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84,4497,4505,4523,4547,4563,4579,4583,4591,4608,4630,4655,4726,4757,4774,4776,4779,4813,4825,4836,4843,4855,4898,4903,4952,5004,5017,5037,5046,5056,5080,5107,5113,5197,5202,5215,5252,5257,5425,5429,5464,5496,5517,5581,5642,5701,5718,5732,5789,5803,5823,5836,5850,5891,5950,5962,5996,6008,6015,6025,6056,6062,6109,6142,6160,6185,6203,6226,6246,6272,6333,6362,6374,6383,6389,6403,6430,6438,6457,6460,6503,6505,6508,6529,6608,6640,6664,6678,6688,6719,6884,6894],"Hematology":[32,942],"(ASH)":[33,943],"meeting":[34,50,944,2839,3298,3503,4241,5122],"in":[35,73,118,158,161,240,247,308,429,487,517,550,564,580,655,802,811,854,874,922,929,960,963,979,990,1017,1037,1086,1113,1125,1142,1192,1235,1242,1255,1283,1312,1326,1335,1344,1385,1428,1431,1533,1589,1743,1788,1836,1878,1995,2013,2023,2041,2077,2095,2119,2123,2146,2180,2182,2261,2390,2402,2445,2511,2525,2544,2573,2598,2613,2645,2663,2670,2678,2691,2722,2815,2826,2840,2889,2899,2959,3126,3167,3270,3319,3351,3371,3375,3379,3389,3426,3474,3485,3495,3504,3523,3546,3565,3834,3854,3914,3928,3955,3996,4011,4023,4037,4101,4127,4377,4399,4426,4459,4470,4481,4493,4499,4509,4565,4646,4713,4724,4736,4740,4839,4884,4900,4920,4927,4960,4985,5019,5088,5164,5167,5171,5195,5205,5288,5410,5420,5499,5506,5522,5577,5587,5645,5666,5675,5687,5691,5708,5794,5853,5858,5919,5923,6066,6106,6113,6117,6125,6169,6189,6208,6213,6229,6297,6307,6313,6335,6345,6353,6413,6444,6471,6483,6514,6606,6661],"Orlando,":[36],"Florida":[37],"December":[39,2841,3505],"7th\u20138th,":[40],"2011.":[41],"Relevant":[42],"data":[43,2457,3073],"was":[45,1131,1184,1346,1799,2141,2240,2244,2258,2268,2447,2736,2759,2874,2920,3036,3154,3304,3369,3459,3521,3531,3580,3687,3813,3906,3911,3926,3952,4035,4198,4262,4299,4333,4375,4447,4468,4734,4865,5116,5193,5217,5235,6324],"presented":[46,59,935,1400,2830,3499,4236],"ASH":[49,995,1402,2838,3297,3502,4240,5121,6859],"as":[51,53,85,399,401,417,479,507,633,645,670,686,688,771,860,1093,1122,1186,1196,1454,1508,1664,2152,2154,3112,3976,4395,4973,5031,5061,5063,5067,5237,5269,5417,5419,6034,6305,6620],"well":[52,400,687,1588,2153,3155,3912,5062,5418],"all":[54,134,298,2742,2753,3915,4998,5752,5888,5997],"other":[55,112,552,666,1709,4947,5064,5148,5203,5206,5588,6150,6655],"recent":[56,390,773,1247,1303,4656,4677,6171,6415,6657],"publications":[57],"were":[58,1576,2097,2211,2806,2824,2848,2881,2957,2989,3011,3074,3083,3109,3201,3292,3333,3428,3466,3493,3614,3653,3708,3773,3867,3870,3989,4003,4021,4150,4158,4171,4235,4310,4354,4368,4424,4550,4717,4722,4831,5150,5162,5278,5407],"discussed":[61,6167],"workshop.":[64],"covers":[67],"frontline":[68,480,508,544,634,658,711,2791,3232,3373,4129,4223,6068,6419,6475],"therapies":[69,110,6476],"BCR-ABL1-positive":[71,129,414],"leukemias,":[72,130,142],"addition":[74,263],"to":[75,93,107,197,266,278,281,326,373,397,484,583,616,706,720,825,842,909,1007,1012,1029,1079,1133,1324,1451,1472,1492,1586,1592,1649,1740,1746,1904,1992,2032,2046,2115,2133,2143,2177,2213,2246,2334,2425,2522,2557,2569,2625,2732,2750,2761,2767,2850,2907,2914,2998,3034,3055,3087,3093,3115,3143,3149,3365,3432,3516,3527,3538,3793,3800,3887,3923,4073,4086,4111,4123,4148,4160,4201,4276,4412,4453,4456,4543,4573,4577,4604,4642,4894,4917,4929,4935,4967,4976,4997,5091,5224,5525,5547,5560,5564,5612,5616,5625,5712,5751,5798,5814,5848,