{"id":"https://openalex.org/W2077588587","doi":"https://doi.org/10.1002/lt.21690","title":"Microdialysis monitoring of porcine liver metabolism during warm ischemia with arterial and portal clamping","display_name":"Microdialysis monitoring of porcine liver metabolism during warm ischemia with arterial and portal clamping","publication_year":2009,"publication_date":"2009-02-25","ids":{"openalex":"https://openalex.org/W2077588587","doi":"https://doi.org/10.1002/lt.21690","mag":"2077588587","pmid":"https://pubmed.ncbi.nlm.nih.gov/19242995"},"language":"en","primary_location":{"id":"doi:10.1002/lt.21690","doi":"https://doi.org/10.1002/lt.21690","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lt.21690","pdf_url":null,"source":{"id":"https://openalex.org/S205547219","display_name":"Liver Transplantation","issn_l":"1527-6465","issn":["1527-6465","1527-6473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074522451","display_name":"Johan Ungerstedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Johan Ungerstedt","raw_affiliation_strings":["Department of Physiology and Pharmacology, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden. johan.ungerstedt@telia.com","Department of Physiology and Pharmacology, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden","Department of Transplantation Surgery, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden. johan.ungerstedt@telia.com","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Transplantation Surgery, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066684311","display_name":"Greg Nowak","orcid":"https://orcid.org/0000-0001-8766-8860","observed_orcids":["https://orcid.org/0000-0001-8766-8860"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Greg Nowak","raw_affiliation_strings":["Department of Transplantation Surgery, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Surgery, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078829134","display_name":"Urban Ungerstedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Urban Ungerstedt","raw_affiliation_strings":["Department of Physiology and Pharmacology, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012898633","display_name":"Bo\u2010G\u00f6ran Ericzon","orcid":"https://orcid.org/0000-0001-5604-2427","observed_orcids":["https://orcid.org/0000-0001-5604-2427"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bo-G\u00f6ran Ericzon","raw_affiliation_strings":["Department of Transplantation Surgery, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Surgery, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074522451"],"corresponding_institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"],"apc_list":{"value":2150,"currency":"USD","value_usd":2150},"apc_paid":null,"fwci":4.7229,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.94549113,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"3","first_page":"280","last_page":"286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microdialysis","display_name":"microdialysis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/liver-metabolism","display_name":"hepatic metabolism","score":0.6570000052452087},{"id":"https://openalex.org/keywords/warm-ischemia","display_name":"warm ischemia","score":0.9200000166893005},{"id":"https://openalex.org/keywords/hepatic-artery-occlusion","display_name":"hepatic artery occlusion","score":0.8970000147819519},{"id":"https://openalex.org/keywords/portal-vein-obstruction","display_name":"portal vein occlusion","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lactate-pyruvate-ratio","display_name":"lactate/pyruvate ratio","score":0.9269999861717224},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.5569999814033508},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.9430000185966492},{"id":"https://openalex.org/keywords/glycerol","display_name":"glycerol","score":0.9829999804496765},{"id":"https://openalex.org/keywords/porcine-liver","display_name":"porcine liver","score":0.6290000081062317},{"id":"https://openalex.org/keywords/reperfusion","display_name":"reperfusion","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.9635307788848877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8066026568412781},{"id":"https://openalex.org/C2777858674","wikidata":"https://www.wikidata.org/wiki/Q1248007","display_name":"Vascular occlusion","level":2,"score":0.5050573945045471},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4736707806587219},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4477887749671936},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4379216432571411},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.344817578792572},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003250","descriptor_name":"Constriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006221","descriptor_name":"Halothane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006499","descriptor_name":"Hepatic Artery","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008102","descriptor_name":"Liver Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008874","descriptor_name":"Midazolam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017551","descriptor_name":"Microdialysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/lt.21690","doi":"https://doi.org/10.1002/lt.21690","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lt.21690","pdf_url":null,"source":{"id":"https://openalex.org/S205547219","display_name":"Liver