{"id":"https://openalex.org/W2077997362","doi":"https://doi.org/10.1111/j.1553-2712.2005.tb01536.x","title":"Adenosine A1Antagonism Attenuates \u03b2-adrenergic\u2013resistant Sudden Hypoxic Cardiac Insufficiency","display_name":"Adenosine A1Antagonism Attenuates \u03b2-adrenergic\u2013resistant Sudden Hypoxic Cardiac Insufficiency","publication_year":2005,"publication_date":"2005-04-28","ids":{"openalex":"https://openalex.org/W2077997362","doi":"https://doi.org/10.1111/j.1553-2712.2005.tb01536.x","mag":"2077997362","pmid":"https://pubmed.ncbi.nlm.nih.gov/15860691"},"language":"en","primary_location":{"id":"doi:10.1111/j.1553-2712.2005.tb01536.x","doi":"https://doi.org/10.1111/j.1553-2712.2005.tb01536.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1553-2712.2005.tb01536.x","pdf_url":null,"source":{"id":"https://openalex.org/S171705774","display_name":"Academic Emergency Medicine","issn_l":"1069-6563","issn":["1069-6563","1553-2712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Academic Emergency Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044556689","display_name":"Erhe Gao","orcid":"https://orcid.org/0000-0002-5151-7857","observed_orcids":["https://orcid.org/0000-0002-5151-7857"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I2801887358","display_name":"Jefferson Einstein Philadelphia Hospital","ror":"https://ror.org/03vzpaf33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801887358","https://openalex.org/I4210111876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erhe Gao","raw_affiliation_strings":["Department of Emergency Medicine, Albert Einstein Medical Center, and Department of Emergency Medicine, Thomas Jefferson University School of Medicine, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Albert Einstein Medical Center, and Department of Emergency Medicine, Thomas Jefferson University School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I2801887358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110141011","display_name":"Justin L. Kaplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I2801887358","display_name":"Jefferson Einstein Philadelphia Hospital","ror":"https://ror.org/03vzpaf33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801887358","https://openalex.org/I4210111876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin L. Kaplan","raw_affiliation_strings":["Department of Emergency Medicine, Albert Einstein Medical Center, and Department of Emergency Medicine, Thomas Jefferson University School of Medicine, Philadelphia","Merck Manuals, Merck & Co., Inc., Blue Bell, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Albert Einstein Medical Center, and Department of Emergency Medicine, Thomas Jefferson University School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I2801887358"]},{"raw_affiliation_string":"Merck Manuals, Merck & Co., Inc., Blue Bell, PA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064004806","display_name":"Michelle S. Victain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I18241798","display_name":"Lake Erie College of Osteopathic Medicine","ror":"https://ror.org/04679fh62","country_code":"US","type":"education","lineage":["https://openalex.org/I18241798"]},{"id":"https://openalex.org/I2801887358","display_name":"Jefferson Einstein Philadelphia Hospital","ror":"https://ror.org/03vzpaf33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801887358","https://openalex.org/I4210111876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle S. Victain","raw_affiliation_strings":["Department of Emergency Medicine, Albert Einstein Medical Center, and Department of Emergency Medicine, Thomas Jefferson University School of Medicine, Philadelphia","Lake Erie College of Osteopathic Medicine, Erie, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Albert Einstein Medical Center, and Department of Emergency Medicine, Thomas Jefferson University School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I2801887358"]},{"raw_affiliation_string":"Lake Erie College of Osteopathic Medicine, Erie, PA","institution_ids":["https://openalex.org/I18241798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063950463","display_name":"William C. Dalsey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William C. Dalsey","raw_affiliation_strings":["Department of Emergency Medicine, Kimball