{"id":"https://openalex.org/W2078569737","doi":"https://doi.org/10.1001/archneurol.2010.143","title":"Natalizumab Treatment in a Patient With Chronic Inflammatory Demyelinating Polyneuropathy","display_name":"Natalizumab Treatment in a Patient With Chronic Inflammatory Demyelinating Polyneuropathy","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2078569737","doi":"https://doi.org/10.1001/archneurol.2010.143","mag":"2078569737","pmid":"https://pubmed.ncbi.nlm.nih.gov/20625098"},"language":"en","primary_location":{"id":"doi:10.1001/archneurol.2010.143","doi":"https://doi.org/10.1001/archneurol.2010.143","is_oa":true,"landing_page_url":"https://doi.org/10.1001/archneurol.2010.143","pdf_url":"https://jamanetwork.com/journals/jamaneurology/articlepdf/800628/nob90021_881_883.pdf","source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jamanetwork.com/journals/jamaneurology/articlepdf/800628/nob90021_881_883.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005633880","display_name":"Christian Wolf","orcid":"https://orcid.org/0000-0002-4683-0507","observed_orcids":["https://orcid.org/0000-0002-4683-0507"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Wolf","raw_affiliation_strings":["Department of Neurology, Heinrich-Heine-University, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Heinrich-Heine-University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082233226","display_name":"Til Menge","orcid":"https://orcid.org/0000-0003-3459-8867","observed_orcids":["https://orcid.org/0000-0003-3459-8867"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Til Menge","raw_affiliation_strings":["Kieseier) and Radiology (Dr Saleh) , Heinrich-Heine University , D\u00fcsseldorf , Germany;","Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","Heinrich-Heine University, D\u00fcsseldorf, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kieseier) and Radiology (Dr Saleh) , Heinrich-Heine University , D\u00fcsseldorf , Germany;","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","institution_ids":[]},{"raw_affiliation_string":"Heinrich-Heine University, D\u00fcsseldorf, Germany;","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022932083","display_name":"Max\u2010Philipp Stenner","orcid":"https://orcid.org/0000-0002-3694-1887","observed_orcids":["https://orcid.org/0000-0002-3694-1887"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Max-Philipp Stenner","raw_affiliation_strings":["Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","Heinrich-Heine University, D\u00fcsseldorf, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","institution_ids":[]},{"raw_affiliation_string":"Heinrich-Heine University, D\u00fcsseldorf, Germany;","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076180609","display_name":"Gerd Meyer zu H\u00f6rste","orcid":"https://orcid.org/0000-0002-4341-4719","observed_orcids":["https://orcid.org/0000-0002-4341-4719"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerd Meyer zu H\u00f6rste","raw_affiliation_strings":["Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","Heinrich-Heine University, D\u00fcsseldorf, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","institution_ids":[]},{"raw_affiliation_string":"Heinrich-Heine University, D\u00fcsseldorf, Germany;","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108496126","display_name":"Andreas Saleh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Saleh","raw_affiliation_strings":["Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","Heinrich-Heine University, D\u00fcsseldorf, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","institution_ids":[]},{"raw_affiliation_string":"Heinrich-Heine University, D\u00fcsseldorf, Germany;","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063615479","display_name":"Hans\u2010Peter Hartung","orcid":"https://orcid.org/0000-0002-0614-6989","observed_orcids":["https://orcid.org/0000-0002-0614-6989"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Peter Hartung","raw_affiliation_strings":["Kieseier) and Radiology (Dr Saleh) , Heinrich-Heine University , D\u00fcsseldorf , Germany;","Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","Heinrich-Heine University, D\u00fcsseldorf, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kieseier) and Radiology (Dr Saleh) , Heinrich-Heine University , D\u00fcsseldorf , Germany;","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","institution_ids":[]},{"raw_affiliation_string":"Heinrich-Heine University, D\u00fcsseldorf, Germany;","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038373894","display_name":"Heinz Wiendl","orcid":"https://orcid.org/0000-0003-4310-3432","observed_orcids":["https://orcid.org/0000-0003-4310-3432","https://orcid.org/0000-0001-5509-1075"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heinz Wiendl","raw_affiliation_strings":["Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","Heinrich-Heine University, D\u00fcsseldorf, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","institution_ids":[]},{"raw_affiliation_string":"Heinrich-Heine University, D\u00fcsseldorf, Germany;","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108883900","display_name":"Bernd C. Kieseier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd C. Kieseier","raw_affiliation_strings":["Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","Heinrich-Heine University, D\u00fcsseldorf, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Heinrich-Heine Uni-versity, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Neurology, Julius-Maximilians University, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Departments of Neurology (Drs Wolf, Menge, Meyer zu H\u00f6rste, Hartung, and Kieseier) and Radiology (Dr Saleh),","institution_ids":[]},{"raw_affiliation_string":"Heinrich-Heine University, D\u00fcsseldorf, Germany;","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4494,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.92603094,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"67","issue":"7","first_page":"881","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natalizumab","display_name":"natalizumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chronic-inflammatory-demyelinating-polyradiculoneuropathy","display_name":"chronic inflammatory demyelinating polyneuropathy","score":1.0},{"id":"https://openalex.org/keywords/integrin-alpha4","display_name":"CD49d","score":0.9399999976158142},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/peripheral-nerve-inflammation","display_name":"peripheral