{"id":"https://openalex.org/W2078288680","doi":"https://doi.org/10.1097/00004872-198912000-00004","title":"Remodelling of the heart in DOCA-salt hypertensive rats by propranolol and by an alpha-2 agonist, rilmenidine","display_name":"Remodelling of the heart in DOCA-salt hypertensive rats by propranolol and by an alpha-2 agonist, rilmenidine","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W2078288680","doi":"https://doi.org/10.1097/00004872-198912000-00004","mag":"2078288680","pmid":"https://pubmed.ncbi.nlm.nih.gov/2576430"},"language":"en","primary_location":{"id":"doi:10.1097/00004872-198912000-00004","doi":"https://doi.org/10.1097/00004872-198912000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004872-198912000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109067189","display_name":"F. Amrani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Francine Callens-EI Amrani","raw_affiliation_strings":["Unit\u00e9 127 de l'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dical, H\u00f4pital Lariboisi\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 127 de l'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dical, H\u00f4pital Lariboisi\u00e8re, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113637296","display_name":"F Paolaggi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210111777","display_name":"Laboratoire de Biochimie","ror":"https://ror.org/01thw2g46","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I4210111777","https://openalex.org/I4210139971","https://openalex.org/I4210161506","https://openalex.org/I98910050"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran??oise Paolaggi","raw_affiliation_strings":["*Laboratoire de Biochimie, H\u00f6pital Lariboisi\u00e8re, 75010 Paris, France; From the Unit\u00e9 127 de I'lnstitut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratoire de Biochimie, H\u00f6pital Lariboisi\u00e8re, 75010 Paris, France; From the Unit\u00e9 127 de I'lnstitut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210111777","https://openalex.org/I4210119095"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056043654","display_name":"Bernard Swynghedauw A","orcid":"https://orcid.org/0000-0002-3616-3798","observed_orcids":["https://orcid.org/0000-0002-3616-3798"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210111777","display_name":"Laboratoire de Biochimie","ror":"https://ror.org/01thw2g46","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I4210111777","https://openalex.org/I4210139971","https://openalex.org/I4210161506","https://openalex.org/I98910050"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Swynghedauw","raw_affiliation_strings":["*Laboratoire de Biochimie, H\u00f6pital Lariboisi\u00e8re, 75010 Paris, France; From the Unit\u00e9 127 de I'lnstitut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratoire de Biochimie, H\u00f6pital Lariboisi\u00e8re, 75010 Paris, France; From the Unit\u00e9 127 de I'lnstitut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210111777","https://openalex.org/I4210119095"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3867,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.65109051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":"12","first_page":"947","last_page":"954"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.27880001068115234,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rilmenidine","display_name":"rilmenidine","score":0.8410000205039978},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/doca-salt-hypertension","display_name":"DOCA-salt hypertension","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.7350000143051147},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.7900000214576721},{"id":"https://openalex.org/keywords/alpha-2-adrenergic-agonists","display_name":"alpha-2 adrenergic agonists","score":0.8679999709129333},{"id":"https://openalex.org/keywords/beta-adrenergic-blocker","display_name":"beta-adrenergic blocker","score":0.859000027179718},{"id":"https://openalex.org/keywords/antihypertensive-effect","display_name":"antihypertensive effect","score":0.8560000061988831},{"id":"https://openalex.org/keywords/nephrectomy","display_name":"nephrectomy","score":0.48100000619888306},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.8945091962814331},{"id":"https://openalex.org/C2780307058","wikidata":"https://www.wikidata.org/wiki/Q967973","display_name":"Rilmenidine","level":4,"score":0.8794929385185242},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7330800890922546},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7010223269462585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6274254322052002},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5613406896591187},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.42155298590660095},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.39505964517593384},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0844910740852356}],"mesh":[{"descriptor_ui":"D000077769","descriptor_name":"Rilmenidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000316","descriptor_name":"Adrenergic