{"id":"https://openalex.org/W2078123723","doi":"https://doi.org/10.1371/journal.pone.0024794","title":"The Worker Honeybee Fat Body Proteome Is Extensively Remodeled Preceding a Major Life-History Transition","display_name":"The Worker Honeybee Fat Body Proteome Is Extensively Remodeled Preceding a Major Life-History Transition","publication_year":2011,"publication_date":"2011-09-28","ids":{"openalex":"https://openalex.org/W2078123723","doi":"https://doi.org/10.1371/journal.pone.0024794","mag":"2078123723","pmid":"https://pubmed.ncbi.nlm.nih.gov/21969861","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3182174"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0024794","doi":"https://doi.org/10.1371/journal.pone.0024794","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0024794","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024794&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024794&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050937872","display_name":"Queenie W. T. Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Queenie W. T. Chan","raw_affiliation_strings":["Centre for High-Throughput Biology and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for High-Throughput Biology and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087142505","display_name":"Navdeep S. Mutti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navdeep S. Mutti","raw_affiliation_strings":["Arizona State University, School of Life Sciences, Tempe, Arizona, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University, School of Life Sciences, Tempe, Arizona, United States of America","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044695259","display_name":"Leonard J. Foster","orcid":"https://orcid.org/0000-0001-8551-4817","observed_orcids":["https://orcid.org/0000-0001-8551-4817"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Leonard J. Foster","raw_affiliation_strings":["Centre for High-Throughput Biology and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for High-Throughput Biology and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041561782","display_name":"Sarah D. Kocher","orcid":"https://orcid.org/0000-0001-5586-0727","observed_orcids":["https://orcid.org/0000-0001-5586-0727"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah D. Kocher","raw_affiliation_strings":["Pennsylvania State University, Department of Entomology, University Park, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennsylvania State University, Department of Entomology, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009288169","display_name":"Gro Vang Amdam","orcid":"https://orcid.org/0000-0001-7797-6464","observed_orcids":["https://orcid.org/0000-0001-7797-6464"]},"institutions":[{"id":"https://openalex.org/I54108979","display_name":"Norwegian University of Life Sciences","ror":"https://ror.org/04a1mvv97","country_code":"NO","type":"education","lineage":["https://openalex.org/I54108979"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["NO","US"],"is_corresponding":false,"raw_author_name":"Gro V. Amdam","raw_affiliation_strings":["Arizona State University, School of Life Sciences, Tempe, Arizona, United States of America","Department of Biotechnology, Chemistry, and Food Science, Norwegian University of Life Sciences, Aas, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University, School of Life Sciences, Tempe, Arizona, United States of America","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Department of Biotechnology, Chemistry, and Food Science, Norwegian University of Life Sciences, Aas, Norway","institution_ids":["https://openalex.org/I54108979"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008235745","display_name":"Florian Wolschin","orcid":"https://orcid.org/0009-0008-6772-1159","observed_orcids":["https://orcid.org/0009-0008-6772-1159"]},"institutions":[{"id":"https://openalex.org/I54108979","display_name":"Norwegian University of Life Sciences","ror":"https://ror.org/04a1mvv97","country_code":"NO","type":"education","lineage":["https://openalex.org/I54108979"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["NO","US"],"is_corresponding":true,"raw_author_name":"Florian Wolschin","raw_affiliation_strings":["Arizona State University, School of Life Sciences, Tempe, Arizona, United States of America","Department of Biotechnology, Chemistry, and Food Science, Norwegian University of Life Sciences, Aas, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University, School of Life Sciences, Tempe, Arizona, United States of America","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Department of Biotechnology, Chemistry, and Food Science, Norwegian University of Life Sciences, Aas, Norway","institution_ids":["https://openalex.org/I54108979"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008235745"],"corresponding_institution_ids":["https://openalex.org/I54108979","https://openalex.org/I55732556"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.5885,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.89528907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"9","first_page":"e24794","last_page":"e24794"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10702","display_name":"Insect and Arachnid Ecology and Behavior","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10702","display_name":"Insect and Arachnid Ecology and Behavior","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11641","display_name":"Insect and Pesticide Research","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/honeybee-workers","display_name":"honeybee workers","score":0.8230000138282776},{"id":"https://openalex.org/keywords/life-history-transitions","display_name":"life-history