Medical Center, Lakewood, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Kimball Medical Center, Lakewood, NJ","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005070247","display_name":"Lawrence de Garavilla","orcid":"https://orcid.org/0000-0001-9075-6984","observed_orcids":["https://orcid.org/0000-0001-9075-6984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lawrence Garavilla","raw_affiliation_strings":["GDL Consulting, Downingtown, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GDL Consulting, Downingtown, PA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":0.1558,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.4055666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"5","first_page":"389","last_page":"395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dobutamine","display_name":"dobutamine","score":0.8289999961853027},{"id":"https://openalex.org/keywords/aminophylline","display_name":"aminophylline","score":0.9980000257492065},{"id":"https://openalex.org/keywords/survival-time","display_name":"survival time","score":0.4410000145435333},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.6890000104904175},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.6320000290870667},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.550000011920929},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2776202631","wikidata":"https://www.wikidata.org/wiki/Q471763","display_name":"Aminophylline","level":2,"score":0.9275219440460205},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8684106469154358},{"id":"https://openalex.org/C2781185063","wikidata":"https://www.wikidata.org/wiki/Q422782","display_name":"Dobutamine","level":3,"score":0.8251593708992004},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6101229786872864},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5157496929168701},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5094898343086243},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.48241767287254333},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.42589670419692993},{"id":"https://openalex.org/C2777383412","wikidata":"https://www.wikidata.org/wiki/Q4770891","display_name":"Antagonism","level":3,"score":0.4180329740047455},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.41492918133735657},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39639055728912354},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37042665481567383},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33497172594070435},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.20793727040290833},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.185951828956604},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18115678429603577},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000628","descriptor_name":"Aminophylline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004280","descriptor_name":"Dobutamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014970","descriptor_name":"Xanthines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058916","descriptor_name":"Adenosine A1 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1553-2712.2005.tb01536.x","doi":"https://doi.org/10.1111/j.1553-2712.2005.tb01536.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1553-2712.2005.tb01536.x","pdf_url":null,"source":{"id":"https://openalex.org/S171705774","display_name":"Academic Emergency Medicine","issn_l":"1069-6563","issn":["1069-6563","1553-2712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Academic Emergency Medicine","raw_type":"journal-article"},{"id":"doi:10.1197/j.aem.2005.02.006","doi":"https://doi.org/10.1197/j.aem.2005.02.006","is_oa":false,"landing_page_url":"https://doi.org/10.1197/j.aem.2005.02.006","pdf_url":null,"source":{"id":"https://openalex.org/S171705774","display_name":"Academic Emergency Medicine","issn_l":"1069-6563","issn":["1069-6563","1553-2712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Academic Emergency Medicine","raw_type":"journal-article"},{"id":"pmid:15860691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15860691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Academic emergency medicine : official journal of the Society for Academic Emergency