{"id":"https://openalex.org/W2078142004","doi":"https://doi.org/10.1074/jbc.272.12.7676","title":"Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin","display_name":"Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W2078142004","doi":"https://doi.org/10.1074/jbc.272.12.7676","mag":"2078142004","pmid":"https://pubmed.ncbi.nlm.nih.gov/9065424"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.272.12.7676","doi":"https://doi.org/10.1074/jbc.272.12.7676","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.12.7676","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.272.12.7676","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063870060","display_name":"Daniel A. Lawrence","orcid":"https://orcid.org/0000-0003-3126-1935","observed_orcids":["https://orcid.org/0000-0003-3126-1935"]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel A. Lawrence","raw_affiliation_strings":["Department of Biochemistry, American Red Cross Holland Laboratory, Rockville, Maryland 20855, USA. lawrencd@usa.redcross.org","Department of Biochemistry, American Red Cross Holland Laboratory, Rockville, Maryland 20855"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, American Red Cross Holland Laboratory, Rockville, Maryland 20855, USA. lawrencd@usa.redcross.org","institution_ids":["https://openalex.org/I1343864894"]},{"raw_affiliation_string":"Department of Biochemistry, American Red Cross Holland Laboratory, Rockville, Maryland 20855","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113799767","display_name":"Selvi Palaniappan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selvi Palaniappan","raw_affiliation_strings":["Departments of Internal Medicine and Human Genetics and Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan, 48109-0650,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Human Genetics and Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan, 48109-0650,","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020782456","display_name":"Steingrimur Stefansson","orcid":"https://orcid.org/0000-0001-7904-9242","observed_orcids":["https://orcid.org/0000-0001-7904-9242"]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steingrimur Stefansson","raw_affiliation_strings":["Department of Biochemistry, American Red Cross Holland Laboratory, Rockville, Maryland 20855"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, American Red Cross Holland Laboratory, Rockville, Maryland 20855","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055990354","display_name":"Steven T. Olson","orcid":"https://orcid.org/0000-0002-6083-7510","observed_orcids":["https://orcid.org/0000-0002-6083-7510"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven.T. Olson","raw_affiliation_strings":["Center for Molecular Biology of Oral Diseases, University of Illinois, Chicago, Illinois 60612-7213, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Biology of Oral Diseases, University of Illinois, Chicago, Illinois 60612-7213, and","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074512929","display_name":"Ann Marie Francis-Chmura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Marie Francis-Chmura","raw_affiliation_strings":["Henry Ford Health System, Detroit, Michigan 48202-3450"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Health System, Detroit, Michigan 48202-3450","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110875015","display_name":"Joseph D. Shore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D. Shore","raw_affiliation_strings":["Henry Ford Health System, Detroit, Michigan 48202-3450"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Health System, Detroit, Michigan 48202-3450","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071223660","display_name":"David Ginsburg","orcid":"https://orcid.org/0000-0002-6436-8942","observed_orcids":["https://orcid.org/0000-0002-6436-8942"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Ginsburg","raw_affiliation_strings":["Departments of Internal Medicine and Human Genetics and Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan, 48109-0650,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Human Genetics and Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan, 48109-0650,","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5063870060"],"corresponding_institution_ids":["https://openalex.org/I1343864894"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.9576,"has_fulltext":false,"cited_by_count":125,"citation_normalized_percentile":{"value":0.92361402,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"272","issue":"12","first_page":"7676","last_page":"7680"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.33570000529289246,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/vitronectin","display_name":"vitronectin","score":0.996999979019165},{"id":"https://openalex.org/keywords/protein-protein-binding","display_name":"protein-protein binding","score":0.8690000176429749},{"id":"https://openalex.org/keywords/conformational-states","display_name":"conformational states","score":0.7519999742507935},{"id":"https://openalex.org/keywords/reactive-center-loop","display_name":"reactive center loop","score":0.6380000114440918},{"id":"https://openalex.org/keywords/beta-trypsin","display_name":"beta-trypsin","score":0.9589999914169312},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.6629999876022339},{"id":"https://openalex.org/keywords/extracellular-matrix-adhesion","display_name":"extracellular matrix adhesion","score":0.6259999871253967},{"id":"https://openalex.org/keywords/plasminogen-activation-inhibition","display_name":"plasminogen activation