nerve inflammation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.5879999995231628},{"id":"https://openalex.org/keywords/mri-findings","display_name":"MRI findings","score":0.5740000009536743},{"id":"https://openalex.org/keywords/immune-mediated-peripheral-neuropathy","display_name":"immune-mediated peripheral neuropathy","score":0.7059999704360962},{"id":"https://openalex.org/keywords/anti-integrin-therapy","display_name":"anti-integrin therapy","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2781004633","wikidata":"https://www.wikidata.org/wiki/Q386119","display_name":"Natalizumab","level":3,"score":0.9733715057373047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8576666116714478},{"id":"https://openalex.org/C2779867792","wikidata":"https://www.wikidata.org/wiki/Q1088030","display_name":"Chronic inflammatory demyelinating polyneuropathy","level":3,"score":0.7283963561058044},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5647706985473633},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5534121990203857},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.5065082311630249},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42358797788619995},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.4195539057254791},{"id":"https://openalex.org/C2775892965","wikidata":"https://www.wikidata.org/wiki/Q1502312","display_name":"Polyneuropathy","level":2,"score":0.4118898808956146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39348769187927246},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3288648724555969},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.24438047409057617},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.10765546560287476},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069442","descriptor_name":"Natalizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013126","descriptor_name":"Spinal Nerve Roots","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013497","descriptor_name":"Sural Nerve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020277","descriptor_name":"Polyradiculoneuropathy, Chronic Inflammatory Demyelinating","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D020277","descriptor_name":"Polyradiculoneuropathy, Chronic Inflammatory Demyelinating","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020277","descriptor_name":"Polyradiculoneuropathy, Chronic Inflammatory Demyelinating","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D039441","descriptor_name":"Integrin alpha4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1001/archneurol.2010.143","doi":"https://doi.org/10.1001/archneurol.2010.143","is_oa":true,"landing_page_url":"https://doi.org/10.1001/archneurol.2010.143","pdf_url":"https://jamanetwork.com/journals/jamaneurology/articlepdf/800628/nob90021_881_883.pdf","source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},{"id":"pmid:20625098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20625098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of neurology","raw_type":"Case Reports"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1333727","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1333727/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Neurology","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1001/archneurol.2010.143","doi":"https://doi.org/10.1001/archneurol.2010.143","is_oa":true,"landing_page_url":"https://doi.org/10.1001/archneurol.2010.143","pdf_url":"https://jamanetwork.com/journals/jamaneurology/articlepdf/800628/nob90021_881_883.pdf","source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2078569737.pdf","grobid_xml":"https://content.openalex.org/works/W2078569737.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W2001212332","https://openalex.org/W2029948816","https://openalex.org/W2040160619","https://openalex.org/W2044808407","https://openalex.org/W2050459059","https://openalex.org/W2079650747","https://openalex.org/W2106467284","https://openalex.org/W2164822027","https://openalex.org/W2291640051"],"related_works":["https://openalex.org/W1546959634","https://openalex.org/W4396791674","https://openalex.org/W3016794183","https://openalex.org/W3172876296","https://openalex.org/W3000051372","https://openalex.org/W2167294837","https://openalex.org/W3198815771","https://openalex.org/W7036766763","https://openalex.org/W3217369302","https://openalex.org/W2196709345"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2],"clinical":[3,101,165],"and":[4,60,104,158],"paraclinical":[5],"effects":[6],"of":[7,23,62,134],"natalizumab":[8,49,126],"in":[9,78,95,131,154,163],"a":[10],"patient":[11,31,140],"with":[12,32,48,85,117,141],"chronic":[13],"inflammatory":[14],"demyelinating":[15],"polyneuropathy":[16],"(CIDP).":[17],"DESIGN:":[18],"Case":[19],"report.":[20],"SETTING:":[21],"Department":[22],"Neurology,":[24],"Heinrich-Heine":[25],"University,":[26],"D\u00fcsseldorf,":[27],"Germany.":[28],"Patient":[29],"A":[30],"highly":[33],"active":[34],"CIDP":[35,142,155],"who":[36],"did":[37,143],"not":[38,144],"respond":[39],"to":[40,88],"standard":[41],"therapies.":[42],"Intervention":[43],"Standard":[44],"therapy":[45],"then":[46],"treatment":[47,116],"(300":[50],"mg).":[51],"MAIN":[52],"OUTCOME":[53],"MEASURES:":[54],"Clinical":[55],"disability,":[56],"magnetic":[57,108],"resonance":[58,109],"imaging,":[59],"saturation":[61],"the":[63,73,79,89,99,135],"alpha(4)":[64,74,90],"integrin":[65,75,91],"on":[66,92,107],"T":[67,70,93],"lymphocytes.":[68],"RESULTS:":[69],"cells":[71],"expressing":[72],"were":[76],"found":[77],"inflamed":[80],"peripheral":[81,136],"nerve.":[82],"Natalizumab":[83,150],"bound":[84],"high":[86],"affinity":[87],"lymphocytes":[94],"our":[96,139],"patient.":[97],"However,":[98],"patient's":[100],"condition":[102],"deteriorated":[103],"as":[105],"seen":[106],"imaging":[110],"without":[111],"any":[112],"measurable":[113],"effect":[114],"after":[115],"this":[118,147],"antibody.":[119],"CONCLUSIONS:":[120],"Although":[121],"experimental":[122],"evidence":[123],"suggests":[124],"that":[125],"could":[127],"theoretically":[128],"be":[129,152,161],"effective":[130],"immune-mediated":[132],"disorders":[133],"nervous":[137],"system,":[138],"benefit":[145],"from":[146],"therapeutic":[148],"approach.":[149],"cannot":[151],"recommended":[153],"at":[156],"present":[157],"should":[159],"only":[160],"explored":[162],"controlled":[164],"trials.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}