{"id":"https://openalex.org/W2077582166","doi":"https://doi.org/10.1002/cncr.26311","title":"Distinct clinical features and outcomes in never\u2010smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement","display_name":"Distinct clinical features and outcomes in never\u2010smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement","publication_year":2011,"publication_date":"2011-06-30","ids":{"openalex":"https://openalex.org/W2077582166","doi":"https://doi.org/10.1002/cncr.26311","mag":"2077582166","pmid":"https://pubmed.ncbi.nlm.nih.gov/21720997"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.26311","doi":"https://doi.org/10.1002/cncr.26311","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cncr.26311","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/89847","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047490140","display_name":"Hye Ryun Kim","orcid":"https://orcid.org/0000-0002-1842-9070","observed_orcids":["https://orcid.org/0000-0002-1842-9070"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4405258038","display_name":"Yonsei Cancer Hospital","ror":"https://ror.org/0005vby86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791","https://openalex.org/I4405258038"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Ryun Kim","raw_affiliation_strings":["Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea","Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4405258038"]},{"raw_affiliation_string":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020903295","display_name":"Hyo Sup Shim","orcid":"https://orcid.org/0000-0002-5718-3624","observed_orcids":["https://orcid.org/0000-0002-5718-3624"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyo Sup Shim","raw_affiliation_strings":["Department of Pathology, Ewha Woman's University School of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ewha Woman's University School of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001356432","display_name":"Jin-Haeng Chung","orcid":"https://orcid.org/0000-0002-6527-3814","observed_orcids":["https://orcid.org/0000-0002-6527-3814"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin\u2010Haeng Chung","raw_affiliation_strings":["Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084081275","display_name":"Young Ju Lee","orcid":"https://orcid.org/0000-0001-5294-7368","observed_orcids":["https://orcid.org/0000-0001-5294-7368","https://orcid.org/0000-0001-6108-2845"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Joo Lee","raw_affiliation_strings":["Department of Medical Oncology, National Cancer Center, Goyang, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, National Cancer Center, Goyang, Korea","institution_ids":["https://openalex.org/I4210120052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004798515","display_name":"Yun Kyoung Hong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun Kyoung Hong","raw_affiliation_strings":["JE UK Institute for Cancer Research, Gumi City, Kyungbuk, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JE UK Institute for Cancer Research, Gumi City, Kyungbuk, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024676627","display_name":"Sun Young Rha","orcid":"https://orcid.org/0000-0002-2512-4531","observed_orcids":["https://orcid.org/0000-0002-2512-4531"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4405258038","display_name":"Yonsei Cancer Hospital","ror":"https://ror.org/0005vby86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791","https://openalex.org/I4405258038"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun Young Rha","raw_affiliation_strings":["Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea","Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4405258038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100734442","display_name":"Se Hoon Kim","orcid":"https://orcid.org/0000-0001-7516-7372","observed_orcids":["https://orcid.org/0000-0001-7516-7372","https://orcid.org/0000-0001-7818-1903"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4405258038","display_name":"Yonsei Cancer Hospital","ror":"https://ror.org/0005vby86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791","https://openalex.org/I4405258038"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Se Hoon Kim","raw_affiliation_strings":["Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea","Department of Pathology, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4405258038"]},{"raw_affiliation_string":"Department of Pathology, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003546968","display_name":"Sang\u2010Jun Ha","orcid":"https://orcid.org/0000-0002-1192-6031","observed_orcids":["https://orcid.org/0000-0002-1192-6031"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang\u2010Jun Ha","raw_affiliation_strings":["Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036711342","display_name":"Se Kyu Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Se Kyu Kim","raw_affiliation_strings":["Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061232210","display_name":"Kyung Soo Chung","orcid":"https://orcid.org/0000-0003-1604-8730","observed_orcids":["https://orcid.org/0000-0003-1604-8730"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung Young Chung","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032293215","display_name":"Ross Andrew Soo","orcid":"https://orcid.org/0000-0002-3053-3997","observed_orcids":["https://orcid.org/0000-0002-3053-3997"]},"institutions":[{"id":"https://openalex.org/I4210103786","display_name":"National University Cancer Institute, Singapore","ror":"https://ror.org/025yypj46","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210103786","https://openalex.org/I4210150261"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ross Soo","raw_affiliation_strings":["Department of Hematology-Oncology, National University Cancer Institute, National University Health System, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology-Oncology, National University Cancer Institute, National