{"id":"https://openalex.org/W2078285522","doi":"https://doi.org/10.1016/0303-8467(92)90028-2","title":"Clinical effects and mechanism of action of sumatriptan in migraine","display_name":"Clinical effects and mechanism of action of sumatriptan in migraine","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2078285522","doi":"https://doi.org/10.1016/0303-8467(92)90028-2","mag":"2078285522","pmid":"https://pubmed.ncbi.nlm.nih.gov/1320526"},"language":"en","primary_location":{"id":"doi:10.1016/0303-8467(92)90028-2","doi":"https://doi.org/10.1016/0303-8467(92)90028-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0303-8467(92)90028-2","pdf_url":null,"source":{"id":"https://openalex.org/S165396890","display_name":"Clinical Neurology and Neurosurgery","issn_l":"0303-8467","issn":["0303-8467","1872-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neurology and Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039941295","display_name":"Michel Dominique Ferrari","orcid":"https://orcid.org/0000-0001-9691-9449","observed_orcids":["https://orcid.org/0000-0001-9691-9449"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Michel D. Ferrari","raw_affiliation_strings":["Department of Neurology, University Hospital, Leiden, The Netherlands","The Dutch Migraine Research Group The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"]},{"raw_affiliation_string":"The Dutch Migraine Research Group The Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113669368","display_name":"Pramod R. Saxena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pramod R.S. Saxena","raw_affiliation_strings":["Department of Pharmacology, Erasmus University, RotterdamThe Netherlands","The Dutch Migraine Research Group The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Erasmus University, RotterdamThe Netherlands","institution_ids":["https://openalex.org/I913958620"]},{"raw_affiliation_string":"The Dutch Migraine Research Group The Netherlands","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039941295"],"corresponding_institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.3124,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.35227273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"94","issue":null,"first_page":"73","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sumatriptan","display_name":"sumatriptan","score":1.0},{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cluster-headache","display_name":"cluster headache","score":1.0},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.8009999990463257},{"id":"https://openalex.org/keywords/5-ht1-receptors","display_name":"5-HT1 receptors","score":0.7630000114440918},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cerebral-vasoconstriction","display_name":"cerebral vasoconstriction","score":0.8700000047683716},{"id":"https://openalex.org/keywords/trigeminovascular-system","display_name":"trigeminovascular system","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.7250000238418579},{"id":"https://openalex.org/keywords/migraine-pathophysiology","display_name":"migraine pathophysiology","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2778871607","wikidata":"https://www.wikidata.org/wiki/Q416978","display_name":"Sumatriptan","level":4,"score":0.9828951358795166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9155275821685791},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.8496833443641663},{"id":"https://openalex.org/C2777942821","wikidata":"https://www.wikidata.org/wiki/Q166907","display_name":"Cluster headache","level":3,"score":0.7698310613632202},{"id":"https://openalex.org/C2776089194","wikidata":"https://www.wikidata.org/wiki/Q7002244","display_name":"Neurogenic inflammation","level":5,"score":0.6442351341247559},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4934305250644684},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.4856492280960083},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4702293574810028},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4551657438278198},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.38161107897758484},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37139931321144104},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24810466170310974},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.23554447293281555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21506759524345398},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.17749792337417603},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.1354919970035553},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D003027","descriptor_name":"Cluster Headache","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014666","descriptor_name":"Vasomotor System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018170","descriptor_name":"Sumatriptan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0303-8467(92)90028-2","doi":"https://doi.org/10.1016/0303-8467(92)90028-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0303-8467(92)90028-2","pdf_url":null,"source":{"id":"https://openalex.org/S165396890","display_name":"Clinical Neurology and Neurosurgery","issn_l":"0303-8467","issn":["0303-8467","1872-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neurology and Neurosurgery","raw_type":"journal-article"},{"id":"pmid:1320526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1320526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neurology and neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.47999998927116394}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W226905139","https://openalex.org/W289821420","https://openalex.org/W618315342","https://openalex.org/W1504964973","https://openalex.org/W1545409067","https://openalex.org/W1771060587","https://openalex.org/W1890116900","https://openalex.org/W1899859068","https://openalex.org/W1964439946","https://openalex.org/W1966687736","https://openalex.org/W1968081766","https://openalex.org/W1974472432","https://openalex.org/W1980668812","https://openalex.org/W1983664314","https://openalex.org/W1987393216","https://openalex.org/W1988490723","https://openalex.org/W1990459441","https://openalex.org/W1997014741","https://openalex.org/W2001151860","https://openalex.org/W2006888340","https://openalex.org/W2007830665","https://openalex.org/W2014547321","https://openalex.org/W2015174666","https://openalex.org/W2018432564","https://openalex.org/W2019023056","https://openalex.org/W2020292192","https://openalex.org/W2024258521","https://openalex.org/W2025084114","https://openalex.org/W2025166930","https://openalex.org/W2026238417","https://openalex.org/W2027671989","https://openalex.org/W2034624034","https://openalex.org/W2037344126","https://openalex.org/W2038985785","https://openalex.org/W2048089058","https://openalex.org/W2054502535","https://openalex.org/W2059402725","https://openalex.org/W2061400112","https://openalex.org/W2070569817","https://openalex.org/W2071585334","https://openalex.org/W2076056900","https://openalex.org/W2078065256","https://openalex.org/W2078596134","https://openalex.org/W2080182289","https://openalex.org/W2083796319","https://openalex.org/W2085595272","https://openalex.org/W2089775429","https://openalex.org/W2108733441","https://openalex.org/W2111013423","https://openalex.org/W2138814983","https://openalex.org/W2164703847","https://openalex.org/W2308319779","https://openalex.org/W2466674868","https://openalex.org/W2506929947","https://openalex.org/W2521121750","https://openalex.org/W2527558851","https://openalex.org/W2734650613","https://openalex.org/W2735640201","https://openalex.org/W4231885092","https://openalex.org/W4241348973","https://openalex.org/W4322701861"],"related_works":["https://openalex.org/W2282906807","https://openalex.org/W2109598736","https://openalex.org/W4247212719","https://openalex.org/W2003840426","https://openalex.org/W2412521937","https://openalex.org/W2125285971","https://openalex.org/W2024899252","https://openalex.org/W2009626941","https://openalex.org/W1989571045","https://openalex.org/W1997152390"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}