{"id":"https://openalex.org/W2078112936","doi":"https://doi.org/10.1172/jci112192","title":"3-Hydroxy-3-methylglutaryl coenzyme A reductase in anencephalic and normal human fetal liver.","display_name":"3-Hydroxy-3-methylglutaryl coenzyme A reductase in anencephalic and normal human fetal liver.","publication_year":1985,"publication_date":"1985-11-01","ids":{"openalex":"https://openalex.org/W2078112936","doi":"https://doi.org/10.1172/jci112192","mag":"2078112936","pmid":"https://pubmed.ncbi.nlm.nih.gov/2997298","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/424248"},"language":"en","primary_location":{"id":"doi:10.1172/jci112192","doi":"https://doi.org/10.1172/jci112192","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci112192","pdf_url":"http://www.jci.org/articles/view/112192/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/112192/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103407886","display_name":"Bruce Richard Carr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16452829","display_name":"The University of Texas System","ror":"https://ror.org/01gek1696","country_code":"US","type":"education","lineage":["https://openalex.org/I16452829"]},{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B R Carr","raw_affiliation_strings":["Ida Green Centerfor Reproductive Biology Sciences , and the Departments of Obstetrics and Gynecology, Cell Biology, and Biochemistry , The University of Texas Health Science Center , Dallas , Texas 75235","Obstetrics & Gynecology - Chairman's Office"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ida Green Centerfor Reproductive Biology Sciences , and the Departments of Obstetrics and Gynecology, Cell Biology, and Biochemistry , The University of Texas Health Science Center , Dallas , Texas 75235","institution_ids":["https://openalex.org/I16452829","https://openalex.org/I4210094379"]},{"raw_affiliation_string":"Obstetrics & Gynecology - Chairman's Office","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112832640","display_name":"William E. Rainey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16452829","display_name":"The University of Texas System","ror":"https://ror.org/01gek1696","country_code":"US","type":"education","lineage":["https://openalex.org/I16452829"]},{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W E Rainey","raw_affiliation_strings":["Ida Green Centerfor Reproductive Biology Sciences , and the Departments of Obstetrics and Gynecology, Cell Biology, and Biochemistry , The University of Texas Health Science Center , Dallas , Texas 75235","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ida Green Centerfor Reproductive Biology Sciences , and the Departments of Obstetrics and Gynecology, Cell Biology, and Biochemistry , The University of Texas Health Science Center , Dallas , Texas 75235","institution_ids":["https://openalex.org/I16452829","https://openalex.org/I4210094379"]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111920812","display_name":"J. Ian Mason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J I Mason","raw_affiliation_strings":["University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":0.591,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.57844791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"76","issue":"5","first_page":"1946","last_page":"1949"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmg-coa-reductase","display_name":"HMG-CoA reductase","score":0.9710000157356262},{"id":"https://openalex.org/keywords/anencephaly","display_name":"anencephaly","score":0.9549999833106995},{"id":"https://openalex.org/keywords/fetal-liver","display_name":"fetal liver","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8190000057220459},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.6470000147819519},{"id":"https://openalex.org/keywords/enzyme-protein-levels","display_name":"enzyme protein levels","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.737122118473053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6878575086593628},{"id":"https://openalex.org/C2779123261","wikidata":"https://www.wikidata.org/wiki/Q407635","display_name":"Coenzyme A","level":4,"score":0.6877307891845703},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6723533272743225},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6711685657501221},{"id":"https://openalex.org/C104950815","wikidata":"https://www.wikidata.org/wiki/Q415607","display_name":"HMG-CoA reductase","level":4,"score":0.6673160195350647},{"id":"https://openalex.org/C2777320049","wikidata":"https://www.wikidata.org/wiki/Q2989497","display_name":"Hydroxymethylglutaryl-CoA reductase","level":5,"score":0.5841384530067444},{"id":"https://openalex.org/C104788683","wikidata":"https://www.wikidata.org/wiki/Q259292","display_name":"7-Dehydrocholesterol reductase","level":4,"score":0.5014307498931885},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4487426280975342},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.44737306237220764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41267114877700806},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3371717929840088},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24962854385375977},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.225821852684021},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.10299718379974365},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000757","descriptor_name":"Anencephaly","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005952","descriptor_name":"Glucose-6-Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007163","descriptor_name":"Immunosorbent Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009251","descriptor_name":"NADPH-Ferrihemoprotein Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci112192","doi":"https://doi.org/10.1172/jci112192","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci112192","pdf_url":"http://www.jci.org/articles/view/112192/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:424248","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/424248","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:2997298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2997298","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.923.7621","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.923.7621","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dm5migu4zj3pb.cloudfront.net/manuscripts/112000/112192/JCI85112192.