transitions","score":0.8619999885559082},{"id":"https://openalex.org/keywords/insulin-receptor-substrate","display_name":"insulin receptor substrate","score":0.781000018119812},{"id":"https://openalex.org/keywords/phenotypic-plasticity","display_name":"phenotypic plasticity","score":0.949999988079071},{"id":"https://openalex.org/keywords/carbohydrate-metabolism","display_name":"carbohydrate metabolism","score":0.9649999737739563},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":1.0},{"id":"https://openalex.org/keywords/abdominal-tissue","display_name":"abdominal tissue","score":0.5370000004768372},{"id":"https://openalex.org/keywords/rnai-knockdown","display_name":"RNAi knockdown","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C165287380","wikidata":"https://www.wikidata.org/wiki/Q2916569","display_name":"Foraging","level":2,"score":0.8862874507904053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7325708866119385},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5602519512176514},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.49180033802986145},{"id":"https://openalex.org/C152630561","wikidata":"https://www.wikidata.org/wiki/Q6997750","display_name":"Nest (protein structural motif)","level":2,"score":0.44705501198768616},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4453684091567993},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.426724910736084},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4148770868778229},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.38161492347717285},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.35757696628570557},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3079235553741455},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28664132952690125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19106075167655945},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1852729618549347},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15881121158599854},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.11901828646659851},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10485401749610901}],"mesh":[{"descriptor_ui":"D000005","descriptor_name":"Abdomen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001516","descriptor_name":"Bees","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001516","descriptor_name":"Bees","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012330","descriptor_name":"RNA, Double-Stranded","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0024794","doi":"https://doi.org/10.1371/journal.pone.0024794","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0024794","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024794&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2190537","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3182174","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3182174","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3182174","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21969861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21969861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.776.5972","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.776.5972","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a8/25/pone.0024794.PMC3182174.pdf","raw_type":"text"},{"id":"pmh:item:43057","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2286/R.I.43057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400254","display_name":"Arizona State University Library Digital Repository (Arizona State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55732556","host_organization_name":"Arizona State University","host_organization_lineage":["https://openalex.org/I55732556"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a44287bb0e98487c8fe242136363c59d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a44287bb0e98487c8fe242136363c59d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 9, p e24794 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/132897","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/The_Worker_Honeybee_Fat_Body_Proteome_Is_Extensively_Remodeled_Preceding_a_Major_Life_History_Transition/132897","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0024794","doi":"https://doi.org/10.1371/journal.pone.0024794","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0024794","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024794&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3640307914","display_name":null,"funder_award_id":"191699","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G4300217723","display_name":null,"funder_award_id":"185306","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G546234630","display_name":"The Biodemographic Determinants of Life Span","funder_award_id":"P01AG022500","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6928983868","display_name":null,"funder_award_id":"NIA P01 AG22500","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8461217701","display_name":null,"funder_award_id":"AG22500","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8943164936","display_name":null,"funder_award_id":"180504","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"}],"funders":[{"id":"https://openalex.org/F4320321864","display_name":"Generalitat Valenciana","ror":"https://ror.org/0097mvx21"},{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320335271","display_name":"British Columbia Knowledge Development Fund","ror":"https://ror.org/011e3e176"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2078123723.pdf","grobid_xml":"https://content.openalex.org/works/W2078123723.