Transplantation","issn_l":"1527-6465","issn":["1527-6465","1527-6473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Transplantation","raw_type":"journal-article"},{"id":"pmid:19242995","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19242995","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7911877105","display_name":null,"funder_award_id":"K2001-33X-03574-30B","funder_id":"https://openalex.org/F4320323764","funder_display_name":"Medicinska Forskningsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320323764","display_name":"Medicinska Forskningsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W272218","https://openalex.org/W1761130430","https://openalex.org/W1966451705","https://openalex.org/W1966854590","https://openalex.org/W1968005739","https://openalex.org/W1970377252","https://openalex.org/W1974283923","https://openalex.org/W1978543130","https://openalex.org/W1987018561","https://openalex.org/W1988436060","https://openalex.org/W2000298120","https://openalex.org/W2002297820","https://openalex.org/W2002963429","https://openalex.org/W2014909289","https://openalex.org/W2024697481","https://openalex.org/W2031149483","https://openalex.org/W2033299680","https://openalex.org/W2034351483","https://openalex.org/W2038741916","https://openalex.org/W2047639047","https://openalex.org/W2056016152","https://openalex.org/W2056821611","https://openalex.org/W2066513755","https://openalex.org/W2069564335","https://openalex.org/W2076864927","https://openalex.org/W2081849695","https://openalex.org/W2087421641","https://openalex.org/W2091360583","https://openalex.org/W2095334865","https://openalex.org/W2104012222","https://openalex.org/W2110161413","https://openalex.org/W2144499458","https://openalex.org/W2147702476","https://openalex.org/W2150707173","https://openalex.org/W2162273714","https://openalex.org/W2215961027","https://openalex.org/W2300756219","https://openalex.org/W2342990029","https://openalex.org/W2405817927","https://openalex.org/W2407792766","https://openalex.org/W2417418147","https://openalex.org/W2422282127","https://openalex.org/W2426477512","https://openalex.org/W3187080404","https://openalex.org/W4300908246","https://openalex.org/W6688259301"],"related_works":["https://openalex.org/W2154313457","https://openalex.org/W3162687449","https://openalex.org/W1988436060","https://openalex.org/W7067673305","https://openalex.org/W2071702768","https://openalex.org/W2016487036","https://openalex.org/W1974283923","https://openalex.org/W2024697481","https://openalex.org/W2027251844","https://openalex.org/W3119728939"],"abstract_inverted_index":{"Early":[0],"detection":[1],"of":[2,21,27,85,165,180,205],"vascular":[3,49,203],"complications":[4,204],"following":[5],"liver":[6,23,156,206,214,234],"surgery":[7,235],"is":[8,175],"crucial.":[9],"In":[10,106,134,193],"the":[11,29,33,55,62,80,101,107,111,121,131,135,141,144,150,163,172,181,195,213,223],"present":[12],"study,":[13],"intrahepatic":[14,238],"microdialysis":[15,42,74,196],"was":[16,38,104],"used":[17,45],"for":[18,69,231],"continuous":[19],"monitoring":[20],"porcine":[22],"metabolism":[24],"during":[25,120,130],"occlusion":[26,124,137,179,186,218],"either":[28],"portal":[30,136,185,217],"vein":[31],"or":[32],"hepatic":[34,63,182],"artery.":[35,183],"Our":[36,152],"aim":[37],"to":[39,46,127,236],"assess":[40],"whether":[41],"can":[43,198],"be":[44,229],"detect":[47,199],"impaired":[48],"inflow":[50],"by":[51,160,178,216],"metabolic":[52,70,191,210,239],"changes":[53,161,211],"in":[54,58,61,140,162,171,188,212,222,233],"liver.":[56],"Changes":[57],"metabolite":[59],"concentrations":[60,164],"interstitium":[64],"were":[65,76,93,147,219],"taken":[66],"as":[67,158],"markers":[68],"changes.":[71,192,240],"After":[72],"laparotomy,":[73],"catheters":[75],"introduced":[77],"directly":[78],"into":[79],"liver,":[81],"enabling":[82],"repeated":[83],"measurements":[84],"local":[86],"metabolism.":[87],"Glucose,":[88],"lactate,":[89,113,167],"pyruvate,":[90],"and":[91,100,115,125,139,168,170,200],"glycerol":[92,169],"analyzed":[94],"at":[95],"bedside":[96],"every":[97],"20":[98],"minutes,":[99],"lactate/pyruvate":[102,116,173],"ratio":[103,117],"calculated.":[105],"arterial":[108,202],"clamping":[109],"group,":[110,143],"glucose,":[112,166],"glycerol,":[114],"significantly":[118],"increased":[119],"2-hour":[122],"vessel":[123],"returned":[126],"baseline":[128],"levels":[129],"3-hour":[132],"reperfusion.":[133],"group":[138],"control":[142],"measured":[145],"metabolites":[146],"stable":[148],"throughout":[149],"experiment.":[151],"findings":[153],"show":[154],"that":[155],"metabolism,":[157],"reflected":[159],"ratio,":[174],"markedly":[176],"affected":[177],"Surprisingly,":[184],"resulted":[187],"no":[189],"major":[190],"conclusion,":[194],"technique":[197],"monitor":[201,237],"surgery,":[207],"whereas":[208],"potential":[209],"induced":[215],"not":[220],"seen":[221],"current":[224],"study.":[225],"Microdialysis":[226],"may":[227],"thus":[228],"suitable":[230],"use":[232]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}