{"id":"https://openalex.org/W2078277232","doi":"https://doi.org/10.1006/nlme.1999.3914","title":"Evidence for Altered Fragile-X Mental Retardation Protein Expression in Response to Behavioral Stimulation","display_name":"Evidence for Altered Fragile-X Mental Retardation Protein Expression in Response to Behavioral Stimulation","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2078277232","doi":"https://doi.org/10.1006/nlme.1999.3914","mag":"2078277232","pmid":"https://pubmed.ncbi.nlm.nih.gov/10686126"},"language":"en","primary_location":{"id":"doi:10.1006/nlme.1999.3914","doi":"https://doi.org/10.1006/nlme.1999.3914","is_oa":false,"landing_page_url":"https://doi.org/10.1006/nlme.1999.3914","pdf_url":null,"source":{"id":"https://openalex.org/S78120914","display_name":"Neurobiology of Learning and Memory","issn_l":"1074-7427","issn":["1074-7427","1095-9564"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Learning and Memory","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2078277232"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021058662","display_name":"Scott A. Irwin","orcid":"https://orcid.org/0000-0001-7868-1641","observed_orcids":["https://orcid.org/0000-0001-7868-1641"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I2801919071","display_name":"University of Illinois System","ror":"https://ror.org/05e94g991","country_code":"US","type":"education","lineage":["https://openalex.org/I2801919071"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A. Irwin","raw_affiliation_strings":["Beckman Institute, University of Illinois, Urbana 61801, USA","Beckman Institute, University of Illinois, Urbana, Illinois, 61801","Medical Scholars Programs","Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Institute, University of Illinois, Urbana 61801, USA","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]},{"raw_affiliation_string":"Beckman Institute, University of Illinois, Urbana, Illinois, 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]},{"raw_affiliation_string":"Medical Scholars Programs","institution_ids":[]},{"raw_affiliation_string":"Neuroscience","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006950411","display_name":"Rodney A. Swain","orcid":"https://orcid.org/0000-0001-8989-3842","observed_orcids":["https://orcid.org/0000-0001-8989-3842"]},"institutions":[{"id":"https://openalex.org/I43579087","display_name":"University of Wisconsin\u2013Milwaukee","ror":"https://ror.org/031q21x57","country_code":"US","type":"education","lineage":["https://openalex.org/I43579087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodney A. Swain","raw_affiliation_strings":["Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, 53201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, 53201","institution_ids":["https://openalex.org/I43579087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068100655","display_name":"Chariya A. Christmon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chariya A. Christmon","raw_affiliation_strings":["Department of Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077173179","display_name":"Aparna B. Chakravarti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aparna Chakravarti","raw_affiliation_strings":["Department of Cell and Structural Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Structural Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007573547","display_name":"Ivan Jeanne Weiler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I2801919071","display_name":"University of Illinois System","ror":"https://ror.org/05e94g991","country_code":"US","type":"education","lineage":["https://openalex.org/I2801919071"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Jeanne Weiler","raw_affiliation_strings":["Beckman Institute, University of Illinois, Urbana, Illinois, 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Institute, University of Illinois, Urbana, Illinois, 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085647019","display_name":"William T. Greenough","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I2801919071","display_name":"University of Illinois System","ror":"https://ror.org/05e94g991","country_code":"US","type":"education","lineage":["https://openalex.org/I2801919071"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William T. Greenough","raw_affiliation_strings":["Beckman Institute, University of Illinois, Urbana, Illinois, 61801","Department of Cell and Structural Biology","Department of Psychiatry","Department of Psychology","Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Institute, University of Illinois, Urbana, Illinois, 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]},{"raw_affiliation_string":"Department of Cell and Structural Biology","institution_ids":[]},{"raw_affiliation_string":"Department of Psychiatry","institution_ids":[]},{"raw_affiliation_string":"Department of Psychology","institution_ids":[]},{"raw_affiliation_string":"Neuroscience","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085647019"],"corresponding_institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":3.3414,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.92428367,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"73","issue":"1","first_page":"87","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fmrp","display_name":"FMRP","score":0.9580000042915344},{"id":"https://openalex.org/keywords/fragile-x-syndrome","display_name":"fragile X syndrome","score":0.9290000200271606},{"id":"https://openalex.org/keywords/environmental-enrichment","display_name":"environmental enrichment","score":0.6159999966621399},{"id":"https://openalex.org/keywords/motor-skill-training","display_name":"motor skill training","score":0.9110000133514404},{"id":"https://openalex.org/keywords/visual-cortex","display_name":"visual cortex","score":0.8069999814033508},{"id":"https://openalex.org/keywords/motor-cortex","display_name":"motor cortex","score":1.0},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.8659999966621399},{"id":"https://openalex.org/keywords/synaptic-structure","display_name":"synaptic structure","score":0.7319999933242798},{"id":"https://openalex.org/keywords/neuronal-morphology","display_name":"neuronal morphology","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7863643765449524},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6748710870742798},{"id":"https://openalex.org/C2777630245","wikidata":"https://www.wikidata.org/wiki/Q221472","display_name":"Fragile X syndrome","level":2,"score":0.646966814994812},{"id":"https://openalex.org/C3020422209","wikidata":"https://www.wikidata.org/wiki/Q221472","display_name":"Fragile x","level":3,"score":0.6168492436408997},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5881849527359009},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.44220009446144104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21279960870742798},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1239352822303772},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009044","descriptor_name":"Motor Cortex","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012931","descriptor_name":"Social Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051860","descriptor_name":"Fragile X Messenger Ribonucleoprotein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1006/nlme.1999.3914","doi":"https://doi.org/10.1006/nlme.1999.3914","is_oa":false,"landing_page_url":"https://doi.org/10.1006/nlme.1999.3914","pdf_url":null,"source":{"id":"https://openalex.org/S78120914","display_name":"Neurobiology of Learning and Memory","issn_l":"1074-7427","issn":["1074-7427","1095-9564"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Learning and Memory","raw_type":"journal-article"},{"id":"pmid:10686126","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10686126","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of learning and memory","raw_type":"Journal Article"},{"id":"pmid:11001622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11001622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of learning and memory","raw_type":"Corrected and Republished Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1151337401","display_name":"REGULATION OF FRAGILE X PROTEIN SYNTHESIS AT SYNAPSES","funder_award_id":"R03HD035565","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5000983702","display_name":"EXPRESSION AND FUNCTION OF FMRP DURING DEVELOPMENT","funder_award_id":"F30MH011272","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5719153393","display_name":null,"funder_award_id":"MH-35321","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8911284370","display_name":null,"funder_award_id":"HD 35565","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W35614978","https://openalex.org/W1576796286","https://openalex.org/W2002760096","https://openalex.org/W2022959185","https://openalex.org/W2024570545","https://openalex.org/W2031044889","https://openalex.org/W2036338927","https://openalex.org/W2051541374","https://openalex.org/W2122591357","https://openalex.org/W2140382995","https://openalex.org/W2144995800"],"related_works":["https://openalex.org/W2019491869","https://openalex.org/W1986218781","https://openalex.org/W2467740350","https://openalex.org/W2074791552","https://openalex.org/W2124161234","https://openalex.org/W2157639531","https://openalex.org/W2032366919","https://openalex.org/W2071482305","https://openalex.org/W2049869358","https://openalex.org/W2022959185"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}