{"id":"https://openalex.org/W2078043377","doi":"https://doi.org/10.1111/j.1440-1711.2005.01407.x","title":"Cellular, molecular and immunological mechanisms in the pathophysiology of vein graft intimal hyperplasia","display_name":"Cellular, molecular and immunological mechanisms in the pathophysiology of vein graft intimal hyperplasia","publication_year":2005,"publication_date":"2005-12-14","ids":{"openalex":"https://openalex.org/W2078043377","doi":"https://doi.org/10.1111/j.1440-1711.2005.01407.x","mag":"2078043377","pmid":"https://pubmed.ncbi.nlm.nih.gov/16519729"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1711.2005.01407.x","doi":"https://doi.org/10.1111/j.1440-1711.2005.01407.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1440-1711.2005.01407.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1711.2005.01407.x","source":{"id":"https://openalex.org/S41617351","display_name":"Immunology and Cell Biology","issn_l":"0004-945X","issn":["0004-945X","0818-9641","1440-1711"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology & Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1711.2005.01407.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017626381","display_name":"Amit Mitra","orcid":"https://orcid.org/0000-0003-4046-7070","observed_orcids":["https://orcid.org/0000-0003-4046-7070"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit K Mitra","raw_affiliation_strings":["Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017758148","display_name":"Deepak M. Gangahar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108358","display_name":"CHI Health Nebraska Heart","ror":"https://ror.org/01srwze89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802665030","https://openalex.org/I2802797007","https://openalex.org/I4210108358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepak M Gangahar","raw_affiliation_strings":["Department of Cardiothoracic and Vascular Surgery, Nebraska Heart Hospital, Lincoln, Nebraska, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic and Vascular Surgery, Nebraska Heart Hospital, Lincoln, Nebraska, USA","institution_ids":["https://openalex.org/I4210108358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019762392","display_name":"Devendra K. Agrawal","orcid":"https://orcid.org/0000-0001-5445-0013","observed_orcids":["https://orcid.org/0000-0001-5445-0013"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devendra K Agrawal","raw_affiliation_strings":["Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, USA","Department of Internal Medicine, Creighton University School of Medicine, Omaha, USA","Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, USA","institution_ids":["https://openalex.org/I114493937"]},{"raw_affiliation_string":"Department of Internal Medicine, Creighton University School of Medicine, Omaha, USA","institution_ids":["https://openalex.org/I114493937"]},{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, USA","institution_ids":["https://openalex.org/I114493937"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.8698,"has_fulltext":true,"cited_by_count":171,"citation_normalized_percentile":{"value":0.65215215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"84","issue":"2","first_page":"115","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.04129999876022339,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vein-graft-intimal-hyperplasia","display_name":"vein graft intimal hyperplasia","score":0.984000027179718},{"id":"https://openalex.org/keywords/vein-graft-restenosis","display_name":"vein graft restenosis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/coronary-artery-bypass-grafting","display_name":"coronary artery bypass grafting","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-migration","display_name":"vascular smooth muscle cell migration","score":0.6850000023841858},{"id":"https://openalex.org/keywords/thrombus-formation","display_name":"thrombus formation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/coagulation-cascade","display_name":"coagulation cascade","score":0.8130000233650208},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.6430000066757202},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":1.0},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.902999997138977},{"id":"https://openalex.org/keywords/graft-patency","display_name":"graft patency","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2779751240","wikidata":"https://www.wikidata.org/wiki/Q16909635","display_name":"Intimal hyperplasia","level":3,"score":0.8334946036338806},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.823912501335144},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5358456373214722},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.49735143780708313},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4816702604293823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4157661199569702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34093227982521057},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.2328827977180481},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10225927829742432}],"mesh":[{"descriptor_ui":"D001026","descriptor_name":"Coronary Artery Bypass","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001026","descriptor_name":"Coronary Artery Bypass","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001157","descriptor_name":"Arterial Occlusive Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001157","descriptor_name":"Arterial Occlusive Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001157","descriptor_name":"Arterial Occlusive Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001157","descriptor_name":"Arterial Occlusive Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006083","descriptor_name":"Graft Occlusion, Vascular","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006083","descriptor_name":"Graft Occlusion, Vascular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006083","descriptor_name":"Graft Occlusion, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051058","descriptor_name":"Oncogene Protein v-akt","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1440-1711.2005.01407.x","doi":"https://doi.org/10.1111/j.1440-1711.2005.01407.