University Health System, Singapore","institution_ids":["https://openalex.org/I4210103786","https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106559017","display_name":"Joo Hang Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4405258038","display_name":"Yonsei Cancer Hospital","ror":"https://ror.org/0005vby86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791","https://openalex.org/I4405258038"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joo Hang Kim","raw_affiliation_strings":["Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea","Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4405258038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064697305","display_name":"Byoung Chul Cho","orcid":"https://orcid.org/0000-0002-5562-270X","observed_orcids":["https://orcid.org/0000-0002-5562-270X"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4405258038","display_name":"Yonsei Cancer Hospital","ror":"https://ror.org/0005vby86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791","https://openalex.org/I4405258038"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Byoung Chul Cho","raw_affiliation_strings":["","Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea","Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4405258038"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5064697305"],"corresponding_institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791","https://openalex.org/I4405258038"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":11.6613,"has_fulltext":true,"cited_by_count":149,"citation_normalized_percentile":{"value":0.98828306,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"118","issue":"3","first_page":"729","last_page":"739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/never-smokers","display_name":"never smokers","score":0.9789999723434448},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":1.0},{"id":"https://openalex.org/keywords/alk-rearrangement","display_name":"ALK rearrangement","score":0.9879999756813049},{"id":"https://openalex.org/keywords/oncogenic-alterations","display_name":"oncogenic alterations","score":0.734000027179718},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9449999928474426},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9829999804496765},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9980000257492065},{"id":"https://openalex.org/keywords/east-asian-patients","display_name":"East Asian patients","score":0.9179999828338623},{"id":"https://openalex.org/keywords/mutually-exclusive-mutations","display_name":"mutually exclusive mutations","score":0.5370000004768372},{"id":"https://openalex.org/keywords/disease-progression-risk","display_name":"disease progression risk","score":0.5210000276565552},{"id":"https://openalex.org/keywords/targeted-therapy-response","display_name":"targeted therapy response","score":0.5460000038146973},{"id":"https://openalex.org/keywords/drug-resistance-mutations","display_name":"drug resistance mutations","score":0.31700000166893005},{"id":"https://openalex.org/keywords/egfr-exon-19-deletion","display_name":"EGFR exon 19 deletion","score":0.4970000088214874},{"id":"https://openalex.org/keywords/egfr-exon-21-l858r","display_name":"EGFR exon 21 L858R","score":0.8370000123977661},{"id":"https://openalex.org/keywords/egfr-tki-resistance","display_name":"EGFR tyrosine kinase inhibitor resistance","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.895104169845581},{"id":"https://openalex.org/C117643217","wikidata":"https://www.wikidata.org/wiki/Q17824987","display_name":"Anaplastic lymphoma kinase","level":4,"score":0.793276309967041},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6527953743934631},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6156221628189087},{"id":"https://openalex.org/C2779422266","wikidata":"https://www.wikidata.org/wiki/Q5186964","display_name":"Crizotinib","level":4,"score":0.5812975168228149},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5729344487190247},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5237914323806763},{"id":"https://openalex.org/C2775999482","wikidata":"https://www.wikidata.org/wiki/Q18031208","display_name":"ROS1","level":4,"score":0.5070409774780273},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5015413761138916},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.46619194746017456},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4558079242706299},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.4432346820831299},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4333837330341339},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4328426122665405},{"id":"https://openalex.org/C2992511266","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"Gene rearrangement","level":3,"score":0.41208207607269287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2535944879055023},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.22902074456214905},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22275778651237488},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.18206283450126648},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1479291021823883},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09387955069541931},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.08249443769454956},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077548","descriptor_name":"Anaplastic Lymphoma Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/cncr.26311","doi":"https://doi.org/10.1002/cncr.26311","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cncr.26311","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:21720997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21720997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"},{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/89847","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/89847","pdf_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/89847","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"T201200216.pdf","raw_type":"Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/116983","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/116983","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/89847","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/89847","pdf_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/89847","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"T201200216.pdf","raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2077582166.pdf","grobid_xml":"https://content.openalex.org/works/W2077582166.