{"id":"https://openalex.org/W2077831710","doi":"https://doi.org/10.1002/em.20178","title":"Metabolism of arsenic in Drosophila melanogaster and the genotoxicity of dimethylarsinic acid in the Drosophila wing spot test","display_name":"Metabolism of arsenic in Drosophila melanogaster and the genotoxicity of dimethylarsinic acid in the Drosophila wing spot test","publication_year":2005,"publication_date":"2005-11-22","ids":{"openalex":"https://openalex.org/W2077831710","doi":"https://doi.org/10.1002/em.20178","mag":"2077831710","pmid":"https://pubmed.ncbi.nlm.nih.gov/16304668"},"language":"en","primary_location":{"id":"doi:10.1002/em.20178","doi":"https://doi.org/10.1002/em.20178","is_oa":false,"landing_page_url":"https://doi.org/10.1002/em.20178","pdf_url":null,"source":{"id":"https://openalex.org/S204663187","display_name":"Environmental and Molecular Mutagenesis","issn_l":"0893-6692","issn":["0893-6692","1098-2280"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental and Molecular Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mostapha Rizki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mostapha Rizki","raw_affiliation_strings":["Grup de Mutag\u00e8nesi, Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain","Institut de Ci\u00e8ncia i Tecnologia Ambiental, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grup de Mutag\u00e8nesi, Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Institut de Ci\u00e8ncia i Tecnologia Ambiental, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085751620","display_name":"Elk Kossatz","orcid":"https://orcid.org/0000-0002-8599-3157","observed_orcids":["https://orcid.org/0000-0002-8599-3157"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elk Kossatz","raw_affiliation_strings":["Grup de Mutage\u0300nesi, Departament de Gene\u0300tica i de Microbiologia, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","Grup de Mutag\u00e8nesi, Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grup de Mutage\u0300nesi, Departament de Gene\u0300tica i de Microbiologia, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Grup de Mutag\u00e8nesi, Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108600590","display_name":"Antonia Vel\u00e1zquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonia Vel\u00e1zquez","raw_affiliation_strings":["Grup de Mutage\u0300nesi, Departament de Gene\u0300tica i de Microbiologia, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","Grup de Mutag\u00e8nesi, Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grup de Mutage\u0300nesi, Departament de Gene\u0300tica i de Microbiologia, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Grup de Mutag\u00e8nesi, Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081259383","display_name":"Amadeu Creus","orcid":"https://orcid.org/0000-0003-0848-9448","observed_orcids":["https://orcid.org/0000-0003-0848-9448"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Amadeu Creus","raw_affiliation_strings":["Grup de Mutage\u0300nesi, Departament de Gene\u0300tica i de Microbiologia, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","Grup de Mutag\u00e8nesi, Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grup de Mutage\u0300nesi, Departament de Gene\u0300tica i de Microbiologia, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Grup de Mutag\u00e8nesi, Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087654635","display_name":"Massimo Farina","orcid":"https://orcid.org/0000-0002-5370-2693","observed_orcids":["https://orcid.org/0000-0002-5370-2693"]},"institutions":[{"id":"https://openalex.org/I2800387288","display_name":"European Commission","ror":"https://ror.org/00k4n6c32","country_code":"BE","type":"government","lineage":["https://openalex.org/I1320481043","https://openalex.org/I2800387288"]},{"id":"https://openalex.org/I4210118689","display_name":"Joint Research Centre","ror":"https://ror.org/02qezmz13","country_code":"IT","type":"government","lineage":["https://openalex.org/I1320481043","https://openalex.org/I2800387288","https://openalex.org/I4210118689","https://openalex.org/I4210161702"]}],"countries":["BE","IT"],"is_corresponding":false,"raw_author_name":"Massimo Farina","raw_affiliation_strings":["European Commission, Institute for Health and Consumer Protection, ECVAM Unit, Joint Research Centre, 21020 Ispra, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Commission, Institute for Health and Consumer Protection, ECVAM Unit, Joint Research Centre, 21020 Ispra, Italy","institution_ids":["https://openalex.org/I2800387288","https://openalex.org/I4210118689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014271924","display_name":"Salvador Fortaner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800387288","display_name":"European Commission","ror":"https://ror.org/00k4n6c32","country_code":"BE","type":"government","lineage":["https://openalex.org/I1320481043","https://openalex.org/I2800387288"]},{"id":"https://openalex.org/I4210118689","display_name":"Joint Research Centre","ror":"https://ror.org/02qezmz13","country_code":"IT","type":"government","lineage":["https://openalex.org/I1320481043","https://openalex.org/I2800387288","https://openalex.org/I4210118689","https://openalex.org/I4210161702"]}],"countries":["BE","IT"],"is_corresponding":false,"raw_author_name":"Salvador Fortaner","raw_affiliation_strings":["European Commission, Institute for Health and Consumer Protection, ECVAM Unit, Joint Research Centre, 21020 