alpha-Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003900","descriptor_name":"Desoxycorticosterone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00004872-198912000-00004","doi":"https://doi.org/10.1097/00004872-198912000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004872-198912000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:2576430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2576430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2417423520","https://openalex.org/W2952846585","https://openalex.org/W831372216","https://openalex.org/W2022962760","https://openalex.org/W2057636715","https://openalex.org/W2168231679","https://openalex.org/W2037466699","https://openalex.org/W2443463695","https://openalex.org/W2003767599","https://openalex.org/W2165677677"],"abstract_inverted_index":{"The":[0,212,298,325,371,404],"effects":[1],"of":[2,21,26,61,407,416],"rilmenidine":[3,66,181,295,342,410],"[(N-dicyclopropylmethyl)":[4],"amino-2-oxazoline;":[5],"S":[6],"3341],":[7],"an":[8,44],"\u03b12":[9],"agonist,":[10],"on":[11],"the":[12,48,54,127,143,221,225,241,276,282,311,329,377,381,408,414,420],"hypertensive":[13],"rat":[14],"heart":[15],"have":[16],"been":[17],"compared":[18],"with":[19,38,220,240],"those":[20],"propranolol,":[22,105,162,195,337,352],"using":[23],"a":[24,59,76,249,260,269],"model":[25],"deoxycorticosterone":[27],"acetate":[28],"(DOCA)-salt":[29],"hypertension.":[30],"One":[31],"week":[32],"after":[33,97,104,114,155,161,170,189,194,203,347,351,356],"nephrectomy":[34],"and":[35,67,78,180,267,281,318,399],"initial":[36],"treatment":[37],"DOCA-salt,":[39,98,156,190,348],"which":[40],"was":[41,320,332,339,385],"continued":[42],"for":[43,65,71,224,376],"additional":[45],"7":[46],"weeks,":[47],"two":[49,289],"drugs":[50,74],"were":[51,286,291,374],"added":[52],"to":[53,394],"rats'":[55],"drinking":[56],"water":[57],"at":[58,83,248],"concentration":[60,327],"10mg/kg":[62],"per":[63,69],"day":[64,70],"15mg/kg":[68],"propranolol.":[72,297],"Both":[73],"had":[75,268],"slight":[77],"similarly":[79],"significant":[80],"antihypertensive":[81,405],"effect":[82,406],"their":[84],"respective":[85],"concentrations":[86],"[systolic":[87],"blood":[88,129,222,263,397],"pressure":[89,130,223,264,398],"in":[90,328,362,380,388,402],"controls,":[91,151,187,344],"141":[92],"\u00b1":[93,100,107,117,153,158,164,173,192,197,206,308,354,359],"15":[94,118],"mmHg":[95,102,109,119],"(n=20);":[96],"209":[99],"22":[101],"(n=24);":[103],"182":[106],"19":[108],"(n=20,":[110],"P":[111,121,228,235,315,368],"<":[112,122,135,168,201,210,229,236,316,369],"0.01);":[113,202],"rilmenidine,":[115,140,171,204,357],"192":[116],"(n=19,":[120],"0.05)].":[123,211],"They":[124],"also":[125],"lowered":[126],"systolic":[128,262,396],"x":[131],"frequency":[132],"product":[133],"(P":[134,167,200,209],"0.001).":[136],"Propranolol,":[137],"but":[138,238,338,418],"not":[139,239,292,321,412],"significantly":[141],"reduced":[142,182,340],"left":[144,183,213,330,366,382],"ventricular":[145,184,214],"weight:":[146,215],"body":[147,216],"weight":[148,185,217],"ratio":[149,218],"[in":[150,186],"2.00":[152],"0.2mg/g;":[154],"3.04":[157],"0.5":[159],"mg/g;":[160],"2.67":[163],"0.4":[165],"mg/g":[166,175],"0.05);":[169],"3.13":[172],"0.6":[174],"(P=NS)].":[176],"However,":[177],"both":[178,275],"propranolol":[179,391],"676\u00b157mg;":[188],"827":[191],"114mg;":[193],"732":[196],"108":[198],"mg":[199,208,363],"760":[205],"100":[207],"correlated":[219],"DOCA-salt-treated":[226,257,300],"(r=0.64,":[227],"0.01)":[230],"or":[231,296,336],"propranolol-treated":[232],"groups":[233],"(r=0.81,":[234],"0.01),":[237,317],"rilmenidine-treated":[242],"group":[243],"(r=0.20,":[244],"P=NS).":[245],"When":[246],"perfused":[247],"normalized":[250],"coronary":[251,278,283],"flow,":[252],"isolated":[253],"Langendorff":[254],"hearts":[255,301,313],"from":[256],"rats":[258],"developed":[259],"higher":[261],"than":[265,310],"controls":[266],"normal":[270],"wall":[271],"stress.":[272],"In":[273],"addition,":[274],"total":[277,421],"vascular":[279,284],"resistance":[280],"resistance/g":[285],"enhanced.":[287],"These":[288],"parameters":[290],"modified":[293,322],"by":[294,323,334,341],"hypertrophied":[299],"contained":[302],"more":[303],"slow":[304],"isomyosins":[305],"(V3:":[306],"11":[307],"4%)":[309],"control":[312],"(0%,":[314],"this":[319],"treatment.":[324],"collagen":[326,378,423],"ventricle":[331],"unaffected":[333],"DOCA-salt":[335,389],"(in":[343],"1.04":[345],"\u00b10.21;":[346],"1.02":[349],"\u00b10.22;":[350],"1.03":[353],"0.19;":[355],"0.81":[358],"0.13":[360],"(measured":[361],"hydroxyproline/g":[364],"fresh":[365],"ventricle,":[367],"0.005).":[370],"same":[372],"results":[373],"found":[375],"mass":[379],"ventricle.":[383],"It":[384],"concluded":[386],"that":[387],"hypertension,":[390],"is":[392],"able":[393],"reduce":[395],"cardiac":[400,422],"hypertrophy":[401,417],"parallel.":[403],"\u03b12-agonist":[409],"does":[411],"modify":[413],"degree":[415],"reduces":[419],"content.":[424]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
