{"id":"https://openalex.org/W2077826375","doi":"https://doi.org/10.1172/jci114584","title":"Molecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypes.","display_name":"Molecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypes.","publication_year":1990,"publication_date":"1990-05-01","ids":{"openalex":"https://openalex.org/W2077826375","doi":"https://doi.org/10.1172/jci114584","mag":"2077826375","pmid":"https://pubmed.ncbi.nlm.nih.gov/2110188","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/296585"},"language":"en","primary_location":{"id":"doi:10.1172/jci114584","doi":"https://doi.org/10.1172/jci114584","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114584","pdf_url":"http://www.jci.org/articles/view/114584/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/114584/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072875873","display_name":"Anne Davidson","orcid":"https://orcid.org/0000-0002-4081-6464","observed_orcids":["https://orcid.org/0000-0002-4081-6464"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Davidson","raw_affiliation_strings":["Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047976389","display_name":"A Manheimer-Lory","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Manheimer-Lory","raw_affiliation_strings":["Departments ofMicrobiology and Immunology, and Medicine, Albert Einstein College ofMedicine, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments ofMicrobiology and Immunology, and Medicine, Albert Einstein College ofMedicine, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015927371","display_name":"Cynthia B. Aranow","orcid":"https://orcid.org/0000-0001-9299-0053","observed_orcids":["https://orcid.org/0000-0001-9299-0053"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Aranow","raw_affiliation_strings":["Departments ofMicrobiology and Immunology, and Medicine, Albert Einstein College ofMedicine, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments ofMicrobiology and Immunology, and Medicine, Albert Einstein College ofMedicine, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108370675","display_name":"Raymond D. A. Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Peterson","raw_affiliation_strings":["Departments ofMicrobiology and Immunology, and Medicine, Albert Einstein College ofMedicine, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments ofMicrobiology and Immunology, and Medicine, Albert Einstein College ofMedicine, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038245924","display_name":"Noreen Hannigan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Hannigan","raw_affiliation_strings":["Departments ofMicrobiology and Immunology, and Medicine, Albert Einstein College ofMedicine, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments ofMicrobiology and Immunology, and Medicine, Albert Einstein College ofMedicine, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089808423","display_name":"Betty Diamond","orcid":"https://orcid.org/0000-0002-3250-3804","observed_orcids":["https://orcid.org/0000-0002-3250-3804"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Diamond","raw_affiliation_strings":["Departments ofMicrobiology and Immunology, and Medicine, Albert Einstein College ofMedicine, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments ofMicrobiology and Immunology, and Medicine, Albert Einstein College ofMedicine, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":13.2304,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.99233157,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"85","issue":"5","first_page":"1401","last_page":"1409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-dna-antibodies","display_name":"anti-DNA antibodies","score":0.8059999942779541},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9490000009536743},{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"somatic hypermutation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/antibody-idiotype","display_name":"antibody idiotype","score":0.6140000224113464},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.7039999961853027},{"id":"https://openalex.org/keywords/myeloma-proteins","display_name":"myeloma proteins","score":0.765999972820282},{"id":"https://openalex.org/keywords/cdr3","display_name":"CDR3","score":0.9179999828338623},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7360000014305115},{"id":"https://openalex.org/keywords/antigen-selection","display_name":"antigen selection","score":0.4650000035762787},{"id":"https://openalex.org/keywords/ebv-transformed-b-cell-lines","display_name":"EBV-transformed B cell lines","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7161813974380493},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5360202193260193},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.5276355147361755},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5038725733757019},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49857664108276367},{"id":"https://openalex.org/C2910082366","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Immunoglobulin Idiotypes","level":5,"score":0.4652840197086334},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.46466171741485596},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.44983798265457153},{"id":"https://openalex.org/C96007430","wikidata":"https://www.wikidata.org/wiki/Q3776943","display_name":"Immunoglobulin heavy