Ispra, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Commission, Institute for Health and Consumer Protection, ECVAM Unit, Joint Research Centre, 21020 Ispra, Italy","institution_ids":["https://openalex.org/I2800387288","https://openalex.org/I4210118689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113566864","display_name":"Enrico Sabbioni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800387288","display_name":"European Commission","ror":"https://ror.org/00k4n6c32","country_code":"BE","type":"government","lineage":["https://openalex.org/I1320481043","https://openalex.org/I2800387288"]},{"id":"https://openalex.org/I4210118689","display_name":"Joint Research Centre","ror":"https://ror.org/02qezmz13","country_code":"IT","type":"government","lineage":["https://openalex.org/I1320481043","https://openalex.org/I2800387288","https://openalex.org/I4210118689","https://openalex.org/I4210161702"]}],"countries":["BE","IT"],"is_corresponding":false,"raw_author_name":"Enrico Sabbioni","raw_affiliation_strings":["European Commission, Institute for Health and Consumer Protection, ECVAM Unit, Joint Research Centre, 21020 Ispra, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Commission, Institute for Health and Consumer Protection, ECVAM Unit, Joint Research Centre, 21020 Ispra, Italy","institution_ids":["https://openalex.org/I2800387288","https://openalex.org/I4210118689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000064654","display_name":"Ricard Marcos","orcid":"https://orcid.org/0000-0001-7891-357X","observed_orcids":["https://orcid.org/0000-0001-7891-357X"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Ricardo Marcos","raw_affiliation_strings":["Grup de Mutage\u0300nesi, Departament de Gene\u0300tica i de Microbiologia, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","Institut de Cie\u0300ncia i Tecnologia Ambiental, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","Grup de Mutag\u00e8nesi, Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain","Institut de Ci\u00e8ncia i Tecnologia Ambiental, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grup de Mutage\u0300nesi, Departament de Gene\u0300tica i de Microbiologia, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Institut de Cie\u0300ncia i Tecnologia Ambiental, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Grup de Mutag\u00e8nesi, Departament de Gen\u00e8tica i de Microbiologia, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Institut de Ci\u00e8ncia i Tecnologia Ambiental, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5000064654"],"corresponding_institution_ids":["https://openalex.org/I123044942"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.0882,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.75742842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"3","first_page":"162","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.461899995803833,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arsenic-metabolism","display_name":"arsenic metabolism","score":0.9470000267028809},{"id":"https://openalex.org/keywords/dimethylarsinic-acid","display_name":"dimethylarsinic acid","score":0.8289999961853027},{"id":"https://openalex.org/keywords/inorganic-arsenic","display_name":"inorganic arsenic","score":0.7760000228881836},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.875},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9570000171661377},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/methylated-arsenic-metabolites","display_name":"methylated arsenic metabolites","score":0.8420000076293945},{"id":"https://openalex.org/keywords/organoarsenic-compounds","display_name":"organoarsenic compounds","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.8801848888397217},{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.8184486031532288},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.6913151741027832},{"id":"https://openalex.org/C2776639595","wikidata":"https://www.wikidata.org/wiki/Q221696","display_name":"Mutagen","level":3,"score":0.6136621236801147},{"id":"https://openalex.org/C127764415","wikidata":"https://www.wikidata.org/wiki/Q6356161","display_name":"Mitotic crossover","level":4,"score":0.5219314098358154},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.5114618539810181},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5068188309669495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4018952548503876},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3845227360725403},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33536893129348755},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.26847946643829346},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.2399713099002838},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.21214643120765686},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12134206295013428},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06403830647468567}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001151","descriptor_name":"Arsenic","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001151","descriptor_name":"Arsenic","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001151","descriptor_name":"Arsenic","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002101","descriptor_name":"Cacodylic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002101","descriptor_name":"Cacodylic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002101","descriptor_name":"Cacodylic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009152","descriptor_name":"Mutagenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009152","descriptor_name":"Mutagenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009152","descriptor_name":"Mutagenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020261","descriptor_name":"Arsenic