{"id":"https://openalex.org/W2078784347","doi":"https://doi.org/10.1073/pnas.97.22.12121","title":"Antagonistic role of vega1 and bozozok/dharma homeobox genes in organizer formation","display_name":"Antagonistic role of vega1 and bozozok/dharma homeobox genes in organizer formation","publication_year":2000,"publication_date":"2000-10-24","ids":{"openalex":"https://openalex.org/W2078784347","doi":"https://doi.org/10.1073/pnas.97.22.12121","mag":"2078784347","pmid":"https://pubmed.ncbi.nlm.nih.gov/11050240","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/17304"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.97.22.12121","doi":"https://doi.org/10.1073/pnas.97.22.12121","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.97.22.12121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/17304","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059925930","display_name":"Atsuo Kawahara","orcid":"https://orcid.org/0000-0001-8536-920X","observed_orcids":["https://orcid.org/0000-0001-8536-920X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atsuo Kawahara","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institute of Child\r Health and Human Development, National Institutes of Health, Bethesda,\r MD 20892; and Department of Molecular Biology, Vanderbilt\r University, Box 1820, Station B, Nashville, TN 37235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child\r Health and Human Development, National Institutes of Health, Bethesda,\r MD 20892; and Department of Molecular Biology, Vanderbilt\r University, Box 1820, Station B, Nashville, TN 37235","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075215361","display_name":"Thomas P. Wilm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Wilm","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institute of Child\r Health and Human Development, National Institutes of Health, Bethesda,\r MD 20892; and Department of Molecular Biology, Vanderbilt\r University, Box 1820, Station B, Nashville, TN 37235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child\r Health and Human Development, National Institutes of Health, Bethesda,\r MD 20892; and Department of Molecular Biology, Vanderbilt\r University, Box 1820, Station B, Nashville, TN 37235","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033104500","display_name":"Lilianna Solnica\u2010Krezel","orcid":"https://orcid.org/0000-0003-0983-221X","observed_orcids":["https://orcid.org/0000-0003-0983-221X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lilianna Solnica-Krezel","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institute of Child\r Health and Human Development, National Institutes of Health, Bethesda,\r MD 20892; and Department of Molecular Biology, Vanderbilt\r University, Box 1820, Station B, Nashville, TN 37235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child\r Health and Human Development, National Institutes of Health, Bethesda,\r MD 20892; and Department of Molecular Biology, Vanderbilt\r University, Box 1820, Station B, Nashville, TN 37235","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I4210144228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064390918","display_name":"Igor B. Dawid","orcid":"https://orcid.org/0000-0003-0579-5693","observed_orcids":["https://orcid.org/0000-0003-0579-5693"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor B. Dawid","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institute of Child\r Health and Human Development, National Institutes of Health, Bethesda,\r MD 20892; and Department of Molecular Biology, Vanderbilt\r University, Box 1820, Station B, Nashville, TN 37235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child\r Health and Human Development, National Institutes of Health, Bethesda,\r MD 20892; and Department of Molecular Biology, Vanderbilt\r University, Box 1820, Station B, Nashville, TN 37235","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6846,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.83370434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"97","issue":"22","first_page":"12121","last_page":"12126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homeobox-genes","display_name":"homeobox genes","score":0.9350000023841858},{"id":"https://openalex.org/keywords/zebrafish-embryonic-development","display_name":"zebrafish embryonic development","score":0.7929999828338623},{"id":"https://openalex.org/keywords/midblastula-transition","display_name":"midblastula transition","score":0.8529999852180481},{"id":"https://openalex.org/keywords/dorsoventral-axis","display_name":"dorsal-ventral