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W88113176","https://openalex.org/W154845424","https://openalex.org/W250963869","https://openalex.org/W1530689181","https://openalex.org/W1531866803","https://openalex.org/W1544591346","https://openalex.org/W1551542325","https://openalex.org/W1609497680","https://openalex.org/W1614231230","https://openalex.org/W1697523131","https://openalex.org/W1966293298","https://openalex.org/W1971047268","https://openalex.org/W1978611087","https://openalex.org/W1980953520","https://openalex.org/W1981153918","https://openalex.org/W1981319205","https://openalex.org/W1986830998","https://openalex.org/W1989324173","https://openalex.org/W1992223827","https://openalex.org/W1992673961","https://openalex.org/W1992843897","https://openalex.org/W1994668150","https://openalex.org/W1996926354","https://openalex.org/W2002810210","https://openalex.org/W2003236418","https://openalex.org/W2006986579","https://openalex.org/W2009745872","https://openalex.org/W2012209682","https://openalex.org/W2016706358","https://openalex.org/W2020260197","https://openalex.org/W2021452913","https://openalex.org/W2022588964","https://openalex.org/W2026455941","https://openalex.org/W2029604353","https://openalex.org/W2033442515","https://openalex.org/W2035506941","https://openalex.org/W2035889834","https://openalex.org/W2036741271","https://openalex.org/W2038506760","https://openalex.org/W2044593992","https://openalex.org/W2044842369","https://openalex.org/W2045488232","https://openalex.org/W2047275456","https://openalex.org/W2050941179","https://openalex.org/W2051178873","https://openalex.org/W2052961933","https://openalex.org/W2058241083","https://openalex.org/W2058249223","https://openalex.org/W2061061015","https://openalex.org/W2061479425","https://openalex.org/W2062989796","https://openalex.org/W2064647254","https://openalex.org/W2066326216","https://openalex.org/W2068780513","https://openalex.org/W2072100156","https://openalex.org/W2076684078","https://openalex.org/W2079139546","https://openalex.org/W2085040781","https://openalex.org/W2089069561","https://openalex.org/W2091510450","https://openalex.org/W2096176410","https://openalex.org/W2098544099","https://openalex.org/W2102750666","https://openalex.org/W2107105699","https://openalex.org/W2107470969","https://openalex.org/W2107498496","https://openalex.org/W2108685753","https://openalex.org/W2110065044","https://openalex.org/W2117327695","https://openalex.org/W2122964302","https://openalex.org/W2123213214","https://openalex.org/W2124971965","https://openalex.org/W2126002967","https://openalex.org/W2128406091","https://openalex.org/W2128635872","https://openalex.org/W2129012099","https://openalex.org/W2131395032","https://openalex.org/W2142213104","https://openalex.org/W2143786004","https://openalex.org/W2143859801","https://openalex.org/W2147158306","https://openalex.org/W2148695400","https://openalex.org/W2153055725","https://openalex.org/W2161091277","https://openalex.org/W2163749582","https://openalex.org/W2206353751","https://openalex.org/W2416402098","https://openalex.org/W7014396012"],"related_works":["https://openalex.org/W2166619901","https://openalex.org/W2021365870","https://openalex.org/W2021452913","https://openalex.org/W2124971965","https://openalex.org/W2355891469","https://openalex.org/W2148695400","https://openalex.org/W7095084564","https://openalex.org/W2141720980","https://openalex.org/W2287127049","https://openalex.org/W2741387185"],"abstract_inverted_index":{"Honeybee":[0],"workers":[1,107],"are":[2],"essentially":[3],"sterile":[4],"female":[5],"helpers":[6],"that":[7,134],"make":[8],"up":[9],"the":[10,41,66,76,83,87,114,140,159,166,186],"majority":[11],"of":[12,54,79,89,101,108,129,148,162,180],"individuals":[13],"in":[14,22,65,82,91,113,165],"a":[15,19,98],"colony.":[16],"Workers":[17],"display":[18],"marked":[20],"change":[21],"physiology":[23],"when":[24],"they":[25,118],"transition":[26,187],"from":[27,188],"in-nest":[28,189],"tasks":[29,190],"to":[30,39,96,137,191],"foraging.":[31,120,192],"Recent":[32],"technological":[33],"advances":[34],"have":[35,50],"made":[36],"it":[37],"possible":[38,102],"unravel":[40],"metabolic":[42],"modifications":[43],"associated":[44],"with":[45,111,125,146,170,185],"this":[46,72],"transition.":[47],"Previous":[48],"studies":[49],"revealed":[51],"extensive":[52],"remodeling":[53],"brain,":[55],"thorax,":[56],"and":[57,145,150,173,177,182],"hypopharyngeal":[58],"gland":[59],"biochemistry.":[60],"However,":[61],"data":[62,154],"on":[63],"changes":[64],"abdomen":[67],"is":[68,135],"scarce.":[69],"To":[70],"narrow":[71],"gap":[73],"we":[74,105],"investigated":[75],"proteomic":[77],"composition":[78],"abdominal":[80],"tissue":[81],"days":[84],"typically":[85],"preceding":[86],"onset":[88],"foraging":[90,138],"honeybee":[92],"workers.":[93],"In":[94],"order":[95],"get":[97],"broader":[99],"representation":[100],"protein":[103],"dynamics,":[104],"used":[106],"two":[109],"genotypes":[110],"differences":[112],"age":[115],"at":[116],"which":[117],"initiate":[119],"This":[121],"approach":[122],"was":[123],"combined":[124],"RNA":[126],"interference-mediated":[127],"downregulation":[128],"an":[130,175],"insulin/insulin-like":[131],"signaling":[132],"component":[133],"central":[136],"behavior,":[139],"insulin":[141],"receptor":[142],"substrate":[143],"(irs),":[144],"measurements":[147],"glucose":[149],"lipid":[151,183],"levels.":[152],"Our":[153],"provide":[155],"new":[156],"insight":[157],"into":[158],"molecular":[160],"underpinnings":[161],"phenotypic":[163],"plasticity":[164],"honeybee,":[167],"invoke":[168],"parallels":[169],"vertebrate":[171],"metabolism,":[172],"support":[174],"integrated":[176],"irs-dependent":[178],"association":[179],"carbohydrate":[181],"metabolism":[184]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}