5880,5905,5991,6154,6235,6446,6489,6569,6599,6646,6699,6713,6743,6762],"addressing":[76],"some":[77,140,5924,6141],"topical":[78],"biological,":[79],"preclinical":[80,114,836,1317,1448],"clinical":[82,116,758,1306,1328,1535,1579,1658,1710,5507,6701],"issues,":[83],"such":[84,193,348,416,669,2317,2804,3186,3975,4673,5005,5025,5066,6033,6342,6384,6458,6619,6765],"new":[86,109,1014,2144,6534,6571],"insights":[87,391],"into":[88,155,203,392,740,766,2808,3260,5627,5977,6019,6081],"genomic":[89,420,5636,5664,5695,5804,5883,5907],"instability":[90,5665,5696,5722,5805],"resistance":[92,396,1514,1991,2230,2766,4584,5546,5559,5569,6488],"tyrosine":[94,148],"kinase":[95,149,1044,2709,4597,4978,5579,5594,5609,5677,5829,5860,5886],"inhibitors":[96,576],"(TKIs),":[97],"risk":[98,363,379,1489,1498,1547,1734,2885,2897,3123,3470,3483,6491],"stratification":[99,364,1490],"optimizing":[101],"molecular":[102,368,411,876,1644,1809,1968,2372,2465,2541,3750,6548,6683,6707],"monitoring.":[103],"A":[104,1246,2800,3419,4419,4811,5483,6386],"pertaining":[106],"pertinent":[113],"issues":[117],"MPNs":[122],"published":[124,2825,3494],"separately.":[125],"For":[126,2067,6311],"patients":[127,178,244,299,336,356,383,491,511,547,581,637,681,715,778,810,873,928,962,1054,1478,1494,1544,1597,1816,1947,2145,2161,2181,2247,2391,2415,2461,2493,2614,2726,2754,2796,2805,2923,2935,2961,3028,3047,3082,3141,3172,3205,3376,3423,3465,3534,3542,3609,3747,3857,3893,3934,4105,4142,4157,4249,4380,4406,4423,4434,4485,4506,4525,4529,4548,4570,4592,4648,4688,4703,4710,4817,4845,4904,4910,4957,4986,5006,5125,5158,5198,5207,5259,5274,5285,5330,5343,5360,5386,5413,5432,5441,5523,6227,6278,6665,6679,6722,6773],"with":[128,174,179,245,261,300,306,384,451,512,548,577,595,638,695,716,1153,1214,1269,1275,1295,1495,1505,1552,1598,1601,1801,1815,1848,1898,1916,1948,1951,1988,2018,2072,2136,2162,2175,2248,2271,2286,2367,2462,2492,2494,2538,2629,2647,2727,2746,2755,2769,2788,2797,2924,2942,2946,2991,2995,3014,3017,3049,3060,3157,3160,3174,3207,3214,3217,3234,3240,3246,3377,3412,3424,3535,3711,3713,3752,3767,3776,3780,3783,3805,3960,3973,4029,4057,4089,4106,4132,4143,4209,4250,4264,4268,4284,4317,4335,4343,4370,4382,4407,4441,4462,4507,4593,4624,4637,4649,4652,4664,4672,4689,4704,4711,4728,4818,4821,4882,4886,4905,4911,4946,4958,4987,5128,5134,5142,5147,5159,5173,5199,5210,5244,5275,5286,5344,5361,5387,5394,5414,5433,5442,5446,5454,5536,5841,5985,6131,6152,6450,6575,6723,6774],"comprise":[132],"Philadelphia":[136],"(Ph)":[137],"chromosome-positive":[138],"Ph-negative":[141,5143],"introduction":[144,4496,6007],"original":[147],"inhibitor":[150,1157,1272,5036],"(TKI),":[151],"imatinib":[152,587,880,1786,1961,1978,3281,3309,3336,4234,5548],"mesylate":[153],"(IM)":[154],"clinics":[157],"1998,":[159],"resulted":[160,2888,3473,5918],"being":[162,675,5248,6690],"a":[163,182,319,340,518,609,646,734,767,772,899,1024,1116,1123,1154,1187,1256,1373,1389,1407,1496,1510,1534,1701,1837,1896,1899,1943,1952,1964,2005,2190,2201,2216,2266,2272,2278,2287,2291,2297,2325,2395,2437,2463,2474,2488,2512,2515,2536,2539,2559,2577,2594,2928,3133,3241,3305,3508,3808,3882,3903,4054,4058,4163,4203,4222,4296,4396,4415,4436,4482,4544,4560,4588,4617,4653,4698,4791,4822,4848,4852,4974,5015,5033,5053,5200,5423,5800,5875,6047,6095,6099,6161,6170,6224,6346,6359,6371,6633,6668,6682,6766,6770],"classic":[164],