{"id":"https://openalex.org/W2077742005","doi":"https://doi.org/10.1021/bi00632a018","title":"Evidence for site equivalence in the reaction mechanism of horse liver alcohol dehydrogenase with aromatic substrates at alkaline pH","display_name":"Evidence for site equivalence in the reaction mechanism of horse liver alcohol dehydrogenase with aromatic substrates at alkaline pH","publication_year":1977,"publication_date":"1977-06-01","ids":{"openalex":"https://openalex.org/W2077742005","doi":"https://doi.org/10.1021/bi00632a018","mag":"2077742005","pmid":"https://pubmed.ncbi.nlm.nih.gov/18165"},"language":"en","primary_location":{"id":"doi:10.1021/bi00632a018","doi":"https://doi.org/10.1021/bi00632a018","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00632a018","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074085891","display_name":"Charles. Weidig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles F. Weidig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039706629","display_name":"Herbert R. Halvorson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herbert R. Halvorson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110875015","display_name":"Joseph D. Shore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph D. Shore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":7.4293,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.98370806,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"16","issue":"13","first_page":"2916","last_page":"2922"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/horse-liver-alcohol-dehydrogenase","display_name":"horse liver alcohol dehydrogenase","score":0.9470000267028809},{"id":"https://openalex.org/keywords/reaction-mechanism","display_name":"reaction mechanism","score":0.7770000100135803},{"id":"https://openalex.org/keywords/aromatic-substrates","display_name":"aromatic substrates","score":0.9850000143051147},{"id":"https://openalex.org/keywords/alkaline-ph","display_name":"alkaline pH","score":0.9100000262260437},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.5519999861717224},{"id":"https://openalex.org/keywords/dehydrogenase","display_name":"dehydrogenase","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.663547158241272},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5788636803627014},{"id":"https://openalex.org/C2780069185","wikidata":"https://www.wikidata.org/wiki/Q7977945","display_name":"Equivalence (formal languages)","level":2,"score":0.5328505635261536},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.45332804322242737},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.3337627351284027},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32028523087501526},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18164792656898499},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.1671943962574005}],"mesh":[{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001547","descriptor_name":"Benzaldehydes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001592","descriptor_name":"Benzyl Alcohols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001593","descriptor_name":"Benzyl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00632a018","doi":"https://doi.org/10.1021/bi00632a018","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00632a018","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:18165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W120446455","https://openalex.org/W1518847852","https://openalex.org/W1589879043","https://openalex.org/W1959540130","https://openalex.org/W1978827049","https://openalex.org/W2004166990","https://openalex.org/W2009740193","https://openalex.org/W2026854579","https://openalex.org/W2027074254","https://openalex.org/W2035626564","https://openalex.org/W2039557588","https://openalex.org/W2043392162","https://openalex.org/W2055550103","https://openalex.org/W2059717838","https://openalex.org/W2066344387","https://openalex.org/W2073312123","https://openalex.org/W2093514476","https://openalex.org/W2329174981","https://openalex.org/W2332775680"],"related_works":["https://openalex.org/W2026854579","https://openalex.org/W1966382672","https://openalex.org/W1987941631","https://openalex.org/W2035626564","https://openalex.org/W2074033202","https://openalex.org/W2951104523","https://openalex.org/W2037575401","https://openalex.org/W17428881","https://openalex.org/W2064347238","https://openalex.org/W2007190423"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVArticleNEXTEvidence":[3],"for":[4,155],"site":[5],"equivalence":[6],"in":[7],"the":[8,59,90,95,124,135,148,151,156,163,169],"reaction":[9],"mechanism":[10],"of":[11,62,97,123],"horse":[12],"liver":[13],"alcohol":[14],"dehydrogenase":[15],"with":[16,144,179],"aromatic":[17],"substrates":[18],"at":[19,142],"alkaline":[20],"pHCharles":[21],"F.":[22],"Weidig,":[23],"Herbert":[24],"R.":[25],"Halvorson,":[26],"and":[27,72,77,106,150,167,183,185],"Joseph":[28],"D.":[29],"ShoreCite":[30],"this:":[31],"Biochemistry":[32],"1977,":[33],"16,":[34],"13,":[35],"2916\u20132922Publication":[36],"Date":[37],"(Print):June":[38],"1,":[39],"1977Publication":[40],"History":[41],"Published":[42],"online1":[43],"May":[44],"2002Published":[45],"inissue":[46],"1":[47],"June":[48],"1977https://pubs.acs.org/doi/10.1021/bi00632a018https://doi.org/10.1021/bi00632a018research-articleACS":[49],"PublicationsRequest":[50],"reuse":[51],"permissionsArticle":[52],"Views61Altmetric-Citations22LEARN":[53],"ABOUT":[54],"THESE":[55],"METRICSArticle":[56],"Views":[57],"are":[58,81,94],"COUNTER-compliant":[60],"sum":[61],"full":[63],"text":[64],"article":[65,129],"downloads":[66],"since":[67],"November":[68],"2008":[69],"(both":[70],"PDF":[71],"HTML)":[73],"across":[74],"all":[75],"institutions":[76],"individuals.":[78],"These":[79],"metrics":[80],"regularly":[82],"updated":[83,107],"to":[84,89],"reflect":[85],"usage":[86],"leading":[87],"up":[88],"last":[91],"few":[92],"days.Citations":[93],"number":[96],"other":[98],"articles":[99],"citing":[100],"this":[101],"article,":[102],"calculated":[103],"by":[104],"Crossref":[105,113],"daily.":[108],"Find":[109,159],"more":[110,160],"information":[111,161],"about":[112,147],"citation":[114],"counts.The":[115],"Altmetric":[116,164],"Attention":[117,165],"Score":[118,166],"is":[119,171],"a":[120,127,140],"quantitative":[121],"measure":[122],"attention":[125],"that":[126],"research":[128],"has":[130],"received":[131],"online.":[132],"Clicking":[133],"on":[134,162],"donut":[136],"icon":[137],"will":[138],"load":[139],"page":[141],"altmetric.com":[143],"additional":[145],"details":[146],"score":[149,170],"social":[152],"media":[153],"presence":[154],"given":[157],"article.":[158],"how":[168],"calculated.":[172],"Share":[173,188],"Add":[174],"toView":[175],"InAdd":[176],"Full":[177],"Text":[178],"ReferenceAdd":[180],"Description":[181],"ExportRISCitationCitation":[182],"abstractCitation":[184],"referencesMore":[186],"Options":[187],"onFacebookTwitterWechatLinked":[189],"InRedditEmail":[190],"Other":[191],"access":[192],"optionsGet":[193],"e-Alertsclose":[194],"Get":[195],"e-Alerts":[196]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}