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1172/jci112192","doi":"https://doi.org/10.1172/jci112192","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci112192","pdf_url":"http://www.jci.org/articles/view/112192/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6894480731","display_name":"HUMAN FETAL LIVER:  STEROID AND LIPOPROTEIN METABOLISM","funder_award_id":"R01HD017814","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2078112936.pdf","grobid_xml":"https://content.openalex.org/works/W2078112936.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1563822976","https://openalex.org/W1657952791","https://openalex.org/W1735396068","https://openalex.org/W1775749144","https://openalex.org/W1875726585","https://openalex.org/W1969444003","https://openalex.org/W1981962520","https://openalex.org/W1994867520","https://openalex.org/W1997302512","https://openalex.org/W1997525203","https://openalex.org/W2003861058","https://openalex.org/W2017306132","https://openalex.org/W2018289835","https://openalex.org/W2021537613","https://openalex.org/W2039107087","https://openalex.org/W2043083005","https://openalex.org/W2058859836","https://openalex.org/W2061732933","https://openalex.org/W2068370967","https://openalex.org/W2072159133","https://openalex.org/W2100837269","https://openalex.org/W2108296023","https://openalex.org/W2111817213","https://openalex.org/W2111921447","https://openalex.org/W2133315146","https://openalex.org/W2400309218","https://openalex.org/W2463229841","https://openalex.org/W4247072601","https://openalex.org/W6693674226","https://openalex.org/W6979212819"],"related_works":["https://openalex.org/W2003861058","https://openalex.org/W2061359032","https://openalex.org/W2306479815","https://openalex.org/W2108296023","https://openalex.org/W2058859836","https://openalex.org/W1608575213","https://openalex.org/W2135982800","https://openalex.org/W2043083005","https://openalex.org/W152251335","https://openalex.org/W2150734480"],"abstract_inverted_index":{"In":[0,61,240],"previous":[1],"investigations,":[2],"we":[3,180,242],"have":[4],"found":[5,122],"that":[6,123,224,244,283],"the":[7,12,18,39,46,52,64,67,71,81,93,99,107,124,245,261,272,303,306,318],"liver":[8,116,133,160,191,255],"appears":[9],"to":[10,45,97,209,230,259],"be":[11],"major":[13],"source":[14,26],"of":[15,27,73,83,92,101,111,127,155,214,233,248,264,274,278,305,308,317],"cholesterol":[16,112,249,287,319],"in":[17,22,38,63,85,114,130,158,187,218,252,266,290,293,295],"human":[19,189],"fetus,":[20,41],"and,":[21],"particular,":[23],"a":[24,199,311],"principal":[25],"circulating":[28,276],"low":[29,37,225,231,246,275],"density":[30],"lipo-protein-cholesterol":[31],"(LDL-C).":[32],"LDL-C":[33,84,265],"plasma":[34,87,268],"levels":[35,82,247,263,277],"are":[36,69,88,256],"normal":[40,118,131,188],"most":[42,300],"likely":[43],"due":[44,229,258],"rapid":[47],"uptake":[48],"and":[49,75,80,117,195,280,282,292,314],"metabolism":[50],"by":[51,197,302],"fetal":[53,86,119,132,190,220,254,267,296],"adrenal":[54],"as":[55,269,271],"precursor":[56],"for":[57],"steroid":[58],"hormone":[59],"biosynthesis.":[60],"contrast,":[62],"anencephalic":[65,115,159,219,253],"fetus":[66],"adrenals":[68],"atrophic,":[70],"rate":[72,154],"estrogen":[74],"glucocorticoid":[76],"production":[77],"is":[78],"low,":[79],"high.":[89],"The":[90,153],"purpose":[91],"present":[94],"investigation":[95],"was":[96,135,163,228],"determine":[98],"activity":[100,126,227],"3-hydroxy-3-methylglutaryl":[102],"coenzyme":[103],"A":[104],"(HMG-CoA)":[105],"reductase,":[106,310],"primary":[108,312],"rate-limiting":[109,313],"enzyme":[110,234,316],"biosynthesis,":[113],"liver.":[120,297],"We":[121,206],"specific":[125],"HMG-CoA":[128,156,182,204,215,309],"reductase":[129,157,183,216,226],"microsomes":[134],"0.428":[136],"+/-":[137,148,167,170],"0.054":[138],"nmol":[139],"mevalonate":[140],"formed":[141],"times":[142],"mg-1":[143],"protein":[144,217,235],"X":[145],"min-1":[146],"(mean":[147,169],"SE,":[149,171],"n":[150,172],"=":[151,173],"9).":[152],"microsome":[161],"preparations":[162],"10-fold":[164],"less":[165,176],"(0.040":[166],"0.003)":[168],"7)":[174],"P":[175],"than":[177,237],"0.001.":[178],"Furthermore,":[179],"detected":[181],"(97,000-mol":[184],"wt":[185],"protein)":[186],"after":[192],"SDS":[193],"PAGE":[194],"immunoblotting":[196],"using":[198],"monoclonal":[200],"antibody":[201],"directed":[202],"against":[203],"reductase.":[205],"were":[207],"unable":[208],"detect":[210],"any":[211],"significant":[212],"quantity":[213],"liver,":[221],"which":[222],"indicates":[223],"amounts":[232],"rather":[236],"inactive":[238],"enzyme.":[239],"summary,":[241],"conclude":[243],"synthesis":[250,288],"observed":[251],"probably":[257,301],"both":[260,289],"high":[262],"well":[270],"presence":[273],"estrogens":[279],"glucocorticoids":[281],"these":[284],"factors":[285],"regulate":[286],"vivo":[291],"vitro":[294],"This":[298],"occurs":[299],"modulation":[304],"amount":[307],"regulatory":[315],"biosynthetic":[320],"sequence.":[321]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}