Medicine","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9726999998092651}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1796803612","https://openalex.org/W1965816788","https://openalex.org/W1977702263","https://openalex.org/W1981105797","https://openalex.org/W1990324219","https://openalex.org/W2004185454","https://openalex.org/W2005787394","https://openalex.org/W2007890766","https://openalex.org/W2008952071","https://openalex.org/W2012905831","https://openalex.org/W2014149352","https://openalex.org/W2032354327","https://openalex.org/W2035807568","https://openalex.org/W2036205982","https://openalex.org/W2052144319","https://openalex.org/W2077119701","https://openalex.org/W2105505691","https://openalex.org/W2114033274","https://openalex.org/W2264142769","https://openalex.org/W2318643618","https://openalex.org/W2410378947","https://openalex.org/W6693219209"],"related_works":["https://openalex.org/W2007890766","https://openalex.org/W2052144319","https://openalex.org/W2318643618","https://openalex.org/W1970701358","https://openalex.org/W2119704115","https://openalex.org/W2274526481","https://openalex.org/W2002507552","https://openalex.org/W3148231094","https://openalex.org/W2166390389","https://openalex.org/W2395963743"],"abstract_inverted_index":{"OBJECTIVES:":[0],"In":[1],"states":[2],"such":[3,33],"as":[4,258],"hypoxia,":[5,158,209,264],"shock,":[6,265],"and":[7,74,115,128,166,195,204,216,224,232,239,249,266],"cardiac":[8,18,35,59,159,267,277],"arrest,":[9,268],"compromised":[10,271],"systemic":[11,272],"oxygenation":[12,275],"or":[13,66,144,274],"perfusion":[14,273],"appears":[15],"to":[16,24,49,76,185,260],"induce":[17],"insufficiency":[19,36,60],"that":[20,53],"can":[21],"be":[22],"resistant":[23],"beta-adrenergic":[25,261],"drugs.":[26],"Elevated":[27],"levels":[28],"of":[29,45,80,99,123,125,174],"adenosine":[30,39,68],"may":[31],"mediate":[32],"beta-adrenergic-resistant":[34],"via":[37],"the":[38,51,100],"A(1)":[40],"receptor":[41],"(A(1)AdoR).":[42],"The":[43],"objective":[44],"this":[46],"study":[47,257],"was":[48,161],"test":[50],"hypothesis":[52],"selective":[54,118],"A(1)AdoR":[55,119,253],"antagonism":[56],"attenuates":[57],"hypoxic":[58],"more":[61,163,245],"efficaciously":[62,246],"than":[63,168,247],"beta(1)-adrenergic":[64],"agonism":[65],"nonselective":[67],"antagonism.":[69],"METHODS:":[70],"Rats":[71],"were":[72,94,212],"paralyzed":[73],"ventilated":[75],"a":[77],"pCO(2)":[78],"level":[79],"35-40":[81],"mm":[82],"Hg.":[83],"Ten":[84],"minutes":[85,127],"before":[86],"hypoxia":[87,179,244],"(inspired":[88],"o(2)":[89],"concentration":[90],"=":[91,106,112,136,142],"5%),":[92],"rats":[93],"treated":[95],"intravenously":[96],"with":[97,121,214,219,228],"one":[98],"following:":[101],"0.1":[102],"mg/kg":[103,109,133],"BG-9719":[104,114,215,231],"(n":[105,111,135,141],"9),":[107],"10":[108,132],"NPC-205":[110,116,217,233],"10;":[113],"are":[117],"antagonists,":[120],"durations":[122],"action":[124],"30-60":[126],"60-90":[129],"minutes,":[130],"respectively),":[131],"aminophylline":[134,165],"12),":[137],"5":[138],"microg/kg/min":[139],"dobutamine":[140,167,220,248],"11),":[143],"control":[145],"solutions.":[146],"These":[147],"drug":[148],"doses":[149],"maximized":[150],"survival":[151,175,235],"duration":[152,173],"in":[153,263,269],"dose-response":[154],"studies.":[155],"RESULTS:":[156],"Before":[157],"work":[160],"increased":[162,180],"by":[164,169],"BG-9719.":[170],"Mean":[171],"(+/-SEM)":[172],"(in":[176],"minutes)":[177],"after":[178,208],"from":[181],"<13":[182],"(control":[183],"solutions)":[184],"13.8":[186],"(+/-1.4)":[187],"(dobutamine),":[188],"20.0":[189],"(+/-1.6)":[190],"(aminophylline),":[191],"31.7":[192],"(+/-4.6)":[193],"(BG-9719),":[194],"40.5":[196],"(+/-7.5)":[197],"(NPC-205)":[198],"(p":[199,221],"<":[200,222],"0.0001).":[201],"Heart":[202],"rate":[203],"dP/dt":[205],"decreased":[206],"rapidly":[207],"but":[210],"decreases":[211],"attenuated":[213],"compared":[218],"0.05)":[223],"tended":[225],"toward":[226],"attenuation":[227],"aminophylline.":[229,251],"CONCLUSIONS:":[230],"improved":[234],"duration,":[236],"heart":[237],"rate,":[238],"left":[240],"ventricular":[241],"contractility":[242],"during":[243],"possibly":[250],"Selective":[252],"antagonists":[254],"warrant":[255],"further":[256],"alternatives":[259],"agonists":[262],"which":[270],"impairs":[276],"output.":[278]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}