/mTOR Signaling Proteins","publication_year":2011,"publication_date":"2011-09-19","ids":{"openalex":"https://openalex.org/W2078882956","doi":"https://doi.org/10.1371/journal.pone.0024873","mag":"2078882956","pmid":"https://pubmed.ncbi.nlm.nih.gov/21949775","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3176272"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0024873","doi":"https://doi.org/10.1371/journal.pone.0024873","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0024873","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024873&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024873&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059298132","display_name":"Janna Hutz","orcid":"https://orcid.org/0000-0002-3528-5689","observed_orcids":["https://orcid.org/0000-0002-3528-5689"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janna E. Hutz","raw_affiliation_strings":["Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Division of Statistical Genomics, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Statistical Genomics, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103987669","display_name":"W. Aaron Manning","orcid":"https://orcid.org/0009-0005-8388-6568","observed_orcids":["https://orcid.org/0009-0005-8388-6568"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Aaron Manning","raw_affiliation_strings":["Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004832167","display_name":"Michael A. Province","orcid":"https://orcid.org/0000-0001-6102-774X","observed_orcids":["https://orcid.org/0000-0001-6102-774X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Province","raw_affiliation_strings":["Division of Statistical Genomics, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Statistical Genomics, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011034688","display_name":"Howard L. McLeod","orcid":"https://orcid.org/0000-0002-9004-9232","observed_orcids":["https://orcid.org/0000-0002-9004-9232"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Howard L. McLeod","raw_affiliation_strings":["Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011034688"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.2581,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.56101316,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"9","first_page":"e24873","last_page":"e24873"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9789999723434448},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.984000027179718},{"id":"https://openalex.org/keywords/inherited-genetic-variation","display_name":"inherited genetic variation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/akt1","display_name":"AKT1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/p70s6k","display_name":"p70S6K","score":0.9980000257492065},{"id":"https://openalex.org/keywords/4e-bp1","display_name":"4E-BP1","score":1.0},{"id":"https://openalex.org/keywords/genetic-linkage","display_name":"genetic linkage","score":0.4880000054836273},{"id":"https://openalex.org/keywords/hsp90aa1","display_name":"HSP90AA1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/raf-1","display_name":"Raf-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/grm7","display_name":"GRM7","score":1.0},{"id":"https://openalex.org/keywords/lymphoblastoid-cell-lines","display_name":"lymphoblastoid cell lines","score":0.8769999742507935},{"id":"https://openalex.org/keywords/candidate-gene-studies","display_name":"candidate gene association","score":0.6010000109672546},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7131657600402832},{"id":"https://openalex.org/C154137905","wikidata":"https://www.wikidata.org/wiki/Q17816452","display_name":"AKT1","level":4,"score":0.7103497385978699},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6492211818695068},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6476815938949585},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5800833106040955},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5069429874420166},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4984729290008545},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4734239876270294},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3985646367073059}],"mesh":[{"descriptor_ui":"D002893","descriptor_name":"Chromosomes, Human, Pair 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038762","descriptor_name":"Ribosomal Protein S6 Kinases, 70-kDa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040582","descriptor_name":"Inheritance Patterns","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0024873","doi":"https://doi.org/10.1371/journal.pone.0024873","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0024873","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024873&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2183187","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3176272","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3176272","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3176272","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21949775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21949775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:w0892j92b","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/cw60-z894","pdf_url":"https://cdr.lib.unc.edu/downloads/dj52wd26d","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PloS One, 6(9)","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.289.2212","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.2212","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/13/1b/PLoS_One_2011_Sep_19_6(9)_e24873.