chain","level":3,"score":0.4180568754673004},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.41049039363861084},{"id":"https://openalex.org/C74505204","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Idiotype","level":4,"score":0.4048537015914917},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2982821464538574},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.23668387532234192},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20080488920211792}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000888","descriptor_name":"Antibodies, Anti-Idiotypic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007130","descriptor_name":"Immunoglobulin Idiotypes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007132","descriptor_name":"Immunoglobulin Isotypes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci114584","doi":"https://doi.org/10.1172/jci114584","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114584","pdf_url":"http://www.jci.org/articles/view/114584/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:296585","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/296585","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:2110188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2110188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci114584","doi":"https://doi.org/10.1172/jci114584","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114584","pdf_url":"http://www.jci.org/articles/view/114584/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1552342080","display_name":"CELL BIOLOGY OF LYMPHOID CELLS","funder_award_id":"P01AI010702","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2839937961","display_name":null,"funder_award_id":"AR32371","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000877850","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA013330","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2077826375.pdf","grobid_xml":"https://content.openalex.org/works/W2077826375.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W161233626","https://openalex.org/W1489816623","https://openalex.org/W1518143030","https://openalex.org/W1535006969","https://openalex.org/W1546739249","https://openalex.org/W1570093729","https://openalex.org/W1582951726","https://openalex.org/W1589632590","https://openalex.org/W1592916805","https://openalex.org/W1600675771","https://openalex.org/W1603320271","https://openalex.org/W1936480433","https://openalex.org/W1949595835","https://openalex.org/W1968981783","https://openalex.org/W1975431323","https://openalex.org/W1976299958","https://openalex.org/W1986244503","https://openalex.org/W1986586522","https://openalex.org/W2002242108","https://openalex.org/W2014861565","https://openalex.org/W2022805735","https://openalex.org/W2024455898","https://openalex.org/W2033134260","https://openalex.org/W2038624224","https://openalex.org/W2042253682","https://openalex.org/W2043863020","https://openalex.org/W2045397591","https://openalex.org/W2059300566","https://openalex.org/W2073493181","https://openalex.org/W2095741007","https://openalex.org/W2104323863","https://openalex.org/W2108912679","https://openalex.org/W2113135200","https://openalex.org/W2122397178","https://openalex.org/W2132320414","https://openalex.org/W2136917720","https://openalex.org/W2151441602","https://openalex.org/W2160209304","https://openalex.org/W2170045209","https://openalex.org/W4313320835"],"related_works":["https://openalex.org/W2162320902","https://openalex.org/W2034055984","https://openalex.org/W2068711579","https://openalex.org/W7096678729","https://openalex.org/W2080839248","https://openalex.org/W2061659811","https://openalex.org/W2102566053","https://openalex.org/W2058753589","https://openalex.org/W2104743689","https://openalex.org/W1975906233"],"abstract_inverted_index":{"We":[0],"report":[1],"the":[2,12,61,68,86,89,99,104,122,164,169],"molecular":[3],"characterization":[4],"of":[5,25,121,131,157,172],"2A4,":[6],"an":[7,37,54],"IgG,":[8,55],"DNA-binding":[9,58],"antibody":[10,33,63,107,166],"bearing":[11],"3I":[13],"and":[14,85,98,161],"F4":[15],"idiotypes":[16],"which":[17],"are":[18],"associated":[19],"with":[20,27,46,127,135],"anti-DNA":[21],"antibodies":[22],"in":[23],"serum":[24],"patients":[26],"systemic":[28],"lupus":[29],"erythematosus":[30],"(SLE).":[31],"The":[32,71,147],"is":[34,52,75,92,103],"produced":[35],"by":[36,77,114],"EBV-transformed":[38],"B":[39],"cell":[40],"line":[41],"derived":[42,93],"from":[43,94],"a":[44,78,81,95,111,115,128,136],"patient":[45],"multiple":[47],"myeloma":[48,50,69],"whose":[49],"protein":[51],"also":[53],"3I-reactive,":[56],"F4-reactive,":[57],"immunoglobulin,":[59],"although":[60],"2A4":[62,72,123,137,165],"does":[64],"not":[65],"itself":[66],"represent":[67],"protein.":[70],"heavy":[73],"chain":[74,91],"encoded":[76,113],"VH4":[79],"gene,":[80],"D-D":[82,116],"gene":[83,97,125],"fusion":[84],"JH6":[87],"gene;":[88],"light":[90],"Vk1":[96],"Jk2":[100],"gene.":[101],"This":[102],"first":[105],"human":[106,152],"shown":[108],"to":[109,143],"have":[110],"CDR3":[112],"fusion.":[117],"DNA":[118,133],"sequence":[119],"analysis":[120],"VH":[124],"together":[126],"Southern":[129],"blot":[130],"genomic":[132],"probed":[134],"VH-specific":[138],"oligonucleotide":[139],"strongly":[140],"suggest":[141,162],"it":[142],"be":[144,155],"somatically":[145,158],"mutated.":[146],"data":[148],"provide":[149],"evidence":[150],"that":[151,163],"autoantibodies":[153],"can":[154],"products":[156],"mutated":[159],"genes":[160],"may":[167],"reflect":[168],"selective":[170],"pressure":[171],"antigen.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