"therapeutic":[165,5480],"landmark":[166],"[1,":[167,235],"2].":[168],"After":[169,2397,2927,3132,3785],"12":[170,2878,2967,3009,3326,3462,3578,3651,3685,5305,6104,6244,6264,6290,6327,6442],"months":[171,2361,2422,2977,3010,3038,3043,3579,3652,3686,3787,4857,6105,6245,6265,6291,6443,6687],"therapy":[173,428,441,481,509,694,762,850,885,1559,1748,1994,2179,2336,2363,2792,3184,3233,3530,3910,6163,6649],"IM,":[175,625,2733,2768,2996,3366,3744,3806,3947,4112,4295,5100],"69%":[176],"CML-CP":[180,301,513,549,1506,2249,2263,2728,2798,4107,4144,4408,5313,5342,5537,5649,5954],"achieve":[181,339,780,6667,6744],"complete":[183,875,3749,4792,4849,4922,5293],"cytogenetic":[184,4621,5302,5314],"response":[185,194,349,375,1563,1591,1745,1803,1849,1903,1929,2176,2333,2341,2373,2466,2497,2542,3238,3257,4518,4580,4603,4622,4972,5295,5303,5373,6076,6285,6343,6461,6610,6641],"(CCyR)":[186],"8":[189,5133,5307],"years":[190,784,2399,4827],"follow-up,":[192,3789],"rates":[195,1804,2953,2988,3007,3239,3254,3332,3613,3647,3716,3726,4309,4519,4623,6014,6024,6044,6077,6108,6242,6262,6344],"increases":[196,1693],"83%.":[198],"remarkable":[200],"activity":[201,425,503,654,1405,1793,1798,1822,1870,4077,4230,5495,5845],"translates":[202],"an":[204,485,788,1169,1358,1367,2222,2495,2529,2661,2689,2704,2780,2832,3077,3358,3571,3642,3899,4116,4400,4553,4601,4943,5475,5669,5986,6331,6481,6696],"estimated":[205,4862],"overall":[206,789,3810],"survival":[207,790,2378,3811,4662,4864,5881],"93%":[209],"(when":[210],"only":[211,2282,2359,2448,3051,3180,3398,4540,5574,5686,6223,6604],"CML-related":[212],"deaths":[213],"are":[214,357,387,572,589,674,704,748,898,907,1322,1565,1671,1753,2038,2052,2104,4869,4914,5012,5710,5945,6166,6195,6216,6356,6421],"accounted":[215],"for),":[216],"substantially":[219,303],"higher":[220,304,1204,1497,1802,1959,1965,3013,3237,3253,3582,3616,3655,3688,3771,6043,6075],"than":[221,622,697,1843,2441,3564,3603,3637,3675,3703,3766,3782,3993,5783,6051],"that":[222,321,331,623,736,776,792,805,848,868,895,906,946,1068,1105,1120,1265,1416,1465,1624,1662,1795,1828,1855,2059,2164,2305,2316,2351,2392,2435,2460,3231,3529,3853,4256,4298,4457,4477,4658,4665,5039,5472,5663,5694,5873,6017,6277,6398,6453,6511,6631,6660,6764],"achieved":[223,2394,3030,3710,3748,4162,4435,4790,4847,5436],"by":[224,389,402,817,911,970,1349,1357,1763,1774,1778,1791,1866,2356,2385,2883,3008,3226,3468,3650,4667,4808,5575,5585,5597,6005,6173,6340,6395,6427,6550,6615,6730],"any":[225,2533,2676,3104,4012],"previous":[226,1227],"medical":[227],"treatment,":[228,5527],"including":[229,951,1040,4439,5126,5208,5438,5856],"allogeneic":[230],"stem":[231,904,987,1140,1194,1240,1342,1422],"cell":[232,1129,1679,2109],"transplantation":[233],"(allo-SCT)":[234],"2,":[236],"3].":[237],"The":[238,274,502,605,756,819,1330,1486,1657,1918,1997,2020,2169,2252,2346,2380,2429,2506,2776,2868,3284,3382,3456,4070,4166,4218,4243,4273,4449,4495,5002,5105,5152,5190,5213,5469,5658,5993,6237,6652,6776],"success":[239,759,2721,3349,4564],"treatment":[242,635,679,712,742,1210,1266,2724,2740,3920,4103,4307,4504,5154,5319,6288,6756],"CML":[246,307,440,647,708,765,777,809,837,858,872,903,927,961,1009,1025,1053,1139,1151,1193,1239,1281,1298,1345,1386,1427,1453,1599,1633,2065,2159,2209,2622,2745,2817,3058,3323,3378,3425,4508,4712,4959,5129,5287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