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W141200712","https://openalex.org/W1517005017","https://openalex.org/W1984852348","https://openalex.org/W1994225895","https://openalex.org/W2010561682","https://openalex.org/W2014187999","https://openalex.org/W2019539885","https://openalex.org/W2029218729","https://openalex.org/W2031494655","https://openalex.org/W2033955437","https://openalex.org/W2034232365","https://openalex.org/W2040511804","https://openalex.org/W2040636001","https://openalex.org/W2041992600","https://openalex.org/W2055402151","https://openalex.org/W2064166219","https://openalex.org/W2070011883","https://openalex.org/W2073688130","https://openalex.org/W2075150949","https://openalex.org/W2091639070","https://openalex.org/W2096132642","https://openalex.org/W2101619794","https://openalex.org/W2101995865","https://openalex.org/W2103225497","https://openalex.org/W2104224322","https://openalex.org/W2104830962","https://openalex.org/W2111025748","https://openalex.org/W2113791135","https://openalex.org/W2114471055","https://openalex.org/W2121005606","https://openalex.org/W2121389354","https://openalex.org/W2122553809","https://openalex.org/W2128401861","https://openalex.org/W2135619328","https://openalex.org/W2138145250","https://openalex.org/W2139110945","https://openalex.org/W2139248078","https://openalex.org/W2140775102","https://openalex.org/W2141534384","https://openalex.org/W2142989887","https://openalex.org/W2143859186","https://openalex.org/W2154905832","https://openalex.org/W2159433279","https://openalex.org/W2161821474","https://openalex.org/W2161876687","https://openalex.org/W2163798887","https://openalex.org/W2166084034","https://openalex.org/W2166351918","https://openalex.org/W2168106545","https://openalex.org/W2317909048","https://openalex.org/W2409732833"],"related_works":["https://openalex.org/W2045083570","https://openalex.org/W2284158343","https://openalex.org/W2906815738","https://openalex.org/W2066758858","https://openalex.org/W2012797512","https://openalex.org/W2534193912","https://openalex.org/W2572661095","https://openalex.org/W1843944436","https://openalex.org/W1973354199","https://openalex.org/W2124502961"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,31,139],"objectives":[2],"of":[3,11,22,106,121,187,257,265],"this":[4,247],"study":[5],"were":[6,70,78,95,136],"to":[7,16,87,255,288,294],"determine":[8],"the":[9,37,104,122,166,180,185,244,249],"proportions":[10],"major":[12,259],"oncogenic":[13,260],"alterations":[14,135,261,282],"and":[15,43,53,77,89,93,113,130,158,171,222,252,277],"examine":[17],"survival":[18,142,236,272],"in":[19,36,61,74,83,119,161,262],"genotype-specific":[20,290],"subsets":[21,291],"never-smokers":[23,65,268],"with":[24,66,145,163,192,207,219,232,269,297],"nonsmall":[25],"cell":[26],"lung":[27],"cancer":[28],"(NSCLC).":[29],"METHODS:":[30],"authors":[32],"concurrently":[33],"analyzed":[34],"mutations":[35,115],"epidermal":[38],"growth":[39],"factor":[40],"receptor":[41],"(EGFR)":[42],"v-Ki-ras2":[44],"Kirsten":[45],"rat":[46],"sarcoma":[47],"viral":[48],"oncogene":[49],"homolog":[50],"(KRAS)":[51],"genes":[52,124],"investigated":[54],"anaplastic":[55],"lymphoma":[56],"kinase":[57,148,299],"(ALK)":[58],"gene":[59],"rearrangements":[60,69],"samples":[62],"from":[63],"229":[64,102],"NSCLC.":[67,270],"ALK":[68,109,172,220],"identified":[71],"by":[72,80,97],"fluorescent":[73],"situ":[75],"hybridization":[76],"confirmed":[79],"immunohistochemistry.":[81],"Mutations":[82],"EGFR":[84,107,146,164,193,208],"(exons":[85],"18":[86],"21)":[88],"KRAS":[90,111,169,233],"(codons":[91],"12":[92],"13)":[94],"determined":[96],"direct":[98],"sequencing.":[99],"RESULTS:":[100],"Of":[101],"tumors,":[103],"frequency":[105],"mutations,":[108,112,165,170,209],"rearrangements,":[110,173,221],"no":[114],"(wild":[116],"type":[117],"[WT])":[118],"any":[120],"3":[123,258],"(WT/WT/WT)":[125],"was":[126,151,195,248],"48%,":[127],"8.3%,":[128],"3.5%,":[129],"40.2%,":[131],"respectively.":[132,174],"All":[133],"genetic":[134,286],"mutually":[137],"exclusive.":[138],"median":[140],"progression-free":[141],"after":[143,190],"treatment":[144,191,296],"tyrosine":[147],"inhibitors":[149],"(TKIs)":[150],"12.8":[152],"months,":[153,155,157],"6.3":[154],"2.1":[156],"1.6":[159],"months":[160],"patients":[162,206,218,231],"WT/WT/WT":[167],"genotype,":[168],"In":[175],"a":[176,263],"Cox":[177],"regression":[178],"model,":[179],"adjusted":[181],"hazard":[182],"ratio":[183],"for":[184,205,217,230],"risk":[186],"disease":[188],"progression":[189],"TKIs":[194],"0.59":[196],"(95%":[197,211,224],"confidence":[198],"interval":[199],"[CI],":[200],"0.40-0.87;":[201],"P":[202,214,227],"=":[203,228],".008)":[204],"4.58":[210],"CI,":[212,225],"2.07-10.15;":[213],"<":[215],".001)":[216],"4.23":[223],"1.65-10.8;":[226],".003)":[229],"mutations.":[234],"Overall":[235],"also":[237],"differed":[238,274],"significantly":[239],"among":[240,275],"genotypes.":[241],"CONCLUSIONS:":[242],"To":[243],"authors'":[245],"knowledge,":[246],"largest":[250],"comprehensive":[251],"concurrent":[253],"analysis":[254],"date":[256],"cohort":[264],"East":[266],"Asian":[267],"Because":[271],"outcomes":[273],"genotypes,":[276],"drugs":[278],"that":[279],"target":[280],"specific":[281],"currently":[283],"are":[284],"available,":[285],"profiling":[287],"identify":[289],"can":[292],"lead":[293],"successful":[295],"appropriate":[298],"inhibitors.":[300]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}