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1440-1711.2005.01407.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1711.2005.01407.x","source":{"id":"https://openalex.org/S41617351","display_name":"Immunology and Cell Biology","issn_l":"0004-945X","issn":["0004-945X","0818-9641","1440-1711"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology & Cell Biology","raw_type":"journal-article"},{"id":"pmid:16519729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16519729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology and cell biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1440-1711.2005.01407.x","doi":"https://doi.org/10.1111/j.1440-1711.2005.01407.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1440-1711.2005.01407.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1711.2005.01407.x","source":{"id":"https://openalex.org/S41617351","display_name":"Immunology and Cell Biology","issn_l":"0004-945X","issn":["0004-945X","0818-9641","1440-1711"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology & Cell Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8700000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1297196697","display_name":null,"funder_award_id":"LB 692","funder_id":"https://openalex.org/F4320309641","funder_display_name":"Creighton University"},{"id":"https://openalex.org/G3001133498","display_name":null,"funder_award_id":"R01HL07349","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4143495861","display_name":"FLT3-LIGAND, IMMUNOMODULATION AND THERAPY IN ASTHMA","funder_award_id":"R01HL070885","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6647610613","display_name":"EARLY VASCULAR DEVELOPMENT IN THE HYPERTENSIVE RAT","funder_award_id":"1f32hl007349-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309641","display_name":"Creighton University","ror":"https://ror.org/05wf30g94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2078043377.pdf","grobid_xml":"https://content.openalex.org/works/W2078043377.grobid-xml"},"referenced_works_count":148,"referenced_works":["https://openalex.org/W36951521","https://openalex.org/W75656559","https://openalex.org/W117709402","https://openalex.org/W130332955","https://openalex.org/W139308946","https://openalex.org/W153662504","https://openalex.org/W156329827","https://openalex.org/W165426504","https://openalex.org/W179238286","https://openalex.org/W1493621917","https://openalex.org/W1561516029","https://openalex.org/W1566737177","https://openalex.org/W1583052190","https://openalex.org/W1585236678","https://openalex.org/W1597535871","https://openalex.org/W1655860314","https://openalex.org/W1668039320","https://openalex.org/W1882983705","https://openalex.org/W1965148671","https://openalex.org/W1972789975","https://openalex.org/W1972922050","https://openalex.org/W1976475029","https://openalex.org/W1977798903","https://openalex.org/W1978228632","https://openalex.org/W1981023296","https://openalex.org/W1982130940","https://openalex.org/W1984393490","https://openalex.org/W1984418041","https://openalex.org/W1986420787","https://openalex.org/W1987108104","https://openalex.org/W1987430295","https://openalex.org/W1987688784","https://openalex.org/W1989908905","https://openalex.org/W1990633863","https://openalex.org/W1990841830","https://openalex.org/W1991066835","https://openalex.org/W1993836723","https://openalex.org/W1995798630","https://openalex.org/W1997850379","https://openalex.org/W1999983218","https://openalex.org/W2001793664","https://openalex.org/W2001881013","https://openalex.org/W2001991657","https://openalex.org/W2004078164","https://openalex.org/W2004680931","https://openalex.org/W2004759537","https://openalex.org/W2006432825","https://openalex.org/W2007737411","https://openalex.org/W2008831395","https://openalex.org/W2010489503","https://openalex.org/W2011502676","https://openalex.org/W2014887370","https://openalex.org/W2018621841","https://openalex.org/W2020931266","https://openalex.org/W2023693583","https://openalex.org/W2025267708","https://openalex.org/W2025839324","https://openalex.org/W2026236910","https://openalex.org/W2028259815","https://openalex.org/W2029080338","https://openalex.org/W2030497421","https://openalex.org/W2031833036","https://openalex.org/W2033801757","https://openalex.org/W2034343686","https://openalex.org/W2037994129","https://openalex.org/W2038638713","https://openalex.org/W2041287806","https://openalex.org/W2041526299","https://openalex.org/W2042349233","https://openalex.org/W2042574622","https://openalex.org/W2042893468","https://openalex.org/W2044868069","https://openalex.org/W2047826668","https://openalex.org/W2048916873","https://openalex.org/W2049401036","https://openalex.org/W2053383702","https://openalex.org/W2054255117","https://openalex.org/W2062934426","https://openalex.org/W2063813098","https://openalex.org/W2064909473","https://openalex.org/W2065547075","https://openalex.org/W2068540074","https