axis","score":0.5899999737739563},{"id":"https://openalex.org/keywords/ventralization","display_name":"ventralization","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.9004071950912476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7501921057701111},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.69710373878479},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.6884093284606934},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5735962986946106},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.5624611973762512},{"id":"https://openalex.org/C103652617","wikidata":"https://www.wikidata.org/wiki/Q18027119","display_name":"Homeobox A1","level":5,"score":0.543100893497467},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5295684337615967},{"id":"https://openalex.org/C61342607","wikidata":"https://www.wikidata.org/wiki/Q17916811","display_name":"EMX2","level":5,"score":0.5279266834259033},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5046604871749878},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.469310998916626},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3623218536376953},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3579036593437195},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32078975439071655},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.2761303186416626}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.97.22.12121","doi":"https://doi.org/10.1073/pnas.97.22.12121","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.97.22.12121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:17304","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/17304","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:11050240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11050240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:17304","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/17304","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1489916230","https://openalex.org/W1527223408","https://openalex.org/W1554593075","https://openalex.org/W1607031549","https://openalex.org/W1811130017","https://openalex.org/W1879493681","https://openalex.org/W1883820456","https://openalex.org/W1944222122","https://openalex.org/W1992300748","https://openalex.org/W1997216571","https://openalex.org/W2014536457","https://openalex.org/W2015212818","https://openalex.org/W2025019677","https://openalex.org/W2026112588","https://openalex.org/W2030071077","https://openalex.org/W2037143749","https://openalex.org/W2042859849","https://openalex.org/W2052970108","https://openalex.org/W2068037010","https://openalex.org/W2079406338","https://openalex.org/W2083513806","https://openalex.org/W2086763989","https://openalex.org/W2088443011","https://openalex.org/W2096614956","https://openalex.org/W2115686163","https://openalex.org/W2116428404","https://openalex.org/W2126122106","https://openalex.org/W2137854993","https://openalex.org/W2149285902","https://openalex.org/W2183290663","https://openalex.org/W2188247991","https://openalex.org/W2285915540","https://openalex.org/W2412339092"],"related_works":["https://openalex.org/W7054599134","https://openalex.org/W1913145210","https://openalex.org/W1980395692","https://openalex.org/W1968983899","https://openalex.org/W2096614956","https://openalex.org/W141691183","https://openalex.org/W2042859849","https://openalex.org/W2071504875","https://openalex.org/W1978122588","https://openalex.org/W2107852539"],"abstract_inverted_index":{"During":[0],"zebrafish":[1],"development,":[2],"zygotic":[3],"gene":[4,55],"expression":[5,42,67,96],"initiated":[6],"at":[7,29],"the":[8,52,87,105,117],"midblastula":[9,30],"transition":[10,31],"converts":[11],"maternal":[12],"information":[13],"on":[14],"embryo":[15],"polarity":[16],"into":[17],"a":[18,23,78,84],"transcriptional":[19],"read-out.":[20],"Expression":[21],"of":[22,43,68,97,104,114],"homeobox":[24,54],"gene,":[25],"vega1,":[26],"is":[27,36,45,58,63,120],"activated":[28],"in":[32,47,50,77,116,125,128],"all":[33],"blastomeres,":[34],"but":[35],"down-regulated":[37],"dorsally":[38],"before":[39],"gastrulation.":[40],"Ubiquitous":[41],"vega1":[44,115],"maintained":[46],"bozozok":[48],"mutants,":[49],"which":[51],"dorsal-specific":[53],"bozozok/dharma":[56],"(boz/dha)":[57],"disrupted":[59],"and":[60,70,73,90,100],"organizer":[61,98,126],"formation":[62,127],"impaired.":[64],"Vega1":[65,88],"inhibits":[66],"boz/dha":[69],"organizer-specific":[71],"genes,":[72],"causes":[74],"ventralization":[75],"resulting":[76],"headless":[79],"phenotype.":[80,108],"In":[81],"contrast,":[82],"VP16-vega1,":[83],"fusion":[85],"including":[86],"homeodomain":[89],"VP16":[91],"activation":[92],"domain,":[93],"elicits":[94],"ectopic":[95],"genes":[99],"suppresses":[101],"several":[102],"aspects":[103],"boz":[106],"mutant":[107],"We":[109],"propose":[110],"that":[111],"boz/dha-dependent":[112],"down-regulation":[113],"dorsal":[118],"region":[119],"an":[121],"early":[122],"essential":[123],"step":[124],"zebrafish.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}