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:5dc6422f507249609523e97cde4feb41","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5dc6422f507249609523e97cde4feb41","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 9, p e24873 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/133398","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Genomewide_Analysis_of_Inherited_Variation_Associated_with_Phosphorylation_of_PI3K_AKT_mTOR_Signaling_Proteins/133398","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.17615/cw60-z894","doi":"https://doi.org/10.17615/cw60-z894","is_oa":true,"landing_page_url":"https://doi.org/10.17615/cw60-z894","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0024873","doi":"https://doi.org/10.1371/journal.pone.0024873","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0024873","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024873&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3206738201","display_name":"Functional Polymorphism Analysis in Drug Pathways","funder_award_id":"U01GM063340","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333566","display_name":"National Defense Science and Engineering Graduate","ror":null},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2078882956.pdf","grobid_xml":"https://content.openalex.org/works/W2078882956.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W161290720","https://openalex.org/W189263682","https://openalex.org/W1969296365","https://openalex.org/W1981711832","https://openalex.org/W1982912197","https://openalex.org/W1988224683","https://openalex.org/W1995540460","https://openalex.org/W2010288342","https://openalex.org/W2010538519","https://openalex.org/W2014096417","https://openalex.org/W2016097940","https://openalex.org/W2017292900","https://openalex.org/W2018130387","https://openalex.org/W2025143098","https://openalex.org/W2032909215","https://openalex.org/W2042727474","https://openalex.org/W2043865307","https://openalex.org/W2048755332","https://openalex.org/W2052502735","https://openalex.org/W2060181803","https://openalex.org/W2062549773","https://openalex.org/W2067245109","https://openalex.org/W2067551453","https://openalex.org/W2072651941","https://openalex.org/W2074579328","https://openalex.org/W2078417023","https://openalex.org/W2080100938","https://openalex.org/W2082122713","https://openalex.org/W2083268838","https://openalex.org/W2086936470","https://openalex.org/W2087861588","https://openalex.org/W2094709780","https://openalex.org/W2099544753","https://openalex.org/W2103618960","https://openalex.org/W2115594567","https://openalex.org/W2118308505","https://openalex.org/W2127096652","https://openalex.org/W2129792561","https://openalex.org/W2138253007","https://openalex.org/W2139133092","https://openalex.org/W2140609764","https://openalex.org/W2144606631","https://openalex.org/W2148860875","https://openalex.org/W2153507021","https://openalex.org/W2153554912","https://openalex.org/W2154608911","https://openalex.org/W2155388118","https://openalex.org/W2155838479","https://openalex.org/W2159422401","https://openalex.org/W2164339823","https://openalex.org/W2165348349","https://openalex.org/W2171884143"],"related_works":["https://openalex.org/W1496351936","https://openalex.org/W7222970668","https://openalex.org/W2567812518","https://openalex.org/W2616761213","https://openalex.org/W2949794353","https://openalex.org/W2105373880","https://openalex.org/W4402827739","https://openalex.org/W2606915774","https://openalex.org/W2086901484","https://openalex.org/W2505556662"],"abstract_inverted_index":{"While":[0],"there":[1],"exists":[2],"a":[3,47,52,138,240],"wealth":[4],"of":[5,26,49,54,65,79,106,112,119,132,160,196,212,243],"information":[6,232],"about":[7,16,233],"genetic":[8,71,107],"influences":[9,20],"on":[10,150,166],"gene":[11,149],"expression,":[12],"less":[13],"is":[14,68],"known":[15],"how":[17],"inherited":[18],"variation":[19],"the":[21,63,84,100,103,110,120,142,147,156,177,194,210,220,234],"expression":[22],"and":[23,56,76,124,162,171,180,201,205,237,250],"post-translational":[24],"modifications":[25],"proteins,":[27],"especially":[28],"those":[29],"involved":[30],"in":[31,46,83,91,189,203],"intracellular":[32],"signaling.":[33],"The":[34],"PI3K/AKT/mTOR":[35,235],"signaling":[36],"pathway":[37,67,85,121,236],"contains":[38],"several":[39,130,181],"such":[40],"proteins":[41,82],"that":[42,145],"have":[43],"been":[44],"implicated":[45],"number":[48],"diseases,":[50],"including":[51,137],"variety":[53],"cancers":[55],"some":[57],"psychiatric":[58],"disorders.":[59],"To":[60],"assess":[61],"whether":[62],"activation":[64],"this":[66],"influenced":[69],"by":[70,89],"factors,":[72],"we":[73],"measured":[74],"phosphorylated":[75,113,197,213],"total":[77,115,199,215],"levels":[78],"three":[80],"key":[81],"(AKT1,":[86],"p70S6K,":[87],"4E-BP1)":[88],"ELISA":[90],"122":[92],"lymphoblastoid":[93],"cell":[94],"lines":[95],"from":[96,175],"14":[97],"families.":[98],"Interestingly,":[99],"phenotypes":[101],"with":[102,193,209],"highest":[104],"proportion":[105],"influence":[108],"were":[109,185,207],"ratios":[111,159],"to":[114,198,214],"protein":[116,158,228],"for":[117,134,141,155,224,245],"two":[118],"members:":[122],"AKT1":[123,143,148,161],"p70S6K.":[125,216],"Genomewide":[126],"linkage":[127,139,178],"analysis":[128],"suggested":[129],"loci":[131],"interest":[133],"these":[135],"phenotypes,":[136],"peak":[140],"phenotype":[144],"contained":[146],"chromosome":[151,167],"14.":[152],"Linkage":[153],"peaks":[154],"phosphorylated:total":[157],"p70S6K":[163],"also":[164],"overlapped":[165],"3.":[168],"We":[169],"selected":[170],"genotyped":[172],"candidate":[173],"genes":[174],"under":[176],"peaks,":[179],"statistically":[182],"significant":[183],"associations":[184],"found.":[186],"One":[187],"polymorphism":[188],"HSP90AA1":[190],"was":[191],"associated":[192,208],"ratio":[195,211],"AKT1,":[200],"polymorphisms":[202],"RAF1":[204],"GRM7":[206],"These":[217],"findings,":[218],"representing":[219],"first":[221],"genomewide":[222],"search":[223],"variants":[225],"influencing":[226],"human":[227,248],"phosphorylation,":[229],"provide":[230],"useful":[231],"serve":[238],"as":[239],"valuable":[241],"proof":[242],"concept":[244],"studies":[246],"integrating":[247],"genomics":[249],"proteomics.":[251]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