Poisoning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020261","descriptor_name":"Arsenic Poisoning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020261","descriptor_name":"Arsenic Poisoning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/em.20178","doi":"https://doi.org/10.1002/em.20178","is_oa":false,"landing_page_url":"https://doi.org/10.1002/em.20178","pdf_url":null,"source":{"id":"https://openalex.org/S204663187","display_name":"Environmental and Molecular Mutagenesis","issn_l":"0893-6692","issn":["0893-6692","1098-2280"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental and Molecular Mutagenesis","raw_type":"journal-article"},{"id":"pmid:16304668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16304668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental and molecular mutagenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1605923556","https://openalex.org/W1964175376","https://openalex.org/W1966447709","https://openalex.org/W1974952864","https://openalex.org/W1977896790","https://openalex.org/W1981076973","https://openalex.org/W1987382327","https://openalex.org/W1996123491","https://openalex.org/W1997565776","https://openalex.org/W2011501030","https://openalex.org/W2017021346","https://openalex.org/W2023632989","https://openalex.org/W2024720872","https://openalex.org/W2024842128","https://openalex.org/W2027327239","https://openalex.org/W2038888949","https://openalex.org/W2041976716","https://openalex.org/W2050562499","https://openalex.org/W2053299183","https://openalex.org/W2058156329","https://openalex.org/W2059115578","https://openalex.org/W2063521203","https://openalex.org/W2064343777","https://openalex.org/W2067947422","https://openalex.org/W2076235131","https://openalex.org/W2079987670","https://openalex.org/W2081265985","https://openalex.org/W2086201153","https://openalex.org/W2087266655","https://openalex.org/W2093860135","https://openalex.org/W2093907780","https://openalex.org/W2101624738","https://openalex.org/W2118621252","https://openalex.org/W2126041423","https://openalex.org/W2127674752","https://openalex.org/W2141106752","https://openalex.org/W2160008637","https://openalex.org/W2162088045","https://openalex.org/W2167586301","https://openalex.org/W2168284337","https://openalex.org/W2169964092","https://openalex.org/W2203139323","https://openalex.org/W2489378082","https://openalex.org/W3193495653","https://openalex.org/W4285719527","https://openalex.org/W4291980969"],"related_works":["https://openalex.org/W2658682382","https://openalex.org/W4323037479","https://openalex.org/W4311607074","https://openalex.org/W4206255385","https://openalex.org/W3025486376","https://openalex.org/W3166827729","https://openalex.org/W2236776555","https://openalex.org/W198173689","https://openalex.org/W2753303236","https://openalex.org/W2082613811"],"abstract_inverted_index":{"Inorganic":[0],"arsenic":[1,25,37,48,62,77,105,178,187,203,209],"is":[2,38],"nongenotoxic":[3,39],"in":[4,17,40,81,85,111,157,193,211],"the":[5,53,70,82,86,103,123,147,158,174,184,197,205,212],"Drosophila":[6,41,64,92,101,194],"melanogaster":[7],"wing":[8,125,214],"somatic":[9],"mutation":[10],"and":[11,59,66,68,142,165,204],"recombination":[12],"test":[13],"(SMART).":[14],"Recent":[15],"evidence":[16],"mammalian":[18],"systems":[19],"indicates":[20],"that":[21,35,91],"methylated":[22,50,73,104,208],"metabolites":[23],"of":[24,72,100,113,131,149,160,177,183,186,191,199,207],"are":[26,44,93,171],"more":[27],"genotoxic":[28],"than":[29],"inorganic":[30,36,61,97,202],"arsenic.":[31,98],"Thus,":[32],"we":[33,56,121],"hypothesized":[34],"because":[42],"they":[43],"unable":[45,94],"to":[46,49,63,95,102,145],"biotransform":[47],"forms.":[51],"In":[52,119],"present":[54],"study,":[55],"fed":[57],"trivalent":[58],"pentavalent":[60],"larvae":[65],"adults":[67],"measured":[69],"production":[71],"derivatives.":[74],"No":[75],"biomethylated":[76],"species":[78,210],"were":[79],"found":[80],"organisms":[83],"or":[84],"growth":[87],"medium,":[88],"which":[89,128],"suggests":[90],"biomethylate":[96],"Exposure":[99],"derivative":[106],"dimethylarsinic":[107],"acid":[108],"(DMA(V))":[109],"resulted":[110],"incorporation":[112],"this":[114],"organoarsenic":[115],"compound":[116],"without":[117],"demethylation.":[118],"addition,":[120],"used":[122],"SMART":[124,213],"spot":[126,215],"assay,":[127],"measures":[129],"loss":[130],"heterozygosity":[132],"(LOH)":[133],"resulting":[134],"from":[135],"gene":[136],"mutation,":[137],"chromosomal":[138],"rearrangement,":[139],"chromosome":[140,143],"breakage,":[141],"loss,":[144],"evaluate":[146],"genotoxicity":[148,185,200,206],"DMA.":[150],"DMA":[151],"by":[152],"itself":[153],"induced":[154],"significant":[155],"increases":[156],"frequency":[159],"total":[161],"spots,":[162,164],"small":[163],"large":[166],"single":[167],"spots.":[168],"These":[169],"results":[170],"consistent":[172],"with":[173],"important":[175],"role":[176],"biomethylation":[179,192],"as":[180],"a":[181],"determinant":[182],"compounds.":[188],"The":[189],"absence":[190],"could":[195],"explain":[196],"lack":[198],"for":[201],"assay.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}