inhibition","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.9522935152053833},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.6255960464477539},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.584689199924469},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.46029385924339294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3710073232650757},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.36196187138557434},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14446479082107544},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14390039443969727},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.13068339228630066},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05729207396507263}],"mesh":[{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.272.12.7676","doi":"https://doi.org/10.1074/jbc.272.12.7676","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.12.7676","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9065424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9065424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.272.12.7676","doi":"https://doi.org/10.1074/jbc.272.12.7676","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.12.7676","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2519008473","display_name":null,"funder_award_id":"HL 39888","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3221211976","display_name":null,"funder_award_id":"HL 55374","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G502008309","display_name":null,"funder_award_id":"HL-45930","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5610038056","display_name":"Molecular Interactions of Fibrinolysis","funder_award_id":"5r01hl045930-13","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000882676","display_name":"Unraveling the role of tPA in the neurovascular unit","funder_award_id":"R01HL055374","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W23122061","https://openalex.org/W38263071","https://openalex.org/W175798264","https://openalex.org/W223025435","https://openalex.org/W292647304","https://openalex.org/W1493779021","https://openalex.org/W1497473690","https://openalex.org/W1498287490","https://openalex.org/W1515220193","https://openalex.org/W1518433473","https://openalex.org/W1531765010","https://openalex.org/W1548286725","https://openalex.org/W1571398079","https://openalex.org/W1586249833","https://openalex.org/W1588599526","https://openalex.org/W1589957034","https://openalex.org/W1590202185","https://openalex.org/W1595622217","https://openalex.org/W1596166355","https://openalex.org/W1601891991","https://openalex.org/W1645568321","https://openalex.org/W1676144090","https://openalex.org/W1926488772","https://openalex.org/W1963843867","https://openalex.org/W1970705434","https://openalex.org/W1971400041","https://openalex.org/W1985335006","https://openalex.org/W1987299633","https://openalex.org/W1988157797","https://openalex.org/W1989959442","https://openalex.org/W1992451189","https://openalex.org/W1995582010","https://openalex.org/W1997637608","https://openalex.org/W2001124978","https://openalex.org/W2013764692","https://openalex.org/W2016918804","https://openalex.org/W2017623352","https://openalex.org/W2023018704","https://openalex.org/W2026458454","https://openalex.org/W2027077889","https://openalex.org/W2029890215","https://openalex.org/W2030390916","https://openalex.org/W2039552227","https://openalex.org/W2047163160","https://openalex.org/W2048653605","https://openalex.org/W2050325685","https://openalex.org/W2061346634","https://openalex.org/W2066279385","https://openalex.org/W2070014993","https://openalex.org/W2092867585","https://openalex.org/W2092903958","https://openalex.org/W2102577298","https://openalex.org/W2107908226","https://openalex.org/W2134311390","https://openalex.org/W2200395040","https://openalex.org/W2237196863","https://openalex.org/W2396732148","https://openalex.org/W2408590235","https://openalex.org/W2411677906"],"related_works":["https://openalex.org/W2094716808","https://openalex.org/W1968450712","https://openalex.org/W1562197596","https://openalex.org/W1531765010","https://openalex.org/W1676144090","https://openalex.org/W2029890215","https://openalex.org/W2415387743","https://openalex.org/W1995034111","https://openalex.org/W1986104649","https://openalex.org/W2042786798"],"abstract_inverted_index":{"Plasminogen":[0],"activator":[1,186],"inhibitor":[2,9],"type":[3],"1":[4],"(PAI-1),":[5],"the":[6,16,24,32,131,146,193,201,210],"primary":[7],"physiologic":[8],"of":[10,34,38,74,95,107,120,133,158,204,224],"plasminogen":[11,86],"activation,":[12],"is":[13,130,143,216],"associated":[14,150,221],"with":[15,61,98,151,222],"adhesive":[17],"glycoprotein":[18],"vitronectin":[19,45],"(Vn)":[20],"in":[21,138,165],"plasma":[22],"and":[23,43,197,207],"extracellular":[25],"matrix.":[26],"In":[27,70],"this":[28],"study":[29],"we":[30],"examined":[31],"binding":[33,49,212],"different":[35],"conformational":[36,202],"forms":[37,73,94],"PAI-1":[39,56,75,117,149,168,196,215],"to":[40,58,67,85,170,184,218],"both":[41,93,205],"native":[42,68],"urea-purified":[44,59],"using":[46],"a":[47],"solid-phase":[48],"assay.":[50],"These":[51],"results":[52,137],"demonstrate":[53,191],"that":[54,128,136,148,192,209],"active":[55,116],"binds":[57],"Vn":[60,140,182,198,211],"approximately":[62],"6-fold":[63],"higher":[64],"affinity":[65,180],"than":[66,104],"Vn.":[69],"contrast,":[71],"inactive":[72,111],"(latent,":[76],"elastase-cleaved,":[77],"synthetic":[78],"reactive":[79],"center":[80],"loop":[81],"peptide-annealed,":[82],"or":[83],"complexed":[84,169],"activators)":[87],"display":[88],"greatly":[89],"reduced":[90,101,139,179],"affinities":[91,100],"for":[92,181],"adsorbed":[96],"Vn,":[97],"relative":[99],"by":[102,118,145],"more":[103],"2":[105],"orders":[106],"magnitude.":[108],"Structurally,":[109],"these":[110,189],"conformations":[112],"all":[113],"differ":[114],"from":[115],"insertion":[119],"an":[121],"additional":[122],"strand":[123],"into":[124],"beta-sheet":[125,159],"A,":[126,160],"suggesting":[127],"it":[129],"rearrangement":[132,157],"sheet":[134,175],"A":[135,176],"affinity.":[141],"This":[142],"supported":[144],"observation":[147],"beta-anhydrotrypsin,":[152],"which":[153,172],"does":[154,173],"not":[155],"undergo":[156,174],"shows":[161],"no":[162],"such":[163],"decrease":[164],"affinity,":[166],"whereas":[167],"beta-trypsin,":[171],"rearrangement,":[177],"displays":[178],"similar":[183],"PAI-1.plasminogen":[185],"complexes.":[187],"Together":[188],"data":[190],"interaction":[194],"between":[195],"depends":[199],"on":[200,214],"state":[203],"proteins":[206],"suggest":[208],"site":[213],"sensitive":[217],"structural":[219],"changes":[220],"loss":[223],"inhibitory":[225],"activity.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