://openalex.org/W2071985572","https://openalex.org/W2073160536","https://openalex.org/W2073861766","https://openalex.org/W2076510057","https://openalex.org/W2077548365","https://openalex.org/W2077884399","https://openalex.org/W2078870412","https://openalex.org/W2079818105","https://openalex.org/W2079926187","https://openalex.org/W2080471069","https://openalex.org/W2081893638","https://openalex.org/W2082229485","https://openalex.org/W2088430561","https://openalex.org/W2092139196","https://openalex.org/W2092834104","https://openalex.org/W2093250775","https://openalex.org/W2093623759","https://openalex.org/W2093647901","https://openalex.org/W2094706674","https://openalex.org/W2095282566","https://openalex.org/W2100709790","https://openalex.org/W2103019593","https://openalex.org/W2104380573","https://openalex.org/W2106647435","https://openalex.org/W2110640974","https://openalex.org/W2111420633","https://openalex.org/W2112676752","https://openalex.org/W2114215066","https://openalex.org/W2115646199","https://openalex.org/W2118678876","https://openalex.org/W2121231382","https://openalex.org/W2121619780","https://openalex.org/W2124479860","https://openalex.org/W2125841464","https://openalex.org/W2134665522","https://openalex.org/W2136608569","https://openalex.org/W2137035181","https://openalex.org/W2137723881","https://openalex.org/W2137787563","https://openalex.org/W2138136884","https://openalex.org/W2141009209","https://openalex.org/W2142649232","https://openalex.org/W2147114673","https://openalex.org/W2152262140","https://openalex.org/W2152327732","https://openalex.org/W2152962086","https://openalex.org/W2153245546","https://openalex.org/W2158369873","https://openalex.org/W2159506419","https://openalex.org/W2161707562","https://openalex.org/W2162804111","https://openalex.org/W2164731175","https://openalex.org/W2165483382","https://openalex.org/W2169083127","https://openalex.org/W2216263243","https://openalex.org/W2233007968","https://openalex.org/W2252299051","https://openalex.org/W2254281453","https://openalex.org/W2265010625","https://openalex.org/W2292605683","https://openalex.org/W2337043297","https://openalex.org/W2339020512","https://openalex.org/W2410766781","https://openalex.org/W4240558947","https://openalex.org/W4322702671","https://openalex.org/W7005891452"],"related_works":["https://openalex.org/W7165762670","https://openalex.org/W2091248204","https://openalex.org/W2052601577","https://openalex.org/W2090465299","https://openalex.org/W2094973990","https://openalex.org/W2324316698","https://openalex.org/W2380611282","https://openalex.org/W1991610257","https://openalex.org/W2037580905","https://openalex.org/W87618110"],"abstract_inverted_index":{"Coronary":[0],"artery":[1,30],"disease,":[2],"leading":[3,18,71,101,236],"to":[4,35,57,72,102,129,161,194,216,237],"myocardial":[5],"infarction":[6],"and":[7,13,22,80,115,151,158,190,199,212,218,223],"ischaemia,":[8],"affects":[9],"millions":[10],"of":[11,16,20,39,46,55,86,109,122,141,176,185,234],"persons":[12],"is":[14,119,127,192],"one":[15],"the":[17,37,47,87,98,110,120,123,139,166,177,196,214,220,232],"causes":[19],"morbidity":[21],"mortality":[23],"worldwide.":[24],"Invasive":[25],"techniques":[26],"such":[27,164],"as":[28,92,165],"coronary":[29],"bypass":[31],"grafting":[32],"are":[33,90,93,179],"used":[34],"alleviate":[36],"sequelae":[38],"arterial":[40],"occlusion.":[41],"Unfortunately,":[42],"restenosis":[43],"or":[44],"occlusion":[45],"grafted":[48],"conduit":[49],"occurs":[50],"over":[51],"a":[52,60,228],"time":[53],"frame":[54],"months":[56],"years":[58],"with":[59],"gradual":[61],"reduction":[62],"in":[63,66,231],"patency,":[64],"especially":[65],"vein":[67,187,238],"grafts.":[68],"The":[69],"events":[70],"intimal":[73,117],"hyperplasia":[74],"(IH)":[75],"formation":[76,125],"involve":[77],"numerous":[78,152,221],"cellular":[79,84],"molecular":[81],"components.":[82],"Various":[83],"elements":[85],"vessel":[88],"wall":[89],"involved":[91],"leucocyte-endothelial":[94],"interactions":[95],"that":[96,126,226],"trigger":[97],"coagulation":[99],"cascade":[100],"localized":[103],"thrombus":[104],"formation.":[105],"Subsequent":[106],"phenotypic":[107],"modification":[108],"medial":[111],"smooth":[112],"muscle":[113],"cells":[114],"their":[116,159],"migration":[118],"basis":[121],"lesion":[124],"thought":[128],"be":[130],"propagated":[131],"by":[132],"an":[133,144],"immune-mediated":[134],"reaction.":[135],"Despite":[136],"intense":[137],"scrutiny,":[138],"pathophysiology":[140],"IH":[142,235],"remains":[143],"enigma.":[145],"Although":[146],"several":[147],"growth":[148],"factors,":[149],"cytokines":[150],"other":[153],"biomolecules":[154],"have":[155,209],"been":[156,172],"implicated":[157],"relationship":[160],"prohyperplasia":[162],"pathways":[163],"phosphatidyl-inositol":[167],"3-kinase":[168],"(PI3K)-Akt":[169],"pathway":[170],"has":[171],"established,":[173],"many":[174],"pieces":[175],"puzzle":[178],"still":[180],"missing.":[181],"An":[182],"in-depth":[183],"understanding":[184],"early":[186],"graft":[188,239],"adaptation":[189],"progression":[191],"necessary":[193],"improve":[195],"long-term":[197],"prognosis":[198],"develop":[200],"more":[201],"effective":[202],"therapeutic":[203],"measures.":[204],"In":[205],"this":[206],"review,":[207],"we":[208],"critically":[210],"evaluated":[211],"summarized":[213],"literature":[215],"elucidate":[217],"interlink":[219],"established":[222],"emerging":[224],"factors":[225],"play":[227],"key":[229],"role":[230],"development":[233],"restenosis.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}